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Matthew N. McCall, Ph.D., M.H.S.

(Pronouns: he/him/his)

Contact Information

Research Labs

Faculty Appointments

Biography

My research interests are in statistical genomics and systems biology. Currently, I am focusing on developing methods to estimate gene regulatory networks from gene pertubation experiments, using microRNA signatures to predict recurrence of hepatocellular carcinoma after liver transplantation, and examining the effect of cellular composition on tissue-level gene expression.

I received a Ph.D. in Biostatistics from The Johns Hopkins University under the supervision of Rafael Irizarry. My thesis work focused on developing statistical methodology for preprocessing and analysis of data from a single microarray.

Professional Background

In 2010, I received a PhD in Biostatistics and an MHS in Bioinformatics from the Johns Hopkins School of Public Health under the supervision of Dr. Rafael Irizarry. From 2010 to 2014, I worked as a Postdoctoral Fellow at the University of Rochester Medical Center under the mentorship of Drs. Anthony Almudevar and Hartmut Land. In the fall of 2014, I accepted a position as an Assistant Professor in the Department of Biostatistics and Computational Biology with a joint appointment in the Department of Biomedical Genetics at the University of Rochester Medical Center.

Research

My research interests are in statistical genomics, systems biology, and bioinformatics. Currently, I am focusing on: (1) developing methods to estimate gene regulatory networks involved in cancer from perturbation experiments, (2) examining the effect of cellular composition on tissue-level gene expression, (3) tackling within-subject genomic heterogeneity, focusing on predicting recurrence of hepatocellular carcinoma after liver transplantation, and (4) developing methods for preprocessing and analysis of genomic data.

Credentials

Education

2004
BS | University of Michigan
Statistics

2010
PhD | Johns Hopkins Bloomberg School of Public Health
Biostatistics

2010
MHS | Johns Hopkins Bloomberg School of Public Health
Bioinformatics

Publications

Journal Articles

1/19/2022
Lowery RL, Latchney SE, Peer RP, Lamantia CE, Lordy KA, Opanashuk LA, McCall M, Majewska AK. "Gestational and lactational exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin primes cortical microglia to tissue injury." Brain, behavior, and immunity.. 2022 Jan 19; Epub 2022 Jan 19.

12/28/2021
McCall MN, Chu CY, Wang L, Benoodt L, Thakar J, Corbett A, Holden-Wiltse J, Slaunwhite C, Grier A, Gill SR, Falsey AR, Topham DJ, Caserta MT, Walsh EE, Qiu X, Mariani TJ. "A systems genomics approach uncovers molecular associates of RSV severity." PLoS computational biology.. 2021 Dec 28; 17(12):e1009617. Epub 2021 Dec 28.

12/21/2021
McMurray HR, Ambeskovic A, Newman LA, Aldersley J, Balakrishnan V, Smith B, Stern HA, Land H, McCall MN. "Gene network modeling via TopNet reveals functional dependencies between diverse tumor-critical mediator genes." Cell reports.. 2021 Dec 21; 37(12):110136.

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