Skip to main content
Explore URMC
menu

Chen Yan, Ph.D.

Publications

Showing all 156 journal articles & 9 books available

Journal Articles

4/2018
Zhang F, Yan C, Wei C, Yao Y, Ma X, Gong Z, Liu S, Zang D, Chen J, Shi FD, Hao J. "Vinpocetine Inhibits NF-?B-Dependent Inflammation in Acute Ischemic Stroke Patients." Translational stroke research.. 2018 Apr; 9(2):174-184. Epub 2017 Jul 09.

2017
Jiang D ; Zhuang J; Peng W; Lu Y; Liu H; Zhao Q; Chi C; Li X; Zhu G; Xu X; Yan C; Xu Y; Ge J; Pang J. "Phospholipase Cg1 mediates intima formation through Akt-Notch1 signaling independent of the phospholipase activity". J Am Heart Assoc. pii: e005537. PMCID: PMC5663637. 2017; : 6(7).

2017
Wu M, Zhang Y, Xu X, Zhou Q, Li J-D, Yan C. "Vinpocetine Attenuates Pathological Cardiac Remodeling by inhibiting Cardiac Hypertrophy and Fibrosis." Cardiovascular Drugs & Therapy. 2017; 31: 157-166.

2016
Knight W; Chen S; Zhang Y; Oikawa M; Wu M-; Abe J-I; Yan C. "PDE1C deficiency antagonizes pathological cardiac remodeling and dysfunction". Proc. Nat. Acad. Sci., USA, pii: 201607728. PMCID: PMC5111646. 2016; .

2016
Knight W; Mickelsen DM; Moravec CS,; Small EM; Abe J-I, and Yan C. "PDE1C deficiency antagonizes pathological cardiac remodeling and dysfunction." Proc. Nat. Acad. Sci., USA, pii: 201607728. PMCID: PMC5111646. 2016; .

2016
Wu M-P; Zhang Y-S; Zhou Q-M; Xiong J; Dong Y-R and Yan C. "Higenamine protects ischemia/reperfusion induced cardiac injury and myocyte apoptosis through activation of ?2-AR/PI3K/AKT signaling." Pharmacological Research, PMCID: PMC4772856. 2016; 104: 115-123.

2015
Huang C-K; Luo J; Lai K-P; Wang ; Pang H; Chang E; Yan C, Sparks J; Lee A-O; Cho J, and Chang C. "Androgen receptor promotes abdominal aortic aneurysm development via modulating inflammatory interleukin-1? and transforming growth factor-?1 expression." Hypertension,PMCID: PMC4658219. 2015; 66: 881-891.

2015
Lee J-Y; Komatsu K; Lee B-C; Miyata M; Bohn AO; Xu H; Yan C*; and Li J-D*. "Vinpocetine inhibits Streptococcus pneumonia-induced up-regulation of mucin MUC5AC expression via induction of MKP-1 phosphatase. The Journal of Immunology, PMCID: PMC4456630. (* Co-corresponding authors)." 2015; 194: 5990-8.

2015
Shi X; O'Neill MM; MacDonnell S; Brookes Paul; Yan C, and Berk BC. "The RSK Inhibitor BIX02565 Limits Cardiac Ischemia/Reperfusion Injury". Journal of Cardiovascular Pharmacology and Therapeutics, pii: 1074248415591700. 2015; .

2015
Lin JR; Shen WL; Yan C, and Gao PJ. "Down regulation of Dynamin-related protein 1 (DRP1) contributes to impaired autophagic flux and angiogenic function in senescent endothelial cells." Arterioscler Thromb Vasc Bio. 2015; 35: 1413-22.

2015
Susuki-Miyata S; Miyata M; Lee B-C; Xu H; Kai H; Yan C*, and Li J-D* (* Co-corresponding authors). "Cross talk between PKA-C? and p65 mediates synergistic induction of PDE4B by roflumilast and NTHi." Proc. Nat. Acad. Sci., USA, 112:E1800-9. PMCID: PMC4394257. 2015; .

2015
Cai Y; Nagel DJ; Zhou Q Li F; Pi X; Knight PA; and Yan C. "Role of cAMP-Phosphodiesterase 1C Signaling in Regulating Growth Factor Receptor Stability, Vascular Smooth Muscle Cell Growth, and Neointimal Hyperplasia. Editorial Commentary: Satoh K, Kikuchi N, Kurosawa R, and Shimokawa H, PDE1C Negatively Regulates Growth Factor Receptor Degradation and Promotes VSMC Proliferation. Circulation Research, 116: 1098-1100". Circulation Research, PMCID: PMC4702253. 2015; : 1120-1132.

2015
Ruan CC; Ge Q; Li Y; Li XD; Chen DR; Ji KD; Wu YJ; Sheng LJ; Yan C; Zhu DL; and Gao PJ. "Complement-mediated macrophage polarization in perivascular adipose tissue contributes to vascular injury in deoxycorticosterone acetate-salt mice." Arterioscler Thromb Vasc Bio. 2015; 35: 598-606.

2014
Yin G, Sheu TJ, Menon P, Pang J, Ho HC, Shi S, Xie C, Smolock E, Yan C, Zuscik MJ, Berk BC. "Impaired angiogenesis during fracture healing in GPCR kinase 2 interacting protein-1 (GIT-1) knock out mice." PLoS One, 9: e89127. 2014; .

2014
Iwaya S; Oikawa M; Yan C; Takeishi Y. "Phosphodiesterase 3A1 protects the heart against angiotensin II-induced cardiac remodeling through regulating transforming growth factor-? expression." International Heart Journal,. 2014; 55: 165-8.

2014
Spindel ON; Burke RM; Yan C; Berk BC. "Thioredoxin-interacting protein is a biomechanical regulator of SRC activity: key role in endothelial cell stress fiber formation." Circulation Research PMCID: PMC3981969. 2014; 114: 1125-32.

2013
Oikawa M; Wu M; Lim S; Knight WE; Miller CL; Cai Y; Lu Y; Blaxall BC; Takeishi Y; Abe J; and Yan C. "Cyclic nucleotide phosphodiesterase 3A1 protects the heart against ischemia-reperfusion injury." J. Mol. Cell. Cardiol. PMCID: PMC3869570. 2013; 64C:(11-19).

2013
Cai Y; Li J-D; and Yan C. "Vinpocetine Attenuates Lipid Accumulation and Atherosclerosis Formation." Biochem. Biophys. Res. Commun., PMCID: PMC3682500. 2013; 434:: 439-43.

2013
Komatsu K; Lee JY; Miyata M; Hyang Lim J; Jono H; Koga T; Xu H,; Yan C; Kai H; Li JD. "Inhibition of PDE4B suppressed inflammation by increasing expression of the deubiquitinase CYLD." Nat. Commun. PMCID: PMC3644066. 2013; 4:: 1684.

2013
Park SY; Shi X; Pang J; Yan C; Berk BC. "Thioredoxin-interacting protein mediates sustained VEGFR2 signaling in endothelial cells required for angiogenesis." Arterioscler Thromb Vasc Biol. PMCID: PMC3629821. 2013; 33:: 737-43.

