Research Bio
My research interests revolve around the use of computer modeling to understand the structure and thermodynamics of biological molecules. In particular, I am most interested in understanding the biology and physics of lipid-protein interactions. These interactions underlie a fantastic array of biological processes, including cell-signaling by GPCRs and some immune reactions, specifically the action of antimicrobial peptides.
2014 Mar
Kimura T, Vukoti K, Lynch DL, Hurst DP, Grossfield A, Pitman MC, Reggio PH, Yeliseev AA, Gawrisch K. "Global fold of human cannabinoid type 2 receptor probed by solid-state 13C-, 15N-MAS NMR and molecular dynamics simulations." Proteins. 2014 Mar; 82(3):452-65. Epub 2013 Oct 17. |
2014 Jan 21
Leioatts N, Mertz B, Martinez-Mayorga K, Romo TD, Pitman MC, Feller SE, Grossfield A, Brown MF. "Retinal ligand mobility explains internal hydration and reconciles active rhodopsin structures." Biochemistry.. 2014 Jan 21; 53(2):376-85. Epub 2014 Jan 08. |
2014
Horn JN, Kao TC, Grossfield A. "Coarse-grained molecular dynamics provides insight into the interactions of lipids and cholesterol with rhodopsin." Advances in experimental medicine and biology. 2014 796:75-94. |
2013 Oct 1
Horn JN, Cravens A, Grossfield A. "Interactions between fengycin and model bilayers quantified by coarse-grained molecular dynamics." Biophysical journal.. 2013 Oct 1; 105(7):1612-23. |
2013 Oct
Seckler JM, Leioatts N, Miao H, Grossfield A. "The interplay of structure and dynamics: insights from a survey of HIV-1 reverse transcriptase crystal structures." Proteins. 2013 Oct; 81(10):1792-801. Epub 2013 Aug 16. |
