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Bin Zhang, Ph.D.

Contact Information

Phone Numbers

Office: (585) 276-8707

Biography

Professional Background

Dr. Bin Zhang is an Assistant Professor in the Department of Pathology & Laboratory Medicine and the Department of Pediatrics at University of Rochester. He serves as a clinical genomicist in the cytogenetics laboratory at Strong Memorial Hospital. He earned his PhD in Molecular Genetics and Genomics and obtained his Clinical Genomics fellowship at Washington University in Saint Louis. He is board certified in Clinical Cytogenetics and board eligible in Clinical Molecular Genetics by the American Board of Medical Genetics and Genomics. Prior to his doctoral studies, he earned his BS in Biology from Sichuan University in China and MS in Biology from Truman State University. He also completed his post-doctoral training at Cold Spring Harbor Laboratory.

Dr. Zhang' clinical responsibilities include the genetic diagnostic evaluation of blood, bone marrow, lymph nodes, amniotic fluid, chorionic villus, product of conception, and tissues for other malignancies. This includes interpretation of molecular genetics and cytogenetics data from sequencing, karyotyping, FISH and microarray analysis.

Research

His graduate study focused on human genetics and mouse modeling of cohesinopathies, and his postdoctoral work on studying function, regulation, and evolution of long (MALAT1 and NEAT1) and small (piRNAs) non-coding RNAs (ncRNAs). He maintains active research interests in RNA-based disease biology, cancer biology, and biomarker discovery using genomic approaches. In particular, his research program at University of Rochester focuses on studying molecular and cellular functions of ncRNAs during tumoriogenesis, and developing novel NGS-based methodologies for efficient circulating tumor DNA (ctDNA) detection and nucleotide-level mapping of disease-associated chromosomal rearrangements.

Credentials

Faculty Appointments

Education

2007
PhD | Washington University in Saint Louis

Publications

Journal Articles

6/2017
Katzman PJ, Metlay LA, McMahon LA, LiQiong L, Zhang B. "Chorionic Histiocytic Hyperplasia is Associated With Chronic Inflammatory Lesions in the Placenta." Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society.. 2017 Jun 0; 20(3):197-205. Epub 2017 Feb 08.

5/23/2017
Zhang B, Mao YS, Diermeier SD, Novikova IV, Nawrocki EP, Jones TA, Lazar Z, Tung CS, Luo W, Eddy SR, Sanbonmatsu KY, Spector DL. "Identification and Characterization of a Class of MALAT1-like Genomic Loci." Cell reports. 2017 May 23; 19(8):1723-1738.

4/6/2017
Sun YH, Xie LH, Zhuo X, Chen Q, Ghoneim D, Zhang B, Jagne J, Yang C, Li XZ. "Domestic chickens activate a piRNA defense against avian leukosis virus." eLife. 2017 Apr 6; 6Epub 2017 Apr 06.

Books & Chapters

2014
Chapter Title: Single Nucleotide Variant Detection Using Next Generation Sequencing
Book Title: Clinical Genomics
Author List: David H. Spencer, Bin Zhang and John Pfeifer
Edited By: Shashikant Kulkarni and John Pfeifer
Published By: Elsevier2014

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