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Mark Y. Sangster, Ph.D.


Showing all 56 journal articles & 0 books available

Journal Articles

"Broad hemagglutinin-specific memory B cell expansion by seasonal influenza virus infection reflects early-life imprinting and adaptation to the infecting virus." Journal of virology.. 2019 Feb 6; Epub 2019 Feb 06.

Topham DJ, Nguyen P, Sangster MY. "Pandemic influenza vaccines: what they have taught us about B cell immunology." Current opinion in immunology.. 2018 Aug 0; 53:203-208. Epub 2018 Jun 26.

Wang J, Hilchey SP, DeDiego M, Perry S, Hyrien O, Nogales A, Garigen J, Amanat F, Huertas N, Krammer F, Martinez-Sobrido L, Topham DJ, Treanor JJ, Sangster MY, Zand MS. "Broad cross-reactive IgG responses elicited by adjuvanted vaccination with recombinant influenza hemagglutinin (rHA) in ferrets and mice." PloS one.. 2018 13(4):e0193680. Epub 2018 Apr 11.

Clark AM, DeDiego ML, Anderson CS, Wang J, Yang H, Nogales A, Martinez-Sobrido L, Zand MS, Sangster MY, Topham DJ. "Antigenicity of the 2015-2016 seasonal H1N1 human influenza virus HA and NA proteins." PloS one.. 2017 12(11):e0188267. Epub 2017 Nov 16.

Jegaskanda S, Luke C, Hickman HD, Sangster MY, Wieland-Alter WF, McBride JM, Yewdell JW, Wright PF, Treanor J, Rosenberger CM, Subbarao K. "Generation and Protective Ability of Influenza Virus-Specific Antibody-Dependent Cellular Cytotoxicity in Humans Elicited by Vaccination, Natural Infection, and Experimental Challenge." The Journal of infectious diseases.. 2016 Sep 15; 214(6):945-52. Epub 2016 Jun 28.

Halliley JL, Khurana S, Krammer F, Fitzgerald T, Coyle EM, Chung KY, Baker SF, Yang H, Martínez-Sobrido L, Treanor JJ, Subbarao K, Golding H, Topham DJ, Sangster MY. "High-Affinity H7 Head and Stalk Domain-Specific Antibody Responses to an Inactivated Influenza H7N7 Vaccine After Priming With Live Attenuated Influenza Vaccine." The Journal of infectious diseases.. 2015 Oct 15; 212(8):1270-8. Epub 2015 Apr 02.

Rangel-Moreno J, de la Luz Garcia-Hernandez M, Ramos-Payan R, Biear J, Hernady E, Sangster MY, Randall TD, Johnston CJ, Finkelstein JN, Williams JP. "Long-Lasting Impact of Neonatal Exposure to Total Body Gamma Radiation on Secondary Lymphoid Organ Structure and Function." Radiation research.. 2015 Oct 0; 184(4):352-66. Epub 2015 Sep 23.

Sundararajan A, Sangster MY, Frey S, Atmar RL, Chen WH, Ferreira J, Bargatze R, Mendelman PM, Treanor JJ, Topham DJ. "Robust mucosal-homing antibody-secreting B cell responses induced by intramuscular administration of adjuvanted bivalent human norovirus-like particle vaccine." Vaccine.. 2015 Jan 15; 33(4):568-76. Epub 2014 Nov 22.

Babu TM, Levine M, Fitzgerald T, Luke C, Sangster MY, Jin H, Topham D, Katz J, Treanor J, Subbarao K. "Live attenuated H7N7 influenza vaccine primes for a vigorous antibody response to inactivated H7N7 influenza vaccine." Vaccine.. 2014 Nov 28; 32(50):6798-804. Epub 2014 Oct 16.

Alam S, Knowlden ZA, Sangster MY, Sant AJ. "CD4 T cell help is limiting and selective during the primary B cell response to influenza virus infection." Journal of virology.. 2014 Jan 0; 88(1):314-24. Epub 2013 Oct 23.

Miao H, Sangster MY, Livingstone AM, Hilchey SP, Zhang L, Topham DJ, Mosmann TR, Holden-Wiltse J, Perelson AS, Wu H, Zand MS. "Modeling the dynamics and migratory pathways of virus-specific antibody-secreting cell populations in primary influenza infection." PloS one.. 2014 9(8):e104781. Epub 2014 Aug 29.

Berry CM, Penhale WJ, Sangster MY. "Passive broad-spectrum influenza immunoprophylaxis." Influenza research and treatment.. 2014 2014:267594. Epub 2014 Sep 22.

