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Matthew N. McCall, Ph.D., M.H.S.

Contact Information

Phone Numbers

Appointment: (585) 276-3000

Research Labs

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Biography

My research interests are in statistical genomics and systems biology. Currently, I am focusing on developing methods to estimate gene regulatory networks from gene pertubation experiments, using microRNA signatures to predict recurrence of hepatocellular carcinoma after liver transplantation, and examining the effect of cellular composition on tissue-level gene expression.

I received a Ph.D. in Biostatistics from The Johns Hopkins University under the supervision of Rafael Irizarry. My thesis work focused on developing statistical methodology for preprocessing and analysis of data from a single microarray.

Professional Background

In 2010, I received a PhD in Biostatistics and an MHS in Bioinformatics from the Johns Hopkins School of Public Health under the supervision of Dr. Rafael Irizarry. From 2010 to 2014, I worked as a Postdoctoral Fellow at the University of Rochester Medical Center under the mentorship of Drs. Anthony Almudevar and Hartmut Land. In the fall of 2014, I accepted a position as an Assistant Professor in the Department of Biostatistics and Computational Biology with a joint appointment in the Department of Biomedical Genetics at the University of Rochester Medical Center.

Research

My research interests are in statistical genomics, systems biology, and bioinformatics. Currently, I am focusing on: (1) developing methods to estimate gene regulatory networks involved in cancer from perturbation experiments, (2) examining the effect of cellular composition on tissue-level gene expression, (3) tackling within-subject genomic heterogeneity, focusing on predicting recurrence of hepatocellular carcinoma after liver transplantation, and (4) developing methods for preprocessing and analysis of genomic data.

Credentials

Faculty Appointments

Education

2004
BS | University of Michigan
Statistics

2010
PhD | Johns Hopkins Bloomberg School of Public Health
Biostatistics

2010
MHS | Johns Hopkins Bloomberg School of Public Health
Bioinformatics

Publications

Journal Articles

10/2017
McCall MN, Kim MS, Adil M, Patil AH, Lu Y, Mitchell CJ, Leal-Rojas P, Xu J, Kumar M, Dawson VL, Dawson TM, Baras AS, Rosenberg AZ, Arking DE, Burns KH, Pandey A, Halushka MK. "Toward the human cellular microRNAome." Genome research.. 2017 Oct 0; 27(10):1769-1781. Epub 2017 Sep 06.

1/10/2017
Komisarof J, McCall M, Newman L, Bshara W, Mohler JL, Morrison C, Land H. "A four gene signature predictive of recurrent prostate cancer." Oncotarget. 2017 Jan 10; 8(2):3430-3440.

9/1/2016
McCall MN, Illei PB, Halushka MK. "Complex Sources of Variation in Tissue Expression Data: Analysis of the GTEx Lung Transcriptome." American journal of human genetics.. 2016 Sep 1; 99(3):624-635.

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