Paul Dunman, Ph.D.

Contact Information

Phone Numbers

Research Labs

Characterizing the S. aureus factors that influence Staphylococcus aureus' ability to cause disease, as well as define the regulatory mechanism(s) that modulate the expression of these genes.

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Locations

University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 672
Rochester, NY 14642

Faculty Appointments

Associate Professor - Department of Microbiology and Immunology (SMD)

Biography

Research

Dunman Laboratory Research Overview:

Staphylococcus aureus is a Gram-positive bacterial pathogen that is reported to cause more U.S. deaths annually than HIV. Acinetobacter baumannii is a Gram-negative pathogen that is emerging as a predominant cause of infections within military personnel injured during Operation Iraqi Freedom and has recently caused deadly outbreaks in the U.S., South America, and Europe. In addition to causing high incidences of morbidity and mortality, both organisms have also developed resistance to all currently available antibiotics, further amplifying public health concern and accentuating the need for new antibiotics for the treatment of S. aureus and A. baumannii infections.

Our laboratory uses S. aureus and A. baumannii as model organisms to study bacterial pathogenesis and develop novel strategies for the therapeutic intervention of bacterial infections. That work has revealed that most bacterial virulence factors are post-transcriptionally regulated in a manner that involves the modulation of their mRNA turnover. Current laboratory projects are geared toward characterizing the molecular components that govern 'native' and temporal changes in mRNA degradation. These factors can be broadly categorized as either: small non-coding RNAs, ribonucleases, or RNA binding proteins. We have purified and exploited several of these factors as targets for antimicrobial drug discovery.

Relevant Recent Publications:

1. Small molecule inhibitors of Staphylococcus aureus RnpA alter cellular mRNA turnover, exhibit antimicrobial activity, and attenuate pathogenesis. Olson PD, Kuechenmeister LJ, Anderson KL, Daily S, Beenken KE, Roux CM, Reniere ML, Lewis TL, Weiss WJ, Pulse M, Nguyen P, Simecka JW, Morrison JM, Sayood K, Asojo OA, Smeltzer MS, Skaar EP, and Dunman PM. PLoS Pathogens 2011 (in press).

2. Characterizing the effects of inorganic acid and alkaline shock on the Staphylococcus aureus transcriptome and messenger RNA turnover. Anderson KL, Roux CM, Olson MW, Luong TT, Lee CY, Olson R, and Dunman PM. FEMS Immunol Med Microbiol 2010 60(3):208.

3. Staphylococcus aureus nonribosomal peptide secondary metabolites regulate virulence. Wyatt MA, Wang W, Roux CM, Beasley FC, Heinrichs DE, Dunman PM and Magarvey NA. Science 2010 329(5989):294.

4. Inactivation of phospholipase D diminishes Acinetobacter baumannii pathogenesis. Jacobs AC, Hood I, Boyd KL, Olson PD, Morrison JM, Carson S, Sayood K, Iwen PC, Skaar EP, and Dunman PM. Infect Immun 2010 78(5):1952.

Credentials

Education

1992
BS | Delaware Valley College
Arts & Sciences

1999
PhD | Univ of Medicine and Dentistry-NJ (UMDNJ)
Microbiology

Post-doctoral Training & Residency

1999 - 2001
Wyeth Research; Post-Doctoral Fellow (Infectious Disease)

Awards

2010
Distinguished Investigator
Sponsor: University of Nebraska Medical Center

2009
Joseph P. Gilmore Outstanding Investigator Award
Sponsor: University of Nebraska Medical Center

2009
Most Promising New Invention Notification
Sponsor: University of Nebraska Medical Center

2003
Young Investigator of the Year
Sponsor: International Conference on Antimicrobial Agents and Chemotherap

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Patents

Patent Title: Synergistic Compositions for Treating Microbial Infections
Patent #: 3212183
Issue Date: Oct 02, 2019
Country: Europe
Invented By: Wayne Childers, Paul M Dunman

Patent Title: Synergistic Compositions for Treating Microbial Infections
Patent #: FR3212183
Issue Date: Oct 02, 2019
Country: France
Invented By: Wayne Childers, Paul M Dunman

Patent Title: Synergistic Compositions for Treating Microbial Infections
Patent #: DE3212183
Issue Date: Oct 02, 2019
Country: Germany
Invented By: Wayne Childers, Paul M Dunman

