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Alayna E. Loiselle, Ph.D.

Contact Information

Phone Numbers

Office: (585) 275-7239

Social Links

@LoiselleLab

Research Labs

Faculty Appointments

Biography

Research

The overarching goal of our research program is to identify novel strategies to improve flexor tendon healing by reducing the formation of range of motion (ROM) limiting adhesions, without compromising mechanical strength. Flexor tendons glide through a synovial sheath to facilitate digit ROM and movement of the hand. Following injury, up to 40% of primary flexor tendon repairs will heal with unsatisfactory outcomes. The primary complication involves a robust scar tissue response, which forms adhesions between the tendon and synovial sheath, resulting impaired gliding function.
We have developed a novel murine model of intrasynovial FT healing, which mimics many aspects of healing in humans including abundant adhesion formation, impaired ROM and early decrements in tendon strength. We continue to use this model to gain a greater understanding of the cell and molecular processes involved in scar and adhesion formation in order to identify therapeutic targets to improve FT healing

Credentials

Education

2004
BS | Niagara University
Biology

2009
PhD | University of Rochester School of Medicine & Dentistry
Pathology

2013
Post-doctoral Fellowship | Penn State College of Medicine
Orthopaedics

Awards

2021 - 2023
Senior Leader Education & Development (SLED) Program
Location: URMC

2014
Goldner Pioneer Award
Sponsor: American Society for Surgery of the Hand

2013
Bond Bradley Award- Outstanding Postdoctoral Fellow
Sponsor: Penn State College of Medicine

2013
Fellows Forum on Metabolic Bone Disease Travel Award
Location: Endocrine Fellows Foundation

2012
Young Investigator Award
Sponsor: American Society of Bone and Mineral Research

2012
Fellows Forum on Metabolic Bone Disease Travel Award
Location: Endocrine Fellows Foundation

2012
New Investigator Research Award Finalist
Location: Orthopaedic Research Society

2011
Alice L. Jee Young Investigator Award
Sponsor: International Bone and Mineral Society

2011
New Investigator Research Award Finalist
Location: Orthopaedic Research Society

2011
Young Investigator Travel Award
Location: American Society of Bone and Mineral Research

2008
Travel Award
Sponsor: American Society of Matrix Biology

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Publications

Journal Articles

11/2022
Muscat S, Nichols AEC, Gira E, Loiselle AE. "CCR2 is expressed by tendon resident macrophage and T cells, while CCR2 deficiency impairs tendon healing via blunted involvement of tendon-resident and circulating monocytes/macrophages." FASEB journal : official publication of the Federation of American Societies for Experimental Biology.. 2022 Nov; 36(11):e22607.

7/28/2022
Korcari A, Przybelski SJ, Gingery A, Loiselle AE. "Impact of aging on tendon homeostasis, tendinopathy development, and impaired healing." Connective tissue research.. 2022 Jul 28; :1-13. Epub 2022 Jul 28.

3/23/2022
Korcari A, Buckley MR, Loiselle AE. "Characterization of scar tissue biomechanics during adult murine flexor tendon healing." Journal of the mechanical behavior of biomedical materials.. 2022 Mar 23; 130:105192. Epub 2022 Mar 23.

Books & Chapters

2021
Chapter Title: Tendon and Ligament Tissue Engineering
Book Title: Musculoskeletal Tissue Engineering
Author List: A Korcari, AEC Nichols, M O'Neil, AE Loiselle
Edited By: Yupeng Chen
Published By: Elsevier 2021

2018
Chapter Title: Skeletal Healing
Book Title: Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism
Author List: AE Loiselle, MJ Zuscik
Edited By: CJ Rosen
Published By: Wiley 2018

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