CONTACT INFORMATIONCREDENTIALSAWARDSPUBLICATIONSMichael D. Bulger, Ph.D.Contact InformationLocationsUniversity of Rochester Medical CenterSchool of Medicine and Dentistry601 Elmwood Ave, Box 703Rochester, NY 14642Faculty AppointmentsAssociate Professor - Department of Pediatrics , Center for Pediatric Biomedical Research (SMD) BiographyResearchDr. Bulger is interested in the interplay between tissue-specific gene expression and large-scale patterns of chromatin structure, as well as mechanisms by which enhancers and locus control regions (LCRs) mediate gene activation over large genomic distances. He addresses these questions using genes up-regulated or specifically expressed during late erythroid differentiation, including the b-globin genes, as models. Ongoing or planned projects in his lab include: (1) Modeling the formation of active chromatin domains in different experimental systems, including stably integrated transgenes in cell culture and reconstituted minichromosomes in cell-free extracts, in order to determine the cis-acting sequences and DNA-binding protein factors involved in their establishment and maintenance; (2) Characterizing non-genic transcription within the b-globin locus, as well as other loci, and investigating the relationship between such transcription and domain-wide gene regulation; (3) Identifying factors that facilitate enhancer-promoter and/or LCR-promoter communication at the b-globin locus, in order to gain clues as to how such communication occurs; (4) Identifying factors that bind to 3'HS1 of the b-globin locus, which is the most prominent site of attachment to nuclear matrix at this region, in order to investigate the relationship between nuclear architecture and gene expression; (5) Investigating the role of serine protease inhibitors (serpins) in chromatin condensation and gene regulation in differentiating erythroid cells.CredentialsEducation1990BS | Pennsylvania State UniversityMolecular and Cell Biology1996PhD | University of California at San DiegoBiologyPost-doctoral Training & Residency1996 - 2003Postdoctoral Fellowship, Fred Hutchinson Cancer Research Center, Seattle, WA.Awards2006 - PresentBeckman Young Investigators Award, Arnold and Mabel Beckman Foundation2000 - PresentBurroughs Wellcome Fund Career Award in the Biomedical Sciences1992Excellence in Teaching Award, University of California, San Diego, CAVIEW ALL expand_morePublicationsJournal Articles2020Fox S; Myers JA; Davidson C; Getman M; Kingsley PD; Frankiewicz N; Bulger M. "Hyperacetylated chromatin domains mark cell type-specific genes and suggest distinct modes of enhancer function". Nat Commun. 2020; : 4544.2018Tucker C; Bhattacharya S; Wakabayashi H; Bellaousov S; Kravets A; Welle SL; Myers J; Hayes JJ; Bulger M; Rustchenko E. "Transcriptional Regulation on Aneuploid Chromosomes in Diverse Candida albicans Mutants". Sci Rep. 2018; : 1630.2017Wakabayashi H, Tucker C, Bethlendy G, Kravets A, Welle SL, Bulger M, Hayes JJ, Rustchenko E. "NuA4 histone acetyltransferase activity is required for H4 acetylation on a dosagecompensated monosomic chromosome that confers resistance to fungal toxins." Epigenetics Chromatin. 2017; 10: 49.VIEW ALL PUBLICATIONSClose WindowSchedule an appointment with Michael D. Bulger, Ph.D.Please answer the following questions to help us find the right appointment for you.Important: If you believe that you have a medical or psychiatric emergency, please call 911 or go to the nearest hospital. This website is not intended for emergency care.Have you seen this provider in the last 2 years?YesNoExisting Patient Schedule or request a follow up appointment online through MyChart. If you do not have a MyChart account, please close this window and call the appointment phone number. Michael D. Bulger, Ph.D. is currently scheduling for the following appointment type(s): Our policy does not permit patients to establish care with multiple providers within the same practice or specialty without prior approval. If you choose a new provider in the same office, we will cancel the appointment. Please contact the office directly with questions on this policy.