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Thomas J. Mariani, Ph.D.


Showing all 123 journal articles & 4 books available

Journal Articles

McCall MN, Chu CY, Wang L, Benoodt L, Thakar J, Corbett A, Holden-Wiltse J, Slaunwhite C, Grier A, Gill SR, Falsey AR, Topham DJ, Caserta MT, Walsh EE, Qiu X, Mariani TJ. "A systems genomics approach uncovers molecular associates of RSV severity." PLoS computational biology.. 2021 Dec 28; 17(12):e1009617. Epub 2021 Dec 28.

Peterson DR, Baran AM, Bhattacharya S, Branche AR, Croft DP, Corbett AM, Walsh EE, Falsey AR, Mariani TJ. "Gene Expression Risk Scores for COVID-19 Illness Severity." The Journal of infectious diseases.. 2021 Nov 30; Epub 2021 Nov 30.

Clair G, Bramer LM, Misra R, McGraw MD, Bhattacharya S, Kitzmiller JA, Feng S, Danna VG, Bandyopadhyay G, Bhotika H, Huyck HL, Deutsch GH, Mariani TJ, Carson J, Whitsett JA, Pryhuber GS, Adkins JN, Ansong C. "Proteomic Analysis of Human Lung Development." American journal of respiratory and critical care medicine.. 2021 Nov 9; Epub 2021 Nov 09.

Wang S, Zhu G, Jiang D, Rhen J, Li X, Liu H, Lyu Y, Tsai P, Rose Y, Nguyen T, White RJ, Pryhuber GS, Mariani TJ, Li C, Mohan A, Xu Y, Pang J. "Reduced Notch1 Cleavage Promotes the Development of Pulmonary Hypertension." Hypertension.. 2021 Nov 5; :HYPERTENSIONAHA12016065. Epub 2021 Nov 05.

Croft DP, Burton DS, Nagel DJ, Bhattacharya S, Falsey AR, Georas SN, Hopke PK, Johnston CJ, Kottmann RM, Litonjua AA, Mariani TJ, Rich DQ, Thevenet-Morrison K, Thurston SW, Utell MJ, McCall MN. "The effect of air pollution on the transcriptomics of the immune response to respiratory infection." Scientific reports.. 2021 Sep 30; 11(1):19436. Epub 2021 Sep 30.

Danopoulos S, Deutsch GH, Dumortier C, Mariani TJ, Al Alam D. "Lung disease manifestations in Down Syndrome." American journal of physiology. Lung cellular and molecular physiology.. 2021 Sep 1; Epub 2021 Sep 01.

Peterson DR, Baran AM, Bhattacharya S, Branche AR, Croft DP, Corbett AM, Walsh EE, Falsey AR, Mariani TJ. "Gene Expression Risk Scores for COVID-19 Illness Severity." bioRxiv : the preprint server for biology.. 2021 Aug 24; Epub 2021 Aug 24.

Meng Y, Groth SW, Hodgkinson CA, Mariani TJ. "Serotonin system genes contribute to the susceptibility to obesity in Black adolescents." Obesity science & practice.. 2021 Aug 0; 7(4):441-449. Epub 2021 Mar 27.

Mereness JA, Mariani TJ. "The critical role of collagen VI in lung development and chronic lung disease." . 2021 Jun 0; 10:100058. Epub 2021 Feb 20.

Danopoulos S, Bhattacharya S, Deutsch G, Nih LR, Slaunwhite C, Mariani TJ, Al Alam D. "Prenatal histological, cellular, and molecular anomalies in Trisomy 21 lung." The Journal of pathology.. 2021 May 29; Epub 2021 May 29.

Wang J, Kim SY, House E, Olson HM, Johnston CJ, Chalupa D, Hernady E, Mariani TJ, Clair G, Ansong C, Qian WJ, Finkelstein JN, McGraw MD. "Repetitive diacetyl vapor exposure promotes ubiquitin proteasome stress and precedes bronchiolitis obliterans pathology." Archives of toxicology.. 2021 May 24; Epub 2021 May 24.

Anderson CS, Chirkova T, Slaunwhite CG, Qiu X, Walsh EE, Anderson LJ, Mariani TJ. "CX3CR1 Engagement by Respiratory Syncytial Virus Leads to Induction of Nucleolin and Dysregulation of Cilia-related Genes." Journal of virology.. 2021 Mar 17; Epub 2021 Mar 17.

Muus C, Luecken MD, Eraslan G, Sikkema L, Waghray A, Heimberg G, Kobayashi Y, Vaishnav ED, Subramanian A, Smillie C, Jagadeesh KA, Duong ET, Fiskin E, Triglia ET, Ansari M, Cai P, Lin B, Buchanan J, Chen S, Shu J, Haber AL, Chung H, Montoro DT, Adams T, Aliee H, Allon SJ, Andrusivova Z, Angelidis I, Ashenberg O, Bassler K, Bécavin C, Benhar I, Bergenstråhle J, Bergenstråhle L, Bolt L, Braun E, Bui LT, Callori S, Chaffin M, Chichelnitskiy E, Chiou J, Conlon TM, Cuoco MS, Cuomo ASE, Deprez M, Duclos G, Fine D, Fischer DS, Ghazanfar S, Gillich A, Giotti B, Gould J, Guo M, Gutierrez AJ, Habermann AC, Harvey T, He P, Hou X, Hu L, Hu Y, Jaiswal A, Ji L, Jiang P, Kapellos TS, Kuo CS, Larsson L, Leney-Greene MA, Lim K, Litvi?uková M, Ludwig LS, Lukassen S, Luo W, Maatz H, Madissoon E, Mamanova L, Manakongtreecheep K, Leroy S, Mayr CH, Mbano IM, McAdams AM, Nabhan AN, Nyquist SK, Penland L, Poirion OB, Poli S, Qi C, Queen R, Reichart D, Rosas I, Schupp JC, Shea CV, Shi X, Sinha R, Sit RV, Slowikowski K, Slyper M, Smith NP, Sountoulidis A, Strunz M, Sullivan TB, Sun D, Talavera-López C, Tan P, Tantivit J, Travaglini KJ, Tucker NR, Vernon KA, Wadsworth MH, Waldman J, Wang X, Xu K, Yan W, Zhao W, Ziegler CGK, , . "Single-cell meta-analysis of SARS-CoV-2 entry genes across tissues and demographics." Nature medicine.. 2021 Mar 2; Epub 2021 Mar 02.

