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Joshua C. Munger, Ph.D.


Showing all 45 journal articles & 0 books available

Journal Articles

Monaghan M, Munger J. "Contributions of the HCMV U30-associated open reading frames to infection." Journal of virology.. 2021 Feb 10; Epub 2021 Feb 10.

Dunn DM, Rodriguez-Sanchez I, Schafer X, Munger J. "Human Cytomegalovirus Induces the Expression of the AMPKa2 Subunit to Drive Glycolytic Activation and Support Productive Viral Infection." Journal of virology.. 2020 Dec 2; Epub 2020 Dec 02.

Dunn DM, Munger J. "Interplay Between Calcium and AMPK Signaling in Human Cytomegalovirus Infection." Frontiers in cellular and infection microbiology.. 2020 10:384. Epub 2020 Jul 29.

Goodwin CM, Schafer X, Munger J. "U26 attenuates IKK?-mediated induction of ISG expression and enhanced protein ISGylation during HCMV infection." Journal of virology.. 2019 Sep 18; Epub 2019 Sep 18.

Meade N, King M, Munger J, Walsh D. "mTOR dysregulation by vaccinia virus F17 controls multiple processes with varying roles in infection." Journal of virology.. 2019 May 22; Epub 2019 May 22.

Rodríguez-Sánchez I, Munger J. "Meal for Two: Human Cytomegalovirus-Induced Activation of Cellular Metabolism." Viruses.. 2019 Mar 19; 11(3)Epub 2019 Mar 19.

Goodwin CM, Munger J. "The I?B kinases restrict human cytomegalovirus infection." Journal of virology.. 2019 Feb 13; Epub 2019 Feb 13.

King MW, Munger J. "Editing the human cytomegalovirus genome with the CRISPR/Cas9 system." Virology.. 2019 Jan 26; 529:186-194. Epub 2019 Jan 26.

Rodríguez-Sánchez I, Schafer XL, Monaghan M, Munger J. "The Human Cytomegalovirus UL38 protein drives mTOR-independent metabolic flux reprogramming by inhibiting TSC2." PLoS pathogens.. 2019 Jan 24; 15(1):e1007569. Epub 2019 Jan 24.

Goodwin CM, Ciesla JH, Munger J. "Who's Driving? Human Cytomegalovirus, Interferon, and NF?B Signaling." Viruses.. 2018 Aug 21; 10(9)Epub 2018 Aug 21.

Nadtochiy SM, Wang YT, Nehrke K, Munger J, Brookes PS. "Cardioprotection by nicotinamide mononucleotide (NMN): Involvement of glycolysis and acidic pH." Journal of molecular and cellular cardiology.. 2018 Aug 0; 121:155-162. Epub 2018 Jun 26.

Zhang J, Wang YT, Miller JH, Day MM, Munger JC, Brookes PS. "Accumulation of Succinate in Cardiac Ischemia Primarily Occurs via Canonical Krebs Cycle Activity." Cell reports.. 2018 May 29; 23(9):2617-2628.

Nadtochiy SM, Wang YT, Zhang J, Nehrke K, Schafer X, Welle K, Ghaemmaghami S, Munger J, Brookes PS. "Potential mechanisms linking SIRT activity and hypoxic 2-hydroxyglutarate generation: no role for direct enzyme (de)acetylation." The Biochemical journal.. 2017 Aug 10; 474(16):2829-2839. Epub 2017 Aug 10.

Murphy PS, Wang J, Bhagwat SP, Munger JC, Janssen WJ, Wright TW, Elliott MR. "CD73 regulates anti-inflammatory signaling between apoptotic cells and endotoxin-conditioned tissue macrophages." Cell death and differentiation.. 2017 Mar 0; 24(3):559-570. Epub 2017 Jan 06.

Smith B, Schafer XL, Ambeskovic A, Spencer CM, Land H, Munger J. "Addiction to Coupling of the Warburg Effect with Glutamine Catabolism in Cancer Cells." Cell reports.. 2016 Oct 11; 17(3):821-836.

Nadtochiy SM, Schafer X, Fu D, Nehrke K, Munger J, Brookes PS. "Acidic pH Is a Metabolic Switch for 2-Hydroxyglutarate Generation and Signaling." The Journal of biological chemistry.. 2016 Sep 16; 291(38):20188-97. Epub 2016 Aug 10.

Xu S, Schafer X, Munger J. "Expression of Oncogenic Alleles Induces Multiple Blocks to Human Cytomegalovirus Infection." Journal of virology.. 2016 May 0; 90(9):4346-4356. Epub 2016 Apr 14.

