Publications
Showing all 112 journal articles & 4 books available
Journal Articles
2/15/2023
Henson TR, Richards KA, Gandhapudi SK, Woodward JG, Sant AJ. "R-DOTAP Cationic Lipid Nanoparticles Outperform Squalene-Based Adjuvant Systems in Elicitation of CD4 T Cells after Recombinant Influenza Hemagglutinin Vaccination." Viruses.. 2023 Feb 15; 15(2)Epub 2023 Feb 15.
10/26/2022
Nelson SA, Richards KA, Glover MA, Chaves FA, Crank MC, Graham BS, Kanekiyo M, Sant AJ. "CD4 T cell epitope abundance in ferritin core potentiates responses to hemagglutinin nanoparticle vaccines." NPJ vaccines.. 2022 Oct 26; 7(1):124. Epub 2022 Oct 26.
9/28/2022
Sant AJ, Stern LJ. "Editorial overview: The life and times of peptide-MHC." Current opinion in immunology.. 2022 Sep 28; 78:102244. Epub 2022 Sep 28.
9/27/2022
Sant AJ, Wilson PC. "Learning from our differences." Nature immunology.. 2022 Sep 27; Epub 2022 Sep 27.
2/24/2022
Moritzky SA, Richards KA, Glover MA, Krammer F, Chaves FA, Topham DJ, Branche A, Nayak JL, Sant AJ. "The negative effect of pre-existing immunity on influenza vaccine responses transcends the impact of vaccine formulation type and vaccination history." The Journal of infectious diseases.. 2022 Feb 24; Epub 2022 Feb 24.
2/15/2022
Rattan A, White CL, Nelson S, Eismann M, Padilla-Quirarte H, Glover MA, Dileepan T, Marathe BM, Govorkova EA, Webby RJ, Richards KA, Sant AJ. "Development of a Mouse Model to Explore CD4 T Cell Specificity, Phenotype, and Recruitment to the Lung after Influenza B Infection." Pathogens.. 2022 Feb 15; 11(2)Epub 2022 Feb 15.
1/4/2022
Richards KA, Lavery C, Keller GLJ, Miller J, Baker BM, Sant AJ. "A previously unappreciated polymorphism in the beta chain of I-A expressed in autoimmunity-prone SJL mice: Combined impact on antibody, CD4 T cell recognition and MHC class II dimer structural stability." Molecular immunology.. 2022 Jan 4; 143:17-26. Epub 2022 Jan 04.
6/2/2021
Nelson SA, Dileepan T, Rasley A, Jenkins MK, Fischer NO, Sant AJ. "Intranasal nanoparticle vaccination elicits a persistent, polyfunctional CD4 T cell response in the murine lung specific for a highly conserved influenza antigen that are sufficient to mediate protection from influenza virus challenge." Journal of virology.. 2021 Jun 2; :JVI0084121. Epub 2021 Jun 02.
2/8/2021
Richards KA, Glover M, Crawford JC, Thomas P, White C, Sant AJ. "Circulating CD4 T cells elicited by endemic coronaviruses display vast disparities in abundance and functional potential linked to both antigen specificity and age." The Journal of infectious diseases.. 2021 Feb 8; Epub 2021 Feb 08.
2021
Nelson SA, Sant AJ. "Potentiating Lung Mucosal Immunity Through Intranasal Vaccination." Frontiers in immunology.. 2021 12:808527. Epub 2021 Dec 14.
8/26/2020
Richards KA, Moritzky S, Shannon I, Fitzgerald T, Yang H, Branche A, Topham DJ, Treanor JJ, Nayak J, Sant AJ. "Recombinant HA-based vaccine outperforms split and subunit vaccines in elicitation of influenza-specific CD4 T cells and CD4 T cell-dependent antibody responses in humans." NPJ vaccines.. 2020 Aug 26; 5(1):77. Epub 2020 Aug 26.
1/10/2020
Koroleva M, Batarse F, Moritzky S, Henry C, Chaves F, Wilson P, Krammer F, Richards K, Sant AJ. "Heterologous viral protein interactions within licensed seasonal influenza virus vaccines." NPJ vaccines.. 2020 Jan 10; 5(1):3. Epub 2020 Jan 10.