2012
Silva J; Polesskaya O; Knight WE; Zheng JT; Granger M; Ontiveros F; Feng C; Yan C; and Dewhurst S. "Transient hypercapnia reveals an underlying cerebrovascular pathology in a murine model for HIV-1 associated neuroinflammation: role of NO-cGMP signaling and normalization by inhibition of cyclic nucleotide phosphodiesterase-5." Journal of Neuroinflammation PMCID: PMC3526511. 2012; 9:: 253.

2012
Ghigo A; Perino A; Mehel H; Zahradnlkova A Jr; Morello F; Leroy J; Nikolaev VO; Damilano F; Cimino J; De Luca E; Richter W; Westenbroek R; Catterall WA; Zhang J,; Yan C; Conti M; Gomez AM,; Vandecasteele G; Hirsch E; Fischmeister R. "Phosphoinositide 3-Kinase ? Protects Against Catecholamine-Induced Ventricular Arrhythmia Through Protein Kinase A-Mediated Regulation of Distinct Phosphodiesterases." CirculationPMCID: PMC3913165. 2012; 126:: 2073-83.

2012
Cai Y; Knight W; Guo S; Li J; Knight P; and Yan C. "Vinpocetine suppresses pathological vascular remodeling through inhibiting vascular smooth muscle cell proliferation and migration." Journal of Pharmacology and Experimental Therapy. PMID: 22915768; PMCID: PMC3477207. 2012; 343: 479-88.

2012
Xu X; Woo CH; Steere RR; Lee BC; Huang Y; Wu J; Pang J; Lim JH; Xu H,; Zhang W; Konduru AS; Yan C, Cheeseman MT; Brown SD; Li JD. "EVI1 acts as an Inducible Negative-Feedback Regulator of NF-?B by Inhibiting p65 Acetylation. J Immunol. PMCID: PMC3370108." 2012; 188(12):: 6371-80.

2012
Lee J; Komatsu K; Lee BC; Lim JH; Jono H; Xu H; Kai H; Zhang ZJ; Yan C; Li JD. "PDE4B mediates ERK-dependent up-regulation of mucin MUC5AC by S. pneumoniae by inhibiting cAMP-PKA-dependent MKP-1 pathway." J Biol Chem. PMCID: PMC3391144. 2012; 287:: 22799-811.

2012
Lim JH; Jono H; Komatsu K; Woo CH; Lee J; Miyata M; Matsuno T,; Xu X; Huang Y; Zhang W; Park SH; Kim YI; Choi YD; Shen H; Heo KS; Xu H; Bourne P; Koga T; Xu H; Yan C; Wang B; Chen LF; Feng XH; Li JD. "CYLD negatively regulates transforming growth factor-?-signaling via deubiquitinating Akt." Nat Commun.PMCID: PMC3337989. 2012; 3:: 771.

2012
Spindel ON; Yan C; and BC Berk. "Thioredoxin Interacting Protein (TXNIP) mediates nuclear-to-plasma membrane communication: role in vascular endothelial growth factor 2 (VEGFR2) signaling." Arterioscler Thromb Vasc Biol. PMCID: PMC3876410. 2012; 32:: 1264-70.

2012
Wang X; Nigro P; World C; Fujiwara K; Yan C; and BC Berk. "Thioredoxin Interacting Protein Promotes Endothelial Cell Inflammation in Response to Disturbed Flow by Increasing Leukocyte Adhesion and Repressing Kruppel-Like Factor 2." Circulation Research. PMCID: PMC3333844. 2012; 110:: 560-8.

2012
Le N; Takei Y; Shishido T; Woo CH; Chang E; Heo KS; Lee H; Lu Y; Morrell C; Oikawa M; McClain C; Wang X; Tournier C; Molina CA; Taunton J; Yan C; Fujiwara K; Patterson C; Yang J; Abe JI. "p90RSK targets the ERK5-CHIP ubiquitin E3 ligase activity in diabetic hearts and promotes cardiac apoptosis and dysfunction." Circulation Research. PMCID: PMC3306797. 2012; 110:: 536-50.

2011
Miller CL; Cai Y; Oikawa M; Thomas T; Dostmann WR; Zaccolo M; Fujiwara K; Yan C. "Cyclic nucleotide phosphodiesterase 1A: a key regulator of cardiac fibroblast activation and extracellular matrix remodeling in the heart." Basic Res. Cardiol. PMCID: PMC4114346. 2011; 106:: 1023-39.

2011
Shi X; Yan C; Nadtochiy SM; Abe J; Brookes PS; Berk BC. "p90 ribosomal S6 kinase regulates activity of the renin-angiotensin system: a pathogenic mechanism for ischemia-reperfusion injury." J Mol Cell Cardiol. PMCID: PMC3124613. 2011; 51:: 272-5.

2011
Cai Y; Miller CL; Nagel DJ; Jeon K; Lim S; Gao P; Kinight P; and Yan C. "Cyclic nucleotide phosphodiesterase 1 regulates lysosome-dependent type I collagen degradation in vascular smooth muscle cells." Arterioscler Thromb Vasc Biol. PMCID: PMC4114343. 2011; 31:: 616-623.

2011
Satoh K; Nigro P; Zeidan A; Soe NN; Jaffré F; Oikawa M; O'Dell MR; Cui Z; Menon P; Lu Y; Mohan A; Yan C; Blaxall BC; Berk BC. "Cyclophilin A Promotes Cardiac Hypertrophy in Apolipoprotein E-Deficient Mice." Arterioscler Thromb Vasc Biol. PMCID: PMC3085960. 2011; 31: 1: 116-23.

2010
Jeon K; Jono H; Cai Y; Lim S; Liu X; Gao P; Abe J; Li J; and Yan C. "Ca2+/calmodulin-stimulated Phosphodiesterase 1A regulates the beta-catenin/TCF signal pathway through PP2A B56 gamma subunit in vascular smooth muscle cells." FEBS Journal PMCID: PMC3059601. 2010; 277:: 5026-39.

2010
Woo CH; Le NT; Shishido T; Chang E; Lee H; Heo KS; Michelsen DM; Lu Y; McClain C; Spangenberg T; Yan C; Molina CA; Yang J; Patterson C,; Abe JI. "Novel role of C terminus of Hsc70-interacting protein (CHIP) ubiquitin ligase on inhibiting cardiac apoptosis and dysfunction via regulating ERK5-mediated degradation of inducible cAMP early repressor." FASEB J. PMCID: PMC2992371. 2010; 24:: 4917-28.

2010
Jeon K; Xu X; Aizawa T; Lim JH,; Jono H; Kwoen D; Abe J; Berk BC; Li J; Yan C. "Vinpocetine inhibits NF-?B-dependent inflammation via an IKK-dependent but PDE-independent mechanism. Editorial Commentary: Alexandre E. Medina (2010). Vinpocetine as a potent anti-inflammatory agent Proc. Nat. Acad. Sci., USA. 107:9921-2." Proc. Nat. Acad. Sci., USA, PMCID: PMC2906898. 2010; 107: 9795-9800.

2010
Wang J: Yin G: Menon P: Pang J: Smolock E: Yan C: and Berk BC. "Phosphorylation of GIT1 tyrosine-392 is required for PLC??activation and podosome formation in vascular smooth muscle cells." Arterioscler Thromb Vasc Biol. PMCID: PMC2941990. 2010; 30:: 1976-82.

