CONTACT INFORMATIONBIOGRAPHYCREDENTIALSAWARDSPATENTSPUBLICATIONSZhenqiang Yao, B.Med., Ph.D.Contact InformationPhone NumbersOffice: (585) 273-4129Fax: (585) 756-4468Research LabsYao-Z LabVisit Yao-Z Lab Lab WebsiteLocationsUniversity of Rochester Medical CenterSchool of Medicine and Dentistry601 Elmwood Ave, Box 626Rochester, NY 14642Faculty AppointmentsAssociate Professor - Department of Pathology and Laboratory Medicine (SMD) Associate Professor - Department of Pharmacology and Physiology (SMD) - JointAssociate Professor - Department of Biomedical Engineering (SMD) - JointAssociate Professor - Department of Dentistry (SMD) - JointBiographyDr. Yao’s research interests focus on the basic and translational studies of musculoskeletal diseases and breast cancer.Research1. Musculoskeletal Research: Our current projects focus on osteoimmunology with aging, which studies how interactions between bone and immune systems during aging cause age-related osteoporosis and immunosenescence, an acquired dysfunctional adaptive and innate immunity with aging, through TRAF3-NF-kappaB signaling. We are also collaborating with chemists to develop a bone-targeted lysosomal inhibitor that stabilizes TRAF3 to treat osteoporosis and immunosenescence. 2. Cancer Research: The most significant challenges in treating cancer are recurrence and metastasis. Our current projects focus on cancer immunotherapy using our newly developed engineered macrophage to prevent and eliminate metastatic cancers specifically while avoiding systemic side effects. We are also interested in the mechanism by which microbiome-derived LPS promotes the development of metastatic cancer and the influence of LPS signaling on the therapeutic response of metastatic cancer to a class of small molecular compounds that degrade IAP proteins.CredentialsEducation1993MS | Kunming Medical CollegeOrthopedic Surgery2016PhD | University of WestminsterBiomedical ScienceAwards2021The Mid-Career Faculty Travel GrantSponsor: American Society for Bone and Mineral Research2007Young Investigator AwardSponsor: American Society for Bone and Mineral Research2006Young Investigator AwardSponsor: International Society of Bone MorphologyVIEW ALL expand_morePatentsPatent Title: Phosphonate-Chloroquine Conjugates and Methods Using Same Patent #: 10,660,884 Issue Date: May 26, 2020 Country: United States Invented By: Robert K Boeckman, Jr., Brendan Boyce, Frank (Hal) Ebetino, Lifeng Xiao, Zhenqiang YaoPublicationsJournal Articles1/11/2023Li J, Yao Z, Liu X, Duan R, Yi X, Ayoub A, Sanders JO, Mesfin A, Xing L, Boyce BF. "TGF?1CCR5 neutrophil subset increases in bone marrow and causes age-related osteoporosis in male mice." Nature communications.. 2023 Jan 11; 14(1):159. Epub 2023 Jan 11. 9/16/2022Yao Z, Boyce BF. "TGF? priming promotes TNF-induced bone erosion: a promising new target in RA?" Nature reviews. Rheumatology.. 2022 Sep 16; Epub 2022 Sep 16. 2/27/2022Shen G, Liu X, Lei W, Duan R, Yao Z. "Plumbagin is a NF-?B-Inducing Kinase Inhibitor with Dual Anabolic and Anti-Resorptive Effects that Prevents Menopausal-Related Osteoporosis in Mice." The Journal of biological chemistry.. 2022 Feb 27; :101767. Epub 2022 Feb 27. Books & Chapters2021 Chapter Title: RANKL-Based Osteoclastic Assay from Murine Bone Marrow Cells Book Title: Skeletal Development and Repair. Methods in Molecular Biology Author List: Yao Z, Xing L and Boyce B. Published By: Springer 20212020 Chapter Title: Osteoclast Signal Transduction Pathways: The RANKL/RANK System. Book Title: Encyclopedia of Bone Biology Author List: Yao Z, Boyce B. Published By: Elsevier 20202020 Chapter Title: Translational Pharmacology in the Development of RANKL Inhibitors Book Title: Encyclopedia of Bone Biology Author List: Boyce B, Yao Z. Published By: Elsevier 2020VIEW ALL PUBLICATIONSClose WindowSchedule an appointment with Zhenqiang Yao, B.Med., Ph.D.Please answer the following questions to help us find the right appointment for you.Important: If you believe that you have a medical or psychiatric emergency, please call 911 or go to the nearest hospital. This website is not intended for emergency care.Have you seen this provider in the last 2 years?YesNoExisting Patient Schedule or request a follow up appointment online through MyChart. If you do not have a MyChart account, please close this window and call the appointment phone number. Zhenqiang Yao, B.Med., Ph.D. is currently scheduling for the following appointment type(s): Our policy does not permit patients to establish care with multiple providers within the same practice or specialty without prior approval. If you choose a new provider in the same office, we will cancel the appointment. Please contact the office directly with questions on this policy.