2020
Koroleva M, Batarse F, Moritzky S, Henry C, Chaves F, Wilson P, Krammer F, Richards K, Sant AJ. "Heterologous viral protein interactions within licensed seasonal influenza virus vaccines." NPJ vaccines.. 2020 5:3. Epub 2020 Jan 10.
2020
Richards KA, Moritzky S, Shannon I, Fitzgerald T, Yang H, Branche A, Topham DJ, Treanor JJ, Nayak J, Sant AJ. "Recombinant HA-based vaccine outperforms split and subunit vaccines in elicitation of influenza-specific CD4 T cells and CD4 T cell-dependent antibody responses in humans." NPJ vaccines.. 2020 5:77. Epub 2020 Aug 26.
11/5/2019
Knowlden ZAG, Richards KA, Moritzky SA, Sant AJ. "Peptide Epitope Hot Spots of CD4 T Cell Recognition Within Influenza Hemagglutinin During the Primary Response to Infection." Pathogens.. 2019 Nov 5; 8(4)Epub 2019 Nov 05.
9/15/2019
DiPiazza AT, Fan S, Rattan A, DeDiego ML, Chaves F, Neumann G, Kawaoka Y, Sant AJ. "A Novel Vaccine Strategy to Overcome Poor Immunogenicity of Avian Influenza Vaccines through Mobilization of Memory CD4 T Cells Established by Seasonal Influenza." The Journal of immunology : official journal of the American Association of Immunologists.. 2019 Sep 15; 203(6):1502-1508. Epub 2019 Aug 09.
8/26/2019
Richards KA, Shannon I, Treanor JJ, Yang H, Nayak JL, Sant AJ. "Evidence that blunted CD4 T cells responses underlie deficient protective antibody responses to influenza vaccines in repeatedly vaccinated human subjects." The Journal of infectious diseases.. 2019 Aug 26; Epub 2019 Aug 26.
7/24/2019
Rattan A, Richards KA, Knowlden ZAG, Sant AJ. "Protein vaccination directs the CD4+ T cell response towards shared protective epitopes that can be recalled after influenza infection." Journal of virology.. 2019 Jul 24; Epub 2019 Jul 24.
1/31/2019
Sant AJ. "The way forward: Potentiating protective immunity to novel and pandemic influenza through engagement of memory CD4 T cells." The Journal of infectious diseases.. 2019 Jan 31; Epub 2019 Jan 31.
2019
Varga SM, Sant AJ. "Editorial: Orchestration of an Immune Response to Respiratory Pathogens." Frontiers in immunology.. 2019 10:690. Epub 2019 Apr 09.
2019
Nelson SA, Sant AJ. "Imprinting and Editing of the Human CD4 T Cell Response to Influenza Virus." Frontiers in immunology.. 2019 10:932. Epub 2019 May 07.
8/24/2018
Richards KA, Treanor JJ, Nayak JL, Sant AJ. "Overarching Immunodominance Patterns and Substantial Diversity in Specificity and Functionality in the Circulating Human Influenza A and B Virus-Specific CD4+ T-Cell Repertoire." The Journal of infectious diseases.. 2018 Aug 24; 218(7):1169-1174.
8/2018
Sant AJ, Richards KA, Nayak J. "Distinct and complementary roles of CD4 T cells in protective immunity to influenza virus." Current opinion in immunology.. 2018 Aug; 53:13-21. Epub 2018 Apr 02.
7/1/2018
DiPiazza A, Laniewski N, Rattan A, Topham DJ, Miller J, Sant AJ. "CD4 T Cell Epitope Specificity and Cytokine Potential Are Preserved as Cells Transition from the Lung Vasculature to Lung Tissue following Influenza Virus Infection." Journal of virology.. 2018 Jul 1; 92(13)Epub 2018 Jun 13.
7/2018
Sant AJ, DiPiazza AT, Nayak JL, Rattan A, Richards KA. "CD4 T cells in protection from influenza virus: Viral antigen specificity and functional potential." Immunological reviews.. 2018 Jul; 284(1):91-105.
2018
Richards KA, DiPiazza AT, Rattan A, Knowlden ZAG, Yang H, Sant AJ. "Diverse Epitope Specificity, Immunodominance Hierarchy, and Functional Avidity of Effector CD4 T Cells Established During Priming Is Maintained in Lung After Influenza A Virus Infection." Frontiers in immunology.. 2018 9:655. Epub 2018 Apr 06.