2010
Menon P; Yin G; Smolock E; Zuscik M; Yan C; and Berk BC. "GPCR kinase 2 interacting protein 1 (GIT1) regulates osteoclast function and bone mass." Journal of Cellular Physiology. PMCID: PMC2939960. 2010; : 777-85.

2010
Menon P; Deane R; Sagare A; Lane SM; Zarcone TJ; O'Dell MR,; Yan C; Zlokovic BV; Berk BC. "Impaired spine formation and learning in GPCR kinase interacting protein-1 (GIT1) deficient mice." Brain Research PMCID: PMC2861918. 2010; 1317:2: 18-26.

2009
Miller CL, Oikawa M, Cai Y, Wojtovich AP, Nagel DJ, Xu X, Xu H, Florio V, Rybalkin SD, Beavo JA, Chen YF, Li JD, Blaxall BC, Abe J and Yan C. "Role of Ca2+/calmodulin stimulated cyclic nucleotide phosphodiesterase 1 in cardiomyocyte hypertrophic growth. Editorial Commentary: Eiki Takimoto (2009). Controlling myocyte cGMP: Phosphodiesterase 1 joins the Fray. Circulation Research 105: 931-933." Circulation Research PMCID: PMC2803071. 2009; 105:: 956-964.

2009
Satoh K; Nigro P; Matoba T; O'Dell MR; Cui Z; Shi X; Mohan A; Yan C; Abe JI; Illig KA; and Berk BC. "Cyclophilin A promotes vascular oxidative stress and accelerates development of angiotensin II-induced aortic aneurysms." Nature Medicine PMCID: PMC2704983. 2009; : 649-56.

2009
Zhou H; Chen W; Zhu D; Wu L; Zhang J; Han W; Li J; Yan C; and Gao P. "The PDE1A-PKCalpha signaling pathway is involved in the upregulation of alpha-smooth muscle actin by TGF-beta1 in adventitial fibroblasts." J. Vasc. Res. PMCID: PMC2855283. 2009; 47:: 9-15.

2009
Chen W; Chu Y; Zhu D; Yan C; Liu J; Ji K; Gao P. "Perivascular gene transfer of dominant-negative N19RhoA attenuates neointimal formation via inhibition of TGF-beta1-Smad2 signaling in rats after carotid artery balloon injury." Biochem Biophys Res Commun. 2009; : 763-768.

2009
Wang J; Taba Y; Pang J; Yin G; Yan C; and Berk B. "GIT1 mediates VEGF-induced podosome formation in endothelial cells: critical role for PLC." Arterioscler Thromb Vasc Biol. PMCID: PMC2735351. 2009; 29:: 202-8.

2009
Ishinaga H; Jono H; Lim JH; Komatsu K; Xu X; Lee J; Woo CH; Xu H; Feng XH; Chen LF; Yan C*; and Li JD* (* Co-corresponding author). "Synergistic induction of NF-kappaB by TGF-beta and TNF-alpha is mediated by PKA-dependent RelA acetylation." Biochem J. 2009; 417:: 583-591.

2009
Pang J; Hoefen R; Pryhuber GS; Wang J; Yin G; White JR; Xu X; O'Dell MR; Mohan A; Michaloski H; Massett; MP; Yan C; and Berk BC. "G-protein-coupled receptor kinase interacting protein-1 is required for pulmonary vascular development." Circulation PMCID: PMC2732662. 2009; 119:: 1524-1532.

2009
Alexis JD; Wang N; Che W; Lerner-Marmarosh N; Sahni A; Korshunov VA; Zou Y; Ding B; Yan C; Berk BC; Abe JI. "Bcr Kinase Activation by Angiotensin II Inhibits Peroxisome Proliferator-Activated Receptor {gamma} Transcriptional Activity in Vascular Smooth Muscle Cells." Circulation Research PMCID: PMC2642522. 2009; : 69-78.

2008
Pang J; Yan C; Natarajan K; Cavet ME; Massett MP; Yin G; Berk BC. "GIT1 mediates HDAC5 activation by angiotensin II in vascular smooth muscle cells." Arterioscler Thromb Vasc Biol. PMCID: PMC2735338. 2008; : 892-8.

2008
Woo CH; Shishido T; McClain C; Lim JH; Li JD; Yang J; Yan C; and Abe JI. "Extracellular signal-regulated kinase 5 SUMOylation antagonizes shear stress-induced anti-inflammatory response and endothelial nitric oxide synthase expression in endothelial cells." Circulation Research. 2008; : 538-45.

2008
Satoh K; Matoba T; Suzuki J; O'Dell MR; Nigro P; Cui Z; Mohan A; Pan S; Li L; Jin ZG; Yan C; Abe JI; and Berk BC. "Cyclophilin A Mediates Vascular Remodeling by Promoting Inflammation and Vascular Smooth Muscle Cell Proliferation." Circulation PMCID: PMC2775430. 2008; 117:: 3088-3098.

2008
Shishido T; Woo CH; Ding B; McClain C; Molina CA; Yan C; Yang J; Abe J. "Effects of MEK5/ERK5 association on small ubiquitin-related modification of ERK5: implications for diabetic ventricular dysfunction after myocardial infarction. PMCID: PMC2614366". Circulation Research. 2008; 102:: 1416-25.

2008
Lu Z; Abe J; Taunton J; Lu Y; Shishido T; McClain C; Yan C; Xu SP; Spangenberg TM; and Xu H. "Reactive oxygen species-induced activation of p90 ribosomal S6 kinase prolongs cardiac repolarization through inhibiting outward K+ channel activity." Circulation Research PMCID: PMC2631445. 2008; : 269-78.

2008
Koga T; Lim JH; Jono H; Ha UH; Xu H; Ishinaga H; Morino S; Xu X; Yan C; Kai H; Li JD. "Tumor suppressor cylindromatosis (CYLD) acts as a negative regulator for streptococcus pneumoniae-induced NFAT signaling." J. Biol. Chem. PMCID: PMC2335367. 2008; : 12546-54.

2008
Komatsu K; Jono H; Hyanglim J; Imasato A; Xu H; Kai H; Yan C; and Li J-D. "Glucocorticoids inhibit nontypeable Haemophilus influenzae-induced MUC5AC mucin expression via MAPK phosphatase-1-dependent inhibition of p38 MAPK." Biochem Biophys Res Commun. 2008; 377:: 763-768.

2008
Li L; Tatake RJ; Natarajan K; Taba Y; Garin G; Tai C; Leung E; Surapisitchat J; Yoshizumi M; Yan C; Abe J; and Berk BC. "Fluid shear stress inhibits TNF-mediated JNK activation via MEK5-BMK1 in endothelial cells." Biochem Biophys Res Commun PMCID: PMC2435412. 2008; 370:: 159-63.

2008
McCahill A; Campbell L; McSorley T; Sood A; Lynch MJ; Li X; Yan C; Baillie GS; Houslay MD. "In cardiac myocytes; cAMP elevation triggers that down-regulation of transcripts and promoter activity for cyclic AMP phosphodiesterase 4A10 (PDE4A10)." Cell Signaling. 2008; 20:: 2071-83.

2008
Ding B; Abe J; Wei H; Huang Q; Walsh RA; Molina; CA; Zhao A; Sadoshima J; Blaxall BC; Berk BC; Yan C. "Functional Role of Phosphodiesterase 3 in Cardiomyocyte Apoptosis: Implication in Heart Failure. PMCID: PMC4108189". Circulation. 1. 2008; : 2469-76.

