The overarching goal of our research program is to identify novel strategies to improve flexor tendon healing by reducing the formation of range of motion (ROM) limiting adhesions, without compromising mechanical strength. Flexor tendons glide through a synovial sheath to facilitate digit ROM and movement of the hand. Following injury, up to 40% of primary flexor tendon repairs will heal with unsatisfactory outcomes. The primary complication involves a robust scar tissue response, which forms adhesions between the tendon and synovial sheath, resulting impaired gliding function.
We have developed a novel murine model of intrasynovial FT healing, which mimics many aspects of healing in humans including abundant adhesion formation, impaired ROM and early decrements in tendon strength. We continue to use this model to gain a greater understanding of the cell and molecular processes involved in scar and adhesion formation in order to identify therapeutic targets to improve FT healing
BS | Niagara University
PhD | University of Rochester School of Medicine & Dentistry
Post-doctoral Fellowship | Penn State College of Medicine
Goldner Pioneer Award
Sponsor: American Society for Surgery of the Hand
Bond Bradley Award- Outstanding Postdoctoral Fellow
Sponsor: Penn State College of Medicine
Young Investigator Award
Sponsor: American Society of Bone and Mineral Research
Alice L. Jee Young Investigator Award
Sponsor: International Bone and Mineral Society
Sponsor: American Society of Matrix Biology
VIEW ALL expand_more
Ackerman JE, Best KT, O'Keefe RJ, Loiselle AE. "Deletion of EP4 in S100a4-lineage cells reduces scar tissue formation during early but not later stages of tendon healing." Scientific reports.. 2017 Aug 17; 7(1):8658. Epub 2017 Aug 17.
Ackerman JE, Bah I, Jonason JH, Buckley MR, Loiselle AE. "Aging does not alter tendon mechanical properties during homeostasis, but does impair flexor tendon healing." Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2017 Apr 17; Epub 2017 Apr 17.
Ackerman JE, Geary MB, Orner CA, Bawany F, Loiselle AE. "Obesity/Type II diabetes alters macrophage polarization resulting in a fibrotic tendon healing response." PloS one. 2017 12(7):e0181127. Epub 2017 Jul 07.
VIEW ALL PUBLICATIONS