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Paul Dunman, Ph.D.

Contact Information

Phone Numbers

Appointment: (585) 276-3000

Research Labs

Characterizing the S. aureus factors that influence Staphylococcus aureus' ability to cause disease, as well as define the regulatory mechanism(s) that modulate the expression of these genes.

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Biography

Research

Dunman Laboratory Research Overview:

Staphylococcus aureus is a Gram-positive bacterial pathogen that is reported to cause more U.S. deaths annually than HIV. Acinetobacter baumannii is a Gram-negative pathogen that is emerging as a predominant cause of infections within military personnel injured during Operation Iraqi Freedom and has recently caused deadly outbreaks in the U.S., South America, and Europe. In addition to causing high incidences of morbidity and mortality, both organisms have also developed resistance to all currently available antibiotics, further amplifying public health concern and accentuating the need for new antibiotics for the treatment of S. aureus and A. baumannii infections.

Our laboratory uses S. aureus and A. baumannii as model organisms to study bacterial pathogenesis and develop novel strategies for the therapeutic intervention of bacterial infections. That work has revealed that most bacterial virulence factors are post-transcriptionally regulated in a manner that involves the modulation of their mRNA turnover. Current laboratory projects are geared toward characterizing the molecular components that govern 'native' and temporal changes in mRNA degradation. These factors can be broadly categorized as either: small non-coding RNAs, ribonucleases, or RNA binding proteins. We have purified and exploited several of these factors as targets for antimicrobial drug discovery.

Relevant Recent Publications:

1. Small molecule inhibitors of Staphylococcus aureus RnpA alter cellular mRNA turnover, exhibit antimicrobial activity, and attenuate pathogenesis. Olson PD, Kuechenmeister LJ, Anderson KL, Daily S, Beenken KE, Roux CM, Reniere ML, Lewis TL, Weiss WJ, Pulse M, Nguyen P, Simecka JW, Morrison JM, Sayood K, Asojo OA, Smeltzer MS, Skaar EP, and Dunman PM. PLoS Pathogens 2011 (in press).


2. Characterizing the effects of inorganic acid and alkaline shock on the Staphylococcus aureus transcriptome and messenger RNA turnover. Anderson KL, Roux CM, Olson MW, Luong TT, Lee CY, Olson R, and Dunman PM. FEMS Immunol Med Microbiol 2010 60(3):208.

3. Staphylococcus aureus nonribosomal peptide secondary metabolites regulate virulence. Wyatt MA, Wang W, Roux CM, Beasley FC, Heinrichs DE, Dunman PM and Magarvey NA. Science 2010 329(5989):294.

4. Inactivation of phospholipase D diminishes Acinetobacter baumannii pathogenesis. Jacobs AC, Hood I, Boyd KL, Olson PD, Morrison JM, Carson S, Sayood K, Iwen PC, Skaar EP, and Dunman PM. Infect Immun 2010 78(5):1952.

Credentials

Faculty Appointments

Education

1992
BS | Delaware Valley College
Arts & Sciences

1999
PhD | Univ of Medicine and Dentistry-NJ (UMDNJ)
Microbiology

Awards

2010
Distinguished Investigator
Sponsor: University of Nebraska Medical Center

2009
Joseph P. Gilmore Outstanding Investigator Award
Sponsor: University of Nebraska Medical Center

2009
Most Promising New Invention Notification
Sponsor: University of Nebraska Medical Center

2003
Young Investigator of the Year
Sponsor: International Conference on Antimicrobial Agents and Chemotherap

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Publications

Journal Articles

11/17/2016
Choby JE, Mike LA, Mashruwala AA, Dutter BF, Dunman PM, Sulikowski GA, Boyd JM, Skaar EP. "A Small-Molecule Inhibitor of Iron-Sulfur Cluster Assembly Uncovers a Link between Virulence Regulation and Metabolism in Staphylococcus aureus." Cell chemical biology.. 2016 Nov 17; 23(11):1351-1361. Epub 2016 Oct 20.

2/2016
Blanchard C, Brooks L, Beckley A, Colquhoun J, Dewhurst S, Dunman PM. "Neomycin Sulfate Improves the Antimicrobial Activity of Mupirocin-Based Antibacterial Ointments." Antimicrobial agents and chemotherapy.. 2016 Feb 0; 60(2):862-72. Epub 2015 Nov 23.

2016
Blanchard C, Brooks L, Ebsworth-Mojica K, Didione L, Wucher B, Dewhurst S, Krysan D, Dunman PM, Wozniak RA. "Zinc Pyrithione Improves the Antibacterial Activity of Silver Sulfadiazine Ointment." mSphere.. 2016 1(5)Epub 2016 Sep 14.

Books & Chapters

2003
Chapter Title: Expression Profiling Uses in Antibacterial Chemotherapy Development.
Book Title: Microbial Genomics and Drug Discovery.
Author List: Dunman, P.M. and S.J. Projan.
Edited By: T.J. Dougherty and S.J. Projan
Published By: Marcel Dekker Inc. New York.2003

2001
Chapter Title: The regulation of virulence in the Staphylococci.
Book Title: Staphylococcal infection a
Author List: Dunman, P.M. and S.J. Projan.
Edited By: A. Honeyman, H. Friedman, and M. Bendinelli (ed.),
Published By: Kluwer Academic/Plenum Publishers, New York.2001

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