Sangster MY, Baer J, Santiago FW, Fitzgerald T, Ilyushina NA, Sundararajan A, Henn AD, Krammer F, Yang H, Luke CJ, Zand MS, Wright PF, Treanor JJ, Topham DJ, Subbarao K. "B cell response and hemagglutinin stalk-reactive antibody production in different age cohorts following 2009 H1N1 influenza virus vaccination." Clinical and vaccine immunology : CVI.. 2013 Jun 0; 20(6):867-76. Epub 2013 Apr 10.

He XS, Sasaki S, Baer J, Khurana S, Golding H, Treanor JJ, Topham DJ, Sangster MY, Jin H, Dekker CL, Subbarao K, Greenberg HB. "Heterovariant cross-reactive B-cell responses induced by the 2009 pandemic influenza virus A subtype H1N1 vaccine." The Journal of infectious diseases.. 2013 Jan 15; 207(2):288-96. Epub 2012 Oct 29.

Sundararajan A, Huan L, Richards KA, Marcelin G, Alam S, Joo H, Yang H, Webby RJ, Topham DJ, Sant AJ, Sangster MY. "Host differences in influenza-specific CD4 T cell and B cell responses are modulated by viral strain and route of immunization." PloS one.. 2012 7(3):e34377. Epub 2012 Mar 23.

Sharma S, Sundararajan A, Suryawanshi A, Kumar N, Veiga-Parga T, Kuchroo VK, Thomas PG, Sangster MY, Rouse BT. "T cell immunoglobulin and mucin protein-3 (Tim-3)/Galectin-9 interaction regulates influenza A virus-specific humoral and CD8 T-cell responses." Proceedings of the National Academy of Sciences of the United States of America.. 2011 Nov 22; 108(47):19001-6. Epub 2011 Nov 03.

Su X, Sangster MY, D'Souza DH. "Time-dependent effects of pomegranate juice and pomegranate polyphenols on foodborne viral reduction." Foodborne pathogens and disease.. 2011 Nov 0; 8(11):1177-83. Epub 2011 Jul 21.

Su X, Sangster MY, D'Souza DH. "In vitro effects of pomegranate juice and pomegranate polyphenols on foodborne viral surrogates." Foodborne pathogens and disease.. 2010 Dec 0; 7(12):1473-9. Epub 2010 Aug 31.

Sundararajan A, Ganapathy R, Huan L, Dunlap JR, Webby RJ, Kotwal GJ, Sangster MY. "Influenza virus variation in susceptibility to inactivation by pomegranate polyphenols is determined by envelope glycoproteins." Antiviral research.. 2010 Oct 0; 88(1):1-9. Epub 2010 Jul 14.

Joo HM, He Y, Sundararajan A, Huan L, Sangster MY. "Quantitative analysis of influenza virus-specific B cell memory generated by different routes of inactivated virus vaccination." Vaccine.. 2010 Mar 2; 28(10):2186-94. Epub 2010 Jan 05.

Li Z, Wang H, Xue L, Shin DM, Roopenian D, Xu W, Qi CF, Sangster MY, Orihuela CJ, Tuomanen E, Rehg JE, Cui X, Zhang Q, Morse HC, Morris SW. "Emu-BCL10 mice exhibit constitutive activation of both canonical and noncanonical NF-kappaB pathways generating marginal zone (MZ) B-cell expansion as a precursor to splenic MZ lymphoma." Blood.. 2009 Nov 5; 114(19):4158-68. Epub 2009 Aug 20.

Zeng J, Joo HM, Rajini B, Wrammert JP, Sangster MY, Onami TM. "The generation of influenza-specific humoral responses is impaired in ST6Gal I-deficient mice." The Journal of immunology : official journal of the American Association of Immunologists.. 2009 Apr 15; 182(8):4721-7.

Joo HM, He Y, Sangster MY. "Broad dispersion and lung localization of virus-specific memory B cells induced by influenza pneumonia." Proceedings of the National Academy of Sciences of the United States of America.. 2008 Mar 4; 105(9):3485-90. Epub 2008 Feb 25.

Vanitha DJ, Joo HM, Rouse BT, Sangster MY. "Quantitative analysis of herpes simplex virus type 1-specific memory B cells generated by different routes of infection." Virology.. 2007 Mar 30; 360(1):136-42. Epub 2006 Nov 17.

Li X, Vanitha DJ, Joo HM, He Y, Rouse BT, Sangster MY. "A strategy for selective, CD4+ T cell-independent activation of virus-specific memory B cells for limiting dilution analysis." Journal of immunological methods.. 2006 Jun 30; 313(1-2):110-8. Epub 2006 May 15.