Wang L, Chu CY, McCall MN, Slaunwhite C, Holden-Wiltse J, Corbett A, Falsey AR, Topham DJ, Caserta MT, Mariani TJ, Walsh EE, Qiu X. "Airway gene-expression classifiers for respiratory syncytial virus (RSV) disease severity in infants." BMC medical genomics.. 2021 Feb 25; 14(1):57. Epub 2021 Feb 25.

Al Alam D, Ballard PL, Jourdan Le Saux C, Ingram JL, Mariani TJ, Moore NS, Weiss DJ, Yu M. "Human Fetal Tissue Regulation. Impact on Pediatric and Adult Respiratory-related Research." Annals of the American Thoracic Society.. 2021 Feb 0; 18(2):204-208.

Grier A, Gill AL, Kessler HA, Corbett A, Bandyopadhyay S, Java J, Holden-Wiltse J, Falsey AR, Topham DJ, Mariani TJ, Caserta MT, Walsh EE, Gill SR. "Temporal Dysbiosis of Infant Nasal Microbiota Relative to Respiratory Syncytial Virus Infection." The Journal of infectious diseases.. 2020 Sep 14; Epub 2020 Sep 14.

Chu CY, Qiu X, McCall MN, Wang L, Corbett A, Holden-Wiltse J, Slaunwhite C, Grier A, Gill SR, Pryhuber GS, Falsey AR, Topham DJ, Caserta MT, Walsh EE, Mariani TJ. "Airway gene expression correlates of RSV disease severity and microbiome composition in infants." The Journal of infectious diseases.. 2020 Sep 14; Epub 2020 Sep 14.

Thakar J, Qian Y, Benoodt L, Roumanes D, Qiu X, Laniewski N, Chu C, Slaunwhite C, Wang L, Mandava A, Chang I, Falsey AR, Caserta MT, Mariani TJ, Scheuermann RH, Walsh EE, Topham DJ. "Unbiased analysis of peripheral blood mononuclear cells reveals CD4 T cell response to RSV matrix protein." . 2020 Aug 7; 5:100065. Epub 2020 Apr 21.

Anderson CS, Sangster MY, Yang H, Mariani TJ, Chaudhury S, Topham DJ. "Implementing sequence-based antigenic distance calculation into immunological shape space model." BMC bioinformatics.. 2020 Jun 19; 21(1):256. Epub 2020 Jun 19.

McGraw MD, Kim SY, Reed C, Hernady E, Rahman I, Mariani TJ, Finkelstein JN. "Airway basal cell injury after acute diacetyl (2,3-butanedione) vapor exposure." Toxicology letters.. 2020 Jun 1; 325:25-33. Epub 2020 Feb 26.

Ren Y, Lyu Y, Mereness JA, Wang S, Pang J, Mariani TJ. "Rare Pulmonary Connective Tissue Type Mast Cells Regulate Lung Endothelial Cell Angiogenesis." The American journal of pathology.. 2020 May 22; Epub 2020 May 22.

Bhattacharya S, Mereness JA, Baran AM, Misra RS, Peterson DR, Ryan RM, Reynolds AM, Pryhuber GS, Mariani TJ. "Lymphocyte-Specific Biomarkers Associated With Preterm Birth and Bronchopulmonary Dysplasia." Frontiers in immunology.. 2020 11:563473. Epub 2021 Jan 21.

Mereness JA, Bhattacharya S, Ren Y, Wang Q, Anderson CS, Donlon K, Dylag AM, Haak J, Angelin A, Bonaldo P, Mariani TJ. "Collagen VI Deficiency Results in Structural Abnormalities in the Mouse Lung." The American journal of pathology.. 2019 Dec 13; Epub 2019 Dec 13.

Anderson CS, Chu CY, Wang Q, Mereness JA, Ren Y, Donlon K, Bhattacharya S, Misra RS, Walsh EE, Pryhuber GS, Mariani TJ. "CX3CR1 as a respiratory syncytial virus receptor in pediatric human lung." Pediatric research.. 2019 Nov 14; Epub 2019 Nov 14.

Pan H, Deutsch GH, Wert SE, , . "Comprehensive anatomic ontologies for lung development: A comparison of alveolar formation and maturation within mouse and human lung." Journal of biomedical semantics. 2019 Oct 24; 10(1):18. Epub 2019 Oct 24.

Danopoulos S, Bhattacharya S, Mariani TJ, Al Alam D. "Transcriptional Characterisation of Human Lung Cells Identifies Novel Mesenchymal Lineage Markers." The European respiratory journal.. 2019 Oct 16; Epub 2019 Oct 16.

Sonawane AR, Tian L, Chu CY, Qiu X, Wang L, Holden-Wiltse J, Grier A, Gill SR, Caserta MT, Falsey AR, Topham DJ, Walsh EE, Mariani TJ, Weiss ST, Silverman EK, Glass K, Liu YY. "Microbiome-Transcriptome Interactions Related to Severity of Respiratory Syncytial Virus Infection." Scientific reports.. 2019 Sep 25; 9(1):13824. Epub 2019 Sep 25.

Ha B, Chirkova T, Boukhvalova MS, Sun HY, Walsh EE, Anderson CS, Mariani TJ, Anderson LJ. "Mutation of Respiratory Syncytial Virus G Protein's CX3C Motif Attenuates Infection in Cotton Rats and Primary Human Airway Epithelial Cells." Vaccines. 2019 Jul 19; 7(3)Epub 2019 Jul 19.