2018
DiPiazza AT, Richards KA, Liu WC, Albrecht RA, Sant AJ. "Analyses of Cellular Immune Responses in Ferrets Following Influenza Virus Infection." Methods in molecular biology.. 2018 1836:513-530.
9/7/2017
DiPiazza A, Nogales A, Poulton N, Wilson PC, Martínez-Sobrido L, Sant AJ. "Pandemic 2009 H1N1 Influenza Venus reporter virus reveals broad diversity of MHC class II-positive antigen-bearing cells following infection in vivo." Scientific reports.. 2017 Sep 7; 7(1):10857. Epub 2017 Sep 07.
3/2017
DiPiazza A, Richards K, Poulton N, Sant AJ. "Avian and Human Seasonal Influenza Hemagglutinin Proteins Elicit CD4 T Cell Responses That Are Comparable in Epitope Abundance and Diversity." Clinical and vaccine immunology : CVI.. 2017 Mar; 24(3)Epub 2017 Mar 06.
9/1/2016
DiPiazza A, Richards K, Batarse F, Lockard L, Zeng H, García-Sastre A, Albrecht RA, Sant AJ. "Flow Cytometric and Cytokine ELISpot Approaches To Characterize the Cell-Mediated Immune Response in Ferrets following Influenza Virus Infection." Journal of virology.. 2016 Sep 1; 90(17):7991-8004. Epub 2016 Aug 12.
6/22/2016
Knowlden ZA, Sant AJ. "CD4 T cell epitope specificity determines follicular versus non-follicular helper differentiation in the polyclonal response to influenza infection or vaccination." Scientific reports.. 2016 Jun 22; 6:28287. Epub 2016 Jun 22.
2016
DiPiazza A, Richards KA, Knowlden ZA, Nayak JL, Sant AJ. "The Role of CD4 T Cell Memory in Generating Protective Immunity to Novel and Potentially Pandemic Strains of Influenza." Frontiers in immunology.. 2016 7:10. Epub 2016 Jan 25.
9/2015
Leddon SA, Richards KA, Treanor JJ, Sant AJ. "Abundance and specificity of influenza reactive circulating memory follicular helper and non-follicular helper CD4 T cells in healthy adults." Immunology.. 2015 Sep; 146(1):157-62. Epub 2015 Jul 14.
7/1/2015
Richards KA, Nayak J, Chaves FA, DiPiazza A, Knowlden ZA, Alam S, Treanor JJ, Sant AJ. "Seasonal Influenza Can Poise Hosts for CD4 T-Cell Immunity to H7N9 Avian Influenza." The Journal of infectious diseases.. 2015 Jul 1; 212(1):86-94. Epub 2014 Dec 09.
5/1/2015
Nayak JL, Richards KA, Yang H, Treanor JJ, Sant AJ. "Effect of influenza A(H5N1) vaccine prepandemic priming on CD4+ T-cell responses." The Journal of infectious diseases.. 2015 May 1; 211(9):1408-17. Epub 2014 Nov 06.
1/2014
Alam S, Knowlden ZA, Sangster MY, Sant AJ. "CD4 T cell help is limiting and selective during the primary B cell response to influenza virus infection." Journal of virology.. 2014 Jan; 88(1):314-24. Epub 2013 Oct 23.
12/2013
Weilhammer DR, Blanchette CD, Fischer NO, Alam S, Loots GG, Corzett M, Thomas C, Lychak C, Dunkle AD, Ruitenberg JJ, Ghanekar SA, Sant AJ, Rasley A. "The use of nanolipoprotein particles to enhance the immunostimulatory properties of innate immune agonists against lethal influenza challenge." Biomaterials.. 2013 Dec; 34(38):10305-18. Epub 2013 Sep 27.
10/23/2013
Sant AJ, Chaves FA, Leddon SA, Tung J. "The control of the specificity of CD4 T cell responses: thresholds, breakpoints, and ceilings." Frontiers in immunology.. 2013 Oct 23; 4:340. Epub 2013 Oct 23.