10/12/2007
Surapisitchat J, Jeon KI, Yan C, Beavo JA. "Differential regulation of endothelial cell permeability by cGMP via phosphodiesterases 2 and 3." Circulation research.. 2007 Oct 12; 101(8):811-8. Epub 2007 Aug 17.

8/2007
Lim JH, Stirling B, Derry J, Koga T, Jono H, Woo CH, Xu H, Bourne P, Ha UH, Ishinaga H, Xu H, Andalibi A, Feng XH, Zhu H, Huang Y, Zhang W, Weng X, Yan C, Yin Z, Briles DE, Davis RJ, Flavell RA, Li JD. "Tumor suppressor CYLD regulates acute lung injury in lethal Streptococcus pneumoniae infections." Immunity.. 2007 Aug; 27(2):349-60.

7/6/2007
Garin G, Abe J, Mohan A, Lu W, Yan C, Newby AC, Rhaman A, Berk BC. "Flow antagonizes TNF-alpha signaling in endothelial cells by inhibiting caspase-dependent PKC zeta processing." Circulation research.. 2007 Jul 6; 101(1):97-105. Epub 2007 May 24.

3/2/2007
Yan C, Ding B, Shishido T, Woo CH, Itoh S, Jeon KI, Liu W, Xu H, McClain C, Molina CA, Blaxall BC, Abe J. "Activation of extracellular signal-regulated kinase 5 reduces cardiac apoptosis and dysfunction via inhibition of a phosphodiesterase 3A/inducible cAMP early repressor feedback loop." Circulation research.. 2007 Mar 2; 100(4):510-9. Epub 2007 Feb 01.

3/2/2007
Yan C, Miller CL, Abe J. "Regulation of phosphodiesterase 3 and inducible cAMP early repressor in the heart." Circulation research.. 2007 Mar 2; 100(4):489-501.

2/21/2007
Ishinaga H, Jono H, Lim JH, Kweon SM, Xu H, Ha UH, Xu H, Koga T, Yan C, Feng XH, Chen LF, Li JD. "TGF-beta induces p65 acetylation to enhance bacteria-induced NF-kappaB activation." The EMBO journal.. 2007 Feb 21; 26(4):1150-62. Epub 2007 Feb 01.

2007
Jin X; Ge X; Zhu DL; Yan C; Chu YF; Chen WD; Liu J; Gao PJ. "Expression and function of vascular endothelial growth factor receptors (Flt-1 and Flk-1) in vascular adventitial fibroblasts. J." Mol. Cell. Cardiol. 2007; 43:: 292-300.

2007
Yan C*; Ding B; Shishido T; Woo C-H; Itoh S; Jeon K; Liu W; Xu H; McClain C; Molina CA; Blaxall BC; and Abe JI * (* Co-corresponding author). "Activation of ERK5 reduces cardiac apoptosis and dysfunction via inhibition of a PDE3A-ICER feedback loop. Circulation Research 100(4): 510-9. PMCID: PMC4115673. (* Co-corresponding author)". Circulation Research PMCID: PMC4115673. 2007; 100(4):: 510-9.

2007
Chen C; Korshunov VA; Massett MP; Yan C; and Berk BC. "Impaired vasorelaxation in inbred mice is associated with alterations in both nitric oxide and super oxide pathways." J Vasc Res. 2007; : 504-512.

2007
Huang Y; Mikami F; Jono H; Zhang W; Weng X; Koga T; Xu H; Yan C; Kai H; Li JD. "Opposing roles of PAK2 and PAK4 in synergistic induction of MUC5AC mucin by bacterium NTHi and EGF. PMID: 17555715. PMCID: PMC3345029." Biochem. Biophys. Res. Commun. 2007; : 691-6.

2007
Chen C; Korshunov VA; Massett MP; Yan C; and Berk BC. "Impaired vasorelaxation in inbred mice is associated with alterations in both nitric oxide and super oxide pathways." J Vasc Res. 2007; : 504-512.

2007
Chen C, Korshunov VA, Massett MP, Yan C, Berk BC. "Impaired vasorelaxation in inbred mice is associated with alterations in both nitric oxide and super oxide pathways." Journal of vascular research.. 2007 44(6):504-12. Epub 2007 Jul 30.

5/15/2006
Qin F, Yan C, Patel R, Liu W, Dong E. "Vitamins C and E attenuate apoptosis, beta-adrenergic receptor desensitization, and sarcoplasmic reticular Ca2+ ATPase downregulation after myocardial infarction." Free radical biology & medicine.. 2006 May 15; 40(10):1827-42. Epub 2006 Feb 08.

4/11/2006
Itoh S, Ding B, Shishido T, Lerner-Marmarosh N, Wang N, Maekawa N, Berk BC, Takeishi Y, Yan C, Blaxall BC, Abe J. "Role of p90 ribosomal S6 kinase-mediated prorenin-converting enzyme in ischemic and diabetic myocardium." Circulation.. 2006 Apr 11; 113(14):1787-98. Epub 2006 Apr 03.

3/31/2006
Nagel DJ, Aizawa T, Jeon KI, Liu W, Mohan A, Wei H, Miano JM, Florio VA, Gao P, Korshunov VA, Berk BC, Yan C. "Role of nuclear Ca2+/calmodulin-stimulated phosphodiesterase 1A in vascular smooth muscle cell growth and survival." Circulation research.. 2006 Mar 31; 98(6):777-84. Epub 2006 Mar 02.

1/15/2006
Qin F, Patel R, Yan C, Liu W. "NADPH oxidase is involved in angiotensin II-induced apoptosis in H9C2 cardiac muscle cells: effects of apocynin." Free radical biology & medicine.. 2006 Jan 15; 40(2):236-46. Epub 2005 Nov 10.

2006
Woo, CH.; Massett, MP.; Shishido, T.; Itoh, S.; Ding, B.; McClain, C.; Che, W.; Vulapalli, SR.; Yan, C.; Abe, J. "ERK5 activation inhibits inflammatory responses via peroxisome proliferators-activated receptor delta (PPARdelta) stimulation." J. Bio. Chem. 2006; 281: 32164-32174.

2006
Nagel DJ; Aizawa T; Jeon K; Liu W; Mohan A; Wei H; Miano JM; Florio VA; Gao P; Korshunov VA; Berk BC; and Yan C. "Role of Nuclear Ca2+/calmodulin-stimulated Phosphodiesterase 1A in Vascular Smooth Muscle Cell Growth and Survival. PMCID: PMC4114760. Editorial Commentary: Bornfeldt KE (2006). Nuclear signaling in smooth muscle cells: cyclic nucleotide phosphodiesterase 1A moves in. Circulation Research 98: 720-722." Circulation Research. 2006; : 777-784.

2006
Itoh S; Ding B; Shishido T; Lerner-Marmarosh N; Wang N; Maekawa N; Berk BC; Takeishi Y; Yan C; Blaxall BC; Abe J. "Role of p90 ribosome s6 kinase (p90RSK)-mediated pro-renin converting enzyme (PRECE) in ischemic and diabetic myocardium". Circulation. 2006; 113:: 1787-1798.