Du Y, Clair GC, Al Alam, Danopoulos S, Schnell D, Kitzmiller JA, Misra RS, Bhattacharya S, Warburton D, Mariani TJ, Pryhuber GS, Whitsett JA, Ansong C, Xu Y. "Integration of transcriptomic and proteomic data identifies biological functions in cell populations from human infant lung." American journal of physiology. Lung cellular and molecular physiology.. 2019 Jul 3; Epub 2019 Jul 03.

Walsh EE, Mariani TJ, Chu C, Grier A, Gill SR, Qiu X, Wang L, Holden-Wiltse J, Corbett A, Thakar J, Benoodt L, McCall MN, Topham DJ, Falsey AR, Caserta MT. "Aims, Study Design, and Enrollment Results From the Assessing Predictors of Infant Respiratory Syncytial Virus Effects and Severity Study." JMIR research protocols. 2019 Jun 6; 8(6):e12907. Epub 2019 Jun 06.

Wang Q, Bhattacharya S, Mereness JA, Anderson C, Lillis JA, Misra RS, Romas S, Huyck H, Howell A, Bandyopadhyay G, Donlon K, Myers JR, Ashton J, Pryhuber GS, Mariani TJ. "A novel in vitro model of primary human pediatric lung epithelial cells." Pediatric research.. 2019 Feb 18; Epub 2019 Feb 18.

Ryan RM, Feng R, Bazacliu C, Ferkol TW, Ren CL, Mariani TJ, Poindexter BB, Wang F, Moore PE, . "Black Race Is Associated with a Lower Risk of Bronchopulmonary Dysplasia." The Journal of pediatrics.. 2019 Jan 4; Epub 2019 Jan 04.

Hamvas A, Feng R, Bi Y, Wang F, Bhattacharya S, Mereness J, Kaushal M, Cotten CM, Ballard PL, Mariani TJ, . "Exome sequencing identifies gene variants and networks associated with extreme respiratory outcomes following preterm birth." BMC genetics.. 2018 Oct 20; 19(1):94. Epub 2018 Oct 20.

Yu J, Peterson DR, Baran AM, Bhattacharya S, Wylie TN, Falsey AR, Mariani TJ, Storch GA. "Host Gene Expression in Nose and Blood for the Diagnosis of Viral Respiratory Infection." The Journal of infectious diseases.. 2018 Oct 18; Epub 2018 Oct 18.

Bandyopadhyay G, Huyck HL, Misra RS, Bhattacharya S, Wang Q, Mereness J, Lillis JA, Myers JR, Ashton J, Bushnell T, Cochran M, Holden-Wiltse J, Katzman P, Deutsch GH, Whitsett JA, Xu Y, Mariani TJ, Pryhuber GS. "Dissociation, cellular isolation, and initial molecular characterization of neonatal and pediatric human lung tissues." American journal of physiology. Lung cellular and molecular physiology.. 2018 Oct 1; 315(4):L576-L583. Epub 2018 Jul 05.

Kyle JE, Clair G, Bandyopadhyay G, Misra RS, Zink EM, Bloodsworth KJ, Shukla AK, Du Y, Lillis J, Myers JR, Ashton J, Bushnell T, Cochran M, Deutsch G, Baker ES, Carson JP, Mariani TJ, Xu Y, Whitsett JA, Pryhuber G, Ansong C. "Cell type-resolved human lung lipidome reveals cellular cooperation in lung function." Scientific reports.. 2018 Sep 7; 8(1):13455. Epub 2018 Sep 07.

Walsh EE, Wang L, Falsey AR, Qiu X, Corbett A, Holden-Wiltse J, Mariani TJ, Topham DJ, Caserta MT. "Virus-Specific Antibody, Viral Load, and Disease Severity in Respiratory Syncytial Virus Infection." The Journal of infectious diseases.. 2018 Jun 20; 218(2):208-217.

Scheible KM, Emo J, Laniewski N, Baran AM, Peterson DR, Holden-Wiltse J, Bandyopadhyay S, Straw AG, Huyck H, Ashton JM, Tripi KS, Arul K, Werner E, Scalise T, Maffett D, Caserta M, Ryan RM, Reynolds AM, Ren CL, Topham DJ, Mariani TJ, Pryhuber GS. "T cell developmental arrest in former premature infants increases risk of respiratory morbidity later in infancy." JCI insight.. 2018 Feb 22; 3(4)Epub 2018 Feb 22.

Karnati S, Oruqaj G, Janga H, Tumpara S, Colasante C, Van Veldhoven PP, Braverman N, Pilatz A, Mariani TJ, Baumgart-Vogt E. "PPAR?-mediated peroxisome induction compensates PPAR?-deficiency in bronchiolar club cells." PloS one.. 2018 13(9):e0203466. Epub 2018 Sep 13.

Mereness JA, Bhattacharya S, Wang Q, Ren Y, Pryhuber GS, Mariani TJ. "Type VI collagen promotes lung epithelial cell spreading and wound-closure." PloS one.. 2018 13(12):e0209095. Epub 2018 Dec 14.

Grier A, Qiu X, Bandyopadhyay S, Holden-Wiltse J, Kessler HA, Gill AL, Hamilton B, Huyck H, Misra S, Mariani TJ, Ryan RM, Scholer L, Scheible KM, Lee YH, Caserta MT, Pryhuber GS, Gill SR. "Impact of prematurity and nutrition on the developing gut microbiome and preterm infant growth." Microbiome.. 2017 Dec 11; 5(1):158. Epub 2017 Dec 11.

Mariani TJ, Qiu X, Chu CY, Wang L, Thakar J, Holden-Wiltse J, Corbett A, Topham DJ, Falsey AR, Caserta MT, Walsh EE. "Association of Dynamic Changes in the CD4 T-Cell Transcriptome With Disease Severity During Primary Respiratory Syncytial Virus Infection in Young Infants." The Journal of infectious diseases.. 2017 Nov 15; 216(8):1027-1037.

