CONTACT INFORMATIONBIOGRAPHYCREDENTIALSPUBLICATIONSMatthew N. McCall, Ph.D., M.H.S.(Pronouns: he/him/his)Contact InformationResearch LabsMcCall Lab WebsiteVisit McCall Lab Website Lab WebsiteLocationsUniversity of Rochester Medical CenterSchool of Medicine and Dentistry601 Elmwood Ave, Box 630Rochester, NY 14642Faculty AppointmentsAssociate Professor - Department of Biostatistics and Computational Biology (SMD) Associate Professor - Department of Biomedical Engineering (SMD) - JointBiographyMy research interests are in statistical genomics and systems biology. Currently, I am focusing on developing methods to estimate gene regulatory networks from gene pertubation experiments, using microRNA signatures to predict recurrence of hepatocellular carcinoma after liver transplantation, and examining the effect of cellular composition on tissue-level gene expression. I received a Ph.D. in Biostatistics from The Johns Hopkins University under the supervision of Rafael Irizarry. My thesis work focused on developing statistical methodology for preprocessing and analysis of data from a single microarray.Professional BackgroundIn 2010, I received a PhD in Biostatistics and an MHS in Bioinformatics from the Johns Hopkins School of Public Health under the supervision of Dr. Rafael Irizarry. From 2010 to 2014, I worked as a Postdoctoral Fellow at the University of Rochester Medical Center under the mentorship of Drs. Anthony Almudevar and Hartmut Land. In the fall of 2014, I accepted a position as an Assistant Professor in the Department of Biostatistics and Computational Biology with a joint appointment in the Department of Biomedical Genetics at the University of Rochester Medical Center.ResearchMy research interests are in statistical genomics, systems biology, and bioinformatics. Currently, I am focusing on: (1) developing methods to estimate gene regulatory networks involved in cancer from perturbation experiments, (2) examining the effect of cellular composition on tissue-level gene expression, (3) tackling within-subject genomic heterogeneity, focusing on predicting recurrence of hepatocellular carcinoma after liver transplantation, and (4) developing methods for preprocessing and analysis of genomic data.CredentialsEducation2004BS | University of MichiganStatistics2010PhD | Johns Hopkins Bloomberg School of Public HealthBiostatistics2010MHS | Johns Hopkins Bloomberg School of Public HealthBioinformaticsPublicationsJournal Articles12/28/2021McCall MN, Chu CY, Wang L, Benoodt L, Thakar J, Corbett A, Holden-Wiltse J, Slaunwhite C, Grier A, Gill SR, Falsey AR, Topham DJ, Caserta MT, Walsh EE, Qiu X, Mariani TJ. "A systems genomics approach uncovers molecular associates of RSV severity." PLoS computational biology.. 2021 Dec 28; 17(12):e1009617. Epub 2021 Dec 28. 12/21/2021McMurray HR, Ambeskovic A, Newman LA, Aldersley J, Balakrishnan V, Smith B, Stern HA, Land H, McCall MN. "Gene network modeling via TopNet reveals functional dependencies between diverse tumor-critical mediator genes." Cell reports.. 2021 Dec 21; 37(12):110136. 9/30/2021Croft DP, Burton DS, Nagel DJ, Bhattacharya S, Falsey AR, Georas SN, Hopke PK, Johnston CJ, Kottmann RM, Litonjua AA, Mariani TJ, Rich DQ, Thevenet-Morrison K, Thurston SW, Utell MJ, McCall MN. "The effect of air pollution on the transcriptomics of the immune response to respiratory infection." Scientific reports.. 2021 Sep 30; 11(1):19436. Epub 2021 Sep 30. VIEW ALL PUBLICATIONSClose WindowSchedule an appointment with Matthew N. McCall, Ph.D., M.H.S.Please answer the following questions to help us find the right appointment for you.Important: If you believe that you have a medical or psychiatric emergency, please call 911 or go to the nearest hospital. This website is not intended for emergency care.Have you seen this provider in the last 2 years?YesNoExisting Patient Schedule or request a follow up appointment online through MyChart. If you do not have a MyChart account, please close this window and call the appointment phone number. Matthew N. McCall, Ph.D., M.H.S. is currently scheduling for the following appointment type(s): Our policy does not permit patients to establish care with multiple providers within the same practice or specialty without prior approval. If you choose a new provider in the same office, we will cancel the appointment. Please contact the office directly with questions on this policy.