2006
Woo CH; Massett MP; Shishido T; Itoh S; Ding B; McClain C; Che W; Vulapalli SR; Yan C; Abe JI (2006). "ERK5 activation inhibits inflammatory responses via peroxisome proliferators-activated receptor delta (PPARdelta) stimulation." J. Bio. Chem. 2006; 281:: 32164-74.

2006
Shen WL; Gao PJ; Che ZQ; Ji KD; Yin M; Yan C; Berk BC; Zhu DL. "NAD(P)H oxidase-derived reactive oxygen species regulate angiotensin-II induced adventitial fibroblast phenotypic differentiation. Biochem. Biophys." Res. Commun.,. 2006; : 337-43.

2006
Shen WL; Gao PJ; Che ZQ; Ji KD; Yin M; Yan C; Berk BC; Zhu DL. "NAD(P)H oxidase-derived reactive oxygen species regulate angiotensin-II induced adventitial fibroblast phenotypic differentiation." Biochem. Biophys. Res. Commun.,. 2006; : 337-43.

2006
Qin F; Yan C; Patel R; Liu W; Dong E. "Vitamins C and E attenuate apoptosis, beta-adrenergic receptor desensitization and sarcoplasmic reticular Ca2+ ATPase downregulation after myocardial infarction." Free Radical Biology and Medicine. 2006; 40:: 1827-1842.

2006
Qin F; Patel R; Yan C; Liu W. "NADPH oxidase is involved in angiotensin II-induced apoptosis in H9C2 cardiac cells: Effects of apocynin." Free Radical Biology and Medicine. 2006; 40:(236-246).

10/11/2005
Ding B, Abe J, Wei H, Xu H, Che W, Aizawa T, Liu W, Molina CA, Sadoshima J, Blaxall BC, Berk BC, Yan C. "A positive feedback loop of phosphodiesterase 3 (PDE3) and inducible cAMP early repressor (ICER) leads to cardiomyocyte apoptosis." Proceedings of the National Academy of Sciences of the United States of America.. 2005 Oct 11; 102(41):14771-6. Epub 2005 Sep 26.

10/2005
Vasta V, Sonnenburg WK, Yan C, Soderling SH, Shimizu-Albergine M, Beavo JA. "Identification of a new variant of PDE1A calmodulin-stimulated cyclic nucleotide phosphodiesterase expressed in mouse sperm." Biology of reproduction.. 2005 Oct; 73(4):598-609. Epub 2005 May 18.

7/29/2005
Yin G, Zheng Q, Yan C, Berk BC. "GIT1 is a scaffold for ERK1/2 activation in focal adhesions." The Journal of biological chemistry.. 2005 Jul 29; 280(30):27705-12. Epub 2005 May 27.

6/24/2005
Itoh S, Ding B, Bains CP, Wang N, Takeishi Y, Jalili T, King GL, Walsh RA, Yan C, Abe J. "Role of p90 ribosomal S6 kinase (p90RSK) in reactive oxygen species and protein kinase C beta (PKC-beta)-mediated cardiac troponin I phosphorylation." The Journal of biological chemistry.. 2005 Jun 24; 280(25):24135-42. Epub 2005 Apr 19.

5/17/2005
Ding B, Abe J, Wei H, Huang Q, Walsh RA, Molina CA, Zhao A, Sadoshima J, Blaxall BC, Berk BC, Yan C. "Functional role of phosphodiesterase 3 in cardiomyocyte apoptosis: implication in heart failure." Circulation.. 2005 May 17; 111(19):2469-2476. Epub 2005 May 02.

1/2005
Kim D, Aizawa T, Wei H, Pi X, Rybalkin SD, Berk BC, Yan C. "Angiotensin II increases phosphodiesterase 5A expression in vascular smooth muscle cells: a mechanism by which angiotensin II antagonizes cGMP signaling." Journal of molecular and cellular cardiology.. 2005 Jan; 38(1):175-84. Epub 2004 Dec 08.

2005
Pi, X.; Garin, G.; Xie, L.; Zheng, Q.; Wei, H.; Abe, J.; Yan, C.; Berk, BC. "BMK1/ERK5 Is a Novel Regulator of Angiogenesis by Destabilizing Hypoxia Inducible Factor 1{alpha}." Circulation Research. 2005; 96(1145-1151).

2005
Shen, W.; Gao, P.; Che, Z.; Ji, K.; Yin, M.; Yan, C.; Berk, BC.; Zhu, D. "NAD(P)H oxidase-derived reactive oxygen species regulate angiotensin-II induced adventitial fibroblast phenotypic differentiation." Biochemical and Biophysical Research Communication. 2005; 339: 337-343.

2005
Yin G; Zheng Q; Yan C; Berk; BC. "GIT1 is a scaffold for ERK1/2 activation in focal adhesion." J. Biol. Chem. 2005; : 27705-12.

2005
Vasta V; Sonnenburg WK; Yan C; Sodeling SH; Shimizu-Albergine M; Beavo JA. "Identification of a New Cyclic Nucleotide Phosphodiesterase Expressed in Mouse Sperm." Biol. Reprod. 2005; : 598-609.

2005
Yan C. "Determination of Ca2+/calmodulin-stimulated phosphodiesterase activity in intact cells." Methods in molecular biology.. 2005 307:85-92.

10/2004
Akaike M, Che W, Marmarosh NL, Ohta S, Osawa M, Ding B, Berk BC, Yan C, Abe J. "The hinge-helix 1 region of peroxisome proliferator-activated receptor gamma1 (PPARgamma1) mediates interaction with extracellular signal-regulated kinase 5 and PPARgamma1 transcriptional activation: involvement in flow-induced PPARgamma activation in endothelial cells." Molecular and cellular biology.. 2004 Oct; 24(19):8691-704.

10/2004
Melaragno MG, Cavet ME, Yan C, Tai LK, Jin ZG, Haendeler J, Berk BC. "Gas6 inhibits apoptosis in vascular smooth muscle: role of Axl kinase and Akt." Journal of molecular and cellular cardiology.. 2004 Oct; 37(4):881-7.

5/21/2004
Cameron SJ, Itoh S, Baines CP, Zhang C, Ohta S, Che W, Glassman M, Lee JD, Yan C, Yang J, Abe J. "Activation of big MAP kinase 1 (BMK1/ERK5) inhibits cardiac injury after myocardial ischemia and reperfusion." FEBS letters.. 2004 May 21; 566(1-3):255-60.

3/5/2004
Zheng Q, Yin G, Yan C, Cavet M, Berk BC. "14-3-3beta binds to big mitogen-activated protein kinase 1 (BMK1/ERK5) and regulates BMK1 function." The Journal of biological chemistry.. 2004 Mar 5; 279(10):8787-91. Epub 2003 Dec 16.

2/20/2004
Pi X, Yan C, Berk BC. "Big mitogen-activated protein kinase (BMK1)/ERK5 protects endothelial cells from apoptosis." Circulation research.. 2004 Feb 20; 94(3):362-9. Epub 2003 Dec 11.

1/2004
Yin G, Haendeler J, Yan C, Berk BC. "GIT1 functions as a scaffold for MEK1-extracellular signal-regulated kinase 1 and 2 activation by angiotensin II and epidermal growth factor." Molecular and cellular biology.. 2004 Jan; 24(2):875-85.

