Research Bio
Dr. Rahman's research interests are:
1) Signaling Mechanisms of Endothelial ICAM-1 Expression
2) Neutrophil-mediated Lung Injury.
They want to know how pro-inflammatory mediators such as thrombin and tumor necrosis factor alpha (TNF) mediate neutrophils (PMN) sequestration and emigration in the lung and thus induce lung vascular injury. In particular, they are interested in defining the critical signaling pathways mediating expression of intercellular adhesion molecule (CAM-1; CD54), an inducible endothelial adhesive protein that serves as a counter-receptor for ²2-integrins (CD11/CD18) present on the surface of leukocytes. Interaction of ICAM-1 with ²2-integrins enables PMN to adhere firmly and stably to the vascular endothelium, and to migrate across the endothelial barrier. PMN binding to endothelial cells by this mechanism contributes to the development of lung vascular injury and tissue edema.
Dr. Rahman uses multidisciplinary approaches ranging from cultured endothelial cells and in vivo mouse models with targeted gene deletions to molecular biology and lung physiology to address these questions of fundamental importance.
2016 Aug 1
Bijli KM, Fazal F, Slavin SA, Leonard A, Grose V, Alexander WB, Smrcka AV, Rahman A. "Phospholipase C-? signaling mediates endothelial cell inflammation and barrier disruption in acute lung injury." American journal of physiology. Lung cellular and molecular physiology. 2016 Aug 1; 311(2):L517-24. Epub 2016 Jul 01. |
2016 Jul 2
Angara S, Syed M, Das P, Janér C, Pryhuber G, Rahman A, Andersson S, Homer RJ, Bhandari V. "Inhibition of RPTOR Prevents Hyperoxia-induced Lung Injury by Enhancing Autophagy and Reducing Apoptosis in Neonatal Mice." American journal of respiratory cell and molecular biology. 2016 Jul 2; Epub 2016 Jul 02. |
2015 Aug 1
Solleti SK, Simon DM, Srisuma S, Arikan MC, Bhattacharya S, Rangasamy T, Bijli KM, Rahman A, Crossno JT, Shapiro SD, Mariani TJ. "Airway epithelial cell PPAR? modulates cigarette smoke-induced chemokine expression and emphysema susceptibility in mice." American journal of physiology. Lung cellular and molecular physiology. 2015 Aug 1; 309(3):L293-304. Epub 2015 May 29. |
2014
Bijli KM, Kanter BG, Minhajuddin M, Leonard A, Xu L, Fazal F, Rahman A. "Regulation of endothelial cell inflammation and lung polymorphonuclear lymphocyte infiltration by transglutaminase 2." Shock. 2014 42(6):562-9. |
2013
Leonard A, Marando C, Rahman A, Fazal F. "Thrombin selectively engages LIM kinase1 and slingshot-1L phosphatase to regulate NF-?B activation and endothelial cell inflammation." Am J Physiol: Lung Cell Mol Physiol. 2013; 305: L651-64. |