8/1/2013
Nayak JL, Alam S, Sant AJ. "Cutting edge: Heterosubtypic influenza infection antagonizes elicitation of immunological reactivity to hemagglutinin." The Journal of immunology : official journal of the American Association of Immunologists.. 2013 Aug 1; 191(3):1001-5. Epub 2013 Jun 21.
7/15/2013
Tung J, Sant AJ. "Orchestration of CD4 T cell epitope preferences after multipeptide immunization." The Journal of immunology : official journal of the American Association of Immunologists.. 2013 Jul 15; 191(2):764-72. Epub 2013 Jun 14.
1/15/2013
Nayak JL, Fitzgerald TF, Richards KA, Yang H, Treanor JJ, Sant AJ. "CD4+ T-cell expansion predicts neutralizing antibody responses to monovalent, inactivated 2009 pandemic influenza A(H1N1) virus subtype H1N1 vaccine." The Journal of infectious diseases.. 2013 Jan 15; 207(2):297-305. Epub 2012 Nov 12.
12/17/2012
Richards KA, Chaves FA, Alam S, Sant AJ. "Trivalent inactivated influenza vaccines induce broad immunological reactivity to both internal virion components and influenza surface proteins." Vaccine.. 2012 Dec 17; 31(1):219-25. Epub 2012 Oct 22.
8/2012
Nayak JL, Sant AJ. "Loss in CD4 T-cell responses to multiple epitopes in influenza due to expression of one additional MHC class II molecule in the host." Immunology.. 2012 Aug; 136(4):425-36.
7/30/2012
Sant AJ, McMichael A. "Revealing the role of CD4(+) T cells in viral immunity." The Journal of experimental medicine.. 2012 Jul 30; 209(8):1391-5.
5/1/2012
Chaves FA, Lee AH, Nayak JL, Richards KA, Sant AJ. "The utility and limitations of current Web-available algorithms to predict peptides recognized by CD4 T cells in response to pathogen infection." The Journal of immunology : official journal of the American Association of Immunologists.. 2012 May 1; 188(9):4235-48. Epub 2012 Mar 30.
3/2012
Engels B, Chervin AS, Sant AJ, Kranz DM, Schreiber H. "Long-term persistence of CD4(+) but rapid disappearance of CD8(+) T cells expressing an MHC class I-restricted TCR of nanomolar affinity." Molecular therapy : the journal of the American Society of Gene Therapy.. 2012 Mar; 20(3):652-60. Epub 2012 Jan 10.
2012
Sundararajan A, Huan L, Richards KA, Marcelin G, Alam S, Joo H, Yang H, Webby RJ, Topham DJ, Sant AJ, Sangster MY. "Host differences in influenza-specific CD4 T cell and B cell responses are modulated by viral strain and route of immunization." PloS one.. 2012 7(3):e34377. Epub 2012 Mar 23.
2012
Leddon SA, Sant AJ. "The peptide specificity of the endogenous T follicular helper cell repertoire generated after protein immunization." PloS one.. 2012 7(10):e46952. Epub 2012 Oct 15.
12/2011
Alam S, Sant AJ. "Infection with seasonal influenza virus elicits CD4 T cells specific for genetically conserved epitopes that can be rapidly mobilized for protective immunity to pandemic H1N1 influenza virus." Journal of virology.. 2011 Dec; 85(24):13310-21. Epub 2011 Oct 05.
6/2011
Richards KA, Chaves FA, Sant AJ. "The memory phase of the CD4 T-cell response to influenza virus infection maintains its diverse antigen specificity." Immunology.. 2011 Jun; 133(2):246-56. Epub 2011 Mar 29.
3/2011
Nayak JL, Sant AJ. "T cell immunology for the clinician." The Pediatric infectious disease journal.. 2011 Mar; 30(3):248-50.
11/1/2010
Richards KA, Topham D, Chaves FA, Sant AJ. "Cutting edge: CD4 T cells generated from encounter with seasonal influenza viruses and vaccines have broad protein specificity and can directly recognize naturally generated epitopes derived from the live pandemic H1N1 virus." The Journal of immunology : official journal of the American Association of Immunologists.. 2010 Nov 1; 185(9):4998-5002. Epub 2010 Oct 01.
8/2010
Leddon SA, Sant AJ. "Generation of MHC class II-peptide ligands for CD4 T-cell allorecognition of MHC class II molecules." Current opinion in organ transplantation.. 2010 Aug; 15(4):505-11.
