CONTACT INFORMATIONBIOGRAPHYCREDENTIALSPUBLICATIONSDean G. Johnson, Ph.D.(Pronouns: he/him/his)Contact InformationLocationsUniversity of Rochester Medical CenterSchool of Medicine and Dentistry601 Elmwood Ave, Box 675Rochester, NY 14642Faculty AppointmentsResearch Assistant Professor - Department of Medicine , Nephrology (SMD) Research Assistant Professor - Department of Biomedical Engineering (SMD) - JointBiographyProfessional BackgroundEDUCATION Ph.D. Microsystems Engineering, Rochester Institute of Technology 2013 Thesis: Integration Technologies for Implantable Microsystems MS Electrical Engineering, Michigan State University 1990 BS Electrical Engineering / Computer Engineering, Michigan State University 1988 ACADEMIC EXPERIENCE University of Rochester Medical Center, Department of Medicine/Division of Nephrology 2021 – present Research Assistant Professor Grants: 1. NIH NIDDK R01 (five years) 2. NIH NIDDK K25 (five years) University of Rochester, Biomedical Engineering Research Assistant Professor 2017 – 2021 Mentor undergraduate Biomedical Engineering students in Senior Design Teams. Co-advise a BME Master's student. PI for Three grants: 1. NIH NIDDK R01 (five years) 2. NIH NIDDK K25 (five years) 3. Fresenius Fellowship (two years) Postdoctoral Fellow 2013 – 2017 The research included wearable/portable hemodialysis devices with ultrathin nanoporous membranes. Laboratory work includes a variety of projects in MEMs, medical devices, and renal replacement therapy, with a strong focus on therapy-directed Microsystems. Teaching includes: MEMs Fabrication, Finite Element Analysis for MEMs Rochester Institute of Technology Graduate Research Assistant 2005 – 2013 Research of implantable microsystems for intra-cochlear drug delivery (NIH NIDCD). Developed a novel phase change actuation mechanism and has published numerous articles in technical literature. Graduate Teaching Assistant Lab instructor: Biomedical Sensors and Transducers, Fundamental Electrophysiology ACADEMIC SERVICE University of Rochester Medical Center, Facilitator: Ethics Course 2018-2021 University of Rochester, Science Buddies Outreach Program 2013 Rochester Institute of Technology, McNair Scholars Program 2009 PROFESSIONAL EXPERIENCE Xerox Corporation 1990 – 2004 Software Application Engineer MILITARY EXPERIENCE Sergeant, United States Marine Corps Reserves 1984 – 1990ResearchDean Johnson is a Research Assistant Professor in the Nephrology Division at the University of Rochester Medical Center in the Department of Medicine. Over the past eight years, beginning as a Postdoctoral Fellow, Dr. Johnson has worked on developing the skills and tools needed to successfully perform the research needed to develop a novel miniaturized hemodialysis dialyzer. The goal of this proposal is to develop an integrated microfluidic system in the form of a wearable hemodialysis dialyzer with ultrathin, nanoporous, sheet membranes. Both my training and experience prepare me to successfully carry out the work proposed in this application. He completed a multidisciplinary doctoral degree in microsystems engineering with training in MEMS and system engineering. As a Ph.D. candidate, he developed integration technologies that brought together MEMS fabrication, direct-write processing, and room temperature polymer deposition in the creation of a biocompatible micropump for intracochlear infusions in the mouse model. As a faculty researcher, Dr. Johnson has developed benchtop membrane chip dialyzers that clear toxins at rates comparable to those of clinical hemodialysis and successfully tested these chip-based membranes in small-animal model hemodialysis experiments. He is a member of the Nanomembrane Research Group, which holds weekly meetings at the University of Rochester and Rochester Institute of Technology where developments and diverse applications of the ultrathin nanoporous membranes are discussed s and also attends Nephrology seminars at the University of Rochester Medical Center. To improve both health outcomes and the quality of life for those on HD my lab is working on technologies to enable portable or wearable HD. The best hope for a healthier future for ESRD patients, short of a replacement kidney, is the emergence of disruptive technologies in HD therapy. The goal of my lab will be to develop MEMS technologies and devices for medical sensors, diagnostics, and therapies. My current research focuses on exploiting the properties of ultrathin nanoporous membranes to enable portable/wearable hemodialysis devices for renal replacement therapy. My group is developing an in vitro benchtop large animal model simulator and has experience with microdialysis, small-format device hemodialysis, uremic toxin metrology, and Multiphysics modeling (COMSOL). In the next three years, I will improve benchtop tests and techniques to help bring compact dialysis devices from benchtop to clinical trials, reducing the number of animals used in pre-clinical trials. I will investigate basic research questions regarding hemodialysis, ESRD, AKI, and other kidney disorders through the development of more efficient HD devices and microfluidic-based diagnostic and benchtop tools. Benchtop tools may include nephron on a chip, kidney on a chip, and a benchtop model of the human vasculature including uremic toxin compartments. My research lab will investigate toxin detection, biomarkers, and therapeutic techniques through the application of these tools.PublicationsJournal Articles6/6/2020Miller JJ, Carter JA, Hill K, DesOrmeaux JS, Carter RN, Gaborski TR, Roussie JA, McGrath JL, Johnson DG. "Free Standing, Large-Area Silicon Nitride Membranes for High Toxin Clearance in Blood Surrogate for Small-Format Hemodialysis." Membranes.. 2020 Jun 6; 10(6)Epub 2020 Jun 06. 1/15/2020Hill K, Walker SN, Salminen A, Chung HL, Li X, Ezzat B, Miller JJ, DesOrmeaux JS, Zhang J, Hayden A, Burgin T, Piraino L, May MN, Gaborski TR, Roussie JA, Taylor J, DiVincenti L, Shestopalov AA, McGrath JL, Johnson DG. "Second Generation Nanoporous Silicon Nitride Membranes for High Toxin Clearance and Small Format Hemodialysis." Advanced healthcare materials.. 2020 Jan 15; :e1900750. Epub 2020 Jan 15. 7/2018Salminen A, Hill K, Henry Chung L, James McGrath L, Johnson DG. "Protein Separation and Hemocompatibility of Nitride Membranes in Microfluidic Filtration Systems." Annual International Conference of the IEEE Engineering in Medicine and Biology Society.. 2018 Jul; 2018:5814-5817. VIEW ALL PUBLICATIONSClose WindowSchedule an appointment with Dean G. Johnson, Ph.D.Please answer the following questions to help us find the right appointment for you.Important: If you believe that you have a medical or psychiatric emergency, please call 911 or go to the nearest hospital. This website is not intended for emergency care.Have you seen this provider in the last 2 years?YesNoExisting Patient Schedule or request a follow up appointment online through MyChart. If you do not have a MyChart account, please close this window and call the appointment phone number. Dean G. 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