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Ravi S. Misra, Ph.D.

(Pronouns: he/him/his)

Contact Information

Phone Numbers

Office: (585) 276-3607

Faculty Appointments

Biography

Professional Background

As I was growing up in the Boston area, I became infatuated with the fledgling Biotechnology Industry. I obtained my Bachelor Degree in Biotechnology with a Concentration in Biochemistry from Worcester Polytechnic Institute. I then attended the University of Vermont and earned my Ph.D. in Cell and Molecular Biology. In my thesis work, I studied the intersection of T cell receptor and Death Receptor signaling in CD4+ T cells. I was fortunate to have been supported by a slot on an Institutional T32 grant where I gained experience in the the field of Lung Biology. I then began my Postdoctoral training at the Trudeau Institute studying the immune system of mouse models of Influenza A virus infection and in a spontaneous model of autoimmunity due to deletion of a G coupled protein receptor subunit. During my first Postdoctoral training period, I moved to the University of Rochester with the lab group. I then began a second Postdoc studying the immunophenotype of peripheral blood from infants with lung disease who were born preterm. I then transitioned into a full time faculty member and have served a prominent role in the processing of primary human lung tissue as a co-Investigator on the Lung Molecular Atlas of Lung Development Program (LungMAP).

Research

I am a highly collaborative Cell and Molecular Biologist who aims to develop a better understanding of diseases that affect the respiratory and immune systems in infants who are born prematurely. I work closely with clinical staff and faculty of the Neonatal Intensive Care Unit and Department of Pediatrics. This includes interactions with physicians, nurses, clinical coordinators, basic scientific researchers, and biostatisticians. By studying how the immune system and lung development are altered in children born prematurely, we will begin to understand how alterations in these systems contribute to specific diseases, such as Bronchopulmonary Dysplasia, viral respiratory infections, and asthma-like morbidities. It may be possible to develop therapeutic interventions that target the inflammatory process to correct these problems. This understanding will have implications in vaccine responses, infectious diseases, and inflammatory lung diseases. Through this work, I am able to integrate my expertise in the fields of Immunology and Lung Biology while using cutting edge methodologies.

Credentials

Education

2000
BS | Worcester Polytech Inst
Biotechnology

2006
PhD | University of Vermont
Cell and Molecular Biology

Post-doctoral Training & Residency

11/2011 - 06/2014
Postdoctoral Research Associate with Dr. Gloria Pryhuber- University of Rochester Medical Center: Department of Pediatrics.

08/2008 - 10/2011
Postdoctoral Fellow with Dr. Frances Lund- University of Rochester Medical Center: Allergy, Immunology and Rheumatology.

04/2006 - 08/2008
Postdoctoral Researcher with Dr. Frances Lund-Trudeau Institute.

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Awards

2022 - Present
Guest Editor. Frontiers in Immunology Reserach Topic. Global Excellence in Inflammatory diseases: North America 2021.

2021 - Present
Associate Editor Frontiers in Immunology.Autoimmune and Autoinflammatory Disorders Section.

2021 - Present
Review Editor: Frontiers in Pharmacology. Respiratory Pharmacology Section.

2021
Member of the URMC Translational Immunology and Infectious Diseases Institute (TIIDI) Faculty

2020 - 2021
Associate Guest Editor: Frontiers in Immunology. Autoimmunity and Chronic Inflammation in Early Life.

2016 - Present
Peer Reviewer
Sponsor: American Lung Association
Location: Chicago, IL

2015 - 2016
Assessing RNA expression patterns in CD4+ T cells from preterm infants at the time of discharge from the Neonatal Intensive Care
Sponsor: Strong Children's Research Center

2015
Recipient of Strong Star Award

2014 - Present
Respiratory Pathogens Research Center Innovation Award.
Sponsor: NIAID

2014 - Present
Steering Committee Member of the LungMAP program.

2010
Work noted by the Journal of the American Medical Association

2010
Work noted by the University of Rochester
Location: (http://www.urmc.rochester.edu/news/story/index.cfm?id=2972)

2009 - 2010
Postdoctoral Research Fellow (University of Rochester)

2008 - 2010
Examining a role for G alpha q in preventing autoimmune disease (Individual award F32AI080104).
Sponsor: NIAID

2007 - 2008
Institutional Research Training in Immunology and Infectious Diseases (Trudeau Institute T32AI049823).
Sponsor: NIAID

2003
Graduate Student Advisory Counsel Travel Award.
Sponsor: UVM

2002 - 2006
Environmental Pathology and Cell Signaling Institutional Training Grant (UVM T32ES007122).

2000
Tau Beta Pi Honors Society (WPI).

2000
Provost's Award (WPI).

2000
Salisbury Prize (WPI).

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Publications

Journal Articles

12/20/2021
Sun X, Perl AK, Li R, Bell SM, Sajti E, Kalinichenko VV, Kalin TV, Misra RS, Deshmukh H, Clair G, Kyle J, Crotty Alexander LE, Silva JM, Kitzmiller JA, Wikenheiser-Brokamp KA, Deutsch G, Guo M, Du Y, Morley MP, Valdez MJ, Yu HV, Jin K, Bardes EE, Zepp JA, Neithamer T, Basil MC, Zacharias WJ, Verheyden J, Young R, Bandyopadhyay G, Lin S, Ansong C, Adkins J, Salomonis N, Aronow BJ, Xu Y, Pryhuber G, Whitsett J, Morrisey EE, . "A census of the lung: CellCards from LungMAP." Developmental cell.. 2021 Dec 20; Epub 2021 Dec 20.

12/20/2021
House EL, Kim SY, Johnston CJ, Groves AM, Hernady E, Misra RS, McGraw MD. "Diacetyl Vapor Inhalation Induces Mixed, Granulocytic Lung Inflammation with Increased CD4CD25 T Cells in the Rat." Toxics.. 2021 Dec 20; 9(12)Epub 2021 Dec 20.

11/9/2021
Clair G, Bramer LM, Misra R, McGraw MD, Bhattacharya S, Kitzmiller JA, Feng S, Danna VG, Bandyopadhyay G, Bhotika H, Huyck HL, Deutsch GH, Mariani TJ, Carson J, Whitsett JA, Pryhuber GS, Adkins JN, Ansong C. "Proteomic Analysis of Human Lung Development." American journal of respiratory and critical care medicine.. 2021 Nov 9; Epub 2021 Nov 09.

Books & Chapters

2019
Chapter Title: Initiating Multiomics Approach to Understand Neonatal Chronic Lung Disease: the LungMAP Experience.
Book Title: Bronchopulmonary Dysplasia
Author List: Mary-Anne E. Ardini-Poleske, Thomas J. Mariani, Ravi S. Misra, and The LungMAP Consortium.
Published By: Elsevier 2019

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