5/10/2010
Desmet EA, Hollenbaugh JA, Sime PJ, Wright TW, Topham DJ, Sant AJ, Takimoto T, Dewhurst S, Maggirwar SB. "Mixed Lineage Kinase 3 deficiency delays viral clearance in the lung and is associated with diminished influenza-induced cytopathic effect in infected cells." Virology.. 2010 May 10; 400(2):224-32. Epub 2010 Feb 25.
4/2010
Nayak JL, Richards KA, Chaves FA, Sant AJ. "Analyses of the specificity of CD4 T cells during the primary immune response to influenza virus reveals dramatic MHC-linked asymmetries in reactivity to individual viral proteins." Viral immunology.. 2010 Apr; 23(2):169-80.
12/2009
Weaver JM, Sant AJ. "Understanding the focused CD4 T cell response to antigen and pathogenic organisms." Immunologic research.. 2009 Dec; 45(2-3):123-43. Epub 2009 Feb 07.
7/2009
Richards KA, Chaves FA, Sant AJ. "Infection of HLA-DR1 transgenic mice with a human isolate of influenza a virus (H1N1) primes a diverse CD4 T-cell repertoire that includes CD4 T cells with heterosubtypic cross-reactivity to avian (H5N1) influenza virus." Journal of virology.. 2009 Jul; 83(13):6566-77. Epub 2009 Apr 22.
5/26/2009
Weaver JM, Chaves FA, Sant AJ. "Abortive activation of CD4 T cell responses during competitive priming in vivo." Proceedings of the National Academy of Sciences of the United States of America.. 2009 May 26; 106(21):8647-52. Epub 2009 May 07.
9/1/2008
Weaver JM, Lazarski CA, Richards KA, Chaves FA, Jenks SA, Menges PR, Sant AJ. "Immunodominance of CD4 T cells to foreign antigens is peptide intrinsic and independent of molecular context: implications for vaccine design." The Journal of immunology : official journal of the American Association of Immunologists.. 2008 Sep 1; 181(5):3039-48.
5/12/2008
Huang S, Gilfillan S, Kim S, Thompson B, Wang X, Sant AJ, Fremont DH, Lantz O, Hansen TH. "MR1 uses an endocytic pathway to activate mucosal-associated invariant T cells." The Journal of experimental medicine.. 2008 May 12; 205(5):1201-11. Epub 2008 Apr 28.
3/2008
Bandyopadhyay A, Arneson L, Beeson C, Sant AJ. "The relative energetic contributions of dominant P1 pocket versus hydrogen bonding interactions to peptide:class II stability: implications for the mechanism of DM function." Molecular immunology.. 2008 Mar; 45(5):1248-57. Epub 2007 Nov 05.
2/15/2008
Larkin J, Rankin AL, Picca CC, Riley MP, Jenks SA, Sant AJ, Caton AJ. "CD4+CD25+ regulatory T cell repertoire formation shaped by differential presentation of peptides from a self-antigen." The Journal of immunology : official journal of the American Association of Immunologists.. 2008 Feb 15; 180(4):2149-57.
2/1/2008
Menges PR, Jenks SA, Bikoff EK, Friedmann DR, Knowlden ZA, Sant AJ. "An MHC class II restriction bias in CD4 T cell responses toward I-A is altered to I-E in DM-deficient mice." The Journal of immunology : official journal of the American Association of Immunologists.. 2008 Feb 1; 180(3):1619-33.
9/2007
Gardiner A, Richards KA, Sant AJ, Arneson LS. "Conformation of MHC class II I-A(g7) is sensitive to the P9 anchor amino acid in bound peptide." International immunology.. 2007 Sep; 19(9):1103-13.
7/2007
Richards KA, Chaves FA, Krafcik FR, Topham DJ, Lazarski CA, Sant AJ. "Direct ex vivo analyses of HLA-DR1 transgenic mice reveal an exceptionally broad pattern of immunodominance in the primary HLA-DR1-restricted CD4 T-cell response to influenza virus hemagglutinin." Journal of virology.. 2007 Jul; 81(14):7608-19. Epub 2007 May 16.
