Rakesh K. Singh, Ph.D., M.Phil.

Contact Information

Phone Numbers

Office: (585) 276-6281

Locations

University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 668
Rochester, NY 14642

Faculty Appointments

Research Associate Professor - Department of Obstetrics and Gynecology (SMD)

Biography

Professional Background

Like thousands of medicinal chemists across the world I frequently spin my magnetic bars overnight, scratch round bottom flasks next morning as if the molecules are hiding somewhere in the flask walls and look at my harvest anxiously standing around my dirty and disorganized chemical hood hoping that NMR and Mass will be okay and my hunt for that elusive molecule which is going to help someone rid of his/her disease to some extent is finally complete. In this tryst, I combine alphabets of cancer biology, tumor immunology, medicinal chemistry and some rudimentary pharmacology and drug design concepts and in vitro and in vivo models of tumors for screening; and seek guidance from molecular modeling/virtual screening experts and most recently with some extraterrestrial artificial intelligence (AI) nerds to design a drug-like molecule against a protein target which physicians or researchers believe has gone awry (based on their trust in p values) and is making some one sick.

Research

In team with renowned physicians, immunologists, cancer biologists and molecular modelling colleagues sitting in different continents and those extraterrestrial AI nerds situated somewhere on the west coast I currently focus on developing small molecule based immunotherapeutics for treatment of high-risk malignancies such as but not limited to:

• Ovarian cancer
• Neuroblastoma
• Medulloblastoma
• Pancreatic cancer
• Melanoma
• Colorectal cancer

Complexities of drug-discovery commerce aside, small molecule based immunotherapeutics can be a viable alternative or a great complementary armamentarium to antibody based immunotherapies for treatment of high-risk malignancies or diseases.

Credentials

Education

1996
M.Phil | India-Birla Institute of Tech and Science
Medicinal Chemistry

2003
PhD | India-Jamia Millia Islamia-Delhi
Medicinal Chemistry

Awards

1999 - 2001
Ranbaxy Research Fellowship
Sponsor: Ranbaxy Research Laboratories
Location: India

1997 - 1998
Senior Research Fellowship
Sponsor: Council of Scientific and Industrial Research (CSIR)
Location: India

Patents

Patent Title: Therapy for Malignant Disease Comprising the Inhibition of Human Epididymal Secretory Protein E4 and Immune Checkpoint Inhibitors
Patent #: 2,981,068
Issue Date: Dec 14, 2021
Country: Canada
Invented By: Richard G Moore, Rakesh K Singh, Naohiro Yano

Patent Title: Therapy for Malignant Disease
Patent #: 10,376,535
Issue Date: Aug 13, 2019
Country: United States
Invented By: Richard G Moore, Rakesh K Singh, Naohiro Yano

Patent Title: Septin Proteins as Novel Biomarkers for Detection and Treatment of Mullerian Cancers
Patent #: 3311165
Issue Date: Dec 09, 2020
Country: Europe
Invented By: Richard G Moore, Rakesh K Singh

Patent Title: Septin Proteins as Novel Biomarkers for Detection and Treatment of Mullerian Cancers
Patent #: FR3311165
Issue Date: Dec 09, 2020
Country: France
Invented By: Richard G Moore, Rakesh K Singh

Patent Title: Septin Proteins as Novel Biomarkers for Detection and Treatment of Mullerian Cancers
Patent #: DE3311165
Issue Date: Dec 09, 2020
Country: Germany
Invented By: Richard G Moore, Rakesh K Singh

Patent Title: Septin Proteins as Novel Biomarkers for Detection and Treatment of Mullerian Cancers
Patent #: GB3311165
Issue Date: Dec 09, 2020
Country: United Kingdom
Invented By: Richard G Moore, Rakesh K Singh

Patent Title: Novel 7-Dehydrocholesterol Derivatives and Methods Using Same
Patent #: 11,034,719
Issue Date: Jun 15, 2021
Country: United States
Invented By: Richard G Moore, Rakesh K Singh

Patent Title: Novel 7-Dehydrocholesterol Derivatives and Methods Using Same
Patent #: 3128996
Issue Date: Jun 02, 2021
Country: Europe
Invented By: Richard G Moore, Rakesh K Singh

Patent Title: Novel 7-Dehydrocholesterol Derivatives and Methods Using Same
Patent #: FR3128996
Issue Date: Jun 02, 2021
Country: France
Invented By: Richard G Moore, Rakesh K Singh

Patent Title: Novel 7-Dehydrocholesterol Derivatives and Methods Using Same
Patent #: DE3128996
Issue Date: Jun 02, 2021
Country: Germany
Invented By: Richard G Moore, Rakesh K Singh