Patent Title: Synergistic Compositions for Treating Microbial Infections
Patent #: GB3212183
Issue Date: Oct 02, 2019
Country: United Kingdom
Invented By: Wayne Childers, Paul M Dunman

Patent Title: Synergistic Compositions for Treating Microbial Infections
Patent #: 6590924
Issue Date: Sep 27, 2019
Country: Japan
Invented By: Wayne Childers, Paul M Dunman

Patent Title: Synergistic Compositions for Treating Microbial Infections
Patent #: 10,028,931
Issue Date: Jul 24, 2018
Country: United States
Invented By: Wayne Childers, Paul M Dunman

Patent Title: Small Molecule RNase Inhibitors and Methods of Use (RNPase2000)
Patent #: 6010548
Issue Date: Sep 23, 2016
Country: Japan
Invented By: Wayne Childers, Paul M Dunman, Patrick D Olson

Patent Title: Small Molecule RNase Inhibitors and Methods of Use (RNPase3000)
Patent #: 6248151
Issue Date: Nov 24, 2017
Country: Japan
Invented By: Wayne Childers, Paul M Dunman, Patrick D Olson

Patent Title: Small Molecule RNase Inhibitors and Methods of Use
Patent #: 2,825,907
Issue Date: Jul 30, 2019
Country: Canada
Invented By: Wayne Childers, Paul M Dunman, Patrick D Olson

Patent Title: Small Molecule RNase Inhibitors and Methods of Use
Patent #: 3243513
Issue Date: Jun 05, 2019
Country: Europe
Invented By: Wayne Childers, Paul M Dunman, Patrick D Olson

Patent Title: Small Molecule RNase Inhibitors and Methods of Use
Patent #: FR3243513
Issue Date: Jun 05, 2019
Country: France
Invented By: Wayne Childers, Paul M Dunman, Patrick D Olson

Patent Title: Small Molecule RNase Inhibitors and Methods of Use
Patent #: 6020120608226
Issue Date: Jun 05, 2019
Country: Germany
Invented By: Wayne Childers, Paul M Dunman, Patrick D Olson

Patent Title: Small Molecule RNase Inhibitors and Methods of Use
Patent #: GB3243513
Issue Date: Jun 05, 2019
Country: United Kingdom
Invented By: Wayne Childers, Paul M Dunman, Patrick D Olson

Patent Title: Small Molecule RNase Inhibitors and Methods of Use
Patent #: 2,825,905
Issue Date: Jun 04, 2019
Country: Canada
Invented By: Wayne Childers, Paul M Dunman, Patrick D Olson

Patent Title: Small Molecule RNase Inhibitors and Methods of Use
Patent #: 2667872
Issue Date: Jan 02, 2019
Country: Europe
Invented By: Wayne Childers, Paul M Dunman, Patrick D Olson

Patent Title: Small Molecule RNase Inhibitors and Methods of Use
Patent #: FR2667872
Issue Date: Jan 02, 2019
Country: France
Invented By: Wayne Childers, Paul M Dunman, Patrick D Olson

Patent Title: Small Molecule RNase Inhibitors and Methods of Use
Patent #: 602012055416.9
Issue Date: Jan 02, 2019
Country: Germany
Invented By: Wayne Childers, Paul M Dunman, Patrick D Olson

Patent Title: Small Molecule RNase Inhibitors and Methods of Use
Patent #: GB2667872
Issue Date: Jan 02, 2019
Country: United Kingdom
Invented By: Wayne Childers, Paul M Dunman, Patrick D Olson

Patent Title: Small Molecule RNase Inhibitors and Methods of Use
Patent #: 2016225942
Issue Date: Dec 18, 2017
Country: Australia
Invented By: Wayne Childers, Paul M Dunman, Patrick D Olson

Patent Title: Small Molecule RNase Inhibitors and Methods of Use
Patent #: 9,693,999
Issue Date: Jul 04, 2017
Country: United States
Invented By: Wayne Childers, Paul M Dunman, Patrick D Olson

Patent Title: Small Molecule RNase Inhibitors and Methods of Use
Patent #: 2667873
Issue Date: May 31, 2017
Country: Europe
Invented By: Wayne Childers, Paul M Dunman, Patrick D Olson

