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Antti E. Seppo, Ph.D.

Antti E. Seppo, Ph.D.

Contact

Call Center (585) 276-3000

About Me

Faculty Appointments

Research Professor - Department of Pediatrics, Pediatric Allergy/Immunology (SMD)

Credentials

Education

PhD | Finland-University of Helsinki. Biotechnology. 1996

Research

My short-term research interest is to develop an understanding of the factors that predispose and cause food allergies in children, and to understand predictive indicators of the severity of allergic reactions in children and adults.

Understanding of the predisposing and causative factors w...
My short-term research interest is to develop an understanding of the factors that predispose and cause food allergies in children, and to understand predictive indicators of the severity of allergic reactions in children and adults.

Understanding of the predisposing and causative factors will help to develop strategies to prevent allergies in children. My research aims to evaluate genetic factors by applying genomic and transcriptomic techniques and environment related factors by biochemical screening of biomarkers.

Generating predictors of food allergy severity will enable better management of newly diagnosed food allergy patients. These predictors will be established by evaluating tests that measure aspects of humoral and cellular immune response in vitro, and selecting promising candidate markers for clinical evaluation.

My long-term interest is to understand the fundamental mechanisms in the developing human immune system and particularly mechanisms that upon failure cause allergic disease. This understanding will in part come from observations in the studies of allergy relevant factors, and in part from mechanistic studies involving candidate pathways of early immune system development.

Separate form allergy research my research interest also include integration of leading edge biocomputing methods into cell based assay research, especially in connection with image analysis.

Publications

Journal Articles

Gut microbiome and breast-feeding: Implications for early immune development.

Davis EC, Castagna VP, Sela DA, Hillard MA, Lindberg S, Mantis NJ, Seppo AE, Järvinen KM

The Journal of allergy and clinical immunology.. 2022 September 150 (3):523-534. Epub 1900 01 01.

Multipathogen Analysis of IgA and IgG Antigen Specificity for Selected Pathogens in Milk Produced by Women From Diverse Geographical Regions: The INSPIRE Study.

McGuire MK, Randall AZ, Seppo AE, Järvinen KM, Meehan CL, Gindola D, Williams JE, Sellen DW, Kamau-Mbuthia EW, Kamundia EW, Mbugua S, Moore SE, Prentice AM, Foster JA, Otoo GE, Rodríguez JM, Pareja RG, Bode L, McGuire MA, Campo JJ

Frontiers in immunology.. 2020 11 :614372. Epub 02/11/2021.

Association of Maternal Probiotic Supplementation With Human Milk Oligosaccharide Composition.

Seppo AE, Kukkonen AK, Kuitunen M, Savilahti E, Yonemitsu C, Bode L, Järvinen KM

JAMA pediatrics.. 2019 January 22 Epub 01/22/2019.

Immunologically Active Components in Human Milk and Development of Atopic Disease, With Emphasis on Food Allergy, in the Pediatric Population.

Rajani PS, Seppo AE, Järvinen KM

Frontiers in pediatrics.. 2018 6 :218. Epub 08/07/2018.

Novel multiplex assay for profiling influenza antibodies in breast milk and serum of mother-infant pairs.

Järvinen KM, Wang J, Seppo AE, Zand M

F1000Research.. 2018 7 :1822. Epub 11/20/2018.

Breast milk IgA to foods has different epitope specificity than serum IgA-Evidence for entero-mammary link for food-specific IgA?

Seppo AE, Savilahti EM, Berin MC, Sampson HA, Järvinen KM

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.. 2017 October 47 (10):1275-1284. Epub 05/26/2017.

Human milk oligosaccharides and development of cow's milk allergy in infants.

Seppo AE, Autran CA, Bode L, Järvinen KM

The Journal of allergy and clinical immunology.. 2017 February 139 (2):708-711.e5. Epub 10/01/2016.

Highly multiplexed single-cell analysis of formalin-fixed, paraffin-embedded cancer tissue.