Patent Title: Novel 7-Dehydrocholesterol Derivatives and Methods Using Same
Patent #: GB3128996
Issue Date: Jun 02, 2021
Country: United Kingdom
Invented By: Richard G Moore, Rakesh K Singh

Patent Title: Novel 7-Dehydrocholesterol Derivatives and Methods Using Same
Patent #: 9,982,010
Issue Date: May 29, 2018
Country: United States
Invented By: Richard G Moore, Rakesh K Singh

Patent Title: N-Amino Tetrahydrothiazine Derivatives, Methods of Manufacture and Use
Patent #: 2,676,527
Issue Date: Aug 11, 2015
Country: Canada
Invented By: Laurent Brard, Kyu Kwang Kim, Giselle Saulnier-Sholler, Rakesh K Singh

Patent Title: N-Amino Tetrahydrothiazine Derivatives, Methods of Manufacture and Use
Patent #: 2114410
Issue Date: Mar 25, 2015
Country: Europe
Invented By: Laurent Brard, Kyu Kwang Kim, Giselle Saulnier-Sholler, Rakesh K Singh

Patent Title: N-Amino Tetrahydrothiazine Derivatives, Methods of Manufacture and Use
Patent #: FR2114410
Issue Date: Mar 25, 2015
Country: France
Invented By: Laurent Brard, Kyu Kwang Kim, Giselle Saulnier-Sholler, Rakesh K Singh

Patent Title: N-Amino Tetrahydrothiazine Derivatives, Methods of Manufacture and Use
Patent #: 8,193,180
Issue Date: Jun 05, 2012
Country: United States
Invented By: Laurent Brard, Kyu Kwang Kim, Giselle Saulnier-Sholler, Rakesh K Singh

Patent Title: Heterocycles and Derivatives Thereof and Methods of Manufacture and Therapeutic Use
Patent #: 9,024,039
Issue Date: May 05, 2015
Country: United States
Invented By: Laurent Brard, Satyan Kalkunte, Rakesh K Singh

Patent Title: Derivatives of Vitamin D and Therapeutic Use Thereof
Patent #: 1968383
Issue Date: May 11, 2011
Country: Europe
Invented By: Laurent Brard, Satyan Kalkunte, Rakesh K Singh

Patent Title: Derivatives of Vitamin D and Therapeutic Use Thereof
Patent #: FR1968383
Issue Date: May 11, 2011
Country: France
Invented By: Laurent Brard, Satyan Kalkunte, Rakesh K Singh

Patent Title: Derivatives of Vitamin D and Therapeutic Use Thereof
Patent #: DE1968383
Issue Date: May 11, 2011
Country: Germany
Invented By: Laurent Brard, Satyan Kalkunte, Rakesh K Singh

Patent Title: 7-Dehydrocholesterol Derivatives and Methods Using Same
Patent #: 10,683,324
Issue Date: Jun 16, 2020
Country: United States
Invented By: Richard G Moore, Rakesh K Singh

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Publications

Journal Articles

4/11/2022
Khazan N, Kim KK, Hansen JN, Singh NA, Moore T, Snyder CWA, Pandita R, Strawderman M, Fujihara M, Takamura Y, Jian Y, Battaglia N, Yano N, Teramoto Y, Arnold LA, Hopson R, Kishor K, Nayak S, Ojha D, Sharon A, Ashton JM, Wang J, Milano MT, Miyamoto H, Linehan DC, Gerber SA, Kawar N, Singh AP, Tabdanov ED, Dokholyan NV, Kakuta H, Jurutka PW, Schor NF, Rowswell-Turner RB, Singh RK, Moore RG. "Identification of a Vitamin-D Receptor Antagonist, MeTC7, which Inhibits the Growth of Xenograft and Transgenic Tumors ." Journal of medicinal chemistry.. 2022 Apr 11; Epub 2022 Apr 11.

10/22/2021
Zhovmer AS, Manning A, Smith C, Hayes JB, Burnette DT, Wang J, Cartagena-Rivera AX, Dokholyan NV, Singh RK, Tabdanov ED. "Mechanical Counterbalance of Kinesin and Dynein Motors in a Microtubular Network Regulates Cell Mechanics, 3D Architecture, and Mechanosensing." ACS nano.. 2021 Oct 22; Epub 2021 Oct 22.

4/26/2021
Rowswell-Turner RB, Singh RK, Urh A, Yano N, Kim KK, Khazan N, Pandita R, Sivagnanalingam U, Hovanesian V, James NE, Ribeiro JR, Kadambi S, Linehan DC, Moore RG. "HE4 Overexpression by Ovarian Cancer Promotes a Suppressive Tumor Immune Microenvironment and Enhanced Tumor and Macrophage PD-L1 Expression." The Journal of immunology : official journal of the American Association of Immunologists.. 2021 Apr 26; Epub 2021 Apr 26.

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