Patent Title: Small Molecule RNase Inhibitors and Methods of Use
Patent #: FR2667873
Issue Date: May 31, 2017
Country: France
Invented By: Wayne Childers, Paul M Dunman, Patrick D Olson

Patent Title: Small Molecule RNase Inhibitors and Methods of Use
Patent #: 602012032962.9
Issue Date: May 31, 2017
Country: Germany
Invented By: Wayne Childers, Paul M Dunman, Patrick D Olson

Patent Title: Small Molecule RNase Inhibitors and Methods of Use
Patent #: GB2667873
Issue Date: May 31, 2017
Country: United Kingdom
Invented By: Wayne Childers, Paul M Dunman, Patrick D Olson

Patent Title: Small Molecule RNase Inhibitors and Methods of Use
Patent #: 2012211299
Issue Date: May 18, 2017
Country: Australia
Invented By: Wayne Childers, Paul M Dunman, Patrick D Olson

Patent Title: Small Molecule RNase Inhibitors and Methods of Use
Patent #: 2012211253
Issue Date: Feb 23, 2017
Country: Australia
Invented By: Wayne Childers, Paul M Dunman, Patrick D Olson

Patent Title: Small Molecule RNase Inhibitors and Methods of Use
Patent #: ZL201280015124.6
Issue Date: Feb 08, 2017
Country: China, People's Republic of
Invented By: Wayne Childers, Paul M Dunman, Patrick D Olson

Patent Title: Small Molecule RNase Inhibitors and Methods of Use
Patent #: 9,517,230
Issue Date: Dec 13, 2016
Country: United States
Invented By: Wayne Childers, Paul M Dunman, Patrick D Olson

Patent Title: Small Molecule RNase Inhibitors and Methods of Use
Patent #: 9,233,095
Issue Date: Jan 12, 2016
Country: United States
Invented By: Wayne Childers, Paul M Dunman, Patrick D Olson

Patent Title: Small Molecule RNase Inhibitors and Methods of Use
Patent #: 9,089,545
Issue Date: Jul 28, 2015
Country: United States
Invented By: Wayne Childers, Paul M Dunman, Patrick D Olson

Patent Title: Methods and Compositions for Treating Infection
Patent #: 10,004,701
Issue Date: Jun 26, 2018
Country: United States
Invented By: Paul M Dunman, Dan Flaherty, Damian J Krysan

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Publications

Journal Articles

7/22/2019
Chojnacki M, Philbrick A, Scherzi T, Pecora N, Dunman PM, Wozniak RAF. "A novel, broad-spectrum antimicrobial combination for the treatment of corneal infections." Antimicrobial agents and chemotherapy.. 2019 Jul 22; Epub 2019 Jul 22.

2/22/2019
Trombetta RP, Ninomiya MJ, El-Atawneh IM, Knapp EK, de Mesy Bentley KL, Dunman PM, Schwarz EM, Kates SL, Awad HA. "Calcium Phosphate Spacers for the Local Delivery of Sitafloxacin and Rifampin to Treat Orthopedic Infections: Efficacy and Proof of Concept in a Mouse Model of Single-Stage Revision of Device-Associated Osteomyelitis." Pharmaceutics.. 2019 Feb 22; 11(2)Epub 2019 Feb 22.

1/2019
Chojnacki M, Philbrick A, Wucher B, Reed JN, Tomaras A, Dunman PM, Wozniak RAF. "Development of a Broad-Spectrum Antimicrobial Combination for the Treatment of Staphylococcus aureus and Pseudomonas aeruginosa Corneal Infections." Antimicrobial agents and chemotherapy.. 2019 Jan 0; 63(1)Epub 2018 Dec 21.

Books & Chapters

2003
Chapter Title: Expression Profiling Uses in Antibacterial Chemotherapy Development.
Book Title: Microbial Genomics and Drug Discovery.
Author List: Dunman, P.M. and S.J. Projan.
Edited By: T.J. Dougherty and S.J. Projan
Published By: Marcel Dekker Inc. New York. 2003

2001
Chapter Title: The regulation of virulence in the Staphylococci.
Book Title: Staphylococcal infection a
Author List: Dunman, P.M. and S.J. Projan.
Edited By: A. Honeyman, H. Friedman, and M. Bendinelli (ed.),
Published By: Kluwer Academic/Plenum Publishers, New York. 2001

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