Gerdes MJ, Sevinsky CJ, Sood A, Adak S, Bello MO, Bordwell A, Can A, Corwin A, Dinn S, Filkins RJ, Hollman D, Kamath V, Kaanumalle S, Kenny K, Larsen M, Lazare M, Li Q, Lowes C, McCulloch CC, McDonough E, Montalto MC, Pang Z, Rittscher J, Santamaria-Pang A, Sarachan BD, Seel ML, Seppo A, Shaikh K, Sui Y, Zhang J, Ginty F

Proceedings of the National Academy of Sciences of the United States of America.. 2013 July 16110 (29):11982-7. Epub 07/01/2013.

Maternal peanut consumption provides protection in offspring against peanut sensitization that is further enhanced when co-administered with bacterial mucosal adjuvant.

López-Expósito I, Järvinen KM, Castillo A, Seppo AE, Song Y, Li XM

Food research international.. 2011 July 44 (6):1649-1656. Epub 1900 01 01.

Prenatal diagnosis of trisomy 21 through detection of trophoblasts in cervical smears.

Sifakis S, Ghatpande S, Seppo A, Kilpatrick MW, Tafas T, Tsipouras P, Fejgin M, Amiel A

Early human development.. 2010 May 86 (5):311-3. Epub 05/14/2010.

Gain of 3q26: a genetic marker in low-grade squamous intraepithelial lesions (LSIL) of the uterine cervix.

Seppo A, Jalali GR, Babkowski R, Symiakaki H, Rodolakis A, Tafas T, Tsipouras P, Kilpatrick MW

Gynecologic oncology.. 2009 July 114 (1):80-3. Epub 04/25/2009.

Detection of circulating tumour cells in peripheral blood with an automated scanning fluorescence microscope.

Ntouroupi TG, Ashraf SQ, McGregor SB, Turney BW, Seppo A, Kim Y, Wang X, Kilpatrick MW, Tsipouras P, Tafas T, Bodmer WF

British journal of cancer.. 2008 September 299 (5):789-95. Epub 1900 01 01.

Detection of circulating fetal cells utilizing automated microscopy: potential for noninvasive prenatal diagnosis of chromosomal aneuploidies.

Seppo A, Frisova V, Ichetovkin I, Kim Y, Evans MI, Antsaklis A, Nicolaides KH, Tafas T, Tsipouras P, Kilpatrick MW

Prenatal diagnosis.. 2008 September 28 (9):815-21. Epub 1900 01 01.

Inactivation of the Mgat1 gene in oocytes impairs oogenesis, but embryos lacking complex and hybrid N-glycans develop and implant.

Shi S, Williams SA, Seppo A, Kurniawan H, Chen W, Ye Z, Marth JD, Stanley P

Molecular and cellular biology.. 2004 November 24 (22):9920-9. Epub 1900 01 01.

Induction of neuron-specific glycosylation by Tollo/Toll-8, a Drosophila Toll-like receptor expressed in non-neural cells.

Seppo A, Matani P, Sharrow M, Tiemeyer M

Development.. 2003 April 130 (7):1439-48. Epub 1900 01 01.

Function and structure of Drosophila glycans.

Seppo A, Tiemeyer M

Glycobiology.. 2000 August 10 (8):751-60. Epub 1900 01 01.

Zwitterionic and acidic glycosphingolipids of the Drosophila melanogaster embryo.

Seppo A, Moreland M, Schweingruber H, Tiemeyer M

European journal of biochemistry. 2000 June 267 (12):3549-58. Epub 1900 01 01.

Enzymatic transfer of a beta1,6-linked N-acetylglucosamine to the alpha-galactose of globo-N-tetraose: in vitro synthesis of a novel hybrid pentasaccharide of lacto-globo type.

Natunen J, Seppo A, Helin J, Reinhold BB, Rabina J, Costello CE, Renkonen O

Glycobiology.. 1997 July 7 (5):711-8. Epub 1900 01 01.

