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John D. Lueck, Ph.D.

Contact Information

Phone Numbers

Office: (585) 276-5489

Fax: (585) 273-2652

Research Labs

Faculty Appointments

Biography

Research

My research focuses on the molecular genetics and experimental treatment of diseases resulting from nonsense mutations. I am investigating the use of engineered tRNAs for suppression of nonsense mutations in cystic fibrosis transmembrane conductance regulator (CFTR) transcripts as therapeutic intervention for cystic fibrosis. Additionally, I am interested in the molecular genetics and experimental treatment of the trinucleotide repeat disorder myotonic dystrophy (DM1). Moving forward, I intend to study pre-mRNA splicing defects in DM1 to determine the causes of muscle weakness and wasting, and develop and test new therapeutic strategies to target the genetic misstep and reverse symptoms. More broadly, I'm interested in applying membrane biophysics, molecular and cellular biology approaches to understand the molecular underpinning of genetic diseases and develop therapeutic interventions.

Publications

Journal Articles

2/18/2019
Lueck JD, Yoon JS, Perales-Puchalt A, Mackey AL, Infield DT, Behlke MA, Pope MR, Weiner DB, Skach WR, McCray PB, Ahern CA. "Engineered transfer RNAs for suppression of premature termination codons." Nature communications.. 2019 Feb 18; 10(1):822. Epub 2019 Feb 18.

4/6/2018
Molinarolo S, Lee S, Leisle L, Lueck JD, Granata D, Carnevale V, Ahern CA. "Cross-kingdom auxiliary subunit modulation of a voltage-gated sodium channel." The Journal of biological chemistry.. 2018 Apr 6; 293(14):4981-4992. Epub 2018 Jan 25.

3/26/2018
Infield DT, Lueck JD, Galpin JD, Galles GD, Ahern CA. "Orthogonality of Pyrrolysine tRNA in the Xenopus oocyte." Scientific reports.. 2018 Mar 26; 8(1):5166. Epub 2018 Mar 26.

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