Ardini-Poleske ME, Clark RF, Ansong C, Carson JP, Corley RA, Deutsch GH, Hagood JS, Kaminski N, Mariani TJ, Potter SS, Pryhuber GS, Warburton D, Whitsett JA, Palmer SM, Ambalavanan N, LungMAP Consortium T. "LungMAP: The Molecular Atlas of Lung Development Program." American journal of physiology. Lung cellular and molecular physiology.. 2017 Nov 1; 313(5):L733-L740. Epub 2017 Aug 10.

Bhattacharya S, Rosenberg AF, Peterson DR, Grzesik K, Baran AM, Ashton JM, Gill SR, Corbett AM, Holden-Wiltse J, Topham DJ, Walsh EE, Mariani TJ, Falsey AR. "Transcriptomic Biomarkers to Discriminate Bacterial from Nonbacterial Infection in Adults Hospitalized with Respiratory Illness." Scientific reports.. 2017 Jul 26; 7(1):6548. Epub 2017 Jul 26.

Du Y, Kitzmiller JA, Sridharan A, Perl AK, Bridges JP, Misra RS, Pryhuber GS, Mariani TJ, Bhattacharya S, Guo M, Potter SS, Dexheimer P, Aronow B, Jobe AH, Whitsett JA, Xu Y. "Lung Gene Expression Analysis (LGEA): an integrative web portal for comprehensive gene expression data analysis in lung development." Thorax.. 2017 May 0; 72(5):481-484. Epub 2017 Jan 09.

Solleti SK, Bhattacharya S, Ahmad A, Wang Q, Mereness J, Rangasamy T, Mariani TJ. "MicroRNA expression profiling defines the impact of electronic cigarettes on human airway epithelial cells." Scientific reports.. 2017 Apr 24; 7(1):1081. Epub 2017 Apr 24.

Misra RS, Bhattacharya S, Huyck HL, Wang JE, Slaunwhite CG, Slaunwhite SL, Wightman TR, Secor-Socha S, Misra SK, Bushnell TP, Reynolds AM, Ryan RM, Quataert SA, Pryhuber GS, Mariani TJ. "Flow-based sorting of neonatal lymphocyte populations for transcriptomics analysis." Journal of immunological methods.. 2016 Oct 0; 437:13-20. Epub 2016 Jul 18.

Chu CY, Qiu X, Wang L, Bhattacharya S, Lofthus G, Corbett A, Holden-Wiltse J, Grier A, Tesini B, Gill SR, Falsey AR, Caserta MT, Walsh EE, Mariani TJ. "The Healthy Infant Nasal Transcriptome: A Benchmark Study." Scientific reports.. 2016 Sep 23; 6:33994. Epub 2016 Sep 23.

Solleti SK, Srisuma S, Bhattacharya S, Rangel-Moreno J, Bijli KM, Randall TD, Rahman A, Mariani TJ. "Serpine2 deficiency results in lung lymphocyte accumulation and bronchus-associated lymphoid tissue formation." FASEB journal : official publication of the Federation of American Societies for Experimental Biology.. 2016 Jul 0; 30(7):2615-26. Epub 2016 Apr 08.

Karnati S, Graulich T, Oruqaj G, Pfreimer S, Seimetz M, Stamme C, Mariani TJ, Weissmann N, Mühlfeld C, Baumgart-Vogt E. "Postnatal development of the bronchiolar club cells of distal airways in the mouse lung: stereological and molecular biological studies." Cell and tissue research.. 2016 Jun 0; 364(3):543-57. Epub 2016 Jan 21.

Ahmad A, Bhattacharya S, Sridhar A, Iqbal AM, Mariani TJ. "Recurrent copy number variants associated with bronchopulmonary dysplasia." Pediatric research.. 2016 Jun 0; 79(6):940-5. Epub 2016 Mar 14.

Yee M, Gelein R, Mariani TJ, Lawrence BP, O'Reilly MA. "The Oxygen Environment at Birth Specifies the Population of Alveolar Epithelial Stem Cells in the Adult Lung." Stem cells.. 2016 May 0; 34(5):1396-406. Epub 2016 Mar 07.

Mariani TJ. "Respiratory disorders: Ironing out smoking-related airway disease." Nature.. 2016 Mar 31; 531(7596):586-7. Epub 2016 Mar 09.

Scheible KM, Emo J, Yang H, Holden-Wiltse J, Straw A, Huyck H, Misra S, Topham DJ, Ryan RM, Reynolds AM, Mariani TJ, Pryhuber GS. "Developmentally determined reduction in CD31 during gestation is associated with CD8+ T cell effector differentiation in preterm infants." Clinical immunology : the official journal of the Clinical Immunology Society.. 2015 Dec 0; 161(2):65-74. Epub 2015 Jul 29.

Mariani TJ. "Update on Molecular Biology of Lung Development--Transcriptomics." Clinics in perinatology.. 2015 Dec 0; 42(4):685-95.

Legoux FP, Lim JB, Cauley AW, Dikiy S, Ertelt J, Mariani TJ, Sparwasser T, Way SS, Moon JJ. "CD4+ T Cell Tolerance to Tissue-Restricted Self Antigens Is Mediated by Antigen-Specific Regulatory T Cells Rather Than Deletion." Immunity.. 2015 Nov 17; 43(5):896-908. Epub 2015 Nov 10.

Solleti SK, Simon DM, Srisuma S, Arikan MC, Bhattacharya S, Rangasamy T, Bijli KM, Rahman A, Crossno JT, Shapiro SD, Mariani TJ. "Airway epithelial cell PPAR? modulates cigarette smoke-induced chemokine expression and emphysema susceptibility in mice." American journal of physiology. Lung cellular and molecular physiology.. 2015 Aug 1; 309(3):L293-304. Epub 2015 May 29.

