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Craig Morrell, D.V.M., Ph.D.


Showing all 61 journal articles & 0 books available

Journal Articles

Hilt ZT, Ture SK, Mohan A, Arne A, Morrell CN. "Platelet-derived ?2m regulates age related monocyte/macrophage functions." Aging.. 2019 Dec 18; 11Epub 2019 Dec 18.

Morrell CN, Hilt ZT, Pariser DN, Maurya P. "PAD4 and von Willebrand Factor Link Inflammation and Thrombosis." Circulation research.. 2019 Aug 16; 125(5):520-522. Epub 2019 Aug 15.

Dugbartey GJ, Quinn B, Luo L, Mickelsen DM, Ture SK, Morrell CN, Czyzyk J, Doyley MM, Yan C, Berk BC, Korshunov VA. "The Protective Role of Natriuretic Peptide Receptor 2 against High Salt Injury in the Renal Papilla." The American journal of pathology.. 2019 Jun 17; Epub 2019 Jun 17.

Bennett JA, Ture SK, Schmidt RA, Mastrangelo MA, Cameron SJ, Terry LE, Yule DI, Morrell CN, Lowenstein CJ. "Acetylcholine inhibits platelet activation." The Journal of pharmacology and experimental therapeutics.. 2019 Feb 14; Epub 2019 Feb 14.

Hilt ZT, Pariser DN, Ture SK, Mohan A, Quijada P, Asante A, Cameron SJ, Sterling JA, Merkel AR, Johanson AL, Jenkins JL, Small EM, McGrath KE, Palis J, Elliott MR, Morrell CN. "Platelet-derived ?2M regulates monocyte inflammatory responses." JCI insight.. 2019 Jan 31; Epub 2019 Jan 31.

Morrell CN, Pariser DN, Hilt ZT, Vega Ocasio. "The Platelet Napoleon Complex-Small Cells, but Big Immune Regulatory Functions." Annual review of immunology.. 2018 Nov 28; Epub 2018 Nov 28.

Yang M, Kholmukhamedov A, Schulte ML, Cooley BC, Scoggins NO, Wood JP, Cameron SJ, Morrell CN, Jobe SM, Silverstein RL. "Platelet CD36 signaling through ERK5 promotes caspase-dependent procoagulant activity and fibrin deposition in vivo." Blood advances.. 2018 Nov 13; 2(21):2848-2861.

Cameron SJ, Mix DS, Ture SK, Schmidt RA, Mohan A, Pariser D, Stoner MC, Shah P, Chen L, Zhang H, Field DJ, Modjeski KL, Toth S, Morrell CN. "Hypoxia and Ischemia Promote a Maladaptive Platelet Phenotype." Arteriosclerosis, thrombosis, and vascular biology.. 2018 Jul 0; 38(7):1594-1606. Epub 2018 May 03.

Schmidt RA, Morrell CN, Ling FS, Simlote P, Fernandez G, Rich DQ, Adler D, Gervase J, Cameron SJ. "The platelet phenotype in patients with ST-segment elevation myocardial infarction is different from non-ST-segment elevation myocardial infarction." Translational research : the journal of laboratory and clinical medicine.. 2018 May 0; 195:1-12. Epub 2017 Dec 02.

Field DJ, Aggrey-Amable AA, Blick SK, Ture SK, Johanson A, Cameron SJ, Roy S, Morrell CN. "Platelet factor 4 increases bone marrow B cell development and differentiation." Immunologic research.. 2017 Oct 0; 65(5):1089-1094.

Chapman LM, Ture SK, Field DJ, Morrell CN. "miR-451 limits CD4 T cell proliferative responses to infection in mice." Immunologic research.. 2017 Aug 0; 65(4):828-840.

Yang M, Cooley BC, Li W, Chen Y, Vasquez-Vivar J, Scoggins NO, Cameron SJ, Morrell CN, Silverstein RL. "Platelet CD36 promotes thrombosis by activating redox sensor ERK5 in hyperlipidemic conditions." Blood.. 2017 May 25; 129(21):2917-2927. Epub 2017 Mar 23.

