Skip to main content
Explore URMC
menu

Matthew N. McCall, Ph.D., M.H.S.

(Pronouns: he/him/his)

Contact Information

Research Labs

Faculty Appointments

Biography

My research interests are in statistical genomics and systems biology. Currently, I am focusing on developing methods to estimate gene regulatory networks from gene pertubation experiments, using microRNA signatures to predict recurrence of hepatocellular carcinoma after liver transplantation, and examining the effect of cellular composition on tissue-level gene expression.

I received a Ph.D. in Biostatistics from The Johns Hopkins University under the supervision of Rafael Irizarry. My thesis work focused on developing statistical methodology for preprocessing and analysis of data from a single microarray.

Professional Background

In 2010, I received a PhD in Biostatistics and an MHS in Bioinformatics from the Johns Hopkins School of Public Health under the supervision of Dr. Rafael Irizarry. From 2010 to 2014, I worked as a Postdoctoral Fellow at the University of Rochester Medical Center under the mentorship of Drs. Anthony Almudevar and Hartmut Land. In the fall of 2014, I accepted a position as an Assistant Professor in the Department of Biostatistics and Computational Biology with a joint appointment in the Department of Biomedical Genetics at the University of Rochester Medical Center.

Research

My research interests are in statistical genomics, systems biology, and bioinformatics. Currently, I am focusing on: (1) developing methods to estimate gene regulatory networks involved in cancer from perturbation experiments, (2) examining the effect of cellular composition on tissue-level gene expression, (3) tackling within-subject genomic heterogeneity, focusing on predicting recurrence of hepatocellular carcinoma after liver transplantation, and (4) developing methods for preprocessing and analysis of genomic data.

Credentials

Education

2004
BS | University of Michigan
Statistics

2010
PhD | Johns Hopkins Bloomberg School of Public Health
Biostatistics

2010
MHS | Johns Hopkins Bloomberg School of Public Health
Bioinformatics

Publications

Journal Articles

3/12/2023
Nieuwenhuis TO, Giles HH, McCall MN, Halushka MK. "Patterns of unwanted biological and technical expression variation across 49 human tissues." bioRxiv : the preprint server for biology.. 2023 Mar 12; Epub 2023 Mar 12.

1/23/2023
Vonkaenel E, Feidler A, Lowery R, Andersh K, Love T, Majewska A, Mccall MN. "A Model-Based Hierarchical Bayesian Approach to Sholl Analysis." bioRxiv : the preprint server for biology.. 2023 Jan 23; Epub 2023 Jan 23.

2023
Cealie MY, Douglas JC, Le LHD, Vonkaenel ED, McCall MN, Drew PD, Majewska AK. "Developmental ethanol exposure has minimal impact on cerebellar microglial dynamics, morphology, and interactions with Purkinje cells during adolescence." Frontiers in neuroscience.. 2023 17:1176581. Epub 2023 May 05.

VIEW ALL PUBLICATIONS