Synthesis of a tetravalent sialyl Lewis x glycan, a high-affinity inhibitor of L-selectin-mediated lymphocyte binding to endothelium.

Seppo A, Turunen JP, Penttilä L, Keane A, Renkonen O, Renkonen R

Glycobiology.. 1996 January 6 (1):65-71. Epub 1900 01 01.

De novo expression of endothelial sialyl Lewis(a) and sialyl Lewis(x) during cardiac transplant rejection: superior capacity of a tetravalent sialyl Lewis(x) oligosaccharide in inhibiting L-selectin-dependent lymphocyte adhesion.

Turunen JP, Majuri ML, Seppo A, Tiisala S, Paavonen T, Miyasaka M, Lemström K, Penttilä L, Renkonen O, Renkonen R

The Journal of experimental medicine.. 1995 October 1182 (4):1133-41. Epub 1900 01 01.

Enzyme-assisted synthesis of a bivalent high-affinity dodecasaccharide inhibitor of mouse gamete adhesion. The length of the chains carrying distal alpha 1,3-bonded galactose residues is critical.

Niemelä R, Penttilä L, Seppo A, Helin J, Leppänen A, Räbinä J, Uusitalo L, Maaheimo H, Taskinen J, Costello CE

FEBS letters.. 1995 June 19367 (1):67-72. Epub 1900 01 01.

Enzymatic synthesis of octadecameric saccharides of multiply branched blood group I-type, carrying four distal alpha 1,3-galactose or beta 1,3-GlcNAc residues.

Seppo A, Penttilä L, Niemelä R, Maaheimo H, Renkonen O, Keane A

Biochemistry.. 1995 April 1134 (14):4655-61. Epub 1900 01 01.

Oligosaccharide constructs with defined structures that inhibit binding of mouse sperm to unfertilized eggs in vitro.

Litscher ES, Juntunen K, Seppo A, Penttilä L, Niemelä R, Renkonen O, Wassarman PM

Biochemistry.. 1995 April 1134 (14):4662-9. Epub 1900 01 01.

Stepwise transfer of alpha-D-Galp-(1-->3)-beta-D-Galp-(1-->4)-beta-D-GlcpNAc sequences to 3-OH and 6-OH of distal galactose residues in bi-, tri-, and tetra-antennary asialo-glycans of N-linked complex type.

Helin J, Maaheimo H, Seppo A, Keane A, Renkonen O

Carbohydrate research.. 1995 January 17266 (2):191-209. Epub 1900 01 01.

Enzymatic synthesis of two lacto-N-neohexaose-related Lewis x heptasaccharides and their separation by chromatography on immobilized wheat germ agglutinin.

Natunen J, Niemelä R, Penttilä L, Seppo A, Ruohtula T, Renkonen O

Glycobiology.. 1994 October 4 (5):577-83. Epub 1900 01 01.

Bi-antennary oligo-(N-acetyllactosamino)glycans of I-type are galactosylated preferentially at the GlcNAc beta 1-6Gal linked arms by alpha 1,3-galactosyltransferase of bovine thymus.

Seppo A, Penttilä L, Leppänen A, Maaheimo H, Niemelä R, Helin J, Wieruszeski JM, Renkonen O

Glycoconjugate journal.. 1994 June 11 (3):217-25. Epub 1900 01 01.

A novel beta-N-acetylglucosaminidase activity in hog gastric mucosal microsomes: preferential hydrolysis of terminal GlcNAc beta 1-3 linkages in GlcNAc beta 1-3(GlcNAc beta 1-6)Gal beta 1-4GlcNAc, but GlcNAc beta 1-6 linkages in GlcNAc beta 1-3(GlcNAc beta 1-6)Gal.

Helin J, Seppo A, Leppänen A, Penttilä L, Maaheimo H, Niemelä R, Lauri S, Renkonen O

FEBS letters.. 1993 December 6335 (2):280-4. Epub 1900 01 01.