2004
Osawa, M.; Itoh, S.; Ohta, S.; Huang, Q.; Berk, BC.; Marmarosh, NL.; Che, W.; Ding, B.; Yan, C.; Abe, J. "ERK1/2 associates with the c-Met binding domain of Gab1: Role in ERK1/2 and Egr-1 nuclear accumulation." J Biol. Chem. 2004; 79(28): 29691-29699.

2004
Pi X; Yan C; and Berk BC. "Big Mitogen-activated protein kinase (BMK1)/ERK5 protects endothelial cells from apoptosis." Circulation Research, PMID: 15879308. 2004; 94:: 362-9.

2004
Yin G; Haendeler J; Yan C; Berk BC. "GIT1 functions as a scaffold for MEK1-ERK1/2 activation by angiotensin II and EGF." Mol. Cell. Biol.,. 2004; : 875-85.

2004
Akaike M; Wei C; Lerner-Marmarosh N; Osawa S; Bo D; Berk BC; Yan C; Abe J. "Hinge-helix1 region of PPAR?1 mediates interaction with ERK5 and PPAR?1 transcriptional activation: Involvement in flow-induced PPAR? activation in endothelial cells. PMCID: PMC516745". Mol Cell Biol. 2004; : 8691-704.

2004
Cameron SJ; Itoh S; Baines CP; Zhang C; Ohta S; Che W; Glassman M; Lee JD; Yan C; Yang J; and Abe JI. "Activation of big MAP kinase 1, (BMK1/ERK5) inhibits cardiac injury, after myocardial ischemia and reperfusion. FEBS Lett 566: 255-260." FEBS Lett. 2004; : 255-260.

2004
Zheng Q; Yin G; Yan C; Cavet M; and Berk BC. "14-3-3beta binds to big mitogen activated protein kinase 1 (BMK1/ERK5) and regulates BMK1 function." J. Biol. Chem. 2004; : 8787-91.

2004
Melaragno MG; Cavet ME; Yan C; Tai L; Jin Z; Haendeler J; Berk BC. "Gas6 inhibits apoptosis in vascular smooth muscle: role of Axl kinase and Akt." J. Mol. Cell. Cardiol. 2004; : 881-887.

2004
Osawa M; Itoh S; Ohta S; Huang Q; Berk BC; Marmarosh NL; Che W; Ding B; Yan C; Abe JI. "ERK1/2 associates with the c-Met binding domain of Gab1: Role in ERK1/2 and Egr-1 nuclear accumulation." J Biol. Chem. 2004; : 29691-9.

12/12/2003
Haendeler J, Yin G, Hojo Y, Saito Y, Melaragno M, Yan C, Sharma VK, Heller M, Aebersold R, Berk BC. "GIT1 mediates Src-dependent activation of phospholipase Cgamma by angiotensin II and epidermal growth factor." The Journal of biological chemistry.. 2003 Dec 12; 278(50):49936-44. Epub 2003 Sep 30.

10/1/2003
Lerner-Marmarosh N, Yoshizumi M, Che W, Surapisitchat J, Kawakatsu H, Akaike M, Ding B, Huang Q, Yan C, Berk BC, Abe J. "Inhibition of tumor necrosis factor-[alpha]-induced SHP-2 phosphatase activity by shear stress: a mechanism to reduce endothelial inflammation." Arteriosclerosis, thrombosis, and vascular biology.. 2003 Oct 1; 23(10):1775-81. Epub 2003 Aug 28.

9/5/2003
Aizawa T, Wei H, Miano JM, Abe J, Berk BC, Yan C. "Role of phosphodiesterase 3 in NO/cGMP-mediated antiinflammatory effects in vascular smooth muscle cells." Circulation research.. 2003 Sep 5; 93(5):406-13. Epub 2003 Aug 14.

8/22/2003
Rybalkin SD, Yan C, Bornfeldt KE, Beavo JA. "Cyclic GMP phosphodiesterases and regulation of smooth muscle function." Circulation research.. 2003 Aug 22; 93(4):280-91.

6/2003
Yin G, Yan C, Berk BC. "Angiotensin II signaling pathways mediated by tyrosine kinases." The international journal of biochemistry & cell biology.. 2003 Jun; 35(6):780-3.

5/16/2003
Cameron SJ, Malik S, Akaike M, Lerner-Marmarosh N, Yan C, Lee JD, Abe J, Yang J. "Regulation of epidermal growth factor-induced connexin 43 gap junction communication by big mitogen-activated protein kinase1/ERK5 but not ERK1/2 kinase activation." The Journal of biological chemistry.. 2003 May 16; 278(20):18682-8. Epub 2003 Mar 12.

1/1/2003
Yan C, Kim D, Aizawa T, Berk BC. "Functional interplay between angiotensin II and nitric oxide: cyclic GMP as a key mediator." Arteriosclerosis, thrombosis, and vascular biology.. 2003 Jan 1; 23(1):26-36.

2003
Aizawa T; Wei H; Miano JM; Abe J; Berk BC; and Yan C. "Anti-inflammatory effects of NO/cGMP are mediated by PDE3 inhibition in vascular smooth muscle cell." Circulation Research,. 2003; : 406-413.

2003
Lerner-Marmarosh N; Yoshizumi M; Che W; Surapisitchat J; Kawakatsu H; Akaike M; Ding B; Huang Q; Yan C; Berk BC; Abe J. "Inhibition of Tumor Necrosis Factor-{alpha}-Induced SHP-2 Phosphatase Activity by Shear Stress. A Mechanism to Reduce Endothelial Inflammation." Arterioscler Thromb Vasc Biol. 2003; : 1775-1781.

2003
Haendeler J; Yin Y; Hojo Y; Saito Y; Melaragno M; Yan C; Heller M; Aebersold R; and Berk BC. "GIT1 Mediates Src-dependent Activation of PLCgamma by Angiotensin II and EGF." J. Biol. Chem. 2003; : 49936-44.

2003
Cameron SJ; Malik; Lerner-Marmarosh N; Yan C; Akaike M; Lee J-D; Abe J; and Yang J;. "Regulation of EGF-induced connexin 43 gap junction communication by BMK1/ERK5 but not ERK1/2 kinase activation." J. Biol. Chem. 2003; 278(20):: 18682-8.

11/1/2002
Tai LK, Okuda M, Abe J, Yan C, Berk BC. "Fluid shear stress activates proline-rich tyrosine kinase via reactive oxygen species-dependent pathway." Arteriosclerosis, thrombosis, and vascular biology.. 2002 Nov 1; 22(11):1790-6.

8/9/2002
Huang Q, Lerner-Marmarosh N, Che W, Ohta S, Osawa M, Yoshizumi M, Glassman M, Yan C, Berk BC, Abe J. "The novel role of the C-terminal region of SHP-2. Involvement of Gab1 and SHP-2 phosphatase activity in Elk-1 activation." The Journal of biological chemistry.. 2002 Aug 9; 277(32):29330-41. Epub 2002 May 14.

6/14/2002
Che W, Lerner-Marmarosh N, Huang Q, Osawa M, Ohta S, Yoshizumi M, Glassman M, Lee JD, Yan C, Berk BC, Abe J. "Insulin-like growth factor-1 enhances inflammatory responses in endothelial cells: role of Gab1 and MEKK3 in TNF-alpha-induced c-Jun and NF-kappaB activation and adhesion molecule expression." Circulation research.. 2002 Jun 14; 90(11):1222-30.

