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Gowrishankar Muthukrishnan, Ph.D.

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Office: (585) 273-5632

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Professional Background

Gowrishankar Muthukrishnan earned his Ph.D. in Biomedical Sciences. He is a microbial immunologist with expertise in host-microbe interactions, bacterial pathogenesis, and immunobiology of Staphylococcus aureus infections. His graduate work aimed at understanding the S. aureus nasal carriage dynamics, in addition to identifying important host and microbial determinants that influence S. aureus nasal colonization in humans. His postdoctoral studies at the University of Rochester Medical Center involved numerous basic research projects related to human immune mechanisms and the development of supporting immunological methods for viral and bacterial vaccine research. He also worked on assessing functional humoral and cell-mediated responses in patients with S. aureus osteomyelitis, diabetic foot ulcer infections, and spine infections. As a faculty member within the Center for Musculoskeletal Research (CMSR), University of Rochester Medical Center, his research group is focused on understanding host-pathogen interactions and the osteoimmunology of orthopaedic infections. His research group is also developing novel small animal models (humanized mice) to study bone infections.



Masters in Engineering | Birla Institute of Technology and Science, Pilani, India

MS | University of Central Florida
Molecular Biology and Microbiology

PhD | University of Central Florida College of Medicine
Biomedical Sciences

Post-doctoral Training & Residency

2017 - 2019
Center for Musculoskeletal Research, Department of Orthopaedics and Rehabilitation, University of Rochester Medical Center

2015 - 2017
Center for Vaccine Biology and Immunology, Department of Microbiology and Immunology, University of Rochester Medical Center


2019 - 2021
AO Research Institute Fellowship (Davos, Switzerland)
Sponsor: AO Trauma

Great Lakes International Imaging and Flow Cytometry Association (GLIIFCA 2016) Travel Award

Great Lakes International Imaging and Flow Cytometry Association (GLIIFCA 2016) Best Poster Award

2011 - 2012
Rudy Wodzinski Memorial Scholarship

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Journal Articles

Hachem AA, Filkins LM, Kidane YH, Raj P, Tareen NG, Arana CA, Muthukrishnan G, Copley LA. "Staphylococcus aureus isolates from children with clinically differentiated osteomyelitis exhibit distinct transcriptomic signatures." PloS one.. 2023 18(8):e0288758. Epub 2023 Aug 10.

Kenney HM, Rangel-Moreno J, Peng Y, Chen KL, Bruno J, Embong A, Pritchett E, Fox JI, Becerril-Villanueva E, Gamboa-Domínguez A, Quataert S, Muthukrishnan G, Wood RW, Korman BD, Anolik JH, Xing L, Ritchlin CT, Schwarz EM, Wu CL. "Multi-omics analysis identifies IgG2b class-switching with ALCAM-CD6 co-stimulation in joint-draining lymph nodes during advanced inflammatory-erosive arthritis." Frontiers in immunology.. 2023 14:1237498. Epub 2023 Aug 25.

Morita Y, Saito M, Rangel-Moreno J, Franchini AM, Owen JR, Martinez JC, Daiss JL, de Mesy Bentley KL, Kates SL, Schwarz EM, Muthukrishnan G. "Systemic IL-27 administration prevents abscess formation and osteolysis via local neutrophil recruitment and activation." Bone research.. 2022 Aug 26; 10(1):56. Epub 2022 Aug 26.