6/2007
Sant AJ, Chaves FA, Krafcik FR, Lazarski CA, Menges P, Richards K, Weaver JM. "Immunodominance in CD4 T-cell responses: implications for immune responses to influenza virus and for vaccine design." Expert review of vaccines.. 2007 Jun; 6(3):357-68.
5/2007
Chaves FA, Sant AJ. "Measurement of peptide dissociation from MHC class II molecules." Current protocols in immunology / edited by John E. Coligan ... [et
al.]. 2007 May; Chapter 18:Unit 18.14.
5/23/2006
Chaves FA, Richards KA, Torelli A, Wedekind J, Sant AJ. "Peptide-binding motifs for the I-Ad MHC class II molecule: alternate pH-dependent binding behavior." Biochemistry.. 2006 May 23; 45(20):6426-33.
5/15/2006
Lazarski CA, Chaves FA, Sant AJ. "The impact of DM on MHC class II-restricted antigen presentation can be altered by manipulation of MHC-peptide kinetic stability." The Journal of experimental medicine.. 2006 May 15; 203(5):1319-28. Epub 2006 May 08.
10/2005
Sant AJ, Chaves FA, Jenks SA, Richards KA, Menges P, Weaver JM, Lazarski CA. "The relationship between immunodominance, DM editing, and the kinetic stability of MHC class II:peptide complexes." Immunological reviews.. 2005 Oct; 207:261-78.
7/1/2005
McFarland BJ, Katz JF, Sant AJ, Beeson C. "Energetics and cooperativity of the hydrogen bonding and anchor interactions that bind peptides to MHC class II protein." Journal of molecular biology.. 2005 Jul 1; 350(1):170-83.
7/2005
Lazarski CA, Chaves FA, Jenks SA, Wu S, Richards KA, Weaver JM, Sant AJ. "The kinetic stability of MHC class II:peptide complexes is a key parameter that dictates immunodominance." Immunity.. 2005 Jul; 23(1):29-40.
5/2005
Chaves FA, Hou P, Wu S, Sant AJ. "Replacement of the membrane proximal region of I-A(d) MHC class II molecule with I-E-derived sequences promotes production of an active and stable soluble heterodimer without altering peptide-binding specificity." Journal of immunological methods.. 2005 May; 300(1-2):74-92.
12/15/2001
Arneson LS, Katz JF, Liu M, Sant AJ. "Hydrogen bond integrity between MHC class II molecules and bound peptide determines the intracellular fate of MHC class II molecules." The Journal of immunology : official journal of the American Association of Immunologists.. 2001 Dec 15; 167(12):6939-46.
7/31/2001
McFarland BJ, Katz JF, Beeson C, Sant AJ. "Energetic asymmetry among hydrogen bonds in MHC class II*peptide complexes." Proceedings of the National Academy of Sciences of the United States of America.. 2001 Jul 31; 98(16):9231-6. Epub 2001 Jul 24.
9/18/2000
Nanda NK, Sant AJ. "DM determines the cryptic and immunodominant fate of T cell epitopes." The Journal of experimental medicine.. 2000 Sep 18; 192(6):781-8.
8/15/2000
Arneson LS, Peterson M, Sant AJ. "The MHC class II molecule I-Ag7 exists in alternate conformations that are peptide dependent." The Journal of immunology : official journal of the American Association of Immunologists.. 2000 Aug 15; 165(4):2059-67.
12/14/1999
McFarland BJ, Sant AJ, Lybrand TP, Beeson C. "Ovalbumin(323-339) peptide binds to the major histocompatibility complex class II I-A(d) protein using two functionally distinct registers." Biochemistry.. 1999 Dec 14; 38(50):16663-70.
12/1999
Sant AJ, Beeson C, McFarland B, Cao J, Ceman S, Bryant PW, Wu S. "Individual hydrogen bonds play a critical role in MHC class II: peptide interactions: implications for the dynamic aspects of class II trafficking and DM-mediated peptide exchange." Immunological reviews.. 1999 Dec; 172:239-53.
10/1/1999
McFarland BJ, Beeson C, Sant AJ. "Cutting edge: a single, essential hydrogen bond controls the stability of peptide-MHC class II complexes." The Journal of immunology : official journal of the American Association of Immunologists.. 1999 Oct 1; 163(7):3567-71.