2002
Berk, BC.; Wang, M.; Yan, C.; Surapisitchat, J.; Hoefen, R. "Atheroprotective Mechanisms Activated by Sheer Stress in Endothelial Cells." Drug News Perspect. 2002; 15: 1-7.

2002
Pi, X.; Yan, C.; Kim, D-S.; Chen, J.; Berk, BC. ( * Contributed equally to this manuscript). "Differential expression of genes from nitrate tolerant rat aortas." Journal of Vascular Research. 2002; 39: 304-310.

2002
Frame, MD.; Fox, RJ.; Kim, D-S.; Mohan, A.; Berk, BC.; Chen, Y. "Diminished arteriolar responses in nitrate tolerance involve ROS and angiotensin II." Am. J. Physiol. 2002; 282: H2377-H2385.

2002
Pi X.*; Yan C*; Kim D-S; Chen J; and Berk BC ( * Contributed equally to this manuscript). "Differential expression of genes from nitrate tolerant rat aorta." Journal of Vascular Research. 2002; : 304-310.

2002
Frame MD; Fox RJ; Kim D-S; Mohan A; Berk BC; and Yan C. "Diminished arteriolar responses in nitrate tolerance involve ROS and angiotensin II." Am. J. Physiol. 2002; : H2377-H2385.

2002
Che W; Lerner-Marmarosh N; Huang Q; Osawa M; Ohta S; Yoshizumi M; Glassman M; Lee J-D; Yan C; Berk BC; and Abe J. "Insulin-like growth factor-1 enhances inflammatory responses in endothelial cells: Role of Gab1 and MEKK3 in TNF-a induced c-Jun and NF-kB activation and adhesion molecule expression." Circulation Research;. 2002; : 1222-1230.

2002
Huang Q; Lerner-Marmarosh N; Che W; Ohta S; Osawa M; Yoshizumi M; Glassman M; Yan C; Berk BC; and Abe J. "The novel role of C-terminal region of SHP-2 : Involvement of Gab1 and SHP-2 phosphatase activity in Elk-1 activation. J. Biol. Chem, 277(32): 29330-29341." J. Biol. Chem,. 2002; : 29330-29341.

2002
Tai L; Okada M; Abe J; Yan C; and Berk BC. "Fluid shear stress activates Pyk2 via a reactive oxygen species dependent pathway." Arterioscler. Thromb. Vasc. Biol. 2002; : 1790-1796.

12/2001
Berk BC, Abe JI, Min W, Surapisitchat J, Yan C. "Endothelial atheroprotective and anti-inflammatory mechanisms." Annals of the New York Academy of Sciences.. 2001 Dec; 947:93-109; discussion 109-11.

11/6/2001
Kim D, Rybalkin SD, Pi X, Wang Y, Zhang C, Munzel T, Beavo JA, Berk BC, Yan C. "Upregulation of phosphodiesterase 1A1 expression is associated with the development of nitrate tolerance." Circulation.. 2001 Nov 6; 104(19):2338-43.

11/2001
Takeishi Y, Huang Q, Wang T, Glassman M, Yoshizumi M, Baines CP, Lee JD, Kawakatsu H, Che W, Lerner-Marmarosh N, Zhang C, Yan C, Ohta S, Walsh RA, Berk BC, Abe J. "Src family kinase and adenosine differentially regulate multiple MAP kinases in ischemic myocardium: modulation of MAP kinases activation by ischemic preconditioning." Journal of molecular and cellular cardiology.. 2001 Nov; 33(11):1989-2005.

9/18/2001
Che W, Abe J, Yoshizumi M, Huang Q, Glassman M, Ohta S, Melaragno MG, Poppa V, Yan C, Lerner-Marmarosh N, Zhang C, Wu Y, Arlinghaus R, Berk BC. "p160 Bcr mediates platelet-derived growth factor activation of extracellular signal-regulated kinase in vascular smooth muscle cells." Circulation.. 2001 Sep 18; 104(12):1399-406.

6/2001
Yan C, Zhao AZ, Sonnenburg WK, Beavo JA. "Stage and cell-specific expression of calmodulin-dependent phosphodiesterases in mouse testis." Biology of reproduction.. 2001 Jun; 64(6):1746-54.

4/6/2001
Yan C, Luo H, Lee JD, Abe J, Berk BC. "Molecular cloning of mouse ERK5/BMK1 splice variants and characterization of ERK5 functional domains." The Journal of biological chemistry.. 2001 Apr 6; 276(14):10870-8. Epub 2001 Jan 03.

1/15/2001
Cavanaugh JE, Ham J, Hetman M, Poser S, Yan C, Xia Z. "Differential regulation of mitogen-activated protein kinases ERK1/2 and ERK5 by neurotrophins, neuronal activity, and cAMP in neurons." The Journal of neuroscience : the official journal of the Society for Neuroscience.. 2001 Jan 15; 21(2):434-43.

2001
Surapisitcht, J.; Hoefen, JR.; Pi, X.; Yoshizumi, M.; Yan, C.; Berk, BC. "Fluid shear stress inhibits TNF-a activation of JNK but not ERK1/2 or p38 in human umbilical vein endothelial cells : inhibitory crosstalk among MAPK family members." Proc. Nat. Acad, Sci. USA. 2001; 98: 6476-6481.

2001
Kim D-S; Rebulkin S; Pi X; Zhang C; Munzel T; Beavo JA; Berk BC; Yan C. "Upregulation of phosphodiestrase 1A1 expression is associated with the development of nitrate tolerance. Editorial Commentary: Parker JD; Gori Tolerance to the Organic Nitrates, New Ideas, New Mechanisms, Continued Mystery. Circulation 104:2263-2265." Circulation. 2001; : 2338-2343.

2001
Yan C; Zhao AZ; Sonnenburg WK; and Beavo JA. "Stage and Cell–Specific Expression of CaM-PDEs in Mouse Testis." Biology of Reproduction,. 2001; : 1746-1754.

2001
Yan C; Luo H; Lee J-D; Abe J; and Berk BC. "Molecular Cloning of Mouse ERK5/BMK1 Splice Variants and Characterization of ERK5 Functional Domains." J. Biol. Chem. 2001; : 10870-10878.

2001
Cavanaugh JE; Ham J; Hetman M; Poser S; Yan C; and Xia Z. "Differential Regulation of Mitogen-Activated Protein Kinases ERK1/2 and ERK5 by Neurotrophins, Neuronal Activity, and cAMP in Neurons." J. Neuroscience. 2001; : 434-443.

2001
Surapisitcht J; Hoefen JR; Pi X; Yoshizumi M; Yan C; Berk BC. "Fluid shear stress inhibits TNF-a activation of JNK but not ERK1/2 or p38 in human umbilical vein endothelial cells: inhibitory crosstalk among MAPK family members." Proc. Nat. Acad. Sci. USA. 2001; : 6476-6481.

2001
Che W; Abe J; Yoshizumi M; Huang Q-H; Glassman M; Ohta S; Melaragno MG; Poppa V; Yan C; Lerner-Marmarosh N; Zhang C; Wu Y; Arlinhaus R; Berk BC. "p160 Bcr mediates platelet-derived growth factor activation of extracellular signal-regulated kinase in vascular smooth muscle cells." Circulation. 2001; : 1399-1406.