Cuna A, Halloran B, Faye-Petersen O, Kelly D, Crossman DK, Cui X, Pandit K, Kaminski N, Bhattacharya S, Ahmad A, Mariani TJ, Ambalavanan N. "Alterations in gene expression and DNA methylation during murine and human lung alveolar septation." American journal of respiratory cell and molecular biology.. 2015 Jul 0; 53(1):60-73.

Misra R, Shah S, Fowell D, Wang H, Scheible K, Misra S, Huyck H, Wyman C, Ryan RM, Reynolds AM, Mariani T, Katzman PJ, Pryhuber GS. "Preterm cord blood CD4? T cells exhibit increased IL-6 production in chorioamnionitis and decreased CD4? T cells in bronchopulmonary dysplasia." Human immunology.. 2015 May 0; 76(5):329-338. Epub 2015 Mar 20.

Pryhuber GS, Maitre NL, Ballard RA, Cifelli D, Davis SD, Ellenberg JH, Greenberg JM, Kemp J, Mariani TJ, Panitch H, Ren C, Shaw P, Taussig LM, Hamvas A, . "Prematurity and respiratory outcomes program (PROP): study protocol of a prospective multicenter study of respiratory outcomes of preterm infants in the United States." BMC pediatrics.. 2015 Apr 10; 15:37. Epub 2015 Apr 10.

Ambalavanan N, Cotten CM, Page GP, Carlo WA, Murray JC, Bhattacharya S, Mariani TJ, Cuna AC, Faye-Petersen OM, Kelly D, Higgins RD, . "Integrated genomic analyses in bronchopulmonary dysplasia." The Journal of pediatrics.. 2015 Mar 0; 166(3):531-7.e13. Epub 2014 Nov 06.

Bhattacharya S, Zhou Z, Yee M, Chu CY, Lopez AM, Lunger VA, Solleti SK, Resseguie E, Buczynski BW, Mariani TJ, O'Reilly MA. "The genome-wide transcriptional response to neonatal hyperoxia identifies Ahr as a key regulator." American journal of physiology. Lung cellular and molecular physiology.. 2014 Oct 1; 307(7):L516-23. Epub 2014 Aug 22.

Qiu W, Rogers AJ, Damask A, Raby BA, Klanderman BJ, Duan QL, Tyagi S, Niu S, Anderson C, Cahir-McFarland E, Mariani TJ, Carey V, Tantisira KG. "Pharmacogenomics: novel loci identification via integrating gene differential analysis and eQTL analysis." Human molecular genetics.. 2014 Sep 15; 23(18):5017-24. Epub 2014 Apr 25.

Eckle T, Brodsky K, Bonney M, Packard T, Han J, Borchers CH, Mariani TJ, Kominsky DJ, Mittelbronn M, Eltzschig HK. "HIF1A reduces acute lung injury by optimizing carbohydrate metabolism in the alveolar epithelium." PLoS biology.. 2013 Sep 0; 11(9):e1001665. Epub 2013 Sep 24.

Mariani TJ, Martinez F. "Chronic obstructive pulmonary disease genomics: yesterday, discovering population biomarkers; tomorrow, defining disease clusters." American journal of respiratory and critical care medicine.. 2013 May 1; 187(9):900-2.

Bhattacharya S, Mariani TJ. "Systems biology approaches to identify developmental bases for lung diseases." Pediatric research.. 2013 Apr 0; 73(4 Pt 2):514-22. Epub 2013 Jan 11.

Morrisey EE, Cardoso WV, Lane RH, Rabinovitch M, Abman SH, Ai X, Albertine KH, Bland RD, Chapman HA, Checkley W, Epstein JA, Kintner CR, Kumar M, Minoo P, Mariani TJ, McDonald DM, Mukouyama YS, Prince LS, Reese J, Rossant J, Shi W, Sun X, Werb Z, Whitsett JA, Gail D, Blaisdell CJ, Lin QS. "Molecular determinants of lung development." Annals of the American Thoracic Society.. 2013 Apr 0; 10(2):S12-6.

Scheible K, Secor-Socha S, Wightman T, Wang H, Mariani TJ, Topham DJ, Pryhuber G, Quataert S. "Stability of T cell phenotype and functional assays following heparinized umbilical cord blood collection." Cytometry. Part A : the journal of the International Society for Analytical Cytology.. 2012 Nov 0; 81(11):937-49. Epub 2012 Oct 01.

Bhattacharya S, Go D, Krenitsky DL, Huyck HL, Solleti SK, Lunger VA, Metlay L, Srisuma S, Wert SE, Mariani TJ, Pryhuber GS. "Genome-wide transcriptional profiling reveals connective tissue mast cell accumulation in bronchopulmonary dysplasia." American journal of respiratory and critical care medicine.. 2012 Aug 15; 186(4):349-58. Epub 2012 Jun 21.

Reddy NM, Potteti HR, Mariani TJ, Biswal S, Reddy SP. "Conditional deletion of Nrf2 in airway epithelium exacerbates acute lung injury and impairs the resolution of inflammation." American journal of respiratory cell and molecular biology.. 2011 Dec 0; 45(6):1161-8. Epub 2011 Jun 09.

Brehm JM, Hagiwara K, Tesfaigzi Y, Bruse S, Mariani TJ, Bhattacharya S, Boutaoui N, Ziniti JP, Soto-Quiros ME, Avila L, Cho MH, Himes B, Litonjua AA, Jacobson F, Bakke P, Gulsvik A, Anderson WH, Lomas DA, Forno E, Datta S, Silverman EK, Celedón JC. "Identification of FGF7 as a novel susceptibility locus for chronic obstructive pulmonary disease." Thorax.. 2011 Dec 0; 66(12):1085-90. Epub 2011 Sep 15.

