Research Bio
Dr. Rahman's research interests are:
1) Signaling Mechanisms of Endothelial ICAM-1 Expression
2) Neutrophil-mediated Lung Injury.
They want to know how pro-inflammatory mediators such as thrombin and tumor necrosis factor alpha (TNF) mediate neutrophils (PMN) sequestration and emigration in the lung and thus induce lung vascular injury. In particular, they are interested in defining the critical signaling pathways mediating expression of intercellular adhesion molecule (CAM-1; CD54), an inducible endothelial adhesive protein that serves as a counter-receptor for ²2-integrins (CD11/CD18) present on the surface of leukocytes. Interaction of ICAM-1 with ²2-integrins enables PMN to adhere firmly and stably to the vascular endothelium, and to migrate across the endothelial barrier. PMN binding to endothelial cells by this mechanism contributes to the development of lung vascular injury and tissue edema.
Dr. Rahman uses multidisciplinary approaches ranging from cultured endothelial cells and in vivo mouse models with targeted gene deletions to molecular biology and lung physiology to address these questions of fundamental importance.
2013
Fazal F, Bijli KM, Murrill M, Leonard A, Minhajuddin M, Anwar KN, Finkelstein JN, Watterson DM, Rahman A. "Critical role of non-muscle myosin light chain kinase in thrombin-induced endothelial cell inflammation and lung PMN infiltration." PloS one. 2013 8(3):e59965. Epub 2013 Mar 21. |
2012 Nov
Bijli KM, Fazal F, Rahman A. "Regulation of Rela/p65 and endothelial cell inflammation by proline-rich tyrosine kinase 2." American journal of respiratory cell and molecular biology. 2012 Nov; 47(5):660-8. Epub 2012 Jul 27. |
2010 Jun 15
Edirisinghe I, Arunachalam G, Wong C, Yao H, Rahman A, Phipps RP, Jin ZG, Rahman I. "Cigarette-smoke-induced oxidative/nitrosative stress impairs VEGF- and fluid-shear-stress-mediated signaling in endothelial cells." Antioxidants & redox signaling. 2010 Jun 15; 12(12):1355-69. |
2009 Jul 31
Fazal F, Bijli KM, Minhajuddin M, Rein T, Finkelstein JN, Rahman A. "Essential role of cofilin-1 in regulating thrombin-induced RelA/p65 nuclear translocation and intercellular adhesion molecule 1 (ICAM-1) expression in endothelial cells." The Journal of biological chemistry. 2009 Jul 31; 284(31):21047-56. Epub 2009 May 29. |
2009 Apr
Rahman A, Fazal F. "Hug tightly and say goodbye: role of endothelial ICAM-1 in leukocyte transmigration." Antioxidants & redox signaling. 2009 Apr; 11(4):823-39. |
