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Takahiro Takano, Ph.D.

Contact Information

Phone Numbers

Administrative: (585) 273-5272

Office: (585) 276-7837

Fax: (585) 273-1237

Faculty Appointments

Biography

Research

Our laboratory is interested in developing alternative treatment strategies for chronic pain, with the focus on peripheral nervous system. Persistent pain causes the sensory nerves to transmit hyperalgesic signals, which contribute to the establishment of pathological condition in central nervous system, manifested as chronic pain. Conversely, manipulation of peripheral signals can reverse the chronic pain condition in central nervous system and thus restore the normal sensory perception. In particular, we study both acute and long-term pain relief by pharmacologically or mechanically manipulating sensory inputs in both orofacial neuropathic and joint inflammatory chronic pain models.

Credentials

Education

1994
BS | York College, City University of New York
Biology

1996
MS | Fordham University
Biology

2003
PhD | New York Medical College
Biology

Post-doctoral Training & Residency

2003 - 2006
Post-Doctoral Fellow; Center for Aging and Developmental Biology; URMC; Rochester, NY

Publications

Journal Articles

10/5/2020
Michelucci A, Boncompagni S, Pietrangelo L, Takano T, Protasi F, Dirksen RT. "Pre-assembled Ca2+ entry units and constitutively active Ca2+ entry in skeletal muscle of calsequestrin-1 knockout mice." The Journal of general physiology.. 2020 Oct 5; 152(10)

10/28/2019
Michelucci A, Boncompagni S, Pietrangelo L, García-Castañeda M, Takano T, Malik S, Dirksen RT, Protasi F. "Transverse tubule remodeling enhances Orai1-dependent Ca entry in skeletal muscle." eLife.. 2019 Oct 28; 8Epub 2019 Oct 28.

6/13/2017
Fujita T, Feng C, Takano T. "Presence of caffeine reversibly interferes with efficacy of acupuncture-induced analgesia." Scientific reports.. 2017 Jun 13; 7(1):3397. Epub 2017 Jun 13.

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