Rakesh K. Singh, Ph.D., M.Phil.

Contact Information

Phone Numbers

Office: (585) 276-6281

Locations

University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 668
Rochester, NY 14642

Faculty Appointments

Research Associate Professor - Department of Obstetrics and Gynecology (SMD)

Biography

Professional Background

Like thousands of medicinal chemists across the world I frequently spin my magnetic bars overnight, scratch round bottom flasks next morning as if the molecules are hiding somewhere in the flask walls and look at my harvest anxiously standing around my dirty and disorganized chemical hood hoping that NMR and Mass will be okay and my hunt for that elusive molecule which is going to help someone rid of his/her disease to some extent is finally complete. In this tryst, I combine alphabets of cancer biology, tumor immunology, medicinal chemistry and some rudimentary pharmacology and drug design concepts and in vitro and in vivo models of tumors for screening; and seek guidance from molecular modeling/virtual screening experts and most recently with some extraterrestrial artificial intelligence (AI) nerds to design a drug-like molecule against a protein target which physicians or researchers believe has gone awry (based on their trust in p values) and is making some one sick.

Research

In team with renowned physicians, immunologists, cancer biologists and molecular modelling colleagues sitting in different continents and those extraterrestrial AI nerds situated somewhere on the west coast I currently focus on developing small molecule based immunotherapeutics for treatment of high-risk malignancies such as but not limited to:

• Ovarian cancer
• Neuroblastoma
• Medulloblastoma
• Pancreatic cancer
• Melanoma
• Colorectal cancer

Complexities of drug-discovery commerce aside, small molecule based immunotherapeutics can be a viable alternative or a great complementary armamentarium to antibody based immunotherapies for treatment of high-risk malignancies or diseases.

Credentials

Education

1996
M.Phil | India-Birla Institute of Tech and Science
Medicinal Chemistry

2003
PhD | India-Jamia Millia Islamia-Delhi
Medicinal Chemistry

Awards

1999 - 2001
Ranbaxy Research Fellowship
Sponsor: Ranbaxy Research Laboratories
Location: India

1997 - 1998
Senior Research Fellowship
Sponsor: Council of Scientific and Industrial Research (CSIR)
Location: India

Patents

Patent Title: Therapy for Malignant Disease
Patent #: 10,376,535
Issue Date: Aug 13, 2019
Country: United States
Invented By: Richard G Moore, Rakesh K Singh, Naohiro Yano

Patent Title: Novel 7-Dehydrocholesterol Derivatives and Methods Using Same
Patent #: 10,683,324
Issue Date: Jun 16, 2020
Country: United States
Invented By: Richard G Moore, Rakesh K Singh

Patent Title: Novel 7-Dehydrocholesterol Derivatives and Methods Using Same
Patent #: 9,982,010
Issue Date: May 29, 2018
Country: United States
Invented By: Richard G Moore, Rakesh K Singh

Patent Title: N-Amino Tetrahydrothiazine Derivatives, Methods of Manufacture and Use
Patent #: 2,676,527
Issue Date: Aug 11, 2015
Country: Canada
Invented By: Laurent Brard, Kyu Kwang Kim, Giselle Saulnier-Sholler, Rakesh K Singh

Patent Title: N-Amino Tetrahydrothiazine Derivatives, Methods of Manufacture and Use
Patent #: 2114410
Issue Date: Mar 25, 2015
Country: Europe
Invented By: Laurent Brard, Kyu Kwang Kim, Giselle Saulnier-Sholler, Rakesh K Singh

Patent Title: N-Amino Tetrahydrothiazine Derivatives, Methods of Manufacture and Use
Patent #: FR2114410
Issue Date: Mar 25, 2015
Country: France
Invented By: Laurent Brard, Kyu Kwang Kim, Giselle Saulnier-Sholler, Rakesh K Singh

Patent Title: N-Amino Tetrahydrothiazine Derivatives, Methods of Manufacture and Use
Patent #: 8,193,180
Issue Date: Jun 05, 2012
Country: United States
Invented By: Laurent Brard, Kyu Kwang Kim, Giselle Saulnier-Sholler, Rakesh K Singh

Patent Title: Heterocycles and Derivatives Thereof and Methods of Manufacture and Therapeutic Use
Patent #: 9,024,039
Issue Date: May 05, 2015
Country: United States
Invented By: Laurent Brard, Satyan Kalkunte, Rakesh K Singh

Patent Title: Derivatives of Vitamin D and Therapeutic Use Thereof
Patent #: 1968383
Issue Date: May 11, 2011
Country: Europe
Invented By: Laurent Brard, Satyan Kalkunte, Rakesh K Singh

Patent Title: Derivatives of Vitamin D and Therapeutic Use Thereof
Patent #: FR1968383
Issue Date: May 11, 2011
Country: France
Invented By: Laurent Brard, Satyan Kalkunte, Rakesh K Singh

Patent Title: Derivatives of Vitamin D and Therapeutic Use Thereof
Patent #: DE1968383
Issue Date: May 11, 2011
Country: Germany
Invented By: Laurent Brard, Satyan Kalkunte, Rakesh K Singh

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Publications

Journal Articles

5/22/2020
James NE, Emerson JB, Borgstadt AD, Beffa L, Oliver MT, Hovanesian V, Urh A, Singh RK, Rowswell-Turner R, DiSilvestro PA, Ou J, Moore RG, Ribeiro JR. "The biomarker HE4 (WFDC2) promotes a pro-angiogenic and immunosuppressive tumor microenvironment via regulation of STAT3 target genes." Scientific reports.. 2020 May 22; 10(1):8558. Epub 2020 May 22.

2/24/2020
Kim KK, Singh RK, Khazan N, Kodza A, Singh NA, Jones A, Sivagnanalingam U, Towner M, Itamochi H, Turner R, Moore RG. "Development of Potent Forchlorfenuron Analogs and Their Cytotoxic Effect in Cancer Cell Lines." Scientific reports.. 2020 Feb 24; 10(1):3241. Epub 2020 Feb 24.

2020
Kim KK, Turner R, Khazan N, Kodza A, Jones A, Singh RK, Moore RG. "Role of trypsin and protease-activated receptor-2 in ovarian cancer." PloS one.. 2020 15(5):e0232253. Epub 2020 May 04.

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