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Paul G. Rothberg, Ph.D.

Contact Information

Phone Numbers

Appointment: (585) 350-2600

Office: (585) 273-2229

Fax: (585) 273-5120

Faculty Appointments


Dr. Rothberg is Director of the Molecular Diagnostics Section of the Strong Health clinical laboratories. The Molecular Diagnostics Section uses the techniques of molecular biology to aid in the diagnosis of human disease. Dr. Rothberg is responsible for the planning and development of laboratory tests that support the care of patients with inherited disease, cancer and infectious disease. His research interests include the development of new testing strategies for the measurement of minimal residual disease in cancer patients, and the development of methods to predict response to therapy.


Dr. Rothberg's research focuses on deciphering the role of human genetic variation in the development of disease. Particular areas of focus include cancer and neurodegeneration. Current areas of investigation include studies on the molecular genetics of neuronal ceroid lipofuscinosis (Batten disease) in collaboration with the Batten Disease Clinical and Research Center, the early prediction of drug resistance in chronic myeloid leukemia, and the role of germline variation in the prognosis of prostate cancer.



  • Clinical Molecular Genetics - American Board of Pathology


BA | Cuny Queens College

PhD | St Univ at Stony Brook
Molecular Biology

Post-doctoral Training & Residency

03/01/1982 - 08/31/1985
Fellowship in at Fox Chase Cancer Center


Journal Articles

Ho C, Rothberg PG. "Next Generation Sequencing (NGS)-Based Antigen-Receptor Gene Clonality Assays: Will They Become the Clinical Standard?" The Journal of molecular diagnostics : JMD.. 2021 Jul 19; Epub 2021 Jul 19.

Lipof JJ, Huselton EJ, Zent CS, Evans A, Zhang B, Rothberg PG, Bennett JM. "A Case of Acute Eosinophilic Leukemia with a Novel 6 Mutation." Case reports in hematology.. 2021 2021:5574766. Epub 2021 Jul 03.

Moncur JT, Bartley AN, Bridge JA, Kamel-Reid S, Lazar AJ, Lindeman NI, Long TA, Merker JD, Rai AJ, Rimm DL, Rothberg PG, Vasalos P, Kim AS. "Performance Comparison of Different Analytic Methods in Proficiency Testing for Mutations in the , , and Genes: A Study of the College of American Pathologists Molecular Oncology Committee." Archives of pathology & laboratory medicine.. 2019 Oct 0; 143(10):1203-1211. Epub 2019 Apr 10.

Books & Chapters

Chapter Title: Use of DNA plymorphisms to monitor engraftment after allogeneic bone marrow transplantation
Book Title: Clinics in Laboratory Medicine 17
Author List: Rothberg, P.G., Gamis, A.S., Baker, D.
Published By: W. B. Saunders 1997

Chapter Title: Adventures in MYC-ology
Book Title: Advances in Genome Biology
Author List: Rothberg, P.G.; Heruth, D.P.
Edited By: Ram S. Verma
Published By: JAI Press Inc 1995

Chapter Title: Amplification and activation of the c-myc oncogene in adenocarcinoma of the large bowel.
Book Title: Familial Adenomatous Polyposis
Author List: Herold, K.M.; Rothberg, P.G
Published By: Alan R. Liss, Inc 1989