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Jennetta W. Hammond, Ph.D.

Contact Information

Phone Numbers

Office: (585) 273-2872

Faculty Appointments

Biography

Research

My research interests are focused on uncovering neuro-immune mechanisms driving synapse and neuron turnover as well as microglia dysregulation throughout the lifespan. Most of my current projects focus on regulation of the complement pathway in the CNS. I have identified and begun characterizing novel complement inhibitory proteins that are specifically expressed in neurons, namely the Sez6 family and Srpx2. These complement inhibitors may serve as protective factors to preserve neurons and neuronal connections during critical windows in brain development when complement is engaged to prune away excess connections. These same complement inhibitors also appear to play a protective role in aging and are likely very important in pathological conditions with heightened inflammation and complement activation like multiple sclerosis.

Credentials

Education

2002
BS | Brigham Young University
Zoology

2008
PhD | University of Michigan
Cell and Developmental Biology

Post-doctoral Training & Residency

11/01/2012 - 01/31/2018
University of Rochester Medical Center; Center for Neurotherapeutics Discovery. Advisor: Harris Gelbard

Awards

2015
Trainee Professional Development Award
Sponsor: Society for Neuroscience

Publications

Journal Articles

3/8/2021
Urban JM, Chiang W, Hammond JW, Cogan NMB, Litzburg A, Burke R, Stern HA, Gelbard HA, Nilsson BL, Krauss TD. "Quantum Dots for Improved Single-Molecule Localization Microscopy." The journal of physical chemistry. B. 2021 Mar 8; Epub 2021 Mar 08.

2021
Qiu WQ, Luo S, Ma SA, Saminathan P, Li H, Gunnersen JM, Gelbard HA, Hammond JW. "The Sez6 Family Inhibits Complement by Facilitating Factor I Cleavage of C3b and Accelerating the Decay of C3 Convertases." Frontiers in immunology.. 2021 12:607641. Epub 2021 Apr 15.

10/1/2020
Nguyen L, Laboissonniere LA, Guo S, Pilotto F, Scheidegger O, Oestmann A, Hammond JW, Li H, Hyysalo A, Peltola R, Pattamatta A, Zu T, Voutilainen MH, Gelbard HA, Saxena S, Ranum LPW. "Survival and Motor Phenotypes in FVB C9-500 ALS/FTD BAC Transgenic Mice Reproduced by Multiple Labs." Neuron.. 2020 Oct 1; Epub 2020 Oct 01.

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