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Takahiro Takano, Ph.D.

Publications

Showing all 56 journal articles & 0 books available

Journal Articles

6/13/2017
Fujita T, Feng C, Takano T. "Presence of caffeine reversibly interferes with efficacy of acupuncture-induced analgesia." Scientific reports.. 2017 Jun 13; 7(1):3397. Epub 2017 Jun 13.

12/2017
Achariyar TM, Li B, Peng W, Verghese PB, Shi Y, McConnell E, Benraiss A, Kasper T, Song W, Takano T, Holtzman DM, Nedergaard M, Deane R. "Erratum to: Glymphatic distribution of CSF-derived apoE into brain is isoform specific and suppressed during sleep deprivation." Molecular neurodegeneration. 2017 12(1):3. Epub 2017 Jan 12.

9/2016
McConnell ED, Wei HS, Reitz KM, Kang H, Takano T, Vates GE, Nedergaard M. "Cerebral microcirculatory failure after subarachnoid hemorrhage is reversed by hyaluronidase." Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.. 2016 Sep 0; 36(9):1537-52. Epub 2015 Oct 14.

1/26/2016
Lou N, Takano T, Pei Y, Xavier AL, Goldman SA, Nedergaard M. "Purinergic receptor P2RY12-dependent microglial closure of the injured blood-brain barrier." Proceedings of the National Academy of Sciences of the United States of America.. 2016 Jan 26; 113(4):1074-9. Epub 2016 Jan 11.

8/2016
Achariyar TM, Li B, Peng W, Verghese PB, Shi Y, McConnell E, Benraiss A, Kasper T, Song W, Takana T, Holtzman DM, Nedergaard M, Deane R. "Glymphatic distribution of CSF-derived apoE into brain is isoform specific and suppressed during sleep deprivation." Molecular neurodegeneration. 2016 11(1):74. Epub 2016 Dec 08.

8/2015
Wei HS, Rasheed ID, Takano T, Kang H, Reitz KM, Gershteyn A, Vates GE, Nedergaard M. "156?Capillary-Level Control of Cerebrovascular Tone." Neurosurgery.. 2015 Aug 0; 62 Suppl 1:216-7.

12/10/2014
Fujita T, Chen MJ, Li B, Smith NA, Peng W, Sun W, Toner MJ, Kress BT, Wang L, Benraiss A, Takano T, Wang S, Nedergaard M. "Neuronal transgene expression in dominant-negative SNARE mice." The Journal of neuroscience : the official journal of the Society for Neuroscience.. 2014 Dec 10; 34(50):16594-604.

1/2014
Takano T, He W, Han X, Wang F, Xu Q, Wang X, Oberheim Bush NA, Cruz N, Dienel GA, Nedergaard M. "Rapid manifestation of reactive astrogliosis in acute hippocampal brain slices." Glia.. 2014 Jan 0; 62(1):78-95. Epub 2013 Nov 06.

10/30/2013
Wang F, Smith NA, Xu Q, Goldman S, Peng W, Huang JH, Takano T, Nedergaard M. "Photolysis of caged Ca2+ but not receptor-mediated Ca2+ signaling triggers astrocytic glutamate release." The Journal of neuroscience : the official journal of the Society for Neuroscience.. 2013 Oct 30; 33(44):17404-12.

9/2013
Langevin H, Fujita T, Bouffard N, Takano T, Koptiuch C, Badger G, Nedergaard M. "Fibroblast cytoskeletal remodeling induced by tissue stretch involves ATP signaling." Journal of cellular physiology.. 2013 Sep 0; 228(9):1922-6.

7/2013
Thrane AS, Takano T, Thrane VR, Wang F, Peng W, Ottersen OP, Nedergaard M, Nagelhus EA. "In vivo NADH fluorescence imaging indicates effect of aquaporin-4 deletion on oxygen microdistribution in cortical spreading depression." Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.. 2013 Jul 0; 33(7):996-9. Epub 2013 Apr 24.

4/2013
Goldman N, Chandler-Militello D, Langevin HM, Nedergaard M, Takano T. "Purine receptor mediated actin cytoskeleton remodeling of human fibroblasts." Cell calcium.. 2013 Apr 0; 53(4):297-301. Epub 2013 Feb 22.

3/7/2013
Han X, Chen M, Wang F, Windrem M, Wang S, Shanz S, Xu Q, Oberheim NA, Bekar L, Betstadt S, Silva AJ, Takano T, Goldman SA, Nedergaard M. "Forebrain engraftment by human glial progenitor cells enhances synaptic plasticity and learning in adult mice." Cell stem cell.. 2013 Mar 7; 12(3):342-53.

