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Douglas M. Anderson, Ph.D.

Contact Information

Phone Numbers

Office: (585) 275-5447

Fax: (585) 276-1530

Research Labs

Anderson Lab

Lab: (585) 276-7726

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Biography

Research

Our lab investigates the regulatory pathways that control striated muscle development and function, and how defects in those pathways can give rise to human disease. The development of striated muscle is controlled by conserved networks of regulatory proteins and noncoding RNAs that coordinate the expression of genes involved in muscle growth, morphogenesis, differentiation and contractility. Our research focuses on the role of muscle-enriched RNA-binding proteins and long noncoding RNAs (lncRNAs) as novel regulators of muscle development and disease. Unexpectedly, we've found that many annotated lncRNAs, in fact, encode small functional proteins, called micropeptides, which play important roles in regulating intracellular signaling. By investigating the function of these regulatory proteins and noncoding RNAs, we aim to uncover novel insights into the regulatory mechanisms important for muscle biology. Our lab utilizes and generates a variety of biochemical and cell-based assays and both gain- and loss-of-function mouse models.

Credentials

Faculty Appointments

Education

2003
Postdoctoral Fellow | UT Southwestern Medical Center, Dallas, Texas
Biology

2003
BS | Arizona State University
Biology

2010
PhD | Arizona State University
Molecular & Cellular Biology

Awards

2014 - 2015
Award for Excellence in Postdoctoral Research at UT Southwestern

Publications

Journal Articles

2016
Anderson KM; Anderson DM; McAnally JR; Shelton JM; Bassel-Duby R; Olson EN. "Widespread control of calcium signaling by a family of SERCA-inhibiting micropeptides". Science Signaling. 2016; 9(457): pp. ra119.

2016
Anderson KM; Anderson DM; McAnally JR; Shelton JM; Bassel-Duby R; Olson EN. "Transcription of the non-coding RNA upperhand controls Hand2 expression and heart development". Nature. 2016; 539: 433-436.

2016
Nelson BR*; Makarewich CA*; Anderson DM; Winders BR; Troupes CD; Wu F; Reese AL; McAnally J; Chen X; Kavalali ET; Cannon SC; Houser SR; Bassel-Duby R; Olson EN. "A micropeptide encoded by a transcript annotated as long noncoding RNA enhances SERCA activity in muscle." Science. 2016; 351: 271-275.

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