My translational research projects focus on understanding mechanisms of pathology in common inflammatory conditions of children. In order to ask targeted research questions and develop testable hypotheses, I work closely with the clinical staff and faculty of the Neonatal Intensive Care Unit and Department of Pediatrics. This includes interactions with physicians, nurses, clinical coordinators, basic scientific researchers and biostatisticians. By studying how the immune system and lung development are altered in children born prematurely, we will begin to understand how alterations in these systems contribute to specific diseases, such as Bronchopulmonary Dysplasia, viral respiratory infections, atopy, and asthma-like morbidities. It may be possible to develop therapeutic interventions that target the inflammatory process to correct these problems. This understanding will have implications in vaccine responses, infectious diseases, and inflammatory lung diseases.
I am focused on cellular and molecular biology of the pulmonary and immune systems, and how they interact to protect infants against infection. Keeping abreast of cutting edge research technologies, developing strong collaborations (both internally and externally), and teaching are keys to a successful biomedical research program. My research is rooted in these key elements. Working in the Department of Pediatrics has shifted my interest toward how immune and lung development in infants who are born prematurely differ from those born at full term. Children who are born preterm have a higher risk of developing inflammatory lung diseases and severe respiratory infections in the first year of life. Immature lung structure and altered immune system function likely contribute to this increased risk. A precedence exists in the literature that early life challenges to the immune system have long-lasting effects and involves the innate and adaptive immune cells. I am particularly interested in examining how the in utero environment can affect the development of the immune system. Resulting changes could be correlated to the increased risk of developing specific infectious diseases and/or lung tissue damage into childhood and beyond. Furthermore, prolonged inflammation and tissue damage could lead to a loss of immunological tolerance, which is one element seen in later-life lung disease. By understanding how the normal and preterm infant immune system inflammatory response functions, we hope to better understand how it relates to specific diseases in this population.
BS | Worcester Polytech Inst
PhD | University of Vermont
Cell and Molecular Biology
2017 - 2017
Selected for participation in the NIH Early Career Reviewer Program
Location: Baltimore, MD.
2017 - 2017
Sponsor: American Lung Association
Location: Chicago, IL
2015 - 2016
Assessing RNA expression patterns in CD4+ T cells from preterm infants at the time of discharge from the Neonatal Intensive Care
Sponsor: Strong Children's Research Center
2014 - Present
Respiratory Pathogens Research Center Innovation Award.
2008 - 2010
Examining a role for G alpha q in preventing autoimmune disease (Individual award F32AI080104).
2007 - 2008
Institutional Research Training in Immunology and Infectious Diseases (Trudeau Institute T32AI049823).
Graduate Student Advisory Counsel Travel Award.
2002 - 2006
Environmental Pathology and Cell Signaling Institutional Training Grant (UVM T32ES007122).
Salisbury Prize (WPI).
Provost's Award (WPI).
Tau Beta Pi Honors Society (WPI).
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D'Angio CT, Wyman CP, Misra RS, Halliley JL, Wang H, Hunn JE, Fallone CM, Lee FE. "Plasma cell and serum antibody responses to influenza vaccine in preterm and full-term infants." Vaccine.. 2017 Sep 12; 35(38):5163-5171. Epub 2017 Aug 12.
Domm W, Yee M, Misra RS, Gelein R, Nogales A, Martinez Sobrido L, O'Reilly MA. "Oxygen-dependent changes in lung development do not affect epithelial infection with influenza A virus." American journal of physiology. Lung cellular and molecular physiology.. 2017 Aug 10; :ajplung.00203.2017. Epub 2017 Aug 10.
Du Y, Kitzmiller JA, Sridharan A, Perl AK, Bridges JP, Misra RS, Pryhuber GS, Mariani TJ, Bhattacharya S, Guo M, Potter SS, Dexheimer P, Aronow B, Jobe AH, Whitsett JA, Xu Y. "Lung Gene Expression Analysis (LGEA): an integrative web portal for comprehensive gene expression data analysis in lung development." Thorax.. 2017 May 0; 72(5):481-484. Epub 2017 Jan 09.
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