Croft DP, Cameron SJ, Morrell CN, Lowenstein CJ, Ling F, Zareba W, Hopke PK, Utell MJ, Thurston SW, Thevenet-Morrison K, Evans KA, Chalupa D, Rich DQ. "Associations between ambient wood smoke and other particulate pollutants and biomarkers of systemic inflammation, coagulation and thrombosis in cardiac patients." Environmental research.. 2017 Apr 0; 154:352-361. Epub 2017 Feb 04.

Morrell CN. "Platelets: killers of parasites or patients?" Blood.. 2017 Mar 23; 129(12):1571-1572.

Zhu QM, Ko KA, Ture S, Mastrangelo MA, Chen MH, Johnson AD, O'Donnell CJ, Morrell CN, Miano JM, Lowenstein CJ. "Novel Thrombotic Function of a Human SNP in STXBP5 Revealed by CRISPR/Cas9 Gene Editing in Mice." Arteriosclerosis, thrombosis, and vascular biology.. 2017 Feb 0; 37(2):264-270. Epub 2016 Dec 29.

Batchu SN, Hughson A, Wadosky KM, Morrell CN, Fowell DJ, Korshunov VA. "Role of Axl in T-Lymphocyte Survival in Salt-Dependent Hypertension." Arteriosclerosis, thrombosis, and vascular biology.. 2016 Aug 0; 36(8):1638-1646. Epub 2016 Jun 30.

Xu S, Liu B, Yin M, Koroleva M, Mastrangelo M, Ture S, Morrell CN, Zhang DX, Fisher EA, Jin ZG. "A novel TRPV4-specific agonist inhibits monocyte adhesion and atherosclerosis." Oncotarget.. 2016 Jun 21; 7(25):37622-37635.

Modjeski KL, Levy SC, Ture SK, Field DJ, Shi G, Ko K, Zhu Q, Morrell CN. "Glutamate Receptor Interacting Protein 1 Regulates CD4(+) CTLA-4 Expression and Transplant Rejection." American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.. 2016 May 0; 16(5):1383-93. Epub 2016 Feb 25.

Lannan KL, Refaai MA, Ture SK, Morrell CN, Blumberg N, Phipps RP, Spinelli SL. "Resveratrol preserves the function of human platelets stored for transfusion." British journal of haematology.. 2016 Mar 0; 172(5):794-806. Epub 2015 Dec 18.

Jackson JW, Singh MV, Singh VB, Jones LD, Davidson GA, Ture S, Morrell CN, Schifitto G, Maggirwar SB. "Novel Antiplatelet Activity of Minocycline Involves Inhibition of MLK3-p38 Mitogen Activated Protein Kinase Axis." PloS one.. 2016 11(6):e0157115. Epub 2016 Jun 06.

Modjeski KL, Ture SK, Field DJ, Cameron SJ, Morrell CN. "Glutamate Receptor Interacting Protein 1 Mediates Platelet Adhesion and Thrombus Formation." PloS one.. 2016 11(9):e0160638. Epub 2016 Sep 15.

Batchu SN, Xia J, Ko KA, Doyley MM, Abe JI, Morrell CN, Korshunov VA. "Axl modulates immune activation of smooth muscle cells in vein graft remodeling." American journal of physiology. Heart and circulatory physiology.. 2015 Sep 15; 309(6):H1048-58. Epub 2015 Aug 14.

Spitalnik SL, Triulzi D, Devine DV, Dzik WH, Eder AF, Gernsheimer T, Josephson CD, Kor DJ, Luban NL, Roubinian NH, Mondoro T, Welniak LA, Zou S, Glynn S, . "2015 proceedings of the National Heart, Lung, and Blood Institute's State of the Science in Transfusion Medicine symposium." Transfusion.. 2015 Sep 0; 55(9):2282-90. Epub 2015 Aug 10.