Himes BE, Klanderman B, Ziniti J, Senter-Sylvia J, Soto-Quiros ME, Avila L, Celedón JC, Lange C, Mariani TJ, Lasky-Su J, Hersh CP, Raby BA, Silverman EK, Weiss ST, Demeo DL. "Association of SERPINE2 with asthma." Chest.. 2011 Sep 0; 140(3):667-674. Epub 2011 Mar 24.

Melen E, Kho AT, Sharma S, Gaedigk R, Leeder JS, Mariani TJ, Carey VJ, Weiss ST, Tantisira KG. "Expression analysis of asthma candidate genes during human and murine lung development." Respiratory research.. 2011 Jun 23; 12:86. Epub 2011 Jun 23.

Hersh CP, Silverman EK, Gascon J, Bhattacharya S, Klanderman BJ, Litonjua AA, Lefebvre V, Sparrow D, Reilly JJ, Anderson WH, Lomas DA, Mariani TJ, . "SOX5 is a candidate gene for chronic obstructive pulmonary disease susceptibility and is necessary for lung development." American journal of respiratory and critical care medicine.. 2011 Jun 1; 183(11):1482-9. Epub 2011 Feb 17.

Bhattacharya S, Tyagi S, Srisuma S, Demeo DL, Shapiro SD, Bueno R, Silverman EK, Reilly JJ, Mariani TJ. "Peripheral blood gene expression profiles in COPD subjects." Journal of clinical bioinformatics. 2011 Apr 24; 1(1):12. Epub 2011 Apr 24.

Simon DM, Tsai LW, Ingenito EP, Starcher BC, Mariani TJ. "PPARgamma deficiency results in reduced lung elastic recoil and abnormalities in airspace distribution." Respiratory research.. 2010 Jun 2; 11:69. Epub 2010 Jun 02.

Blake DJ, Singh A, Kombairaju P, Malhotra D, Mariani TJ, Tuder RM, Gabrielson E, Biswal S. "Deletion of Keap1 in the lung attenuates acute cigarette smoke-induced oxidative stress and inflammation." American journal of respiratory cell and molecular biology.. 2010 May 0; 42(5):524-36. Epub 2009 Jun 11.

Srisuma S, Bhattacharya S, Simon DM, Solleti SK, Tyagi S, Starcher B, Mariani TJ. "Fibroblast growth factor receptors control epithelial-mesenchymal interactions necessary for alveolar elastogenesis." American journal of respiratory and critical care medicine.. 2010 Apr 15; 181(8):838-50. Epub 2010 Jan 21.

Sharma S, Tantisira K, Carey V, Murphy AJ, Lasky-Su J, Celedón JC, Lazarus R, Klanderman B, Rogers A, Soto-Quirós M, Avila L, Mariani T, Gaedigk R, Leeder S, Torday J, Warburton D, Raby B, Weiss ST. "A role for Wnt signaling genes in the pathogenesis of impaired lung function in asthma." American journal of respiratory and critical care medicine.. 2010 Feb 15; 181(4):328-36. Epub 2009 Nov 19.

Kho AT, Bhattacharya S, Tantisira KG, Carey VJ, Gaedigk R, Leeder JS, Kohane IS, Weiss ST, Mariani TJ. "Transcriptomic analysis of human lung development." American journal of respiratory and critical care medicine.. 2010 Jan 1; 181(1):54-63. Epub 2009 Oct 08.

DeMeo DL, Mariani T, Bhattacharya S, Srisuma S, Lange C, Litonjua A, Bueno R, Pillai SG, Lomas DA, Sparrow D, Shapiro SD, Criner GJ, Kim HP, Chen Z, Choi AM, Reilly J, Silverman EK. "Integration of genomic and genetic approaches implicates IREB2 as a COPD susceptibility gene." American journal of human genetics.. 2009 Oct 0; 85(4):493-502.

Bhattacharya S, Mariani TJ. "Array of hope: expression profiling identifies disease biomarkers and mechanism." Biochemical Society transactions.. 2009 Aug 0; 37(Pt 4):855-62.

Du R, Tantisira K, Carey V, Bhattacharya S, Metje S, Kho AT, Klanderman BJ, Gaedigk R, Lazarus R, Mariani TJ, Leeder JS, Weiss ST. "Platform dependence of inference on gene-wise and gene-set involvement in human lung development." BMC bioinformatics.. 2009 Jun 19; 10:189. Epub 2009 Jun 19.

Bhattacharya S, Srisuma S, Demeo DL, Shapiro SD, Bueno R, Silverman EK, Reilly JJ, Mariani TJ. "Molecular biomarkers for quantitative and discrete COPD phenotypes." American journal of respiratory cell and molecular biology.. 2009 Mar 0; 40(3):359-67. Epub 2008 Oct 10.

Kho AT, Bhattacharya S, Mecham BH, Hong J, Kohane IS, Mariani TJ. "Expression profiles of the mouse lung identify a molecular signature of time-to-birth." American journal of respiratory cell and molecular biology.. 2009 Jan 0; 40(1):47-57. Epub 2008 Jul 29.

Planagumà A, Kazani S, Marigowda G, Haworth O, Mariani TJ, Israel E, Bleecker ER, Curran-Everett D, Erzurum SC, Calhoun WJ, Castro M, Chung KF, Gaston B, Jarjour NN, Busse WW, Wenzel SE, Levy BD. "Airway lipoxin A4 generation and lipoxin A4 receptor expression are decreased in severe asthma." American journal of respiratory and critical care medicine.. 2008 Sep 15; 178(6):574-82. Epub 2008 Jun 26.

Reynolds SD, Zemke AC, Giangreco A, Brockway BL, Teisanu RM, Drake JA, Mariani T, Di PY, Taketo MM, Stripp BR. "Conditional stabilization of beta-catenin expands the pool of lung stem cells." Stem cells.. 2008 May 0; 26(5):1337-46. Epub 2008 Mar 20.

