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Ravi S. Misra, Ph.D.

Contact Information

Phone Numbers

Office: (585) 276-3607

Faculty Appointments


My translational research projects focus on understanding mechanisms of pathology in common inflammatory conditions of children. In order to ask targeted research questions and develop testable hypotheses, I work closely with the clinical staff and faculty of the Neonatal Intensive Care Unit and Department of Pediatrics. This includes interactions with physicians, nurses, clinical coordinators, basic scientific researchers and biostatisticians. By studying how the immune system and lung development are altered in children born prematurely, we will begin to understand how alterations in these systems contribute to specific diseases, such as Bronchopulmonary Dysplasia, viral respiratory infections, atopy, and asthma-like morbidities. It may be possible to develop therapeutic interventions that target the inflammatory process to correct these problems. This understanding will have implications in vaccine responses, infectious diseases, and inflammatory lung diseases.


I am focused on cellular and molecular biology of the pulmonary and immune systems, and how they interact to protect infants against infection. Keeping abreast of cutting edge research technologies, developing strong collaborations (both internally and externally), and teaching are keys to a successful biomedical research program. My research is rooted in these key elements. Working in the Department of Pediatrics has shifted my interest toward how immune and lung development in infants who are born prematurely differ from those born at full term. Children who are born preterm have a higher risk of developing inflammatory lung diseases and severe respiratory infections in the first year of life. Immature lung structure and altered immune system function likely contribute to this increased risk. A precedence exists in the literature that early life challenges to the immune system have long-lasting effects and involves the innate and adaptive immune cells. I am particularly interested in examining how the in utero environment can affect the development of the immune system. Resulting changes could be correlated to the increased risk of developing specific infectious diseases and/or lung tissue damage into childhood and beyond. Furthermore, prolonged inflammation and tissue damage could lead to a loss of immunological tolerance, which is one element seen in later-life lung disease. By understanding how the normal and preterm infant immune system inflammatory response functions, we hope to better understand how it relates to specific diseases in this population.



BS | Worcester Polytech Inst

PhD | University of Vermont
Cell and Molecular Biology

Post-doctoral Training & Residency

11/2011 - 06/2014
Postdoctoral Research Associate with Dr. Gloria Pryhuber- University of Rochester Medical Center: Department of Pediatrics.

08/2008 - 10/2011
Postdoctoral Fellow with Dr. Frances Lund- University of Rochester Medical Center: Allergy, Immunology and Rheumatology.

04/2006 - 08/2008
Postdoctoral Researcher with Dr. Frances Lund-Trudeau Institute.

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2018 - 2018
Peer Reviewer
Sponsor: American Lung Association
Location: Chicago, IL

2017 - 2017
Selected for participation in the NIH Early Career Reviewer Program
Sponsor: NIH
Location: Baltimore, MD.

2017 - 2017
Peer Reviewer
Sponsor: American Lung Association
Location: Chicago, IL

2015 - 2016
Assessing RNA expression patterns in CD4+ T cells from preterm infants at the time of discharge from the Neonatal Intensive Care
Sponsor: Strong Children's Research Center

Recipient of Strong Star Award

2014 - Present
Respiratory Pathogens Research Center Innovation Award.
Sponsor: NIAID

2014 - Present
Steering Committee Member of the LungMAP program.

Work noted by the Journal of the American Medical Association

Work noted by the University of Rochester
Location: (

2009 - 2010
Postdoctoral Research Fellow (University of Rochester)

2008 - 2010
Examining a role for G alpha q in preventing autoimmune disease (Individual award F32AI080104).
Sponsor: NIAID

2007 - 2008
Institutional Research Training in Immunology and Infectious Diseases (Trudeau Institute T32AI049823).
Sponsor: NIAID

Graduate Student Advisory Counsel Travel Award.
Sponsor: UVM

2002 - 2006
Environmental Pathology and Cell Signaling Institutional Training Grant (UVM T32ES007122).

Tau Beta Pi Honors Society (WPI).

Provost's Award (WPI).

Salisbury Prize (WPI).

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Journal Articles

Misra RS, Nayak JL. "The Importance of Vaccinating Children and Pregnant Women against Influenza Virus Infection." Pathogens.. 2019 Nov 26; 8(4)Epub 2019 Nov 26.

Anderson CS, Chu CY, Wang Q, Mereness JA, Ren Y, Donlon K, Bhattacharya S, Misra RS, Walsh EE, Pryhuber GS, Mariani TJ. "CX3CR1 as a respiratory syncytial virus receptor in pediatric human lung." Pediatric research.. 2019 Nov 14; Epub 2019 Nov 14.

Du Y, Clair GC, Al Alam, Danopoulos S, Schnell D, Kitzmiller JA, Misra RS, Bhattacharya S, Warburton D, Mariani TJ, Pryhuber GS, Whitsett JA, Ansong C, Xu Y. "Integration of transcriptomic and proteomic data identifies biological functions in cell populations from human infant lung." American journal of physiology. Lung cellular and molecular physiology.. 2019 Jul 3; Epub 2019 Jul 03.

Books & Chapters

Chapter Title: Initiating Multiomics Approach to Understand Neonatal Chronic Lung Disease: the LungMAP Experience.
Book Title: Bronchopulmonary Dysplasia
Author List: Mary-Anne E. Ardini-Poleske, Thomas J. Mariani, Ravi S. Misra, and The LungMAP Consortium.
Published By: Elsevier 2019