9/1999
Bryant PW, Roos P, Ploegh HL, Sant AJ. "Deviant trafficking of I-Ad mutant molecules is reflected in their peptide binding properties." European journal of immunology.. 1999 Sep; 29(9):2729-39.
6/1/1999
Siemasko K, Eisfelder BJ, Stebbins C, Kabak S, Sant AJ, Song W, Clark MR. "Ig alpha and Ig beta are required for efficient trafficking to late endosomes and to enhance antigen presentation." The Journal of immunology : official journal of the American Association of Immunologists.. 1999 Jun 1; 162(11):6518-25.
1999
McFarland, B. J.; Sant, A. J.; Beeson, C.;. "Identification of two distinct structural transitions in the dissociation of peptides from class II proteins of the major histocompatibility complex" . 1999; 121: 11225-11226.
12/7/1998
Ceman S, Wu S, Jardetzky TS, Sant AJ. "Alteration of a single hydrogen bond between class II molecules and peptide results in rapid degradation of class II molecules after invariant chain removal." The Journal of experimental medicine.. 1998 Dec 7; 188(11):2139-49.
9/15/1998
Peterson M, Sant AJ. "The inability of the nonobese diabetic class II molecule to form stable peptide complexes does not reflect a failure to interact productively with DM." The Journal of immunology : official journal of the American Association of Immunologists.. 1998 Sep 15; 161(6):2961-7.
6/1997
Tan LJ, Ceman S, Chervonsky A, Rodriguez-Paris J, Steck TL, Sant AJ. "Late events in the intracellular sorting of major histocompatibility complex class II molecules are regulated by the 80-82 segment of the class II beta chain." European journal of immunology.. 1997 Jun; 27(6):1479-88.
12/1/1996
Stebbins CC, Peterson ME, Suh WM, Sant AJ. "DM-mediated release of a naturally occurring invariant chain degradation intermediate from MHC class II molecules." The Journal of immunology : official journal of the American Association of Immunologists.. 1996 Dec 1; 157(11):4892-8.
11/1/1996
Katz JF, Stebbins C, Appella E, Sant AJ. "Invariant chain and DM edit self-peptide presentation by major histocompatibility complex (MHC) class II molecules." The Journal of experimental medicine.. 1996 Nov 1; 184(5):1747-53.
12/1995
Ceman S, Sant AJ. "The function of invariant chain in class II-restricted antigen presentation." Seminars in immunology.. 1995 Dec; 7(6):373-87.
5/1/1995
Zuckerman LA, Sant AJ, Miller J. "Identification of a unique costimulatory activity for murine T helper 1 T cell clones." The Journal of immunology : official journal of the American Association of Immunologists.. 1995 May 1; 154(9):4503-12.
4/1995
Chervonsky A, Sant AJ. "In the absence of major histocompatibility complex class II molecules, invariant chain is translocated to late endocytic compartments by autophagy." European journal of immunology.. 1995 Apr; 25(4):911-8.
1/1/1995
Stebbins CC, Loss GE, Elias CG, Chervonsky A, Sant AJ. "The requirement for DM in class II-restricted antigen presentation and SDS-stable dimer formation is allele and species dependent." The Journal of experimental medicine.. 1995 Jan 1; 181(1):223-34.
7/1994
Chervonsky AV, Gordon L, Sant AJ. "A segment of the MHC class II beta chain plays a critical role in targeting class II molecules to the endocytic pathway." International immunology.. 1994 Jul; 6(7):973-82.
2/15/1994
Katz JF, Sant AJ. "T cell receptor recognition of MHC class II alloantigens is highly cell type dependent." The Journal of immunology : official journal of the American Association of Immunologists.. 1994 Feb 15; 152(4):1629-40.
2/1994
Sant AJ, Miller J. "MHC class II antigen processing: biology of invariant chain." Current opinion in immunology.. 1994 Feb; 6(1):57-63.
1994
Sant AJ. "Endogenous antigen presentation by MHC class II molecules." Immunologic research.. 1994 13(4):253-67.
7/1/1993
Loss GE, Elias CG, Fields PE, Ribaudo RK, McKisic M, Sant AJ. "Major histocompatibility complex class II-restricted presentation of an internally synthesized antigen displays cell-type variability and segregates from the exogenous class II and endogenous class I presentation pathways." The Journal of experimental medicine.. 1993 Jul 1; 178(1):73-85.