Fedulov AV, Leme A, Yang Z, Dahl M, Lim R, Mariani TJ, Kobzik L. "Pulmonary exposure to particles during pregnancy causes increased neonatal asthma susceptibility." American journal of respiratory cell and molecular biology.. 2008 Jan 0; 38(1):57-67. Epub 2007 Jul 26.

Tantisira KG, Silverman ES, Mariani TJ, Xu J, Richter BG, Klanderman BJ, Litonjua AA, Lazarus R, Rosenwasser LJ, Fuhlbrigge AL, Weiss ST. "FCER2: a pharmacogenetic basis for severe exacerbations in children with asthma." The Journal of allergy and clinical immunology.. 2007 Dec 0; 120(6):1285-91. Epub 2007 Nov 05.

Hirakawa H, Pierce RA, Bingol-Karakoc G, Karaaslan C, Weng M, Shi GP, Saad A, Weber E, Mariani TJ, Starcher B, Shapiro SD, Cataltepe S. "Cathepsin S deficiency confers protection from neonatal hyperoxia-induced lung injury." American journal of respiratory and critical care medicine.. 2007 Oct 15; 176(8):778-85. Epub 2007 Aug 02.

Simeone-Penney MC, Severgnini M, Tu P, Homer RJ, Mariani TJ, Cohn L, Simon AR. "Airway epithelial STAT3 is required for allergic inflammation in a murine model of asthma." The Journal of immunology : official journal of the American Association of Immunologists.. 2007 May 15; 178(10):6191-9.

Simon DM, Mariani TJ. "Role of PPARs and Retinoid X Receptors in the Regulation of Lung Maturation and Development." PPAR research. 2007 2007:91240.

Chu EK, Cheng J, Foley JS, Mecham BH, Owen CA, Haley KJ, Mariani TJ, Kohane IS, Tschumperlin DJ, Drazen JM. "Induction of the plasminogen activator system by mechanical stimulation of human bronchial epithelial cells." American journal of respiratory cell and molecular biology.. 2006 Dec 0; 35(6):628-38. Epub 2006 Jun 22.

Bhattacharya S, Srisuma S, Demeo DL, Reilly JJ, Bueno R, Silverman EK, Mariani TJ. "Microarray data-based prioritization of chronic obstructive pulmonary disease susceptibility genes." Proceedings of the American Thoracic Society.. 2006 Aug 0; 3(6):472.

Simon DM, Arikan MC, Srisuma S, Bhattacharya S, Andalcio T, Shapiro SD, Mariani TJ. "Epithelial cell PPARgamma is an endogenous regulator of normal lung maturation and maintenance." Proceedings of the American Thoracic Society.. 2006 Aug 0; 3(6):510-1.

Simon DM, Arikan MC, Srisuma S, Bhattacharya S, Tsai LW, Ingenito EP, Gonzalez F, Shapiro SD, Mariani TJ. "Epithelial cell PPAR[gamma] contributes to normal lung maturation." FASEB journal : official publication of the Federation of American Societies for Experimental Biology.. 2006 Jul 0; 20(9):1507-9. Epub 2006 May 23.

Ji H, Houghton AM, Mariani TJ, Perera S, Kim CB, Padera R, Tonon G, McNamara K, Marconcini LA, Hezel A, El-Bardeesy N, Bronson RT, Sugarbaker D, Maser RS, Shapiro SD, Wong KK. "K-ras activation generates an inflammatory response in lung tumors." Oncogene.. 2006 Mar 30; 25(14):2105-12.

Demeo DL, Mariani TJ, Lange C, Srisuma S, Litonjua AA, Celedon JC, Lake SL, Reilly JJ, Chapman HA, Mecham BH, Haley KJ, Sylvia JS, Sparrow D, Spira AE, Beane J, Pinto-Plata V, Speizer FE, Shapiro SD, Weiss ST, Silverman EK. "The SERPINE2 gene is associated with chronic obstructive pulmonary disease." American journal of human genetics.. 2006 Feb 0; 78(2):253-64. Epub 2005 Dec 15.

Bhattacharya S, Mariani TJ. "Transformation of expression intensities across generations of Affymetrix microarrays using sequence matching and regression modeling." Nucleic acids research.. 2005 Oct 13; 33(18):e157. Epub 2005 Oct 13.

Arikan MC, Shapiro SD, Mariani TJ. "Induction of macrophage elastase (MMP-12) gene expression by statins." Journal of cellular physiology.. 2005 Jul 0; 204(1):139-45.

Mecham BH, Wetmore DZ, Szallasi Z, Sadovsky Y, Kohane I, Mariani TJ. "Increased measurement accuracy for sequence-verified microarray probes." Physiological genomics.. 2004 Aug 11; 18(3):308-15. Epub 2004 Aug 11.

Mecham BH, Klus GT, Strovel J, Augustus M, Byrne D, Bozso P, Wetmore DZ, Mariani TJ, Kohane IS, Szallasi Z. "Sequence-matched probes produce increased cross-platform consistency and more reproducible biological results in microarray-based gene expression measurements." Nucleic acids research.. 2004 May 25; 32(9):e74. Epub 2004 May 25.

Mariani, T.J. "Regulation of alveogenesis by reciprocal proximo-distal fibroblast growth factor and retinoic acid signaling." Am J Resp Cell Mol Biol. 2004; 31(2 Suppl): S1-S81.

Mariani TJ, Kaminski N. "Gene expression studies in lung development and lung stem cell biology." Current topics in developmental biology.. 2004 64:57-71.

Mariani TJ, Budhraja V, Mecham BH, Gu CC, Watson MA, Sadovsky Y. "A variable fold change threshold determines significance for expression microarrays." FASEB journal : official publication of the Federation of American Societies for Experimental Biology.. 2003 Feb 0; 17(2):321-3. Epub 2002 Dec 03.

"Chest 2002 Scientific Highlights. Abstracts of original investigations and case reports. 2-7 November 2002, San Diego, California, USA." Chest.. 2002 Oct 0; 122(4 Suppl):1S-269S.