12/2012
Takano T, Chen X, Luo F, Fujita T, Ren Z, Goldman N, Zhao Y, Markman JD, Nedergaard M. "Traditional acupuncture triggers a local increase in adenosine in human subjects." The journal of pain : official journal of the American Pain Society.. 2012 Dec 0; 13(12):1215-23.

5/15/2012
Wang F, Xu Q, Wang W, Takano T, Nedergaard M. "Bergmann glia modulate cerebellar Purkinje cell bistability via Ca2+-dependent K+ uptake." Proceedings of the National Academy of Sciences of the United States of America.. 2012 May 15; 109(20):7911-6. Epub 2012 Apr 30.

4/17/2012
Lovatt D, Xu Q, Liu W, Takano T, Smith NA, Schnermann J, Tieu K, Nedergaard M. "Neuronal adenosine release, and not astrocytic ATP release, mediates feedback inhibition of excitatory activity." Proceedings of the National Academy of Sciences of the United States of America.. 2012 Apr 17; 109(16):6265-70. Epub 2012 Mar 15.

4/3/2012
Wang F, Smith NA, Xu Q, Fujita T, Baba A, Matsuda T, Takano T, Bekar L, Nedergaard M. "Astrocytes modulate neural network activity by Ca²+-dependent uptake of extracellular K+." Science signaling. 2012 Apr 3; 5(218):ra26. Epub 2012 Apr 03.

3/7/2012
Huang C, Han X, Li X, Lam E, Peng W, Lou N, Torres A, Yang M, Garre JM, Tian GF, Bennett MV, Nedergaard M, Takano T. "Critical role of connexin 43 in secondary expansion of traumatic spinal cord injury." The Journal of neuroscience : the official journal of the Society for Neuroscience.. 2012 Mar 7; 32(10):3333-8.

1/24/2012
Torres A, Wang F, Xu Q, Fujita T, Dobrowolski R, Willecke K, Takano T, Nedergaard M. "Extracellular Ca²? acts as a mediator of communication from neurons to glia." Science signaling. 2012 Jan 24; 5(208):ra8. Epub 2012 Jan 24.

1/2012
Fujita T, Williams EK, Jensen TK, Smith NA, Takano T, Tieu K, Nedergaard M. "Cultured astrocytes do not release adenosine during hypoxic conditions." Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.. 2012 Jan 0; 32(1):e1-7. Epub 2011 Oct 12.

1/11/2011
Thrane AS, Rappold PM, Fujita T, Torres A, Bekar LK, Takano T, Peng W, Wang F, Thrane VR, Enger R, Haj-Yasein NN, Skare O, Holen T, Klungland A, Ottersen OP, Nedergaard M, Nagelhus EA. "Critical role of aquaporin-4 (AQP4) in astrocytic Ca2+ signaling events elicited by cerebral edema." Proceedings of the National Academy of Sciences of the United States of America.. 2011 Jan 11; 108(2):846-51. Epub 2010 Dec 27.

9/2010
Vates GE, Takano T, Zlokovic B, Nedergaard M. "Pericyte constriction after stroke: the jury is still out." Nature medicine.. 2010 Sep 0; 16(9):959; author reply 960.

7/2010
Goldman N, Chen M, Fujita T, Xu Q, Peng W, Liu W, Jensen TK, Pei Y, Wang F, Han X, Chen JF, Schnermann J, Takano T, Bekar L, Tieu K, Nedergaard M. "Adenosine A1 receptors mediate local anti-nociceptive effects of acupuncture." Nature neuroscience.. 2010 Jul 0; 13(7):883-8. Epub 2010 May 30.

10/2009
Rempe DA, Takano T, Nedergaard M. "TR(I)Pping towards treatment for ischemia." Nature neuroscience.. 2009 Oct 0; 12(10):1215-6.

7/28/2009
Peng W, Cotrina ML, Han X, Yu H, Bekar L, Blum L, Takano T, Tian GF, Goldman SA, Nedergaard M. "Systemic administration of an antagonist of the ATP-sensitive receptor P2X7 improves recovery after spinal cord injury." Proceedings of the National Academy of Sciences of the United States of America.. 2009 Jul 28; 106(30):12489-93. Epub 2009 Jul 27.

3/17/2009
Biswas T, Okunieff P, Schell MC, Smudzin T, Pilcher WH, Bakos RS, Vates GE, Walter KA, Wensel A, Korones DN, Milano MT. "Stereotactic radiosurgery for glioblastoma: retrospective analysis." Radiation oncology. 2009 Mar 17; 4:11. Epub 2009 Mar 17.