Lipatov AS, Andreansky S, Webby RJ, Hulse DJ, Rehg JE, Krauss S, Perez DR, Doherty PC, Webster RG, Sangster MY. "Pathogenesis of Hong Kong H5N1 influenza virus NS gene reassortants in mice: the role of cytokines and B- and T-cell responses." The Journal of general virology.. 2005 Apr 0; 86(Pt 4):1121-30.

Sangster MY, Riberdy JM, Gonzalez M, Topham DJ, Baumgarth N, Doherty PC. "An early CD4+ T cell-dependent immunoglobulin A response to influenza infection in the absence of key cognate T-B interactions." The Journal of experimental medicine.. 2003 Oct 6; 198(7):1011-21. Epub 2003 Sep 29.

Marshall DR, Turner SJ, Belz GT, Wingo S, Andreansky S, Sangster MY, Riberdy JM, Liu T, Tan M, Doherty PC. "Measuring the diaspora for virus-specific CD8+ T cells." Proceedings of the National Academy of Sciences of the United States of America.. 2001 May 22; 98(11):6313-8. Epub 2001 May 08.

Doherty PC, Christensen JP, Belz GT, Stevenson PG, Sangster MY. "Dissecting the host response to a gamma-herpesvirus." Philosophical transactions of the Royal Society of London. Series B, Biological sciences.. 2001 Apr 29; 356(1408):581-93.

Wang D, Feng J, Wen R, Marine JC, Sangster MY, Parganas E, Hoffmeyer A, Jackson CW, Cleveland JL, Murray PJ, Ihle JN. "Phospholipase Cgamma2 is essential in the functions of B cell and several Fc receptors." Immunity.. 2000 Jul 0; 13(1):25-35.

Sangster MY, Topham DJ, D'Costa S, Cardin RD, Marion TN, Myers LK, Doherty PC. "Analysis of the virus-specific and nonspecific B cell response to a persistent B-lymphotropic gammaherpesvirus." The Journal of immunology : official journal of the American Association of Immunologists.. 2000 Feb 15; 164(4):1820-8.

Marshall D, Sealy R, Sangster M, Coleclough C. "TH cells primed during influenza virus infection provide help for qualitatively distinct antibody responses to subsequent immunization." The Journal of immunology : official journal of the American Association of Immunologists.. 1999 Nov 1; 163(9):4673-82.

Urosevic N, Silvia OJ, Sangster MY, Mansfield JP, Hodgetts SI, Shellam GR. "Development and characterization of new flavivirus-resistant mouse strains bearing Flv(r)-like and Flv(mr) alleles from wild or wild-derived mice." The Journal of general virology.. 1999 Apr 0; 80 ( Pt 4):897-906.

Moriggl R, Topham DJ, Teglund S, Sexl V, McKay C, Wang D, Hoffmeyer A, van Deursen J, Sangster MY, Bunting KD, Grosveld GC, Ihle JN. "Stat5 is required for IL-2-induced cell cycle progression of peripheral T cells." Immunity.. 1999 Feb 0; 10(2):249-59.

Brown MP, Topham DJ, Sangster MY, Zhao J, Flynn KJ, Surman SL, Woodland DL, Doherty PC, Farr AG, Pattengale PK, Brenner MK. "Thymic lymphoproliferative disease after successful correction of CD40 ligand deficiency by gene transfer in mice." Nature medicine.. 1998 Nov 0; 4(11):1253-60.

Shellam GR, Sangster MY, Urosevic N. "Genetic control of host resistance to flavivirus infection in animals." Revue scientifique et technique. 1998 Apr 0; 17(1):231-48.

Bunting KD, Sangster MY, Ihle JN, Sorrentino BP. "Restoration of lymphocyte function in Janus kinase 3-deficient mice by retroviral-mediated gene transfer." Nature medicine.. 1998 Jan 0; 4(1):58-64.

Sangster MY, Mackenzie JS, Shellam GR. "Genetically determined resistance to flavivirus infection in wild Mus musculus domesticus and other taxonomic groups in the genus Mus." Archives of virology.. 1998 143(4):697-715.

Walker WS, Castrucci MR, Sangster MY, Carson RT, Kawaoka Y. "HEL-Flu: an influenza virus containing the hen egg lysozyme epitope recognized by CD4+ T cells from mice transgenic for an alphabeta TCR." The Journal of immunology : official journal of the American Association of Immunologists.. 1997 Sep 15; 159(6):2563-6.

