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Paul Spencer Brookes, Ph.D.

Contact Information

Research Labs

Faculty Appointments

Credentials

Education

1993
BS | UK - Non-Medical School
Biochemistry

1997
PhD | UK-Cambridge U Med Sch
Biochemistry

Awards

2006 - 2006
Anthony Linnane Award for outstanding contribution to mitochondrial research
Sponsor: United Mitochondrial Disease Foundation

1999
Young Investigator Award
Sponsor: 6th Annual Meeting, Society for Free Radical Biology & Medicine

Patents

Patent Title: Mitochondria-Targeted Antioxidant Prodrugs and Methods of Use
Patent #: 8,470,861
Issue Date: Jun 25, 2013
Country: United States
Invented By: Marion W Anders, Paul S Brookes, Leif Olson, Richard L Parton, James L Robotham, Shey-Shing Sheu, Jalai Shojaie

Publications

Journal Articles

7/11/2022
Paine A, Brookes PS, Bhattacharya S, Li D, Garcia-Hernandez ML, Tausk F, Ritchlin C. "Dysregulation of bile acids, lipids, and nucleotides in psoriatic arthritis revealed by unbiased profiling of serum metabolites." Arthritis & rheumatology.. 2022 Jul 11; Epub 2022 Jul 11.

6/29/2022
Milliken AS, Nadtochiy SM, Brookes PS. "Inhibiting Succinate Release Worsens Cardiac Reperfusion Injury by Enhancing Mitochondrial Reactive Oxygen Species Generation." Journal of the American Heart Association.. 2022 Jun 29; :e026135. Epub 2022 Jun 29.

9/20/2021
Kotla S, Zhang A, Imanishi M, Ko KA, Lin SH, Gi YJ, Moczygemba M, Isgandarova S, Schadler KL, Chung C, Milgrom SA, Banchs J, Yusuf SW, Amaya DN, Guo H, Thomas TN, Shen YH, Deswal A, Herrmann J, Kleinerman ES, Entman ML, Cooke JP, Schifitto G, Maggirwar SB, McBeath E, Gupte AA, Krishnan S, Patel ZS, Yoon Y, Burks JK, Fujiwara K, Brookes PS, Le NT, Hamilton DJ, Abe JI. "Nucleus-mitochondria positive feedback loop formed by ERK5 S496 phosphorylation-mediated poly (ADP-ribose) polymerase activation provokes persistent pro-inflammatory senescent phenotype and accelerates coronary atherosclerosis after chemo-radiation." Redox biology.. 2021 Sep 20; 47:102132. Epub 2021 Sep 20.

Books & Chapters

2008
Chapter Title: Aging & Cardiac Ischemia: Mitochondrial Free Radical Considerations
Book Title: Oxidative Stress in Aging: From Model Systems to Human Diseases
Author List: Brookes PS, Hoffman DL
Edited By: S Miwa, K Beckman, F Muller
Published By: Springer Verlag 2008 in NY

2008
Chapter Title: The interaction of mitochondrial membranes with reactive oxygen and nitrogen species
Book Title: Free Radical Effects on Membranes
Author List: Brookes PS, Wojtovich AP, Burwell LS, Hoffman DL, Nadtochiy SM
Edited By: S Matalon, S Simon, D Benos
Published By: Elsevier 2008 in NY

2006
Chapter Title: Methods for measuring the regulation of respiration by nitric oxide
Book Title: Mitochondria - Methods in Cell Biology Series
Author List: Shiva, S; Brookes, PS; Darley-Usmar, VM
Edited By: Eds. L Pon and Eric Schon
Published By: Press/Elsevier 2006 in San Diego

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