CONTACT INFORMATIONCREDENTIALSAWARDSPUBLICATIONSAlayna E. Loiselle, Ph.D.Contact InformationPhone NumbersOffice: (585) 275-7239Social Links@LoiselleLabResearch LabsLoiselle LabVisit Loiselle Lab Lab WebsiteLocationsUniversity of Rochester Medical CenterSchool of Medicine and Dentistry601 Elmwood Ave, Box 665Rochester, NY 14642Faculty AppointmentsAssociate Professor - Department of Orthopaedics , Center for Musculoskeletal Research (SMD) Associate Professor - Department of Biomedical Engineering (SMD) - JointAssociate Professor - Department of Pathology and Laboratory Medicine (SMD) - JointBiographyResearchThe overarching goal of our research program is to identify novel strategies to improve flexor tendon healing by reducing the formation of range of motion (ROM) limiting adhesions, without compromising mechanical strength. Flexor tendons glide through a synovial sheath to facilitate digit ROM and movement of the hand. Following injury, up to 40% of primary flexor tendon repairs will heal with unsatisfactory outcomes. The primary complication involves a robust scar tissue response, which forms adhesions between the tendon and synovial sheath, resulting impaired gliding function. We have developed a novel murine model of intrasynovial FT healing, which mimics many aspects of healing in humans including abundant adhesion formation, impaired ROM and early decrements in tendon strength. We continue to use this model to gain a greater understanding of the cell and molecular processes involved in scar and adhesion formation in order to identify therapeutic targets to improve FT healingCredentialsEducation2004BS | Niagara UniversityBiology2009PhD | University of Rochester School of Medicine & DentistryPathology2013Post-doctoral Fellowship | Penn State College of MedicineOrthopaedicsAwards2021 - 2023Senior Leader Education & Development (SLED) ProgramLocation: URMC2014Goldner Pioneer AwardSponsor: American Society for Surgery of the Hand2013Bond Bradley Award- Outstanding Postdoctoral FellowSponsor: Penn State College of Medicine2013Fellows Forum on Metabolic Bone Disease Travel AwardLocation: Endocrine Fellows Foundation2012Young Investigator AwardSponsor: American Society of Bone and Mineral Research2012Fellows Forum on Metabolic Bone Disease Travel AwardLocation: Endocrine Fellows Foundation2012New Investigator Research Award FinalistLocation: Orthopaedic Research Society2011Alice L. Jee Young Investigator AwardSponsor: International Bone and Mineral Society2011New Investigator Research Award FinalistLocation: Orthopaedic Research Society2011Young Investigator Travel AwardLocation: American Society of Bone and Mineral Research2008Travel AwardSponsor: American Society of Matrix BiologyVIEW ALL expand_morePublicationsJournal Articles11/2022Muscat S, Nichols AEC, Gira E, Loiselle AE. "CCR2 is expressed by tendon resident macrophage and T cells, while CCR2 deficiency impairs tendon healing via blunted involvement of tendon-resident and circulating monocytes/macrophages." FASEB journal : official publication of the Federation of American Societies for Experimental Biology.. 2022 Nov; 36(11):e22607. 7/28/2022Korcari A, Przybelski SJ, Gingery A, Loiselle AE. "Impact of aging on tendon homeostasis, tendinopathy development, and impaired healing." Connective tissue research.. 2022 Jul 28; :1-13. Epub 2022 Jul 28. 3/23/2022Korcari A, Buckley MR, Loiselle AE. "Characterization of scar tissue biomechanics during adult murine flexor tendon healing." Journal of the mechanical behavior of biomedical materials.. 2022 Mar 23; 130:105192. Epub 2022 Mar 23. Books & Chapters2021 Chapter Title: Tendon and Ligament Tissue Engineering Book Title: Musculoskeletal Tissue Engineering Author List: A Korcari, AEC Nichols, M O'Neil, AE Loiselle Edited By: Yupeng Chen Published By: Elsevier 20212018 Chapter Title: Skeletal Healing Book Title: Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism Author List: AE Loiselle, MJ Zuscik Edited By: CJ Rosen Published By: Wiley 2018VIEW ALL PUBLICATIONSClose WindowSchedule an appointment with Alayna E. Loiselle, Ph.D.Please answer the following questions to help us find the right appointment for you.Important: If you believe that you have a medical or psychiatric emergency, please call 911 or go to the nearest hospital. This website is not intended for emergency care.Have you seen this provider in the last 2 years?YesNoExisting Patient Schedule or request a follow up appointment online through MyChart. If you do not have a MyChart account, please close this window and call the appointment phone number. Alayna E. Loiselle, Ph.D. is currently scheduling for the following appointment type(s): Our policy does not permit patients to establish care with multiple providers within the same practice or specialty without prior approval. If you choose a new provider in the same office, we will cancel the appointment. Please contact the office directly with questions on this policy.