Hollenbaugh JA, Montero C, Schinazi RF, Munger J, Kim B. "Metabolic profiling during HIV-1 and HIV-2 infection of primary human monocyte-derived macrophages." Virology.. 2016 Apr 0; 491:106-14. Epub 2016 Feb 16.

Campbell A, Bushman J, Munger J, Noble M, Pröschel C, Mayer-Pröschel M. "Mutation of ataxia-telangiectasia mutated is associated with dysfunctional glutathione homeostasis in cerebellar astroglia." Glia.. 2016 Feb 0; 64(2):227-39. Epub 2015 Oct 15.

Goodwin CM, Xu S, Munger J. "Stealing the Keys to the Kitchen: Viral Manipulation of the Host Cell Metabolic Network." Trends in microbiology.. 2015 Dec 0; 23(12):789-798. Epub 2015 Oct 01.

Nadtochiy SM, Urciuoli W, Zhang J, Schafer X, Munger J, Brookes PS. "Metabolomic profiling of the heart during acute ischemic preconditioning reveals a role for SIRT1 in rapid cardioprotective metabolic adaptation." Journal of molecular and cellular cardiology.. 2015 Nov 0; 88:64-72. Epub 2015 Sep 24.

Buescher JM, Antoniewicz MR, Boros LG, Burgess SC, Brunengraber H, Clish CB, DeBerardinis RJ, Feron O, Frezza C, Ghesquiere B, Gottlieb E, Hiller K, Jones RG, Kamphorst JJ, Kibbey RG, Kimmelman AC, Locasale JW, Lunt SY, Maddocks OD, Malloy C, Metallo CM, Meuillet EJ, Munger J, Nöh K, Rabinowitz JD, Ralser M, Sauer U, Stephanopoulos G, St-Pierre J, Tennant DA, Wittmann C, Vander Heiden MG, Vazquez A, Vousden K, Young JD, Zamboni N, Fendt SM. "A roadmap for interpreting (13)C metabolite labeling patterns from cells." Current opinion in biotechnology.. 2015 Aug 0; 34:189-201. Epub 2015 Feb 28.

Xu S, Spencer CM, Munger J. "Transformation with oncogenic Ras and the simian virus 40 T antigens induces caspase-dependent sensitivity to fatty acid biosynthetic inhibition." Journal of virology.. 2015 Jun 0; 89(12):6406-17. Epub 2015 Apr 08.

DeVito SR, Ortiz-Riaño E, Martínez-Sobrido L, Munger J. "Cytomegalovirus-mediated activation of pyrimidine biosynthesis drives UDP-sugar synthesis to support viral protein glycosylation." Proceedings of the National Academy of Sciences of the United States of America.. 2014 Dec 16; 111(50):18019-24. Epub 2014 Dec 03.

Mathers C, Schafer X, Martinez-Sobrido L, Munger J. "The human cytomegalovirus UL26 protein antagonizes NF-?B activation." Journal of virology.. 2014 Dec 0; 88(24):14289-300. Epub 2014 Oct 01.

Proschel C, Stripay JL, Shih CH, Munger JC, Noble MD. "Delayed transplantation of precursor cell-derived astrocytes provides multiple benefits in a rat model of Parkinsons." EMBO molecular medicine.. 2014 Apr 0; 6(4):504-18. Epub 2014 Jan 29.

Ortiz-Riaño E, Ngo N, Devito S, Eggink D, Munger J, Shaw ML, de la Torre JC, Martínez-Sobrido L. "Inhibition of arenavirus by A3, a pyrimidine biosynthesis inhibitor." Journal of virology.. 2014 Jan 0; 88(2):878-89. Epub 2013 Nov 06.

Mathers C, Spencer CM, Munger J. "Distinct domains within the human cytomegalovirus U(L)26 protein are important for wildtype viral replication and virion stability." PloS one.. 2014 9(2):e88101. Epub 2014 Feb 05.

Pei S, Minhajuddin M, Callahan KP, Balys M, Ashton JM, Neering SJ, Lagadinou ED, Corbett C, Ye H, Liesveld JL, O'Dwyer KM, Li Z, Shi L, Greninger P, Settleman J, Benes C, Hagen FK, Munger J, Crooks PA, Becker MW, Jordan CT. "Targeting aberrant glutathione metabolism to eradicate human acute myelogenous leukemia cells." The Journal of biological chemistry.. 2013 Nov 22; 288(47):33542-58. Epub 2013 Oct 02.

