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Alan M. Grossfield, Ph.D.

Contact Information

Phone Numbers

Office: (585) 276-4193

Fax: (585) 271-2683

Research Labs

My lab's research is focused on understanding the atomic-level interactions that drive the function of membranes and membrane proteins, using computer simulation as our primary tool.

Visit My lab's research is focused on understanding the atomic-level interactions that drive the function of membranes and membrane proteins, using computer simulation as our primary tool. Lab Website

Faculty Appointments

Biography

Research

My research interests revolve around the use of computer modeling to understand the structure and thermodynamics of biological molecules. In particular, I am most interested in understanding the biology and physics of lipid-protein interactions. These interactions underlie a fantastic array of biological processes, including cell-signaling by GPCRs and some immune reactions, specifically the action of antimicrobial peptides.

Publications

Journal Articles

5/3/2022
Onukwufor JO, Farooqi MA, Vodi?ková A, Koren SA, Baldzizhar A, Berry BJ, Beutner G, Porter GA, Belousov V, Grossfield A, Wojtovich AP. "A reversible mitochondrial complex I thiol switch mediates hypoxic avoidance behavior in C. elegans." Nature communications.. 2022 May 3; 13(1):2403. Epub 2022 May 03.

4/18/2022
Getsy PM, Young AP, Grossfield A, Seckler JM, Wilson CG, Gaston B, Bates JN, Lewis SJ. "D-Cysteine ethylester and D-cystine dimethylester reverse the deleterious effects of morphine on arterial blood-gas chemistry and Alveolar-arterial gradient in anesthetized rats." Respiratory physiology & neurobiology.. 2022 Apr 18; :103912. Epub 2022 Apr 18.

4/14/2022
Sur S, Grossfield A. "Effects of Cholesterol on the mechanism of fengycin, a biofungicide." Biophysical journal.. 2022 Apr 14; Epub 2022 Apr 14.

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