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Antti E. Seppo, Ph.D.

Contact Information

Faculty Appointments

Biography

Research

My short-term research interest is to develop an understanding of the factors that predispose and cause food allergies in children, and to understand predictive indicators of the severity of allergic reactions in children and adults.

Understanding of the predisposing and causative factors will help to develop strategies to prevent allergies in children. My research aims to evaluate genetic factors by applying genomic and transcriptomic techniques and environment related factors by biochemical screening of biomarkers.

Generating predictors of food allergy severity will enable better management of newly diagnosed food allergy patients. These predictors will be established by evaluating tests that measure aspects of humoral and cellular immune response in vitro, and selecting promising candidate markers for clinical evaluation.

My long-term interest is to understand the fundamental mechanisms in the developing human immune system and particularly mechanisms that upon failure cause allergic disease. This understanding will in part come from observations in the studies of allergy relevant factors, and in part from mechanistic studies involving candidate pathways of early immune system development.

Separate form allergy research my research interest also include integration of leading edge biocomputing methods into cell based assay research, especially in connection with image analysis.

Credentials

Education

1996
PhD | Finland-University of Helsinki
Biotechnology

Publications

Journal Articles

2020
McGuire MK, Randall AZ, Seppo AE, Järvinen KM, Meehan CL, Gindola D, Williams JE, Sellen DW, Kamau-Mbuthia EW, Kamundia EW, Mbugua S, Moore SE, Prentice AM, Foster JA, Otoo GE, Rodríguez JM, Pareja RG, Bode L, McGuire MA, Campo JJ. "Multipathogen Analysis of IgA and IgG Antigen Specificity for Selected Pathogens in Milk Produced by Women From Diverse Geographical Regions: The INSPIRE Study." Frontiers in immunology.. 2020 11:614372. Epub 2021 Feb 11.

1/22/2019
Seppo AE, Kukkonen AK, Kuitunen M, Savilahti E, Yonemitsu C, Bode L, Järvinen KM. "Association of Maternal Probiotic Supplementation With Human Milk Oligosaccharide Composition." JAMA pediatrics.. 2019 Jan 22; Epub 2019 Jan 22.

2018
Rajani PS, Seppo AE, Järvinen KM. "Immunologically Active Components in Human Milk and Development of Atopic Disease, With Emphasis on Food Allergy, in the Pediatric Population." Frontiers in pediatrics.. 2018 6:218. Epub 2018 Aug 07.

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