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Amy Kiernan, Ph.D.


Showing all 31 journal articles & 0 books available

Journal Articles

Heffer A, Gilels FA, Kiernan AE. "Deletion of during cochlear maturation leads to rapid supporting cell death and profound deafness." The Journal of neuroscience : the official journal of the Society for Neuroscience.. 2022 Nov 23; Epub 2022 Nov 23.

Gilels FA, Wang J, Bullen A, White PM, Kiernan AE. "Deletion of the Notch ligand Jagged1 during cochlear maturation leads to inner hair cell defects and hearing loss." Cell death & disease.. 2022 Nov 18; 13(11):971. Epub 2022 Nov 18.

Brown RM, Nelson JC, Zhang H, Kiernan AE, Groves AK. "Notch-mediated lateral induction is necessary to maintain vestibular prosensory identity during inner ear development." Developmental biology.. 2020 Mar 5; Epub 2020 Mar 05.

Steevens AR, Glatzer JC, Kellogg CC, Low WC, Santi PA, Kiernan AE. "SOX2 is required for inner ear growth and cochlear nonsensory formation prior to sensory development." Development.. 2019 May 31; Epub 2019 May 31.

Rausch RL, Libby RT, Kiernan AE. "Trabecular meshwork morphogenesis: A comparative analysis of wildtype and anterior segment dysgenesis mouse models." Experimental eye research.. 2018 May; 170:81-91. Epub 2018 Feb 13.

Johnson KR, Gagnon LH, Tian C, Longo-Guess CM, Low BE, Wiles MV, Kiernan AE. "Deletion of a Long-Range Enhancer Disrupts Inner Ear Development in Mice." Genetics.. 2018 Mar; 208(3):1165-1179. Epub 2018 Jan 03.

Rausch RL, Libby RT, Kiernan AE. "Ciliary margin-derived BMP4 does not have a major role in ocular development." PloS one.. 2018 13(5):e0197048. Epub 2018 May 08.

Steevens AR, Sookiasian DL, Glatzer JC, Kiernan AE. "SOX2 is required for inner ear neurogenesis." Scientific reports.. 2017 Jun 22; 7(1):4086. Epub 2017 Jun 22.

Fernandes KA, Harder JM, Williams PA, Rausch RL, Kiernan AE, Nair KS, Anderson MG, John SW, Howell GR, Libby RT. "Using genetic mouse models to gain insight into glaucoma: Past results and future possibilities." Experimental eye research.. 2015 Dec; 141:42-56. Epub 2015 Jun 24.

Deng M, Luo XJ, Pan L, Yang H, Xie X, Liang G, Huang L, Hu F, Kiernan AE, Gan L. "LMO4 functions as a negative regulator of sensory organ formation in the mammalian cochlea." The Journal of neuroscience : the official journal of the Society for Neuroscience.. 2014 Jul 23; 34(30):10072-7.

Savoy-Burke G, Gilels FA, Pan W, Pratt D, Que J, Gan L, White PM, Kiernan AE. "Activated notch causes deafness by promoting a supporting cell phenotype in developing auditory hair cells." PloS one.. 2014 9(9):e108160. Epub 2014 Sep 29.

Pan W, Jin Y, Chen J, Rottier RJ, Steel KP, Kiernan AE. "Ectopic expression of activated notch or SOX2 reveals similar and unique roles in the development of the sensory cell progenitors in the mammalian inner ear." The Journal of neuroscience : the official journal of the Society for Neuroscience.. 2013 Oct 9; 33(41):16146-57.

Zhou Y, Tanzie C, Yan Z, Chen S, Duncan M, Gaudenz K, Li H, Seidel C, Lewis B, Moran A, Libby RT, Kiernan AE, Xie T. "Notch2 regulates BMP signaling and epithelial morphogenesis in the ciliary body of the mouse eye." Proceedings of the National Academy of Sciences of the United States of America.. 2013 May 28; 110(22):8966-71. Epub 2013 May 15.

Kiernan AE. "Notch signaling during cell fate determination in the inner ear." Seminars in cell & developmental biology.. 2013 May; 24(5):470-9. Epub 2013 Apr 08.

Steffes G, Lorente-Cánovas B, Pearson S, Brooker RH, Spiden S, Kiernan AE, Guénet JL, Steel KP. "Mutanlallemand (mtl) and Belly Spot and Deafness (bsd) are two new mutations of Lmx1a causing severe cochlear and vestibular defects." PloS one.. 2012 7(11):e51065. Epub 2012 Nov 30.

