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Patricia M. White, Ph.D.

Contact Information

Phone Numbers

Office: (585) 273-2340

Research Labs

Faculty Appointments

Biography

Professional Background

Dr. White received her bachelor's degree in Biology from the California Institute of Technology in Pasadena in 1989. She completed her Ph.D. degree in Developmental Biology, also at Caltech, in 2000, where she researched neural stem cells. She began post-doctoral work in hearing regeneration at the House Ear Institute, and joined the faculty at the University of Rochester Medical and Dental Center in 2010.

Dr. White's goal is to find a biological treatment to reverse noise-induced hearing loss through a better understanding of the function of different genes in the cochlea.

Research

Scientific Goals

I want to realize the promise of developmental biology for human medicine. If we can define, describe, and understand the molecular mechanisms that regulate cell division and differentiation, then in principle, we can manipulate cells and tissues to rebuild damaged or diseased organs.

We have begun this process for human deafness, which impacts one quarter of adults over the age of 65. For many of these individuals, decades of noise exposure results in the progressive loss of mechanosensory hair cells, which detect sound vibration in the cochlea. In mammals, lost hair cells are not replaced; consequently, damage accumulates as people age. Surprisingly, when we tested the developmental capacities of nearby cells to divide and create new sensory cells, we found a latent ability for regeneration. My work here at Rochester centers on identifying what molecules regulate inner ear regeneration in mammals. My goal is to find a biological treatment for noise-induced hearing loss.

Credentials

Education

1989
BS | California Inst of Tech
Biology

2000
PhD | California Inst of Tech
Developmental Biology

Post-doctoral Training & Residency

12/2000 - 12/2009
House Ear Institute, Los Angeles, CA

Awards


ARCS Scholar


Hearst Scholar

Publications

Journal Articles

7/7/2021
Beaulac HJ, Gilels F, Zhang J, Jeoung S, White PM. "Primed to die: an investigation of the genetic mechanisms underlying noise-induced hearing loss and cochlear damage in homozygous Foxo3-knockout mice." Cell death & disease.. 2021 Jul 7; 12(7):682. Epub 2021 Jul 07.

10/20/2020
White PM. "Perspectives on Human Hearing Loss, Cochlear Regeneration, and the Potential for Hearing Restoration Therapies." Brain sciences. 2020 Oct 20; 10(10)Epub 2020 Oct 20.

2020
Patel S, Shah L, Dang N, Tan X, Almudevar A, White PM. "SIRT3 promotes auditory function in young adult FVB/nJ mice but is dispensable for hearing recovery after noise exposure." PloS one.. 2020 15(7):e0235491. Epub 2020 Jul 13.

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