CONTACT INFORMATIONCREDENTIALSAWARDSPUBLICATIONSGillian M. Schiralli Lester, Ph.D.Contact InformationLocationsUniversity of Rochester Medical CenterSchool of Medicine and Dentistry601 Elmwood Ave, Box 850Rochester, NY 14642Faculty AppointmentsResearch Assistant Professor - Department of Pediatrics , Neonatology (SMD) BiographyResearchIn general, I am interested in the regulation of gene expression and how that relates to disease progression. My previous studies have centered on investigating cell signaling mechanisms which regulate Human Immunodeficiency Virus (HIV) replication with the goal of identifying novel factors which could then be targeted for therapeutic development. I now turn my focus onto developing gene delivery strategies to treat acute lung injury. I am particularly interested in dissecting cellular pathways which are required for cytoplasmic trafficking fo plasmid DNA into the nucleus, the site of efficient transcription. Understanding the minimal signals and cell machinery that are required for DNA movement will provide the needed background for developing novel routes for targeted gene delivery in specific cell types.CredentialsEducation2003BS | Niagara UniversityBiology2009PhD | Pennsylvania State University, State CollegeImmunology of Infectious DiseasePost-doctoral Training & Residency07/2009 - 01/2015Postdoctoral Research Fellow, Boston University Medical Center, Boston, MAAwards2014Young Investigator AwardSponsor: Conference on Retroviruses and Opportunistic Infections (CROI)2011Young Investigator AwardSponsor: Conference on Retroviruses and Opportunistic Infections (CROI)2010 - 2011Ruth L. Kirschstein Postdoctoral FellowshipSponsor: Boston University Immunology Training Program2008Graduate Student Travel AwardSponsor: The Huck Institute of Life SciencesLocation: Pennsylvania State University2003 - 2004Graduate Fellowship AwardSponsor: The Huck Institute of Life SciencesLocation: Pennsylvania State UniversityVIEW ALL expand_morePublicationsJournal Articles9/6/2013Natarajan M, Schiralli Lester GM, Lee C, Missra A, Wasserman GA, Steffen M, Gilmour DS, Henderson AJ. "Negative elongation factor (NELF) coordinates RNA polymerase II pausing, premature termination, and chromatin remodeling to regulate HIV transcription." The Journal of biological chemistry.. 2013 Sep 6; 288(36):25995-6003. Epub 2013 Jul 24. 2/5/2013Schiralli Lester GM, Akiyama H, Evans E, Singh J, Gummuluru S, Henderson AJ. "Interleukin 2-inducible T cell kinase (ITK) facilitates efficient egress of HIV-1 by coordinating Gag distribution and actin organization." Virology.. 2013 Feb 5; 436(1):235-43. Epub 2012 Dec 20. 2012Schiralli Lester GM, Henderson AJ. "Mechanisms of HIV Transcriptional Regulation and Their Contribution to Latency." Molecular biology international. 2012 2012:614120. Epub 2012 Jun 03. VIEW ALL PUBLICATIONSClose WindowSchedule an appointment with Gillian M. Schiralli Lester, Ph.D.Please answer the following questions to help us find the right appointment for you.Important: If you believe that you have a medical or psychiatric emergency, please call 911 or go to the nearest hospital. This website is not intended for emergency care.Have you seen this provider in the last 2 years?YesNoExisting Patient Schedule or request a follow up appointment online through MyChart. If you do not have a MyChart account, please close this window and call the appointment phone number. Gillian M. Schiralli Lester, Ph.D. is currently scheduling for the following appointment type(s): Our policy does not permit patients to establish care with multiple providers within the same practice or specialty without prior approval. If you choose a new provider in the same office, we will cancel the appointment. Please contact the office directly with questions on this policy.