3/11/2009
Oberheim NA, Takano T, Han X, He W, Lin JH, Wang F, Xu Q, Wyatt JD, Pilcher W, Ojemann JG, Ransom BR, Goldman SA, Nedergaard M. "Uniquely hominid features of adult human astrocytes." The Journal of neuroscience : the official journal of the Society for Neuroscience.. 2009 Mar 11; 29(10):3276-87.

3/2009
Takano T, Oberheim N, Cotrina ML, Nedergaard M. "Astrocytes and ischemic injury." Stroke.. 2009 Mar 0; 40(3 Suppl):S8-12. Epub 2008 Dec 08.

1/2009
Takano T, Nedergaard M. "Deciphering migraine." The Journal of clinical investigation.. 2009 Jan 0; 119(1):16-9.

2009
Wang X, Takano T, Nedergaard M. "Astrocytic Ca2+ Signaling: Mechanism and implications for functional brain imaging". Humana Press. 2009; .

2009
Wang X, Takano T, Nedergaard M. "Astrocytic calcium signaling: mechanism and implications for functional brain imaging." Methods in molecular biology.. 2009 489:93-109.

3/26/2008
Oberheim NA, Tian GF, Han X, Peng W, Takano T, Ransom B, Nedergaard M. "Loss of astrocytic domain organization in the epileptic brain." The Journal of neuroscience : the official journal of the Society for Neuroscience.. 2008 Mar 26; 28(13):3264-76.

1/16/2008
Lin JH, Lou N, Kang N, Takano T, Hu F, Han X, Xu Q, Lovatt D, Torres A, Willecke K, Yang J, Kang J, Nedergaard M. "A central role of connexin 43 in hypoxic preconditioning." The Journal of neuroscience : the official journal of the Society for Neuroscience.. 2008 Jan 16; 28(3):681-95.

1/2008
Bekar L, Libionka W, Tian GF, Xu Q, Torres A, Wang X, Lovatt D, Williams E, Takano T, Schnermann J, Bakos R, Nedergaard M. "Adenosine is crucial for deep brain stimulation-mediated attenuation of tremor." Nature medicine.. 2008 Jan 0; 14(1):75-80. Epub 2007 Dec 23.

11/7/2007
Lovatt D, Sonnewald U, Waagepetersen HS, Schousboe A, He W, Lin JH, Han X, Takano T, Wang S, Sim FJ, Goldman SA, Nedergaard M. "The transcriptome and metabolic gene signature of protoplasmic astrocytes in the adult murine cortex." The Journal of neuroscience : the official journal of the Society for Neuroscience.. 2007 Nov 7; 27(45):12255-66.

8/28/2007
Jaiswal JK, Fix M, Takano T, Nedergaard M, Simon SM. "Resolving vesicle fusion from lysis to monitor calcium-triggered lysosomal exocytosis in astrocytes." Proceedings of the National Academy of Sciences of the United States of America.. 2007 Aug 28; 104(35):14151-6. Epub 2007 Aug 21.

6/2007
Takano T, Tian GF, Peng W, Lou N, Lovatt D, Hansen AJ, Kasischke KA, Nedergaard M. "Cortical spreading depression causes and coincides with tissue hypoxia." Nature neuroscience.. 2007 Jun 0; 10(6):754-62. Epub 2007 Apr 29.

5/2007
Takano T, Nedergaard M. "DM-nitrophen provides physiologically significant increases of intracellular [Ca2+] in the presence of Mg2+." Cell calcium.. 2007 May 0; 41(5):503-4. Epub 2006 Oct 19.

2/1/2007
Lin JH, Takano T, Arcuino G, Wang X, Hu F, Darzynkiewicz Z, Nunes M, Goldman SA, Nedergaard M. "Purinergic signaling regulates neural progenitor cell expansion and neurogenesis." Developmental biology.. 2007 Feb 1; 302(1):356-66. Epub 2006 Sep 16.

2/2007
Takano T, Han X, Deane R, Zlokovic B, Nedergaard M. "Two-photon imaging of astrocytic Ca2+ signaling and the microvasculature in experimental mice models of Alzheimer's disease." Annals of the New York Academy of Sciences.. 2007 Feb 0; 1097:40-50.

9/15/2006
Tian GF, Takano T, Lin JH, Wang X, Bekar L, Nedergaard M. "Imaging of cortical astrocytes using 2-photon laser scanning microscopy in the intact mouse brain." Advanced drug delivery reviews.. 2006 Sep 15; 58(7):773-87. Epub 2006 Aug 04.

6/2006
Wang X, Lou N, Xu Q, Tian GF, Peng WG, Han X, Kang J, Takano T, Nedergaard M. "Astrocytic Ca2+ signaling evoked by sensory stimulation in vivo." Nature neuroscience.. 2006 Jun 0; 9(6):816-23. Epub 2006 May 14.

