Jennetta W. Hammond, Ph.D.

My research interests are focused on uncovering neuro-immune mechanisms driving synapse and neuron turnover as well as microglia dysregulation throughout the lifespan. Most of my current projects focus on regulation of the complement pathway in the CNS. I have identified and begun characterizing novel complement inhibitory proteins that are specifically expressed in neurons, namely the Sez6 family and Srpx2. These complement inhibitors may serve as protective factors to preserve neurons and neuronal connections during critical windows in brain development when complement is engaged to prune away excess connections. These same complement inhibitors also appear to play a protective role in aging and are likely very important in pathological conditions with heightened inflammation and complement activation like multiple sclerosis.