Cameron SJ, Ture SK, Mickelsen D, Chakrabarti E, Modjeski KL, McNitt S, Seaberry M, Field DJ, Le NT, Abe JI, Morrell CN. "Platelet Extracellular Regulated Protein Kinase 5 Is a Redox Switch and Triggers Maladaptive Platelet Responses and Myocardial Infarct Expansion." Circulation.. 2015 Jul 7; 132(1):47-58. Epub 2015 May 01.

Cameron SJ, Morrell CN, Bao C, Swaim AF, Rodriguez A, Lowenstein CJ. "A Novel Anti-Inflammatory Effect for High Density Lipoprotein." PloS one.. 2015 10(12):e0144372. Epub 2015 Dec 17.

Morrell CN. "Understanding platelets in malaria infection." Current opinion in hematology.. 2014 Sep 0; 21(5):445-9.

Wang L, Soe NN, Sowden M, Xu Y, Modjeski K, Baskaran P, Kim Y, Smolock EM, Morrell C, Berk BC. "Cyclophilin A is an important mediator of platelet function by regulating integrin ?IIb?3 bidirectional signalling." Thrombosis and haemostasis.. 2014 May 5; 111(5):873-82. Epub 2014 Jan 16.

Morrell CN, Aggrey AA, Chapman LM, Modjeski KL. "Emerging roles for platelets as immune and inflammatory cells." Blood.. 2014 May 1; 123(18):2759-67. Epub 2014 Feb 28.

Metcalf Pate KA, Lyons CE, Dorsey JL, Queen SE, Adams RJ, Morrell CN, Mankowski JL. "TGF?-Mediated Downregulation of Thrombopoietin Is Associated With Platelet Decline in Asymptomatic SIV Infection." Journal of acquired immune deficiency syndromes : JAIDS.. 2014 Apr 15; 65(5):510-6.

Modjeski KL, Morrell CN. "Small cells, big effects: the role of platelets in transplant vasculopathy." Journal of thrombosis and thrombolysis.. 2014 Jan 0; 37(1):17-23.

Shi G, Field DJ, Long X, Mickelsen D, Ko KA, Ture S, Korshunov VA, Miano JM, Morrell CN. "Platelet factor 4 mediates vascular smooth muscle cell injury responses." Blood.. 2013 May 23; 121(21):4417-27. Epub 2013 Apr 08.

Aggrey AA, Srivastava K, Ture S, Field DJ, Morrell CN. "Platelet induction of the acute-phase response is protective in murine experimental cerebral malaria." The Journal of immunology : official journal of the American Association of Immunologists.. 2013 May 1; 190(9):4685-91. Epub 2013 Mar 27.

Chapman LM, Aggrey AA, Field DJ, Srivastava K, Ture S, Yui K, Topham DJ, Baldwin WM, Morrell CN. "Platelets present antigen in the context of MHC class I." The Journal of immunology : official journal of the American Association of Immunologists.. 2012 Jul 15; 189(2):916-23. Epub 2012 Jun 15.

Morrell CN, Maggirwar SB. "Recently recognized platelet agonists." Current opinion in hematology.. 2011 Sep 0; 18(5):309-14.

Shi G, Morrell CN. "Platelets as initiators and mediators of inflammation at the vessel wall." Thrombosis research.. 2011 May 0; 127(5):387-90. Epub 2010 Nov 20.

Morrell CN, Srivastava K, Swaim A, Lee MT, Chen J, Nagineni C, Hooks JJ, Detrick B. "Beta interferon suppresses the development of experimental cerebral malaria." Infection and immunity.. 2011 Apr 0; 79(4):1750-8. Epub 2011 Jan 18.

Davidson DC, Hirschman MP, Spinelli SL, Morrell CN, Schifitto G, Phipps RP, Maggirwar SB. "Antiplatelet activity of valproic acid contributes to decreased soluble CD40 ligand production in HIV type 1-infected individuals." The Journal of immunology : official journal of the American Association of Immunologists.. 2011 Jan 1; 186(1):584-91. Epub 2010 Nov 29.

