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Alayna E. Loiselle, Ph.D.

Contact Information

Phone Numbers

Office: (585) 275-7239

Research Labs

Faculty Appointments

Biography

Research

The overarching goal of our research program is to identify novel strategies to improve flexor tendon healing by reducing the formation of range of motion (ROM) limiting adhesions, without compromising mechanical strength. Flexor tendons glide through a synovial sheath to facilitate digit ROM and movement of the hand. Following injury, up to 40% of primary flexor tendon repairs will heal with unsatisfactory outcomes. The primary complication involves a robust scar tissue response, which forms adhesions between the tendon and synovial sheath, resulting impaired gliding function.
We have developed a novel murine model of intrasynovial FT healing, which mimics many aspects of healing in humans including abundant adhesion formation, impaired ROM and early decrements in tendon strength. We continue to use this model to gain a greater understanding of the cell and molecular processes involved in scar and adhesion formation in order to identify therapeutic targets to improve FT healing

Credentials

Education

2004
BS | Niagara University
Biology

2009
PhD | University of Rochester School of Medicine & Dentistry
Pathology

2013
Post-doctoral Fellowship | Penn State College of Medicine
Orthopaedics

Awards

2014
Goldner Pioneer Award
Sponsor: American Society for Surgery of the Hand

2013
Bond Bradley Award- Outstanding Postdoctoral Fellow
Sponsor: Penn State College of Medicine

2012
Young Investigator Award
Sponsor: American Society of Bone and Mineral Research

2011
Alice L. Jee Young Investigator Award
Sponsor: International Bone and Mineral Society

2008
Travel Award
Sponsor: American Society of Matrix Biology

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Publications

Journal Articles

7/29/2019
Best KT, Lee FK, Knapp E, Awad HA, Loiselle AE. "Deletion of NFKB1 enhances canonical NF-?B signaling and increases macrophage and myofibroblast content during tendon healing." Scientific reports.. 2019 Jul 29; 9(1):10926. Epub 2019 Jul 29.

7/2019
Best KT, Loiselle AE. "Scleraxis lineage cells contribute to organized bridging tissue during tendon healing and identify a subpopulation of resident tendon cells." FASEB journal : official publication of the Federation of American Societies for Experimental Biology.. 2019 Jul 0; 33(7):8578-8587. Epub 2019 Apr 05.

6/24/2019
Ackerman JE, Studentsova V, Myers M, Buckley MR, Richards MS, Loiselle AE. "Non-Invasive Ultrasound Quantification of Scar Tissue Volume Identifies Early Functional Changes During Tendon Healing." Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2019 Jun 24; Epub 2019 Jun 24.

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