2001
Takeishi Y; Hang Q; Wang T; Glassman M; Yoshizumi M; Baines CP; Lee J-D; Kawakatsu H; Che W; Lerner-Marmarosh N; Zhang C; Yan C; Ohta S; Walsh RA; Berk BC; and Abe J. "Src family kinase and adenosine differentially regulate multiple MAP kinases in ischemic myocardium: Modulation of MAP kinases activation by ischemic preconditioning." J. Mol. Cell. Cardiol. 2001; 33:: 1989-2005.

2000
Jin Z-G; Melaragno MG; Liao D-F; Yan C; Haendelaer J; Suh Y-A; Lambeth JD; and Berk BC. "Cyclophilin A is a Secreted Growth Factor Induced by Oxidative Stress". Circulation Research. 2000; : 789-796.

1999
Yan C; Takahashi M; Lee JD; Ulevitch RJ; and Berk BC. "Fluid shear stress stimulates big MAP kinase 1 (BMK1) activity in endothelial cells: roles of tyrosine kinases and Ca2+." J. Biol. Chem. 1999; : 143-150.

1999
Peterson TE; Poppa V; Ueba H; Wu A; Yan C; and Berk BC. "Opposing effects of reactive oxygen species and cholesterol on endothelial nitric oxide synthase and endothelial cell caveolae." Circulation Research. 1999; : 29-37.

1996
Yan C; Zhao AZ; Bentley JK; and Beavo JA. "The calmodulin-dependent phosphodiesterase gene PDE1C encodes several functionally different splice variants in a tissue specific manner." J. Biol. Chem. 1996; : 25699-25706.

1995
Yan C; Zhao AZ; Bentley JK; Loughney K; Ferguson K; and Beavo JA. "Molecular cloning and characterization of a novel calmodulin-dependent phosphodiesterase enriched in olfactory sensory neurons." Proc. Nat. Acad. Sci. USA. 1995; : 9677-9681.

1995
Villacres EC; Wu Z; Hua W; Nielsen MD; Watters JJ; Yan C; Beavo JA; and Storm DR. "Developmentally expressed Ca2+-sensitive adenylyl cyclase activity is disrupted in the brain of type I adenylyl cyclase mutant mice." J. Biochem. 1995; 270: 14352-14357.

1994
Yan C; Bentley JK; Sonnenburg WK; and Beavo JA. "Differential expression of the 61 kDa and 63 kDa calmodulin-dependent phosphodiesterases in the mouse brain." J. Neuroscience (Cover article). 1994; : 973-984.

1990
Yan C; Costa RH; Darnell JE; Chen J; and Van Dyke TA. "Distinct positive and negative elements control the limited hepatocyte and choroid plexus expression of transthyretin in transgenic mice." EMBO J. 1990; : 869-878.

1990
Costa RH; Van Dyke TA; Yan C; Kuo F; and Darnell JE. "Hepatocyte nuclear factor binding correlates with the transcription of the transthyretin gene." Proc. Nat. Acad. Sci., USA. 1990; 87: 6589-6593.

1990
Chen HZ; Yan C; and Liu ZD. "Studies on the systematic status of a new species of Drosophila (Sophophora)--from morphological to molecular level." I-Chuan-Hsueh-Pao. 1990; 17(3):: 189-210.

1986
Yan C. "Introduction of a sensitive rapid silver staining method." Heredity and Disease. 1986; 3: 185-186.

1986
Qi M; Qiu XF; Xiu XL.; and Yan C. "Isolation and characterization of ouabain-resistant mutants of Chinese hamster cell." Acta Biologiae Experimentalis Sinica. 1986; 19: 161-171.

Korshunov VA*: Wang H: Ahmed R: Mickelsen DM: Zhou Q: Yan C*: Doyley MM* (2017). "Model-based vascular elastograph improves the detection of flow-induced carotid artery remodeling in mice. Scientific Report, Sep 21;7(1):12081. doi: 10.1038/s41598-017-12321-7. PMCID: PMC5608712. (* Co-corresponding authors).".

Books & Chapters

2006
Chapter Title: Regulation and Function of Cyclic Nucleotide Phosphodiesterases in Vascular Smooth Muscle and Vascular Diseases.
Book Title: Cyclic Nucleotide Phosphodiesterases in Health and Disease
Author List: Yan C, Nagel DJ, Jeon K
Edited By: Joseph Beavo, Sharron Francis, and Miles Houslay
Published By: CRC Press2006

2005
Chapter Title: Determination of Ca2+/Calmodulin-Stimulated Phosphodiesterase Activity in Intact Cells
Book Title: Methods Mol Biol
Author List: Yan C.
Published By: N/A2005

2003
Chapter Title: Identification of secreted oxidative stress-induced factors (SOXF) and associated proteins: proteomics in vascular biology
Book Title: In Proteomic and Genomic Analysis of Cardiovascular Disease
Author List: Jin Z-G, Liao D-F, Yan C, and Berk BC
Edited By: Jennifer Van Eyk and Michael J. Dunn
Published By: Wiley-VCH publishers2003

2001
Chapter Title: Atheroprotective mechanisms of fluid shear stress: nitric oxide independent inhibition of signal transduction mediated by inflammatory cytokine
Book Title: Vascular Endothelium-Source and Target of Inflammatory Mediators
Author List: Berk BC, Surapisitchat J, Yoshizumi M, Yan C. Hoefen R, and Abe J
Edited By: J. D. Catravas, A. D. Callow, U. S. Ryan, and M. Simionescu.
Published By: IOS Press2001

2001
Chapter Title: Flow-mediated Activation of MAP Kinase
Book Title: Vascular Protection: Molecular Mechanisms, Novel Therapeutic Principles, and Cli
Author List: Surapisitchat J, Yan C, and Berk BC
Edited By: Gabor M. Rubanyi, Victor J. Dzau, and John P. Cooke
Published By: N/A2001

2000
Chapter Title: Kinase Signaling in the Cardiovascular System
Book Title: Heart Physiology and Pathophysiology
Author List: Abe J, Yan C, Surapisitchat J, and Berk BC
Edited By: Nicholas Sperelakis et al.
Published By: Academic Press2000

1998
Chapter Title: In Vitro stimulation of shear stress and mitogen-activated protein kinase responses to shear stress in endothelial cells
Book Title: Mechanical Forces and the Endothelium
Author List: Traub O, Yan C, and Berk BC
Edited By: Peter Lelkes
Published By: Hardwood Academic Publishers.1998

1997
Chapter Title: Recent advances in the study of Ca2+/CaM activated phosphodiesterases: Expression and physiological functions
Book Title: Signal Transduction in Health and Disease, Advances in Second Messenger and P...
Author List: Zhao AZ, Yan C, Sonnenburg WK, and Beavo JA
Edited By: Corbin, J. and Francis, S.
Published By: Raven Press1997

1997
Chapter Title: cAMP Phosphodiesterase / Adenylate Cyclase
Book Title: Calcium as a Cellular Regulator
Author List: Yan C, Chan GC, Storm DR, and Beavo JA
Edited By: Klee, C. and E. Carafoli
Published By: Oxford University Press1997