Morrell CN. "Immunomodulatory mediators in platelet transfusion reactions." Hematology. 2011 2011:470-4.

Ombrello C, Block RC, Morrell CN. "Our expanding view of platelet functions and its clinical implications." Journal of cardiovascular translational research. 2010 Oct 0; 3(5):538-46. Epub 2010 Jul 27.

Srivastava K, Field DJ, Aggrey A, Yamakuchi M, Morrell CN. "Platelet factor 4 regulation of monocyte KLF4 in experimental cerebral malaria." PloS one.. 2010 May 3; 5(5):e10413. Epub 2010 May 03.

Steele BM, Harper MT, Macaulay IC, Morrell CN, Perez-Tamayo A, Foy M, Habas R, Poole AW, Fitzgerald DJ, Maguire PB. "Canonical Wnt signaling negatively regulates platelet function." Proceedings of the National Academy of Sciences of the United States of America.. 2009 Nov 24; 106(47):19836-41. Epub 2009 Nov 09.

Sun H, Swaim A, Herrera JE, Becker D, Becker L, Srivastava K, Thompson LE, Shero MR, Perez-Tamayo A, Suktitpat B, Mathias R, Contractor A, Faraday N, Morrell CN. "Platelet kainate receptor signaling promotes thrombosis by stimulating cyclooxygenase activation." Circulation research.. 2009 Sep 11; 105(6):595-603. Epub 2009 Aug 13.

Jeong Y, Chaupin DF, Matsushita K, Yamakuchi M, Cameron SJ, Morrell CN, Lowenstein CJ. "Aldosterone activates endothelial exocytosis." Proceedings of the National Academy of Sciences of the United States of America.. 2009 Mar 10; 106(10):3782-7. Epub 2009 Feb 17.

Srivastava K, Cockburn IA, Swaim A, Thompson LE, Tripathi A, Fletcher CA, Shirk EM, Sun H, Kowalska MA, Fox-Talbot K, Sullivan D, Zavala F, Morrell CN. "Platelet factor 4 mediates inflammation in experimental cerebral malaria." Cell host & microbe.. 2008 Aug 14; 4(2):179-87.

Morrell CN, Sun H, Ikeda M, Beique JC, Swaim AM, Mason E, Martin TV, Thompson LE, Gozen O, Ampagoomian D, Sprengel R, Rothstein J, Faraday N, Huganir R, Lowenstein CJ. "Glutamate mediates platelet activation through the AMPA receptor." The Journal of experimental medicine.. 2008 Mar 17; 205(3):575-84. Epub 2008 Feb 18.

Shi C, Parker AR, Hua L, Morrell CN, Lee SC, Bandaru V, Dumler JS, Wu TC, Eshleman JR. "Anti-gene padlocks eliminate Escherichia coli based on their genotype." The Journal of antimicrobial chemotherapy.. 2008 Feb 0; 61(2):262-72. Epub 2007 Dec 22.

Morrell, CN.; Mason, EA.; Martin, TV.; Swaim, AM.; Ballard, M.; Murata, K.; Baldwin, WM. "Alloantibodies to MHC Induce Platelet-Endothelial Cell Interactions". Circulation Research. 2008; 102(7): 777-785.

Yamakuchi M, Ferlito M, Morrell CN, Matsushita K, Fletcher CA, Cao W, Lowenstein CJ. "Exocytosis of endothelial cells is regulated by N-ethylmaleimide-sensitive factor." Methods in molecular biology.. 2008 440:203-15.

Matsushita K, Morrell CN, Mason RJ, Yamakuchi M, Khanday FA, Irani K, Lowenstein CJ. "Hydrogen peroxide regulation of endothelial exocytosis by inhibition of N-ethylmaleimide sensitive factor." The Journal of cell biology.. 2005 Jul 4; 170(1):73-9.

