Alan M. Grossfield, Ph.D.

Contact Information

Phone Numbers

Office: (585) 276-4193

Fax: (585) 275-6007

Research Labs

My lab's research is focused on understanding the atomic-level interactions that drive the function of membranes and membrane proteins, using computer simulation as our primary tool.

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Locations

University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 712
Rochester, NY 14642

Faculty Appointments

Associate Professor - Department of Biochemistry and Biophysics (SMD)

Biography

Research

My research interests revolve around the use of computer modeling to understand the structure and thermodynamics of biological molecules. In particular, I am most interested in understanding the biology and physics of lipid-protein interactions. These interactions underlie a fantastic array of biological processes, including cell-signaling by GPCRs and some immune reactions, specifically the action of antimicrobial peptides.

Publications

Journal Articles

10/30/2018
Smith LG, Tan Z, Spasic A, Dutta D, Salas-Estrada LA, Grossfield A, Mathews DH. "Chemically Accurate Relative Folding Stability of RNA Hairpins from Molecular Simulations." Journal of chemical theory and computation.. 2018 Oct 30; Epub 2018 Oct 30.

7/13/2018
Thompson JL, Lai-Zhao Y, Stathopulos PB, Grossfield A, Shuttleworth TJ. "Phosphorylation-mediated structural changes within the SOAR domain of stromal interaction molecule 1 enable specific activation of distinct Orai channels." The Journal of biological chemistry.. 2018 Jul 13; 293(28):11241.

3/2/2018
Thompson JL, Zhao Y, Stathopulos PB, Grossfield A, Shuttleworth TJ. "Phosphorylation-mediated structural changes within the SOAR domain of stromal interaction molecule 1 enable specific activation of distinct Orai channels." The Journal of biological chemistry.. 2018 Mar 2; 293(9):3145-3155. Epub 2018 Jan 11.

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