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Alayna E. Loiselle, Ph.D.

Contact Information

Phone Numbers

Office: (585) 275-7239

Research Labs

Faculty Appointments

  • Assistant Professor - Department of Orthopaedics , Center for Musculoskeletal Research (SMD)
  • Assistant Professor - Department of Biomedical Engineering (SMD) - Joint

Biography

Research

The overarching goal of our research program is to identify novel strategies to improve flexor tendon healing by reducing the formation of range of motion (ROM) limiting adhesions, without compromising mechanical strength. Flexor tendons glide through a synovial sheath to facilitate digit ROM and movement of the hand. Following injury, up to 40% of primary flexor tendon repairs will heal with unsatisfactory outcomes. The primary complication involves a robust scar tissue response, which forms adhesions between the tendon and synovial sheath, resulting impaired gliding function.
We have developed a novel murine model of intrasynovial FT healing, which mimics many aspects of healing in humans including abundant adhesion formation, impaired ROM and early decrements in tendon strength. We continue to use this model to gain a greater understanding of the cell and molecular processes involved in scar and adhesion formation in order to identify therapeutic targets to improve FT healing

Credentials

Education

2004
BS | Niagara University
Biology

2009
PhD | University of Rochester School of Medicine & Dentistry
Pathology

2013
Post-doctoral Fellowship | Penn State College of Medicine
Orthopaedics

Awards

2014
Goldner Pioneer Award
Sponsor: American Society for Surgery of the Hand

2013
Bond Bradley Award- Outstanding Postdoctoral Fellow
Sponsor: Penn State College of Medicine

2012
Young Investigator Award
Sponsor: American Society of Bone and Mineral Research

2011
Alice L. Jee Young Investigator Award
Sponsor: International Bone and Mineral Society

2008
Travel Award
Sponsor: American Society of Matrix Biology

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Publications

Journal Articles

6/2019
Studentsova V, Knapp E, Loiselle AE. "Insulin Receptor deletion in S100a4-lineage cells accelerates age-related bone loss." Bone reports.. 2019 Jun 0; 10:100197. Epub 2019 Feb 05.

2/8/2019
Nichols AEC, Best KT, Loiselle AE. "The Cellular basis of fibrotic tendon healing: challenges and opportunities." Translational research : the journal of laboratory and clinical medicine.. 2019 Feb 8; Epub 2019 Feb 08.

6/15/2018
Studentsova V, Mora KM, Glasner MF, Buckley MR, Loiselle AE. "Obesity/Type II Diabetes Promotes Function-limiting Changes in Murine Tendons that are not reversed by Restoring Normal Metabolic Function." Scientific reports.. 2018 Jun 15; 8(1):9218. Epub 2018 Jun 15.

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