Zelko IN, Mariani TJ, Folz RJ. "Superoxide dismutase multigene family: a comparison of the CuZn-SOD (SOD1), Mn-SOD (SOD2), and EC-SOD (SOD3) gene structures, evolution, and expression." Free radical biology & medicine.. 2002 Aug 1; 33(3):337-49.

Mariani TJ, Reed JJ, Shapiro SD. "Expression profiling of the developing mouse lung: insights into the establishment of the extracellular matrix." American journal of respiratory cell and molecular biology.. 2002 May 0; 26(5):541-8.

Mariani TJ, Shapiro SD. "Thomas A. Neff lecture. Application of expression profiling to the developing lung: identification of putative regulatory networks controlling matrix production." Chest.. 2002 Mar 0; 121(3 Suppl):42S-44S.

Mariani TJ, Arikan MC, Pierce RA. "Fibroblast tropoelastin and alpha-smooth-muscle actin expression are repressed by particulate-activated macrophage-derived tumor necrosis factor-alpha in experimental silicosis." American journal of respiratory cell and molecular biology.. 1999 Aug 0; 21(2):185-92.

Mariani TJ, Sandefur S, Roby JD, Pierce RA. "Collagenase-3 induction in rat lung fibroblasts requires the combined effects of tumor necrosis factor-alpha and 12-lipoxygenase metabolites: a model of macrophage-induced, fibroblast-driven extracellular matrix remodeling during inflammatory lung injury." Molecular biology of the cell.. 1998 Jun 0; 9(6):1411-24.

Mariani TJ, Dunsmore SE, Li Q, Ye X, Pierce RA. "Regulation of lung fibroblast tropoelastin expression by alveolar epithelial cells." American journal of physiology. Lung cellular and molecular physiology.. 1998 Jan 1; 274(1):L47-L57.

Mariani TJ, Dunsmore SE, Li Q, Ye X, Pierce RA. "Regulation of lung fibroblast tropoelastin expression by alveolar epithelial cells." The American journal of physiology.. 1998 Jan 0; 274(1 Pt 1):L47-57.

Mariani TJ, Sandefur S, Pierce RA. "Elastin in lung development." Experimental lung research.. 1997 23(2):131-45.

Mariani TJ, Roby JD, Mecham RP, Parks WC, Crouch E, Pierce RA. "Localization of type I procollagen gene expression in silica-induced granulomatous lung disease and implication of transforming growth factor-beta as a mediator of fibrosis." The American journal of pathology.. 1996 Jan 0; 148(1):151-64.

Mariani TJ, Crouch E, Roby JD, Starcher B, Pierce RA. "Increased elastin production in experimental granulomatous lung disease." The American journal of pathology.. 1995 Oct 0; 147(4):988-1000.

Schwartz E, Feinberg E, Lebwohl M, Mariani TJ, Boyd CD. "Ultraviolet radiation increases tropoelastin accumulation by a post-transcriptional mechanism in dermal fibroblasts." The Journal of investigative dermatology.. 1995 Jul 0; 105(1):65-9.

Boyd CD, Mariani TJ, Kim Y, Csiszar K. "The size heterogeneity of human lysyl oxidase mRNA is due to alternate polyadenylation site and not alternate exon usage." Molecular biology reports.. 1995 21(2):95-103.

Pierce RA, Mariani TJ, Senior RM. "Elastin in lung development and disease." Ciba Foundation symposium.. 1995 192:199-212; discussion 212-4.

Csiszar K, Mariani TJ, Gosin JS, Deak SB, Boyd CD. "A restriction fragment length polymorphism results in a nonconservative amino acid substitution encoded within the first exon of the human lysyl oxidase gene." Genomics.. 1993 May 0; 16(2):401-6.

Mariani TJ, Trackman PC, Kagan HM, Eddy RL, Shows TB, Boyd CD, Deak SB. "The complete derived amino acid sequence of human lysyl oxidase and assignment of the gene to chromosome 5 (extensive sequence homology with the murine ras recision gene)." Matrix (Stuttgart, Germany). 1992 Jun 0; 12(3):242-8.

Deak SB, Ricotta JJ, Mariani TJ, Deak ST, Zatina MA, Mackenzie JW, Boyd CD. "The role of abnormal type III collagen in the development of common aneurysms." Journal of vascular surgery.. 1992 May 0; 15(5):926-7.

Deak SB, Ricotta JJ, Mariani TJ, Deak ST, Zatina MA, Mackenzie JW, Boyd CD. "Abnormalities in the biosynthesis of type III procollagen in cultured skin fibroblasts from two patients with multiple aneurysms." Matrix (Stuttgart, Germany). 1992 Apr 0; 12(2):92-100.

Books & Chapters

Chapter Title: Developmental genetics of the pulmonary system
Book Title: Principles of Developmental Genetics
Author List: Mariani, T.J
Edited By: Moody, S.A
Published By: Elsevier2006 in San Diego, CA

Chapter Title: Microarray techniques and data in asthma and COPD
Book Title: Lung Biology in Health and Disease
Author List: Mariani, T.J.; Ramoni, M.F
Edited By: Postma, D.S.; Weiss, S.T
Published By: Informa Health Care2006 in New York, NY

Chapter Title: Extracellular matrix gene expression in developing mouse aorta
Book Title: Extracellular Matrices and Development
Author List: McLean, S.E.; Mecham, B.H.; Kelleher, C.M.; Mariani, T.J.; Mecham, R.P
Edited By: Miner, J.H., Editor; Wassarman, P.M., Series Editor.
Published By: Elsevier2005

Chapter Title: Development of lung elastic matrix
Book Title: Lung Development
Author List: Mariani, T.J.; Pierce, R.A
Edited By: Gaultier, G.I.; Bourbon, J.; Post, M
Published By: Oxford University Press1999 in New York, NY