Skip to main content
Explore URMC

Antti E. Seppo, Ph.D.

Contact Information

Faculty Appointments



My short-term research interest is to develop an understanding of the factors that predispose and cause food allergies in children, and to understand predictive indicators of the severity of allergic reactions in children and adults.

Understanding of the predisposing and causative factors will help to develop strategies to prevent allergies in children. My research aims to evaluate genetic factors by applying genomic and transcriptomic techniques and environment related factors by biochemical screening of biomarkers.

Generating predictors of food allergy severity will enable better management of newly diagnosed food allergy patients. These predictors will be established by evaluating tests that measure aspects of humoral and cellular immune response in vitro, and selecting promising candidate markers for clinical evaluation.

My long-term interest is to understand the fundamental mechanisms in the developing human immune system and particularly mechanisms that upon failure cause allergic disease. This understanding will in part come from observations in the studies of allergy relevant factors, and in part from mechanistic studies involving candidate pathways of early immune system development.

Separate form allergy research my research interest also include integration of leading edge biocomputing methods into cell based assay research, especially in connection with image analysis.



PhD | Finland-University of Helsinki


Journal Articles

Davis EC, Castagna VP, Sela DA, Hillard MA, Lindberg S, Mantis NJ, Seppo AE, Järvinen KM. "Gut microbiome and breast-feeding: Implications for early immune development." The Journal of allergy and clinical immunology.. 2022 Sep; 150(3):523-534.

McGuire MK, Randall AZ, Seppo AE, Järvinen KM, Meehan CL, Gindola D, Williams JE, Sellen DW, Kamau-Mbuthia EW, Kamundia EW, Mbugua S, Moore SE, Prentice AM, Foster JA, Otoo GE, Rodríguez JM, Pareja RG, Bode L, McGuire MA, Campo JJ. "Multipathogen Analysis of IgA and IgG Antigen Specificity for Selected Pathogens in Milk Produced by Women From Diverse Geographical Regions: The INSPIRE Study." Frontiers in immunology.. 2020 11:614372. Epub 2021 Feb 11.

Seppo AE, Kukkonen AK, Kuitunen M, Savilahti E, Yonemitsu C, Bode L, Järvinen KM. "Association of Maternal Probiotic Supplementation With Human Milk Oligosaccharide Composition." JAMA pediatrics.. 2019 Jan 22; Epub 2019 Jan 22.