Morrell CN, Matsushita K, Lowenstein CJ. "A novel inhibitor of N-ethylmaleimide-sensitive factor decreases leukocyte trafficking and peritonitis." The Journal of pharmacology and experimental therapeutics.. 2005 Jul 0; 314(1):155-61. Epub 2005 Mar 18.

Yamakuchi M, Greer JJ, Cameron SJ, Matsushita K, Morrell CN, Talbot-Fox K, Baldwin WM, Lefer DJ, Lowenstein CJ. "HMG-CoA reductase inhibitors inhibit endothelial exocytosis and decrease myocardial infarct size." Circulation research.. 2005 Jun 10; 96(11):1185-92. Epub 2005 May 19.

Matsushita K, Morrell CN, Lowenstein CJ. "A novel class of fusion polypeptides inhibits exocytosis." Molecular pharmacology.. 2005 Apr 0; 67(4):1137-44. Epub 2004 Dec 17.

Morrell CN, Matsushita K, Chiles K, Scharpf RB, Yamakuchi M, Mason RJ, Bergmeier W, Mankowski JL, Baldwin WM, Faraday N, Lowenstein CJ. "Regulation of platelet granule exocytosis by S-nitrosylation." Proceedings of the National Academy of Sciences of the United States of America.. 2005 Mar 8; 102(10):3782-7. Epub 2005 Feb 28.

Matsushita K, Yamakuchi M, Morrell CN, Ozaki M, O'Rourke B, Irani K, Lowenstein CJ. "Vascular endothelial growth factor regulation of Weibel-Palade-body exocytosis." Blood.. 2005 Jan 1; 105(1):207-14. Epub 2004 Sep 02.

Bhatia R, Matsushita K, Yamakuchi M, Morrell CN, Cao W, Lowenstein CJ. "Ceramide triggers Weibel-Palade body exocytosis." Circulation research.. 2004 Aug 6; 95(3):319-24. Epub 2004 Jun 24.

Matsushita K, Morrell CN, Lowenstein CJ. "Sphingosine 1-phosphate activates Weibel-Palade body exocytosis." Proceedings of the National Academy of Sciences of the United States of America.. 2004 Aug 3; 101(31):11483-7. Epub 2004 Jul 23.

Matsushita K, Morrell CN, Cambien B, Yang SX, Yamakuchi M, Bao C, Hara MR, Quick RA, Cao W, O'Rourke B, Lowenstein JM, Pevsner J, Wagner DD, Lowenstein CJ. "Nitric oxide regulates exocytosis by S-nitrosylation of N-ethylmaleimide-sensitive factor." Cell.. 2003 Oct 17; 115(2):139-50.

Chen WY, Zeng X, Carter MG, Morrell CN, Chiu Yen RW, Esteller M, Watkins DN, Herman JG, Mankowski JL, Baylin SB. "Heterozygous disruption of Hic1 predisposes mice to a gender-dependent spectrum of malignant tumors." Nature genetics.. 2003 Feb 0; 33(2):197-202. Epub 2003 Jan 21.

Morrell CN, Volk MV, Mankowski JL. "A carcinoid tumor in the gallbladder of a dog." Veterinary pathology.. 2002 Nov 0; 39(6):756-8.

Mathiowitz E, Jacob JS, Jong YS, Carino GP, Chickering DE, Chaturvedi P, Santos CA, Vijayaraghavan K, Montgomery S, Bassett M, Morrell C. "Biologically erodable microspheres as potential oral drug delivery systems." Nature.. 1997 Mar 27; 386(6623):410-4.

Chickering, D.E.; Jacob, J.S.; Desai, M.; Harrison, W.P.; Morrell, C.N.; Chatuverdi, P.; Mathiowitz, E. "Bioadhesive Microspheres: III. An In Vivo Transit and Bioavailability Study of Drug-Loaded Alginate and Poly(Fumaric-co-Sebacic Anhydride) Microspheres". Journal of Controlled Release. 1997; 48: 35-46.