Alan M. Grossfield, Ph.D.

Contact Information

Phone Numbers

Office: (585) 276-4193

Fax: (585) 275-6007

Research Labs

My lab's research is focused on understanding the stomic-level interactions that drive the function of membranes and membrane proteins, using computer simulation as our primary tool.

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Locations

University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 712
Rochester, NY 14642

Faculty Appointments

Associate Professor - Department of Biochemistry and Biophysics (SMD) - Primary

Biography

Research

My research interests revolve around the use of computer modeling to understand the structure and thermodynamics of biological molecules. In particular, I am most interested in understanding the biology and physics of lipid-protein interactions. These interactions underlie a fantastic array of biological processes, including cell-signaling by GPCRs and some immune reactions, specifically the action of antimicrobial peptides.

Publications

Journal Articles

3/2/2018
Thompson JL, Zhao Y, Stathopulos PB, Grossfield A, Shuttleworth TJ. "Phosphorylation-mediated structural changes within the SOAR domain of stromal interaction molecule 1 enable specific activation of distinct Orai channels." The Journal of biological chemistry.. 2018 Mar 2; 293(9):3145-3155. Epub 2018 Jan 11.

3/1/2018
Sur S, Romo TD, Grossfield A. "Selectivity and Mechanism of Fengycin, an Antimicrobial Lipopeptide, from Molecular Dynamics." The journal of physical chemistry. B. 2018 Mar 1; 122(8):2219-2226. Epub 2018 Feb 15.

1/23/2018
Salas-Estrada LA, Leioatts N, Romo TD, Grossfield A. "Lipids Alter Rhodopsin Function via Ligand-like and Solvent-like Interactions." Biophysical journal.. 2018 Jan 23; 114(2):355-367.

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