Sangster MY, Mo XY, Sealy R, Coleclough C. "Matching antibody class with pathogen type and portal of entry: cognate mechanisms regulate local isotype expression patterns in lymph nodes draining the respiratory tract of mice inoculated with respiratory viruses, according to virus replication competence and site of inoculation." The Journal of immunology : official journal of the American Association of Immunologists.. 1997 Aug 15; 159(4):1893-902.

Hurwitz JL, Soike KF, Sangster MY, Portner A, Sealy RE, Dawson DH, Coleclough C. "Intranasal Sendai virus vaccine protects African green monkeys from infection with human parainfluenza virus-type one." Vaccine.. 1997 Apr 0; 15(5):533-40.

Mo XY, Tripp RA, Sangster MY, Doherty PC. "The cytotoxic T-lymphocyte response to Sendai virus is unimpaired in the absence of gamma interferon." Journal of virology.. 1997 Mar 0; 71(3):1906-10.

Mo XY, Sangster MY, Tripp RA, Doherty PC. "Modification of the Sendai virus-specific antibody and CD8+ T-cell responses in mice homozygous for disruption of the interleukin-4 gene." Journal of virology.. 1997 Mar 0; 71(3):2518-21.

Thierfelder WE, van Deursen JM, Yamamoto K, Tripp RA, Sarawar SR, Carson RT, Sangster MY, Vignali DA, Doherty PC, Grosveld GC, Ihle JN. "Requirement for Stat4 in interleukin-12-mediated responses of natural killer and T cells." Nature.. 1996 Jul 11; 382(6587):171-4.

Hall RA, Brand TN, Lobigs M, Sangster MY, Howard MJ, Mackenzie JS. "Protective immune responses to the E and NS1 proteins of Murray Valley encephalitis virus in hybrids of flavivirus-resistant mice." The Journal of general virology.. 1996 Jun 0; 77 ( Pt 6):1287-94.

Shimoda K, van Deursen J, Sangster MY, Sarawar SR, Carson RT, Tripp RA, Chu C, Quelle FW, Nosaka T, Vignali DA, Doherty PC, Grosveld G, Paul WE, Ihle JN. "Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted Stat6 gene." Nature.. 1996 Apr 18; 380(6575):630-3.

Topham DJ, Tripp RA, Sarawar SR, Sangster MY, Doherty PC. "Immune CD4+ T cells promote the clearance of influenza virus from major histocompatibility complex class II -/- respiratory epithelium." Journal of virology.. 1996 Feb 0; 70(2):1288-91.

Sangster M, Smith FS, Coleclough C, Hurwitz JL. "Human parainfluenza virus type 1 immunization of infant mice protects from subsequent Sendai virus infection." Virology.. 1995 Sep 10; 212(1):13-9.

Mo XY, Sangster M, Sarawar S, Coleclough C, Doherty PC. "Differential antigen burden modulates the gamma interferon but not the immunoglobulin response in mice that vary in susceptibility to Sendai virus pneumonia." Journal of virology.. 1995 Sep 0; 69(9):5592-8.

Sangster M, Hyland L, Sealy R, Coleclough C. "Distinctive kinetics of the antibody-forming cell response to Sendai virus infection of mice in different anatomical compartments." Virology.. 1995 Feb 20; 207(1):287-91.

Hyland L, Sangster M, Sealy R, Coleclough C. "Respiratory virus infection of mice provokes a permanent humoral immune response." Journal of virology.. 1994 Sep 0; 68(9):6083-6.

Sarawar SR, Sangster M, Coffman RL, Doherty PC. "Administration of anti-IFN-gamma antibody to beta 2-microglobulin-deficient mice delays influenza virus clearance but does not switch the response to a T helper cell 2 phenotype." The Journal of immunology : official journal of the American Association of Immunologists.. 1994 Aug 1; 153(3):1246-53.

Sangster MY, Urosevic N, Mansfield JP, Mackenzie JS, Shellam GR. "Mapping the Flv locus controlling resistance to flaviviruses on mouse chromosome 5." Journal of virology.. 1994 Jan 0; 68(1):448-52.

Sangster MY, Heliams DB, MacKenzie JS, Shellam GR. "Genetic studies of flavivirus resistance in inbred strains derived from wild mice: evidence for a new resistance allele at the flavivirus resistance locus (Flv)." Journal of virology.. 1993 Jan 0; 67(1):340-7.

Weaver D, Skinner S, Walker L, Sangster M. "Phenotypic inhibition of the renin-angiotensin system, emergence of the Ren-2 gene, and adaptive radiation of mice." General and comparative endocrinology.. 1991 Aug 0; 83(2):306-15.

Sangster MY, Shellam GR. "Genetically controlled resistance to flaviviruses within the house mouse complex of species." Current topics in microbiology and immunology.. 1986 127:313-8.