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Xi Lin, Ph.D.

Contact Information

Phone Numbers

Office: (585) 275-5945

Faculty Appointments


Professional Background

Dr. Xi Lin obtained her medical degree at Xiangya School of Medicine, China in 2014, and her Ph.D in Pathology at University of Rochester in 2019, where she studied the role of the lymphatic system in the pathogenesis of osteoarthritis. She continued her research as a postdoctoral fellow in Dr. Lianping Xing’s laboratory from 2019 to 2022, where she worked on the lymphatic signaling VEGF-C/VEGFR3 pathway in osteoarthritis and skeletal muscle stem cell in fracture during aging. In 2022, Dr. Lin joined the Department of Pathology as a research assistant professor.


Dr. Lin's research focuses on the pathology and mechanisms of osteoarthritis. She is interested in how changes in the synovial tissues surrounding the joint modulate osteoarthritis pathology post-injury or during natural aging. She has expertise in genetic and surgical murine models of osteoarthritis, in vivo imaging techniques, in vivo and in vitro cellular and molecular biology techniques, and histology/immunohistochemistry/immunocytology. She also utilizes bioinformatics analysis as a tool to generate novel hypotheses and validate experimental findings by analyzing independent published datasets.


Journal Articles

Lin X, Bell RD, Catheline SE, Takano T, McDavid A, Jonason JH, Schwarz EM, Xing L. "Targeting synovial lymphatic function as a novel therapeutic intervention for age-related osteoarthritis in mice." Arthritis & rheumatology.. 2023 Jan 10; Epub 2023 Jan 10.

Liu J, Lin X, McDavid A, Yang Y, Zhang H, Boyce BF, Xing L. "Molecular signatures distinguish senescent cells from inflammatory cells in aged mouse callus stromal cells." Frontiers in endocrinology.. 2023 14:1090049. Epub 2023 Feb 16.

Liu J, Zhang J, Lin X, Boyce BF, Zhang H, Xing L. "Age-associated callus senescent cells produce TGF-?1 that inhibits fracture healing in aged mice." The Journal of clinical investigation.. 2022 Apr 15; 132(8)