2/2006
Takano T, Tian GF, Peng W, Lou N, Libionka W, Han X, Nedergaard M. "Astrocyte-mediated control of cerebral blood flow." Nature neuroscience.. 2006 Feb 0; 9(2):260-7. Epub 2005 Dec 25.

11/8/2005
Takano T, Kang J, Jaiswal JK, Simon SM, Lin JH, Yu Y, Li Y, Yang J, Dienel G, Zielke HR, Nedergaard M. "Receptor-mediated glutamate release from volume sensitive channels in astrocytes." Proceedings of the National Academy of Sciences of the United States of America.. 2005 Nov 8; 102(45):16466-71. Epub 2005 Oct 27.

9/2005
Tian GF, Azmi H, Takano T, Xu Q, Peng W, Lin J, Oberheim N, Lou N, Wang X, Zielke HR, Kang J, Nedergaard M. "An astrocytic basis of epilepsy." Nature medicine.. 2005 Sep 0; 11(9):973-81. Epub 2005 Aug 14.

2005
Takano,T.; Kang,J.; Jaiswal,J. K.; Simon,S. M.; Lin,J. H.; Yu,Y.; Li,Y.; Yang,J.; Dienel,G.; Zielke,H. R.; Nedergaard,M. "Receptor-mediated glutamate release from volume sensitive channels in astrocytes". Proceedings of the National Academy of Sciences, U.S.A. 2005; 102(45): 16466-16471.

8/2004
Wang X, Arcuino G, Takano T, Lin J, Peng WG, Wan P, Li P, Xu Q, Liu QS, Goldman SA, Nedergaard M. "P2X7 receptor inhibition improves recovery after spinal cord injury." Nature medicine.. 2004 Aug 0; 10(8):821-7. Epub 2004 Jul 18.

2004
Wang,X.; Arcuino,G.; Takano,T.; Lin,J.; Peng,W. G.; Wan,P.; Li,P.; Xu,Q.; Liu,Q. S.; Goldman,S. A.; Nedergaard,M. "P2X7 receptor inhibition improves recovery after spinal cord injury". Nature Medicine. 2004; 102(8): 821-827.

10/8/2003
Simard M, Arcuino G, Takano T, Liu QS, Nedergaard M. "Signaling at the gliovascular interface." The Journal of neuroscience : the official journal of the Society for Neuroscience.. 2003 Oct 8; 23(27):9254-62.

1/15/2003
Lin JH, Yang J, Liu S, Takano T, Wang X, Gao Q, Willecke K, Nedergaard M. "Connexin mediates gap junction-independent resistance to cellular injury." The Journal of neuroscience : the official journal of the Society for Neuroscience.. 2003 Jan 15; 23(2):430-41.

9/2002
Nedergaard M, Takano T, Hansen AJ. "Beyond the role of glutamate as a neurotransmitter." Nature reviews. Neuroscience.. 2002 Sep 0; 3(9):748-55.

7/23/2002
Arcuino G, Lin JH, Takano T, Liu C, Jiang L, Gao Q, Kang J, Nedergaard M. "Intercellular calcium signaling mediated by point-source burst release of ATP." Proceedings of the National Academy of Sciences of the United States of America.. 2002 Jul 23; 99(15):9840-5. Epub 2002 Jul 03.

6/1/2002
Lin JH, Takano T, Cotrina ML, Arcuino G, Kang J, Liu S, Gao Q, Jiang L, Li F, Lichtenberg-Frate H, Haubrich S, Willecke K, Goldman SA, Nedergaard M. "Connexin 43 enhances the adhesivity and mediates the invasion of malignant glioma cells." The Journal of neuroscience : the official journal of the Society for Neuroscience.. 2002 Jun 1; 22(11):4302-11.

2002
Arcuino,G.; Lin,J. H.; Takano,T.; Liu,C.; Jiang,L.; Gao,Q.; Kang,J.; Nedergaard,M. "Intercellular calcium signaling mediated by point-source burst release of ATP;". Proceedings of the National Academy of Sciences, U.S.A. 2002; 99(15): 9840-9845.

9/2001
Takano T, Lin JH, Arcuino G, Gao Q, Yang J, Nedergaard M. "Glutamate release promotes growth of malignant gliomas." Nature medicine.. 2001 Sep 0; 7(9):1010-5.

10/1/2000
Zhang W, Couldwell WT, Song H, Takano T, Lin JH, Nedergaard M. "Tamoxifen-induced enhancement of calcium signaling in glioma and MCF-7 breast cancer cells." Cancer research.. 2000 Oct 1; 60(19):5395-400.