Sasaki M, Knobbe CB, Munger JC, Lind EF, Brenner D, Brüstle A, Harris IS, Holmes R, Wakeham A, Haight J, You-Ten A, Li WY, Schalm S, Su SM, Virtanen C, Reifenberger G, Ohashi PS, Barber DL, Figueroa ME, Melnick A, Zúñiga-Pflücker JC, Mak TW. "IDH1(R132H) mutation increases murine haematopoietic progenitors and alters epigenetics." Nature.. 2012 Aug 30; 488(7413):656-9.

McArdle J, Moorman NJ, Munger J. "HCMV targets the metabolic stress response through activation of AMPK whose activity is important for viral replication." PLoS pathogens.. 2012 Jan 0; 8(1):e1002502. Epub 2012 Jan 26.

Wang R, Dillon CP, Shi LZ, Milasta S, Carter R, Finkelstein D, McCormick LL, Fitzgerald P, Chi H, Munger J, Green DR. "The transcription factor Myc controls metabolic reprogramming upon T lymphocyte activation." Immunity.. 2011 Dec 23; 35(6):871-82.

Hollenbaugh JA, Munger J, Kim B. "Metabolite profiles of human immunodeficiency virus infected CD4+ T cells and macrophages using LC-MS/MS analysis." Virology.. 2011 Jul 5; 415(2):153-9. Epub 2011 May 11.

Spencer CM, Schafer XL, Moorman NJ, Munger J. "Human cytomegalovirus induces the activity and expression of acetyl-coenzyme A carboxylase, a fatty acid biosynthetic enzyme whose inhibition attenuates viral replication." Journal of virology.. 2011 Jun 0; 85(12):5814-24. Epub 2011 Apr 06.

McArdle J, Schafer XL, Munger J. "Inhibition of calmodulin-dependent kinase kinase blocks human cytomegalovirus-induced glycolytic activation and severely attenuates production of viral progeny." Journal of virology.. 2011 Jan 0; 85(2):705-14. Epub 2010 Nov 17.

Munger J, Bennett BD, Parikh A, Feng XJ, McArdle J, Rabitz HA, Shenk T, Rabinowitz JD. "Systems-level metabolic flux profiling identifies fatty acid synthesis as a target for antiviral therapy." Nature biotechnology.. 2008 Oct 0; 26(10):1179-86. Epub 2008 Sep 28.

Munger J, Bajad SU, Coller HA, Shenk T, Rabinowitz JD. "Dynamics of the cellular metabolome during human cytomegalovirus infection." PLoS pathogens.. 2006 Dec 0; 2(12):e132.

Munger J, Yu D, Shenk T. "UL26-deficient human cytomegalovirus produces virions with hypophosphorylated pp28 tegument protein that is unstable within newly infected cells." Journal of virology.. 2006 Apr 0; 80(7):3541-8.

Benetti L, Munger J, Roizman B. "The herpes simplex virus 1 US3 protein kinase blocks caspase-dependent double cleavage and activation of the proapoptotic protein BAD." Journal of virology.. 2003 Jun 0; 77(11):6567-73.

Munger J, Hagglund R, Roizman B. "Infected cell protein No. 22 is subject to proteolytic cleavage by caspases activated by a mutant that induces apoptosis." Virology.. 2003 Jan 20; 305(2):364-70.

Munger, J.; Zhou, G.; Roizman, B.;. "Cell death on demand: Herpes simplex viruses and apoptosis" . In C. D. O?Connor (ed.), Microbial Subversion of Host Cells, Cambridge University Press, Cambridge. 2003; : 229-245.

Hagglund R, Munger J, Poon AP, Roizman B. "U(S)3 protein kinase of herpes simplex virus 1 blocks caspase 3 activation induced by the products of U(S)1.5 and U(L)13 genes and modulates expression of transduced U(S)1.5 open reading frame in a cell type-specific manner." Journal of virology.. 2002 Jan 0; 76(2):743-54.

Munger J, Roizman B. "The US3 protein kinase of herpes simplex virus 1 mediates the posttranslational modification of BAD and prevents BAD-induced programmed cell death in the absence of other viral proteins." Proceedings of the National Academy of Sciences of the United States of America.. 2001 Aug 28; 98(18):10410-5. Epub 2001 Aug 21.

Munger J, Chee AV, Roizman B. "The U(S)3 protein kinase blocks apoptosis induced by the d120 mutant of herpes simplex virus 1 at a premitochondrial stage." Journal of virology.. 2001 Jun 0; 75(12):5491-7.

Galvan V, Brandimarti R, Munger J, Roizman B. "Bcl-2 blocks a caspase-dependent pathway of apoptosis activated by herpes simplex virus 1 infection in HEp-2 cells." Journal of virology.. 2000 Feb 0; 74(4):1931-8.