CONTACT INFORMATIONCREDENTIALSPUBLICATIONSAlan M. Grossfield, Ph.D.Contact InformationPhone NumbersOffice: (585) 276-4193Fax: (585) 271-2683Research LabsMy lab's research is focused on understanding the atomic-level interactions that drive the function of membranes and membrane proteins, using computer simulation as our primary tool.Visit My lab's research is focused on understanding the atomic-level interactions that drive the function of membranes and membrane proteins, using computer simulation as our primary tool. Lab WebsiteLocationsUniversity of Rochester Medical CenterSchool of Medicine and Dentistry601 Elmwood Ave, Box 712Rochester, NY 14642Faculty AppointmentsAssociate Professor - Department of Biochemistry and Biophysics (SMD) BiographyResearchMy research interests revolve around the use of computer modeling to understand the structure and thermodynamics of biological molecules. In particular, I am most interested in understanding the biology and physics of lipid-protein interactions. These interactions underlie a fantastic array of biological processes, including cell-signaling by GPCRs and some immune reactions, specifically the action of antimicrobial peptides.PublicationsJournal Articles5/11/2021Gaston B, Baby SM, May WJ, Young AP, Grossfield A, Bates JN, Seckler JM, Wilson CG, Lewis SJ. "D-Cystine di(m)ethyl ester reverses the deleterious effects of morphine on ventilation and arterial blood gas chemistry while promoting antinociception." Scientific reports.. 2021 May 11; 11(1):10038. Epub 2021 May 11. 10/26/2020Romo TD, Grossfield A, Markelz AG. "Persistent Protein Motions in a Rugged Energy Landscape Revealed by Normal Mode Ensemble Analysis." Journal of chemical information and modeling.. 2020 Oct 26; Epub 2020 Oct 26. 11/7/2019Maji D, Grossfield AM, Kielkopf CL. "Structures of SF3b1 reveal a dynamic Achilles heel of spliceosome assembly: Implications for cancer-associated abnormalities and drug discovery." Biochimica et biophysica acta. Gene regulatory mechanisms.. 2019 Nov 7; :194440. Epub 2019 Nov 07. VIEW ALL PUBLICATIONSClose WindowSchedule an appointment with Alan M. Grossfield, Ph.D.Please answer the following questions to help us find the right appointment for you.Important: If you believe that you have a medical or psychiatric emergency, please call 911 or go to the nearest hospital. This website is not intended for emergency care.Have you seen this provider in the last 2 years?YesNoExisting Patient Schedule or request a follow up appointment online through MyChart. If you do not have a MyChart account, please close this window and call the appointment phone number. Alan M. Grossfield, Ph.D. is currently scheduling for the following appointment type(s): Our policy does not permit patients to establish care with multiple providers within the same practice or specialty without prior approval. If you choose a new provider in the same office, we will cancel the appointment. Please contact the office directly with questions on this policy.