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Zhenqiang Yao, B.Med., Ph.D.

Contact Information

Phone Numbers

Office: (585) 273-4129

Fax: (585) 756-4468

Research Labs

Faculty Appointments

Biography

Dr. Yao’s research interests focus on the basic and translational studies of musculoskeletal diseases and breast cancer.

Research

1. Musculoskeletal Research: Our current projects focus on osteoimmmunology with aging, which study how interactions between bone and immune systems during aging cause age-related osteoporosis with low bone turnover and immunosenescence, an acquired dysfunctional adaptive and innate immunity with aging, through TRAF3-NF-kappaB signaling. We are also collaborating with chemist to develop a bone-targeted lysosomal inhibitor that stabilizes TRAF3 to treat both osteoporosis and immunosenescence.
2. Cancer Research: The greatest challenging issues in treating cancer are the recurrence and metastasis. Our current projects focus on cancer immunotherapy using our newly developed engineered macrophage to prevent and eliminate metastatic cancers specifically while avoiding systemic side-effects. We are also interested in the mechanism by which microbiome-derived LPS promotes the development of metastatic cancer and the influence of LPS signaling on the therapeutic response of metastatic cancer to a class of small molecular IAP antagonist.

Credentials

Education

1993
MS | Kunming Medical College
Orthopedic Surgery

2016
PhD | University of Westminster
Biomedical Science

Awards

2021
The Mid-Career Faculty Travel Grant
Sponsor: American Society for Bone and Mineral Research

2007
Young Investigator Award
Sponsor: American Society for Bone and Mineral Research

2006
Young Investigator Award
Sponsor: International Society of Bone Morphology

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Patents

Patent Title: Phosphonate-Chloroquine Conjugates and Methods Using Same
Patent #: 10,660,884
Issue Date: May 26, 2020
Country: United States
Invented By: Robert K Boeckman, Jr., Brendan Boyce, Frank (Hal) Ebetino, Lifeng Xiao, Zhenqiang Yao

Publications

Journal Articles

9/16/2022
Yao Z, Boyce BF. "TGF? priming promotes TNF-induced bone erosion: a promising new target in RA?" Nature reviews. Rheumatology.. 2022 Sep 16; Epub 2022 Sep 16.

2/27/2022
Shen G, Liu X, Lei W, Duan R, Yao Z. "Plumbagin is a NF-?B-Inducing Kinase Inhibitor with Dual Anabolic and Anti-Resorptive Effects that Prevents Menopausal-Related Osteoporosis in Mice." The Journal of biological chemistry.. 2022 Feb 27; :101767. Epub 2022 Feb 27.

2022
Liu X, Yao JJ, Chen Z, Lei W, Duan R, Yao Z. "Lipopolysaccharide sensitizes the therapeutic response of breast cancer to IAP antagonist." Frontiers in immunology.. 2022 13:906357. Epub 2022 Aug 31.

Books & Chapters

2021
Chapter Title: RANKL-Based Osteoclastic Assay from Murine Bone Marrow Cells
Book Title: Skeletal Development and Repair. Methods in Molecular Biology
Author List: Yao Z, Xing L and Boyce B.
Published By: Springer 2021

2020
Chapter Title: Osteoclast Signal Transduction Pathways: The RANKL/RANK System.
Book Title: Encyclopedia of Bone Biology
Author List: Yao Z, Boyce B.
Published By: Elsevier 2020

2020
Chapter Title: Translational Pharmacology in the Development of RANKL Inhibitors
Book Title: Encyclopedia of Bone Biology
Author List: Boyce B, Yao Z.
Published By: Elsevier 2020

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