Deacetylase activity of human tumor cells producing immunosuppressive aminosugars: its possible role in resistance to cell-mediated cytotoxicity.

Yagita M, Seppo A, Renkonen O, Saksela E

Cancer research.. 1993 December 153 (23):5600-4. Epub 1900 01 01.

Elongation of both branches of biantennary backbones of oligo-(N-acetyllactosamino)glycans by human serum (1----3)-N-acetyl-beta-D- glucosaminyltransferase.

Vilkman A, Niemelä R, Penttilä L, Helin J, Leppänen A, Seppo A, Maaheimo H, Lusa S, Renkonen O

Carbohydrate research.. 1992 March 16226 (1):155-74. Epub 1900 01 01.

Enzymatic in vitro synthesis of radiolabeled pentasaccharides GlcNAc beta 1-3(Gal beta 1-4GlcNAc beta 1-6)Gal beta 1-4GlcNAc/Glc and the isomeric Gal beta 1-4GlcNAc beta 1-3(GlcNAc beta 1-6)Gal beta 1-4GlcNAc/Glc.

Renkonen O, Leppänen A, Niemelä R, Vilkman A, Helin J, Penttilä L, Maaheimo H, Seppo A, Suopanki J

Biochemistry and cell biology = Biochimie et biologie cellulaire.. 1992 January 70 (1):86-9. Epub 1900 01 01.

Human serum contains a novel beta 1,6-N-acetylglucosaminyltransferase activity that is involved in midchain branching of oligo (N-acetyllactosaminoglycans).

Leppänen A, Penttilä L, Niemelä R, Helin J, Seppo A, Lusa S, Renkonen O

Biochemistry.. 1991 September 2430 (38):9287-96. Epub 1900 01 01.

Oligo-N-acetyllactosaminoglycans bearing Gal beta 1-4(Fuc alpha 1-3)GlcNAc sequences reveal lower affinities than their nonfucosylated, or alpha(1-2) fucosylated counterparts for immobilized wheat germ agglutinin.

Renkonen O, Helin J, Penttilä L, Maaheimo H, Niemelä R, Leppänen A, Seppo A, Hård K

Glycoconjugate journal.. 1991 August 8 (4):361-7. Epub 1900 01 01.

Construction of linear GlcNAc beta 1-6Gal beta 1-OR type oligosaccharides by partial cleavage of GlcNAc beta 1-3(GlcNAc beta 1-6)Gal beta 1-OR sequences with jack bean beta-N-acetylhexosaminidase.

Renkonen O, Niemelä R, Leppänen A, Maaheimo H, Seppo A, Penttilä L, Vilkman A

Glycoconjugate journal.. 1991 August 8 (4):368-75. Epub 1900 01 01.

N-acetyllactosaminooligosaccharides that contain the beta-D-GlcpNAc-(1----6)-D-Gal or beta-D-GlcpNAc-(1----6)-D-GalNAc sequences reveal reduction-sensitive affinities for wheat germ agglutinin.

Renkonen O, Penttilä L, Niemelä R, Vainio A, Leppänen A, Helin J, Seppo A, Makkonen A, Maaheimo H

Carbohydrate research.. 1991 June 25213 :169-83. Epub 1900 01 01.

Wheat germ agglutinin chromatography of GlcNac beta 1-3(GlcNAc beta 1-6)Gal and GlcNAc beta 1-3(GlcNAc beta 1-6)Gal beta 1-4GlcNAc, obtained by in vitro synthesis and by partial cleavage of teratocarcinoma poly-N-acetyllactosaminoglycans.

Seppo A, Penttilä L, Makkonen A, Leppänen A, Niemelä R, Jäntti J, Helin J, Renkonen O

Biochemistry and cell biology = Biochimie et biologie cellulaire.. 1990 January 68 (1):44-53. Epub 1900 01 01.