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Patricia M. White, Ph.D.

Contact Information

Phone Numbers

Office: (585) 273-2340

Biography

Professional Background

Dr. White received her bachelor's degree in Biology from the California Institute of Technology in Pasadena in 1989. She completed her Ph.D. degree in Developmental Biology, also at Caltech, in 2000, where she researched neural stem cells. She began post-doctoral work in hearing regeneration at the House Ear Institute, and joined the faculty at the University of Rochester Medical and Dental Center in 2010.

Dr. White's goal is to find a biological treatment to reverse noise-induced hearing loss through a better understanding of the function of different genes in the cochlea.

Research

Scientific Goals

I want to realize the promise of developmental biology for human medicine. If we can define, describe, and understand the molecular mechanisms that regulate cell division and differentiation, then in principle, we can manipulate cells and tissues to rebuild damaged or diseased organs.

We have begun this process for human deafness, which impacts one quarter of adults over the age of 65. For many of these individuals, decades of noise exposure results in the progressive loss of mechanosensory hair cells, which detect sound vibration in the cochlea. In mammals, lost hair cells are not replaced; consequently, damage accumulates as people age. Surprisingly, when we tested the developmental capacities of nearby cells to divide and create new sensory cells, we found a latent ability for regeneration. My work here at Rochester centers on identifying what molecules regulate inner ear regeneration in mammals. My goal is to find a biological treatment for noise-induced hearing loss.

Credentials

Faculty Appointments

Education

1989
BS | California Inst of Tech
Biology

2000
PhD | California Inst of Tech
Developmental Biology

Awards


ARCS Scholar


Hearst Scholar

Publications

Journal Articles

5/10/2016
Paquette ST, Gilels F, White PM. "Noise exposure modulates cochlear inner hair cell ribbon volumes, correlating with changes in auditory measures in the FVB/nJ mouse." Scientific reports.. 2016 May 10; 6:25056. Epub 2016 May 10.

2014
Savoy-Burke G, Gilels FA, Pan W, Pratt D, Que J, Gan L, White PM, Kiernan AE. "Activated notch causes deafness by promoting a supporting cell phenotype in developing auditory hair cells." PloS one. 2014 9(9):e108160. Epub 2014 Sep 29.

11/20/2013
Gilels F, Paquette ST, Zhang J, Rahman I, White PM. "Mutation of Foxo3 causes adult onset auditory neuropathy and alters cochlear synapse architecture in mice." The Journal of neuroscience : the official journal of the Society for Neuroscience.. 2013 Nov 20; 33(47):18409-24.

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