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Matthew N. McCall, Ph.D., M.H.S.

Contact Information

Phone Numbers

Appointment: (585) 276-3000

Research Labs

Faculty Appointments

Biography

My research interests are in statistical genomics and systems biology. Currently, I am focusing on developing methods to estimate gene regulatory networks from gene pertubation experiments, using microRNA signatures to predict recurrence of hepatocellular carcinoma after liver transplantation, and examining the effect of cellular composition on tissue-level gene expression.

I received a Ph.D. in Biostatistics from The Johns Hopkins University under the supervision of Rafael Irizarry. My thesis work focused on developing statistical methodology for preprocessing and analysis of data from a single microarray.

Professional Background

In 2010, I received a PhD in Biostatistics and an MHS in Bioinformatics from the Johns Hopkins School of Public Health under the supervision of Dr. Rafael Irizarry. From 2010 to 2014, I worked as a Postdoctoral Fellow at the University of Rochester Medical Center under the mentorship of Drs. Anthony Almudevar and Hartmut Land. In the fall of 2014, I accepted a position as an Assistant Professor in the Department of Biostatistics and Computational Biology with a joint appointment in the Department of Biomedical Genetics at the University of Rochester Medical Center.

Research

My research interests are in statistical genomics, systems biology, and bioinformatics. Currently, I am focusing on: (1) developing methods to estimate gene regulatory networks involved in cancer from perturbation experiments, (2) examining the effect of cellular composition on tissue-level gene expression, (3) tackling within-subject genomic heterogeneity, focusing on predicting recurrence of hepatocellular carcinoma after liver transplantation, and (4) developing methods for preprocessing and analysis of genomic data.

Credentials

Education

2004
BS | University of Michigan
Statistics

2010
PhD | Johns Hopkins Bloomberg School of Public Health
Biostatistics

2010
MHS | Johns Hopkins Bloomberg School of Public Health
Bioinformatics

Publications

Journal Articles

8/1/2019
Wang YT, Lim Y, McCall MN, Huang KT, Haynes CM, Nehrke K, Brookes PS. "Cardioprotection by the mitochondrial unfolded protein response requires ATF5." American journal of physiology. Heart and circulatory physiology.. 2019 Aug 1; 317(2):H472-H478. Epub 2019 Jul 05.

6/6/2019
Walsh EE, Mariani TJ, Chu C, Grier A, Gill SR, Qiu X, Wang L, Holden-Wiltse J, Corbett A, Thakar J, Benoodt L, McCall MN, Topham DJ, Falsey AR, Caserta MT. "Aims, Study Design, and Enrollment Results From the Assessing Predictors of Infant Respiratory Syncytial Virus Effects and Severity Study." JMIR research protocols. 2019 Jun 6; 8(6):e12907. Epub 2019 Jun 06.

11/7/2018
Spinelli P, Latchney SE, Reed JM, Fields A, Baier BS, Lu X, McCall MN, Murphy SP, Mak W, Susiarjo M. "Identification of the novel Ido1 imprinted locus and its potential epigenetic role in pregnancy loss." Human molecular genetics.. 2018 Nov 7; Epub 2018 Nov 07.

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