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Arshad Rahman, Ph.D.

Contact Information

Phone Numbers

Office: (585) 275-5948

Faculty Appointments



My laboratory has a long-standing interest in endothelial cell biology and lung physiology especially as it relates to molecular analysis of signal transduction and gene regulation, and in vivo gene delivery to the lung endothelium. Specifically, we want to know how the otherwise "antiadhesive, anticoagulant, and relatively restrictive (semipermeable)" microvasculature is rendered into a "proadhesive, procoagulant, and leaky" one during acute lung injury (ALI). We have made contributions to the understanding of regulation of nuclear factor-kappaB (NF-?B), a master regulator of inflammation that is implicated in regulating these phenotypes of microvasculature during ALI and other inflammatory conditions. Another area of my research focuses on understanding the regulation and function of endothelial cells (EC) autophagy and its relationship with EC inflammation in the context of ALI. Our novel and exciting findings that autophagy and inflammation are linked in the lung endothelium and collaborate in causing lung injury form the basis of our ongoing research to identify the mechanistic link between these two fundamental processes (autophagy and inflammation), and address the relevance of this linkage in the pathogenesis of ALI.

More recently, we have been focusing on Spleen Tyrosine Kinase (Syk) and Mechanistic/Mammalian Target of Rapamycin (MTOR) as critical mechanistic targets for modulation of ALI pathogenesis. The Syk project seeks to clarify the mechanism by which Syk regulates EC dysfunction (permeability and inflammation) in ALI and evaluate the therapeutic efficacy of Syk inhibition against evolving ALI in mice with sepsis. The MTOR project builds logically on our prior work and seeks to clarify the role of MTOR in ALI and evaluate the preventive and therapeutic efficacy of modulation of MTOR signaling against ALI. In a nutshell, the research in my lab uses genetically modified mice, primary cell cultures, and multidisciplinary approaches ranging from biochemical, cellular, and molecular biology to in vivo gene delivery (cell-specific transfer of genes and shRNA to endothelial cells in the lung) and multiple mouse models of ALI to identify viable therapeutic targets and mechanisms to limit ALI.



BSc | AM University

MSc | AM University

PhD | AM University

Post-doctoral Training & Residency

1993 - 1995
Senior Research Associate, Department of Pharmacology, Rush Medical Center, Chicago, IL

1992 - 1993
Research Associate, Department of Microbiology and Immunology, Northwestern University Medical School, Chicago, IL


Journal Articles

Leonard A, Rahman A, Fazal F. "Importins ? and ? signaling mediates endothelial cell inflammation and barrier disruption." Cellular signalling.. 2018 Apr 0; 44:103-117. Epub 2018 Jan 11.

Slavin SA, Leonard A, Grose V, Fazal F, Rahman A. "Autophagy inhibitor 3-methyladenine protects against endothelial cell barrier dysfunction in acute lung injury." American journal of physiology. Lung cellular and molecular physiology.. 2018 Mar 1; 314(3):L388-L396. Epub 2017 Oct 26.

Angara S, Syed M, Das P, Janér C, Pryhuber G, Rahman A, Andersson S, Homer RJ, Bhandari V. "Inhibition of Regulatory-Associated Protein of Mechanistic Target of Rapamycin Prevents Hyperoxia-Induced Lung Injury by Enhancing Autophagy and Reducing Apoptosis in Neonatal Mice." American journal of respiratory cell and molecular biology.. 2016 Nov 0; 55(5):722-735.

Books & Chapters

Chapter Title: Nuclear Factor-kappaB Signaling in Endothelium
Book Title: Endothelial Biomedicine
Author List: Bijli KM, Rahman A
Edited By: Aird WC
Published By: Cambridge University Press2007

Chapter Title: Transcriptional regulation of endothelial adhesion molecule gene expression by oxidants and cytokines.
Book Title: Nitric Oxide and Radicals in the Pulmonary Vasculature. Proceedings of the VII
Author List: Rahman A, Roebuck KA, Malik AB
Edited By: Weir EK, Archer SL, Reeves JT
Published By: Futura Publishing Co.1996 in New York, NY

Chapter Title: Strand scission in DNA induced by dietary flavonoids: role of Cu(I) and oxygen free radicals.
Book Title: Glimpses in Plant Research XI: Medicinal Plants; New Vistas of Research-Part 2
Author List: Rahman A, Fazal F, Hadi SM
Edited By: Govil JN, Singh VK, Hashmi S
Published By: Today and Tomorrow's Printers and Publishers1993 in New Delhi, India