Skip to main content
Explore URMC

URMC Logo

menu

Antti E. Seppo, Ph.D.

Contact Information

Phone Numbers

Appointment: (585) 276-3000

Biography

Research

My short-term research interest is to develop an understanding of the factors that predispose and cause food allergies in children, and to understand predictive indicators of the severity of allergic reactions in children and adults.

Understanding of the predisposing and causative factors will help to develop strategies to prevent allergies in children. My research aims to evaluate genetic factors by applying genomic and transcriptomic techniques and environment related factors by biochemical screening of biomarkers.

Generating predictors of food allergy severity will enable better management of newly diagnosed food allergy patients. These predictors will be established by evaluating tests that measure aspects of humoral and cellular immune response in vitro, and selecting promising candidate markers for clinical evaluation.

My long-term interest is to understand the fundamental mechanisms in the developing human immune system and particularly mechanisms that upon failure cause allergic disease. This understanding will in part come from observations in the studies of allergy relevant factors, and in part from mechanistic studies involving candidate pathways of early immune system development.

Separate form allergy research my research interest also include integration of leading edge biocomputing methods into cell based assay research, especially in connection with image analysis.

Credentials

Faculty Appointments

Education

1996
PhD | Finland-University of Helsinki
Biotechnology

Publications

Journal Articles

7/16/2013
Gerdes MJ, Sevinsky CJ, Sood A, Adak S, Bello MO, Bordwell A, Can A, Corwin A, Dinn S, Filkins RJ, Hollman D, Kamath V, Kaanumalle S, Kenny K, Larsen M, Lazare M, Li Q, Lowes C, McCulloch CC, McDonough E, Montalto MC, Pang Z, Rittscher J, Santamaria-Pang A, Sarachan BD, Seel ML, Seppo A, Shaikh K, Sui Y, Zhang J, Ginty F. "Highly multiplexed single-cell analysis of formalin-fixed, paraffin-embedded cancer tissue." Proceedings of the National Academy of Sciences of the United States of America.. 2013 Jul 16; 110(29):11982-7. Epub 2013 Jul 01.

7/2011
López-Expósito I, Järvinen KM, Castillo A, Seppo AE, Song Y, Li XM. "Maternal peanut consumption provides protection in offspring against peanut sensitization that is further enhanced when co-administered with bacterial mucosal adjuvant." Food research international.. 2011 Jul 0; 44(6):1649-1656.

5/2010
Sifakis S, Ghatpande S, Seppo A, Kilpatrick MW, Tafas T, Tsipouras P, Fejgin M, Amiel A. "Prenatal diagnosis of trisomy 21 through detection of trophoblasts in cervical smears." Early human development.. 2010 May 0; 86(5):311-3. Epub 2010 May 14.

VIEW ALL PUBLICATIONS