CONTACT INFORMATIONBIOGRAPHYCREDENTIALSAWARDSPUBLICATIONSPatricia M. White, Ph.D.Contact InformationPhone NumbersOffice: (585) 273-2340Research LabsVisit Lab WebsiteLocationsUniversity of Rochester Medical CenterSchool of Medicine and Dentistry601 Elmwood Ave, Box 603Rochester, NY 14642Faculty AppointmentsResearch Associate Professor - Department of Neuroscience (SMD) Research Associate Professor - Department of Otolaryngology (SMD) - JointBiographyProfessional BackgroundDr. White received her bachelor's degree in Biology from the California Institute of Technology in Pasadena in 1989. She completed her Ph.D. degree in Developmental Biology, also at Caltech, in 2000, where she researched neural stem cells. She began post-doctoral work in hearing regeneration at the House Ear Institute, and joined the faculty at the University of Rochester Medical and Dental Center in 2010. Dr. White's goal is to find a biological treatment to reverse noise-induced hearing loss through a better understanding of the function of different genes in the cochlea.ResearchScientific Goals I want to realize the promise of developmental biology for human medicine. If we can define, describe, and understand the molecular mechanisms that regulate cell division and differentiation, then in principle, we can manipulate cells and tissues to rebuild damaged or diseased organs. We have begun this process for human deafness, which impacts one quarter of adults over the age of 65. For many of these individuals, decades of noise exposure results in the progressive loss of mechanosensory hair cells, which detect sound vibration in the cochlea. In mammals, lost hair cells are not replaced; consequently, damage accumulates as people age. Surprisingly, when we tested the developmental capacities of nearby cells to divide and create new sensory cells, we found a latent ability for regeneration. My work here at Rochester centers on identifying what molecules regulate inner ear regeneration in mammals. My goal is to find a biological treatment for noise-induced hearing loss.CredentialsEducation1989BS | California Inst of TechBiology2000PhD | California Inst of TechDevelopmental BiologyPost-doctoral Training & Residency12/2000 - 12/2009House Ear Institute, Los Angeles, CAAwardsARCS ScholarHearst ScholarPublicationsJournal Articles7/7/2021Beaulac HJ, Gilels F, Zhang J, Jeoung S, White PM. "Primed to die: an investigation of the genetic mechanisms underlying noise-induced hearing loss and cochlear damage in homozygous Foxo3-knockout mice." Cell death & disease.. 2021 Jul 7; 12(7):682. Epub 2021 Jul 07. 2020Patel S, Shah L, Dang N, Tan X, Almudevar A, White PM. "SIRT3 promotes auditory function in young adult FVB/nJ mice but is dispensable for hearing recovery after noise exposure." PloS one.. 2020 15(7):e0235491. Epub 2020 Jul 13. 11/2018Zhang J, Wang Q, Abdul-Aziz D, Mattiacio J, Edge ASB, White PM. "ERBB2 signaling drives supporting cell proliferation in vitro and apparent supernumerary hair cell formation in vivo in the neonatal mouse cochlea." The European journal of neuroscience.. 2018 Nov 0; 48(10):3299-3316. Epub 2018 Oct 24. VIEW ALL PUBLICATIONSClose WindowSchedule an appointment with Patricia M. White, Ph.D.Please answer the following questions to help us find the right appointment for you.Important: If you believe that you have a medical or psychiatric emergency, please call 911 or go to the nearest hospital. This website is not intended for emergency care.Have you seen this provider in the last 2 years?YesNoExisting Patient Schedule or request a follow up appointment online through MyChart. If you do not have a MyChart account, please close this window and call the appointment phone number. Patricia M. White, Ph.D. is currently scheduling for the following appointment type(s): Our policy does not permit patients to establish care with multiple providers within the same practice or specialty without prior approval. If you choose a new provider in the same office, we will cancel the appointment. Please contact the office directly with questions on this policy.