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Patricia M. White, Ph.D.

Contact Information

Phone Numbers

Office: (585) 273-2340

Research Labs

Faculty Appointments


Professional Background

Dr. White received her bachelor's degree in Biology from the California Institute of Technology in Pasadena in 1989. She completed her Ph.D. degree in Developmental Biology, also at Caltech, in 2000, where she researched neural stem cells. She began post-doctoral work in hearing regeneration at the House Ear Institute, and joined the faculty at the University of Rochester Medical and Dental Center in 2010.

Dr. White's goal is to find a biological treatment to reverse noise-induced hearing loss through a better understanding of the function of different genes in the cochlea.


Scientific Goals

I want to realize the promise of developmental biology for human medicine. If we can define, describe, and understand the molecular mechanisms that regulate cell division and differentiation, then in principle, we can manipulate cells and tissues to rebuild damaged or diseased organs.

We have begun this process for human deafness, which impacts one quarter of adults over the age of 65. For many of these individuals, decades of noise exposure results in the progressive loss of mechanosensory hair cells, which detect sound vibration in the cochlea. In mammals, lost hair cells are not replaced; consequently, damage accumulates as people age. Surprisingly, when we tested the developmental capacities of nearby cells to divide and create new sensory cells, we found a latent ability for regeneration. My work here at Rochester centers on identifying what molecules regulate inner ear regeneration in mammals. My goal is to find a biological treatment for noise-induced hearing loss.



BS | California Inst of Tech

PhD | California Inst of Tech
Developmental Biology

Post-doctoral Training & Residency

12/2000 - 12/2009
House Ear Institute, Los Angeles, CA


ARCS Scholar

Hearst Scholar


Journal Articles

Gilels FA, Wang J, Bullen A, White PM, Kiernan AE. "Deletion of the Notch ligand Jagged1 during cochlear maturation leads to inner hair cell defects and hearing loss." Cell death & disease.. 2022 Nov 18; 13(11):971. Epub 2022 Nov 18.

Beaulac HJ, Gilels F, Zhang J, Jeoung S, White PM. "Primed to die: an investigation of the genetic mechanisms underlying noise-induced hearing loss and cochlear damage in homozygous Foxo3-knockout mice." Cell death & disease.. 2021 Jul 7; 12(7):682. Epub 2021 Jul 07.

Patel S, Shah L, Dang N, Tan X, Almudevar A, White PM. "SIRT3 promotes auditory function in young adult FVB/nJ mice but is dispensable for hearing recovery after noise exposure." PloS one.. 2020 15(7):e0235491. Epub 2020 Jul 13.