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Alan M. Grossfield, Ph.D.

Contact Information

Phone Numbers

Office: (585) 276-4193

Fax: (585) 271-2683

Research Labs

My lab's research is focused on understanding the atomic-level interactions that drive the function of membranes and membrane proteins, using computer simulation as our primary tool.

Visit My lab's research is focused on understanding the atomic-level interactions that drive the function of membranes and membrane proteins, using computer simulation as our primary tool. Lab Website

Faculty Appointments

Biography

Research

My research interests revolve around the use of computer modeling to understand the structure and thermodynamics of biological molecules. In particular, I am most interested in understanding the biology and physics of lipid-protein interactions. These interactions underlie a fantastic array of biological processes, including cell-signaling by GPCRs and some immune reactions, specifically the action of antimicrobial peptides.

Publications

Journal Articles

9/2022
Getsy PM, Young AP, Bates JN, Baby SM, Seckler JM, Grossfield A, Hsieh YH, Lewis THJ, Jenkins MW, Gaston B, Lewis SJ. "S-nitroso-L-cysteine stereoselectively blunts the adverse effects of morphine on breathing and arterial blood gas chemistry while promoting analgesia." Biomedicine & pharmacotherapy = Biomédecine & pharmacothérapie.. 2022 Sep; 153:113436. Epub 2022 Jul 26.

8/21/2022
Seckler JM, Robinson EN, Lewis SJ, Grossfield A. "Surveying non-visual arrestins reveals allosteric interactions between functional sites." Proteins.. 2022 Aug 21; Epub 2022 Aug 21.

5/3/2022
Onukwufor JO, Farooqi MA, Vodi?ková A, Koren SA, Baldzizhar A, Berry BJ, Beutner G, Porter GA, Belousov V, Grossfield A, Wojtovich AP. "A reversible mitochondrial complex I thiol switch mediates hypoxic avoidance behavior in C. elegans." Nature communications.. 2022 May 3; 13(1):2403. Epub 2022 May 03.

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