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Andrei Seluanov, Ph.D.

Andrei Seluanov, Ph.D.

Contact

Office (585) 275-6636

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About Me

Faculty Appointments

Professor - Department of Medicine, Geriatrics/Aging (SMD) - Joint

Research

Our research is focused on understanding the mechanisms of longevity and cancer resistance. Aging is the major cause of death in developed countries. By finding ways to delay aging, it will be possible to delay the onset of multiple age-related diseases. Cancer is another major killer in the develop...
Our research is focused on understanding the mechanisms of longevity and cancer resistance. Aging is the major cause of death in developed countries. By finding ways to delay aging, it will be possible to delay the onset of multiple age-related diseases. Cancer is another major killer in the developed world, where 25% of human mortality is caused by cancer. Cancer incidence increases exponentially with age. To achieve long life, species must evolve efficient tumor suppressor mechanisms. Our goal is to understand such mechanisms in mammalian species that are naturally cancer-resistant.

Patents

RAD51-Derived Cancer Cell-Specific Promoters for Targeted Anti-Cancer Therapy

Issue date: May 29, 2012

Patent #: 8,188,252

Country: United States

Inventors: Vera Gorbunova, Christopher Hine, Andrei Seluanov

Compositions and Methods for Recombinant Synthesis of High Molecular Weight Hyaluronic Acid

Issue date: April 19, 2016

Patent #: 9,315,588

Country: United States

Inventors: Vera Gorbunova, Andrei Seluanov

Publications

Journal Articles

Unlocking rejuvenating potential of mesenchymal progenitor cells.

Gorbunova V, Seluanov A

Cell.. 2025 November 13188 (23):6391-6392. Epub 1900 01 01.

Open problems in ageing science: a roadmap for biogerontology.

Talay A, Belikov AV, To PKP, Alfatemi HH, Alon U, Deelen J, Ewald CY, Gems D, Gorbunova V, Gruber J, Hägg S, Hemming J, Horvath S, Kaya A, Lewis CJ, Maier AB, Marinova MB, Pawelec G, Peleg S, Rattan S, Scheibye-Knudsen M, Schmauck-Medina T, Saroyan V, Seluanov A, Stolzing A, Teeling E, Williams RW, White T, Unfried M, de Magalhães JP

GeroScience.. 2025 November 8 Epub 11/08/2025.

African spiny mice show resistance to DMBA/TPA-induced squamous carcinogenesis with distinct benign tumor profile.

Athar F, Morandini F, Fatima I, Silvestri I, Kim SB, Lee M, Liao X, Sharov A, Botchkarev V, Seluanov A, Gorbunova V

Protein & cell.. 2025 October 3116 (10):896-904. Epub 1900 01 01.

Evidence for improved DNA repair in long-lived bowhead whale.

Firsanov D, Zacher M, Tian X, Sformo TL, Zhao Y, Tombline G, Lu JY, Zheng Z, Perelli L, Gurreri E, Zhang L, Guo J, Korotkov A, Volobaev V, Biashad SA, Zhang Z, Heid J, Maslov AY, Sun S, Wu Z, Gigas J, Hillpot EC, Martinez JC, Lee M, Williams A, Gilman A, Hamilton N, Strelkova E, Haseljic E, Patel A, Straight ME, Miller N, Ablaeva J, Tam LM, Couderc C, Hoopmann MR, Moritz RL, Fujii S, Pelletier A, Hayman DJ, Liu H, Cai Y, Leung AKL, Zhang Z, Nelson CB, Abegglen LM, Schiffman JD, Gladyshev VN, Maley CC, Modesti M, Genovese G, Simons MJP, Vijg J, Seluanov A, Gorbunova V

Nature.. 2025 October 29 Epub 10/29/2025.

Longevity steps on the cGAS.

Martinez JC, Seluanov A, Gorbunova V

Science.. 2025 October 9390 (6769):126-127. Epub 10/09/2025.

Advancing cancer research via comparative oncology.

Vincze O, Spada B, Bilder D, Cagan A, DeGregori J, Gorbunova V, Maley CC, Schiffman JD, Seluanov A, Giraudeau M, Pradeu T

Nature reviews. Cancer.. 2025 September 25 (9):740-748. Epub 06/27/2025.

Unlocking longevity through the comparative biology of aging.

Rechsteiner C, Morandini F, Kim SJ, Seluanov A, Gorbunova V

Nature aging.. 2025 September 5 (9):1686-1703. Epub 08/28/2025.

Structures of Naked Mole-Rat, Tuco-Tuco, and Guinea Pig Ribosomes-Is rRNA Fragmentation Linked to Translational Fidelity?

Gutierrez-Vargas C, De S, Maji S, Liu Z, Ke Z, Nieß M, Seluanov A, Gorbunova V, Frank J

bioRxiv : the preprint server for biology.. 2025 August 2 Epub 08/02/2025.