6/15/1993
Sant AJ. "Isotypic residues in the membrane proximal domain of MHC class II beta-chains control activation of CD4+ T cells." The Journal of immunology : official journal of the American Association of Immunologists.. 1993 Jun 15; 150(12):5299-310.
4/15/1993
Loss GE, Sant AJ. "Invariant chain retains MHC class II molecules in the endocytic pathway." The Journal of immunology : official journal of the American Association of Immunologists.. 1993 Apr 15; 150(8 Pt 1):3187-97.
11/1/1991
McKisic MD, Sant AJ, Fitch FW. "Some cloned murine CD4+ T cells recognize H-2Ld class I MHC determinants directly. Other cloned CD4+ T cells recognize H-2Ld class I MHC determinants in the context of class II MHC molecules." The Journal of immunology : official journal of the American Association of Immunologists.. 1991 Nov 1; 147(9):2868-74.
10/1/1991
Sant AJ, Hendrix LR, Coligan JE, Maloy WL, Germain RN. "Defective intracellular transport as a common mechanism limiting expression of inappropriately paired class II major histocompatibility complex alpha/beta chains." The Journal of experimental medicine.. 1991 Oct 1; 174(4):799-808.
1/1/1990
Lechler RI, Sant AJ, Braunstein NS, Sekaly R, Long E, Germain RN. "Cell surface expression of hybrid murine/human MHC class II beta alpha dimers. Key influence of residues in the amino-terminal portion of the beta 1 domain." The Journal of immunology : official journal of the American Association of Immunologists.. 1990 Jan 1; 144(1):329-33.
6/2/1989
Sant AJ, Germain RN. "Intracellular competition for component chains determines class II MHC cell surface phenotype." Cell.. 1989 Jun 2; 57(5):797-805.
1/1/1988
Sant AJ, Zacheis M, Rumbarger T, Giacoletto KS, Schwartz BD. "Human Ia alpha- and beta-chains are sulfated." The Journal of immunology : official journal of the American Association of Immunologists.. 1988 Jan 1; 140(1):155-60.
1988
Germain RN, Sant AJ, Braunstein NS, Ronchese F. "The molecular basis of antigen presentation." Princess Takamatsu symposia. 1988 19:179-91.
11/1987
Sant AJ, Braunstein NS, Germain RN. "Predominant role of amino-terminal sequences in dictating efficiency of class II major histocompatibility complex alpha beta dimer expression." Proceedings of the National Academy of Sciences of the United States of America.. 1987 Nov; 84(22):8065-9.
11/1/1986
Giacoletto KS, Sant AJ, Bono C, Gorka J, O'Sullivan DM, Quaranta V, Schwartz BD. "The human invariant chain is the core protein of the human class II-associated proteoglycan." The Journal of experimental medicine.. 1986 Nov 1; 164(5):1422-39.
12/1/1985
Sant AJ, Cullen SE, Giacoletto KS, Schwartz BD. "Invariant chain is the core protein of the Ia-associated chondroitin sulfate proteoglycan." The Journal of experimental medicine.. 1985 Dec 1; 162(6):1916-34.
7/1985
Sant AJ, Cullen SE, Schwartz BD. "Biosynthetic relationships of the chondroitin sulfate proteoglycan with Ia and invariant chain glycoproteins." The Journal of immunology : official journal of the American Association of Immunologists.. 1985 Jul; 135(1):416-22.
7/1985
Sant AJ, Schwartz BD, Cullen SE. "Cellular distribution of the Ia-associated chondroitin sulfate proteoglycan." The Journal of immunology : official journal of the American Association of Immunologists.. 1985 Jul; 135(1):408-15.
3/1984
Sant AJ, Cullen SE, Schwartz BD. "Identification of a sulfate-bearing molecule associated with HLA class II antigens." Proceedings of the National Academy of Sciences of the United States of America.. 1984 Mar; 81(5):1534-8.
12/1/1983
Sant AJ, Schwartz BD, Cullen SE. "Identification of a new component in the murine Ia molecular complex." The Journal of experimental medicine.. 1983 Dec 1; 158(6):1979-92.