Takahiro Takano, Ph.D.

Takahiro Takano, Ph.D.

Contact Information

University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 611
Rochester, NY 14642

Lab: (585) 276-8365
Administrative: (585) 273-5272
Fax: (585) 273-1237
Office: (585) 276-7837

Research Bio

Our laboratory is interested in developing alternative treatment strategies for chronic pain, with the focus on peripheral nervous system. Persistent pain causes the sensory nerves to transmit hyperalgesic signals, which contribute to the establishment of pathological condition in central nervous system, manifested as chronic pain. Conversely, manipulation of peripheral signals can reverse the chronic pain condition in central nervous system and thus restore the normal sensory perception. In particular, we study both acute and long-term pain relief by pharmacologically or mechanically manipulating sensory inputs in both orofacial neuropathic and joint inflammatory chronic pain models.

Recent Journal Articles

Showing the 5 most recent journal articles. 53 available »

2016 Sep
McConnell ED, Wei HS, Reitz KM, Kang H, Takano T, Vates GE, Nedergaard M. "Cerebral microcirculatory failure after subarachnoid hemorrhage is reversed by hyaluronidase." Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 2016 Sep; 36(9):1537-52. Epub 2015 Oct 14.
2016 Jan 26
Lou N, Takano T, Pei Y, Xavier AL, Goldman SA, Nedergaard M. "Purinergic receptor P2RY12-dependent microglial closure of the injured blood-brain barrier." Proceedings of the National Academy of Sciences of the United States of America. 2016 Jan 26; 113(4):1074-9. Epub 2016 Jan 11.
2015 Aug
Wei HS, Rasheed ID, Takano T, Kang H, Reitz KM, Gershteyn A, Vates GE, Nedergaard M. "156?Capillary-Level Control of Cerebrovascular Tone." Neurosurgery. 2015 Aug; 62 Suppl 1:216-7.
2014 Dec 10
Fujita T, Chen MJ, Li B, Smith NA, Peng W, Sun W, Toner MJ, Kress BT, Wang L, Benraiss A, Takano T, Wang S, Nedergaard M. "Neuronal transgene expression in dominant-negative SNARE mice." The Journal of neuroscience : the official journal of the Society for Neuroscience. 2014 Dec 10; 34(50):16594-604.
2014 Jan
Takano T, He W, Han X, Wang F, Xu Q, Wang X, Oberheim Bush NA, Cruz N, Dienel GA, Nedergaard M. "Rapid manifestation of reactive astrogliosis in acute hippocampal brain slices." Glia. 2014 Jan; 62(1):78-95. Epub 2013 Nov 06.

Current Appointments

Research Assistant Professor - Department of Dentistry (SMD) - Primary
Research Assistant Professor - Center for Oral Biology


PhD | Biology | New York Medical College2003
MS | Biology | Fordham University1996
BS | Biology | York College, City University of New York1994

Post-Doctoral Training & Residency

Post-Doctoral Fellow; Center for Aging and Developmental Biology; URMC; Rochester, NY 2006