Neuropeptides specify and reprogram division of labor in the leafcutter ant Atta cephalotes.

Gilbert MB, Glastad KM, Fioriti M, Sorek M, Scarpa T, Purnell FS, Xu D, Pino LK, Korotkov A, Biashad A, Baeza J, Lauman R, Filippova A, Kacsoh BZ, Bonasio R, Mathis MW, Garcia BA, Seluanov A, Gorbunova V, Berger SL

Cell.. 2025 July 24188 (15):3974-3991.e21. Epub 06/11/2025.

Fucoidans are senotherapeutics that enhance SIRT6-dependent DNA repair.

Robbins P, Zhang L, Elsallabi O, Soto-Palma C, Bartz J, Salekeen R, Nunes A, Xu W, Lee K, Hughes B, Zhang B, Mohamed A, McGowan S, Angelini L, O'Kelly R, Biashad SA, Hillpot E, Morandini F, Seluanov A, Gorbunova V, Dong X, Niedernhofer L

Research square.. 2025 June 6 Epub 06/06/2025.

Proteome Birthdating: A Single-Sample Approach for Measuring Global Turnover Dynamics and "Protein Age".

Meadow ME, Broas S, Hoare M, Ahmed M, Alimohammadi F, Welle KA, Swovick K, Hryhorenko JR, Jain A, Martinez JC, Seluanov A, Gorbunova V, Buchwalter A, Ghaemmaghami S

Bio-protocol.. 2025 May 515 (9):e5296. Epub 05/05/2025.

Limited cell-autonomous anticancer mechanisms in long-lived bats.

Athar F, Zheng Z, Riquier S, Zacher M, Lu JY, Zhao Y, Volobaev V, Alcock D, Galazyuk A, Cooper LN, Schountz T, Wang LF, Teeling EC, Seluanov A, Gorbunova V

Nature communications.. 2025 May 316 (1):4125. Epub 05/03/2025.

From geroscience to precision geromedicine: Understanding and managing aging.

Kroemer G, Maier AB, Cuervo AM, Gladyshev VN, Ferrucci L, Gorbunova V, Kennedy BK, Rando TA, Seluanov A, Sierra F, Verdin E, López-Otín C

Cell.. 2025 April 17188 (8):2043-2062. Epub 1900 01 01.

p53 enhances DNA repair and suppresses cytoplasmic chromatin fragments and inflammation in senescent cells.

Miller KN, Li B, Pierce-Hoffman HR, Patel S, Lei X, Rajesh A, Teneche MG, Havas AP, Gandhi A, Macip CC, Lyu J, Victorelli SG, Woo SH, Lagnado AB, LaPorta MA, Liu T, Dasgupta N, Li S, Davis A, Korotkov A, Hultenius E, Gao Z, Altman Y, Porritt RA, Garcia G, Mogler C, Seluanov A, Gorbunova V, Kaech SM, Tian X, Dou Z, Chen C, Passos JF, Adams PD

Nature communications.. 2025 March 516 (1):2229. Epub 03/05/2025.

SIRT5 slows skeletal muscle ageing by alleviating inflammation.

Gorbunova V, Seluanov A

Nature metabolism.. 2025 March 7 (3):447-449. Epub 1900 01 01.

Disagreement on foundational principles of biological aging.

Gladyshev VN, Anderson B, Barlit H, Barré B, Beck S, Behrouz B, Belsky DW, Chaix A, Chamoli M, Chen BH, Cheng K, Chuprin J, Churchill GA, Cipriano A, Colville A, Deelen J, Deigin Y, Edmonds KK, English BW, Fang R, Florea M, Gershteyn IM, Gill D, Goetz LH, Gorbunova V, Griffin PT, Horvath S, Borch Jensen M, Jin X, Jovanovska S, Kajderowicz KM, Kasahara T, Kerepesi C, Kulkarni S, Labunskyy VM, Levine ME, Libert S, Lu JY, Lu YR, Marioni RE, McCoy BM, Mitchell W, Moqri M, Nasirian F, Niimi P, Oh HS, Okundaye B, Parkhitko AA, Peshkin L, Petljak M, Poganik JR, Pridham G, Promislow DEL, Prusisz W, Quiniou M, Raj K, Richard D, Ricon JL, Rutledge J, Scheibye-Knudsen M, Schork NJ, Seluanov A, Shadpour M, Shindyapina AV, Shuken SR, Sivakumar S, Stoeger T, Sugiura A, Sutton NR, Suvorov A, Tarkhov AE, Teeling EC, Trapp A, Tyshkovskiy A, Unfried M, Ward-Caviness CK, Yim SH, Ying K, Yunes J, Zhang B, Zhavoronkov A

PNAS nexus.. 2024 December 3 (12):pgae499. Epub 12/03/2024.