Pan W, Jin Y, Stanger B, Kiernan AE. "Notch signaling is required for the generation of hair cells and supporting cells in the mammalian inner ear." Proceedings of the National Academy of Sciences of the United States of America.. 2010 Sep 7; 107(36):15798-803. Epub 2010 Aug 23.

Kiernan AE, Li R, Hawes NL, Churchill GA, Gridley T. "Genetic background modifies inner ear and eye phenotypes of jag1 heterozygous mice." Genetics.. 2007 Sep; 177(1):307-11.

Kiernan AE. "The paintfill method as a tool for analyzing the three-dimensional structure of the inner ear." Brain research.. 2006 May 26; 1091(1):270-6. Epub 2006 Apr 05.

Kiernan AE, Xu J, Gridley T. "The Notch ligand JAG1 is required for sensory progenitor development in the mammalian inner ear." PLoS genetics.. 2006 Jan; 2(1):e4. Epub 2006 Jan 13.

Kiernan AE, Cordes R, Kopan R, Gossler A, Gridley T. "The Notch ligands DLL1 and JAG2 act synergistically to regulate hair cell development in the mammalian inner ear." Development.. 2005 Oct; 132(19):4353-62. Epub 2005 Sep 01.

Kiernan AE, Pelling AL, Leung KK, Tang AS, Bell DM, Tease C, Lovell-Badge R, Steel KP, Cheah KS. "Sox2 is required for sensory organ development in the mammalian inner ear." Nature.. 2005 Apr 21; 434(7036):1031-5.

Hulander M, Kiernan AE, Blomqvist SR, Carlsson P, Samuelsson EJ, Johansson BR, Steel KP, Enerbäck S. "Lack of pendrin expression leads to deafness and expansion of the endolymphatic compartment in inner ears of Foxi1 null mutant mice." Development.. 2003 May; 130(9):2013-25.

Kiernan AE, Erven A, Voegeling S, Peters J, Nolan P, Hunter J, Bacon Y, Steel KP, Brown SD, Guénet JL. "ENU mutagenesis reveals a highly mutable locus on mouse Chromosome 4 that affects ear morphogenesis." Mammalian genome : official journal of the International Mammalian Genome Society.. 2002 Mar; 13(3):142-8.

Alavizadeh A, Kiernan AE, Nolan P, Lo C, Steel KP, Bucan M. "The Wheels mutation in the mouse causes vascular, hindbrain, and inner ear defects." Developmental biology.. 2001 Jun 1; 234(1):244-60.

Kiernan AE, Ahituv N, Fuchs H, Balling R, Avraham KB, Steel KP, Hrabé de Angelis M. "The Notch ligand Jagged1 is required for inner ear sensory development." Proceedings of the National Academy of Sciences of the United States of America.. 2001 Mar 27; 98(7):3873-8. Epub 2001 Mar 20.

Tsai H, Hardisty RE, Rhodes C, Kiernan AE, Roby P, Tymowska-Lalanne Z, Mburu P, Rastan S, Hunter AJ, Brown SD, Steel KP. "The mouse slalom mutant demonstrates a role for Jagged1 in neuroepithelial patterning in the organ of Corti." Human molecular genetics.. 2001 Mar 1; 10(5):507-12.

Brigande JV, Kiernan AE, Gao X, Iten LE, Fekete DM. "Molecular genetics of pattern formation in the inner ear: do compartment boundaries play a role?" Proceedings of the National Academy of Sciences of the United States of America.. 2000 Oct 24; 97(22):11700-6.

Kiernan AE, Steel KP. "Mouse homologues for human deafness." Advances in oto-rhino-laryngology. 2000 56:233-43.

Kiernan AE, Zalzman M, Fuchs H, Hrabe de Angelis M, Balling R, Steel KP, Avraham KB. "Tailchaser (Tlc): a new mouse mutation affecting hair bundle differentiation and hair cell survival." Journal of neurocytology.. 1999 28(10-11):969-85.

Kiernan AE, Nunes F, Wu DK, Fekete DM. "The expression domain of two related homeobox genes defines a compartment in the chicken inner ear that may be involved in semicircular canal formation." Developmental biology.. 1997 Nov 15; 191(2):215-29.

Kiernan AE, Fekete DM. "In vivo gene transfer into the embryonic inner ear using retroviral vectors." Audiology & neuro-otology.. 1997 2(1-2):12-24.