Alan M. Grossfield, Ph.D.

Contact Information

Phone Numbers

Research Labs

My lab's research is focused on understanding the atomic-level interactions that drive the function of membranes and membrane proteins, using computer simulation as our primary tool.

Visit My lab's research is focused on understanding the atomic-level interactions that drive the function of membranes and membrane proteins, using computer simulation as our primary tool. Lab Website

Locations

University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 712
Rochester, NY 14642

Faculty Appointments

Associate Professor - Department of Biochemistry and Biophysics (SMD)

Biography

Research

My research interests revolve around the use of computer modeling to understand the structure and thermodynamics of biological molecules. In particular, I am most interested in understanding the biology and physics of lipid-protein interactions. These interactions underlie a fantastic array of biological processes, including cell-signaling by GPCRs and some immune reactions, specifically the action of antimicrobial peptides.

Publications

Journal Articles

5/11/2021
Gaston B, Baby SM, May WJ, Young AP, Grossfield A, Bates JN, Seckler JM, Wilson CG, Lewis SJ. "D-Cystine di(m)ethyl ester reverses the deleterious effects of morphine on ventilation and arterial blood gas chemistry while promoting antinociception." Scientific reports.. 2021 May 11; 11(1):10038. Epub 2021 May 11.

10/26/2020
Romo TD, Grossfield A, Markelz AG. "Persistent Protein Motions in a Rugged Energy Landscape Revealed by Normal Mode Ensemble Analysis." Journal of chemical information and modeling.. 2020 Oct 26; Epub 2020 Oct 26.

11/7/2019
Maji D, Grossfield AM, Kielkopf CL. "Structures of SF3b1 reveal a dynamic Achilles heel of spliceosome assembly: Implications for cancer-associated abnormalities and drug discovery." Biochimica et biophysica acta. Gene regulatory mechanisms.. 2019 Nov 7; :194440. Epub 2019 Nov 07.

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