Alan M. Grossfield, Ph.D.

Alan M. Grossfield, Ph.D.

Contact Information

University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 712
Rochester, NY 14642

Office: (585) 276-4193
Fax: (585) 275-6007

Lab Information

My lab's research is focused on understanding the stomic-level interactions that drive the function of membranes and membrane proteins, using computer simulation as our primary tool.

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Research Bio

My research interests revolve around the use of computer modeling to understand the structure and thermodynamics of biological molecules. In particular, I am most interested in understanding the biology and physics of lipid-protein interactions. These interactions underlie a fantastic array of biological processes, including cell-signaling by GPCRs and some immune reactions, specifically the action of antimicrobial peptides.

Recent Journal Articles

Showing the 5 most recent journal articles. 33 available »

2014 Mar
Kimura T, Vukoti K, Lynch DL, Hurst DP, Grossfield A, Pitman MC, Reggio PH, Yeliseev AA, Gawrisch K. "Global fold of human cannabinoid type 2 receptor probed by solid-state 13C-, 15N-MAS NMR and molecular dynamics simulations." Proteins. 2014 Mar; 82(3):452-65. Epub 2013 Oct 17.
2014 Jan 21
Leioatts N, Mertz B, Martinez-Mayorga K, Romo TD, Pitman MC, Feller SE, Grossfield A, Brown MF. "Retinal ligand mobility explains internal hydration and reconciles active rhodopsin structures." Biochemistry.. 2014 Jan 21; 53(2):376-85. Epub 2014 Jan 08.
Horn JN, Kao TC, Grossfield A. "Coarse-grained molecular dynamics provides insight into the interactions of lipids and cholesterol with rhodopsin." Advances in experimental medicine and biology. 2014 796:75-94.
2013 Oct 1
Horn JN, Cravens A, Grossfield A. "Interactions between fengycin and model bilayers quantified by coarse-grained molecular dynamics." Biophysical journal.. 2013 Oct 1; 105(7):1612-23.
2013 Oct
Seckler JM, Leioatts N, Miao H, Grossfield A. "The interplay of structure and dynamics: insights from a survey of HIV-1 reverse transcriptase crystal structures." Proteins. 2013 Oct; 81(10):1792-801. Epub 2013 Aug 16.

Current Appointments

Associate Professor - Department of Biochemistry and Biophysics (SMD) - Primary