Thomas J. Mariani, Ph.D.

Thomas J. Mariani, Ph.D.

Contact Information

University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 651
Rochester, NY 14642

Office: (585) 276-4616
Fax: (585) 276-2642

Lab Information

Mariani Lab

Visit Lab Website »

View Research Network »

Research Bio

Premature infant morbidity and mortality often results from pulmonary complications, primarily insufficient lung maturation or alveolar formation. Likewise, many adult lung diseases involve obliteration of the distal respiratory structure. With the advent of clinical means to dramatically improve pre-term infant survival, there has been a growing appreciation of a relationship between developmental complications and susceptibility to chronic lung disease. The broad objectives of Dr. Mariani's laboratory are to identify the genetic mechanisms of susceptibility to chronic lung diseases, particularly focusing upon their developmental antecedents and the influence of environmental factors. Dr. Mariani's research program focuses upon defining regulatory networks involved in lung development and maturation, and which may be perturbed in diseased states. His laboratory uses a combination of animal modeling research and studies of human subjects. He is a leader in the application of gene expression array methods to pulmonary biology and lung disease. Current research projects in the Mariani lab include:

1. Defining genetic regulatory networks contributing to airspace morphogenesis using the FGFR3/4 mutant mouse model of abnormal alveolar formation.

2. Determining the physiological role of PPARg in lung epithelial cells during airspace formation and in lung injury/repair.

3. Investigating the cellular and molecular mechanisms by which the protease inhibitor SERPINE2 contributes to airspace formation and susceptibility to COPD.

This work is currently supported by the NIH and FAMRI.

Awards & Honors (National)

Mentored 2nd place winner - Respiratory Disease Young Investigators' Forum 2006
Mentored 1st place winner - Respiratory Disease Young Investigators' Forum 2005
Parker B. Francis Fellowship in Pulmonary Research 2000 - 2003
Novartis (Ciba) Foundation Bursar | Ciba 1994 - 1994
Individual National Research Service Award | NHLBI 1994 - 1997

Recent Journal Articles

Showing the 5 most recent journal articles. 63 available »

2015 Nov 17
Legoux FP, Lim JB, Cauley AW, Dikiy S, Ertelt J, Mariani TJ, Sparwasser T, Way SS, Moon JJ. "CD4(+) T Cell Tolerance to Tissue-Restricted Self Antigens Is Mediated by Antigen-Specific Regulatory T Cells Rather Than Deletion." Immunity. 2015 Nov 17; 43(5):896-908. Epub 2015 Nov 10.
2015 Jul
Cuna A, Halloran B, Faye-Petersen O, Kelly D, Crossman DK, Cui X, Pandit K, Kaminski N, Bhattacharya S, Ahmad A, Mariani TJ, Ambalavanan N. "Alterations in gene expression and DNA methylation during murine and human lung alveolar septation." American journal of respiratory cell and molecular biology. 2015 Jul; 53(1):60-73.
2015 May
Misra R, Shah S, Fowell D, Wang H, Scheible K, Misra S, Huyck H, Wyman C, Ryan RM, Reynolds AM, Mariani T, Katzman PJ, Pryhuber GS. "Preterm cord blood CD4? T cells exhibit increased IL-6 production in chorioamnionitis and decreased CD4? T cells in bronchopulmonary dysplasia." Human immunology. 2015 May; 76(5):329-38. Epub 2015 Mar 20.
2015 Mar
Ambalavanan N, Cotten CM, Page GP, Carlo WA, Murray JC, Bhattacharya S, Mariani TJ, Cuna AC, Faye-Petersen OM, Kelly D, Higgins RD, . "Integrated genomic analyses in bronchopulmonary dysplasia." The Journal of pediatrics. 2015 Mar; 166(3):531-7.e13. Epub 2014 Nov 06.
Pryhuber GS, Maitre NL, Ballard RA, Cifelli D, Davis SD, Ellenberg JH, Greenberg JM, Kemp J, Mariani TJ, Panitch H, Ren C, Shaw P, Taussig LM, Hamvas A, . "Prematurity and respiratory outcomes program (PROP): study protocol of a prospective multicenter study of respiratory outcomes of preterm infants in the United States." BMC pediatrics. 2015 15:37. Epub 2015 Apr 10.

Current Appointments

Associate Professor - Department of Pediatrics, Neonatology (SMD) - Primary
Associate Professor - Department of Environmental Medicine (SMD)


PhD | Microbiology and Molecular Genetics | Rutgers University1993
B.S. | Biology | Rutgers University, Cook College1989

Post-Doctoral Training & Residency

Research Associate, Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St. Louis, MO 1998
Postdoctoral Fellow, Dermatology Division, Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO 1997