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Charles C. Chu, Ph.D.

Publications

Showing all 47 journal articles & 5 books available

Journal Articles

10/2018
VanDerMeid KR, Elliott MR, Baran AM, Barr PM, Chu CC, Zent CS. "Cellular Cytotoxicity of Next-Generation CD20 Monoclonal Antibodies." Cancer immunology research.. 2018 Oct 0; 6(10):1150-1160. Epub 2018 Aug 08.

4/2018
Baliakas P, Mattsson M, Hadzidimitriou A, Minga E, Agathangelidis A, Sutton LA, Scarfo L, Davis Z, Yan XJ, Plevova K, Sandberg Y, Vojdeman FJ, Tzenou T, Chu CC, Veronese S, Mansouri L, Smedby KE, Giudicelli V, Nguyen-Khac F, Panagiotidis P, Juliusson G, Anagnostopoulos A, Lefranc MP, Trentin L, Catherwood M, Montillo M, Niemann CU, Langerak AW, Pospisilova S, Stavroyianni N, Chiorazzi N, Oscier D, Jelinek DF, Shanafelt T, Darzentas N, Belessi C, Davi F, Ghia P, Rosenquist R, Stamatopoulos K. "No improvement in long-term survival over time for chronic lymphocytic leukemia patients in stereotyped subsets #1 and #2 treated with chemo(immuno)therapy." Haematologica.. 2018 Apr 0; 103(4):e158-e161. Epub 2017 Dec 21.

9/1/2017
Xochelli A, Baliakas P, Kavakiotis I, Agathangelidis A, Sutton LA, Minga E, Ntoufa S, Tausch E, Yan XJ, Shanafelt TD, Plevova K, Boudjogra M, Rossi D, Davis Z, Navarro A, Sandberg Y, Vojdeman FJ, Scarfò L, Stavroyianni N, Sudarikov A, Veronese S, Tzenou T, Karan Djurasevic T, Catherwood MA, Kienle D, Chatzouli M, Facco M, Bahlo J, Pott C, Pedersen LB, Mansouri L, Smedby KE, Chu CC, Giudicelli V, Lefranc MP, Panagiotidis P, Juliusson G, Anagnostopoulos A, Vlahavas I, Antic D, Trentin L, Montillo M, Niemann CU, Dohner H, Langerak AW, Pospisilova S, Hallek M, Campo E, Chiorazzi N, Maglaveras N, Oscier D, Gaidano G, Jelinek DF, Stilgenbauer S, Chouvarda I, Darzentas N, Belessi C, Davi F, Hadzidimitriou A, Rosenquist R, Ghia P, Stamatopoulos K. "Chronic Lymphocytic Leukemia with Mutated IGHV4-34 Receptors: Shared and Distinct Immunogenetic Features and Clinical Outcomes." Clinical cancer research : an official journal of the American Association for Cancer Research.. 2017 Sep 1; 23(17):5292-5301. Epub 2017 May 23.

3/2017
Catera R, Liu Y, Gao C, Yan XJ, Magli A, Allen SL, Kolitz JE, Rai KR, Chu CC, Feizi T, Stamatopoulos K, Chiorazzi N. "Binding of CLL subset 4 B-cell receptor immunoglobulins to viable human memory B lymphocytes requires a distinctive IGKV somatic mutation." Molecular medicine.. 2017 Mar 0; 23:1-12. Epub 2017 Jan 12.

2017
Yuan C, Chu CC, Yan XJ, Bagnara D, Chiorazzi N, MacCarthy T. "The Number of Overlapping AID Hotspots in Germline IGHV Genes Is Inversely Correlated with Mutation Frequency in Chronic Lymphocytic Leukemia." PloS one.. 2017 12(1):e0167602. Epub 2017 Jan 26.

11/2016
Hatzi K, Catera R, Moreno Atanasio C, Fischetti VA, Allen SL, Kolitz JE, Rai KR, Chu CC, Chiorazzi N. "Chronic lymphocytic leukemia immunoglobulins display bacterial reactivity that converges and diverges from auto-/poly-reactivity and IGHV mutation status." Clinical immunology : the official journal of the Clinical Immunology Society.. 2016 Nov 0; 172:44-51. Epub 2016 Aug 29.

4/7/2016
Patten PE, Ferrer G, Chen SS, Simone R, Marsilio S, Yan XJ, Gitto Z, Yuan C, Kolitz JE, Barrientos J, Allen SL, Rai KR, MacCarthy T, Chu CC, Chiorazzi N. "Chronic lymphocytic leukemia cells diversify and differentiate in vivo via a nonclassical Th1-dependent, Bcl-6-deficient process." JCI insight.. 2016 Apr 7; 1(4)

1/2016
Cui X, Zhang L, Magli AR, Catera R, Yan XJ, Griffin DO, Rothstein TL, Barrientos J, Kolitz JE, Allen SL, Rai KR, Chiorazzi N, Chu CC. "Cytoplasmic myosin-exposed apoptotic cells appear with caspase-3 activation and enhance CLL cell viability." Leukemia.. 2016 Jan 0; 30(1):74-85. Epub 2015 Jul 29.

8/1/2015
Mongini PK, Gupta R, Boyle E, Nieto J, Lee H, Stein J, Bandovic J, Stankovic T, Barrientos J, Kolitz JE, Allen SL, Rai K, Chu CC, Chiorazzi N. "TLR-9 and IL-15 Synergy Promotes the In Vitro Clonal Expansion of Chronic Lymphocytic Leukemia B Cells." The Journal of immunology : official journal of the American Association of Immunologists.. 2015 Aug 1; 195(3):901-23. Epub 2015 Jul 01.

6/4/2015
Gounari M, Ntoufa S, Apollonio B, Papakonstantinou N, Ponzoni M, Chu CC, Rossi D, Gaidano G, Chiorazzi N, Stamatopoulos K, Ghia P. "Excessive antigen reactivity may underlie the clinical aggressiveness of chronic lymphocytic leukemia stereotyped subset #8." Blood.. 2015 Jun 4; 125(23):3580-7. Epub 2015 Apr 21.

3/25/2015
Liu L, Yu H, Huang X, Tan H, Li S, Luo Y, Zhang L, Jiang S, Jia H, Xiong Y, Zhang R, Huang Y, Chu CC, Tian W. "A novel engineered VEGF blocker with an excellent pharmacokinetic profile and robust anti-tumor activity." BMC cancer.. 2015 Mar 25; 15:170. Epub 2015 Mar 25.

1/29/2015
Baliakas P, Agathangelidis A, Hadzidimitriou A, Sutton LA, Minga E, Tsanousa A, Scarfò L, Davis Z, Yan XJ, Shanafelt T, Plevova K, Sandberg Y, Vojdeman FJ, Boudjogra M, Tzenou T, Chatzouli M, Chu CC, Veronese S, Gardiner A, Mansouri L, Smedby KE, Pedersen LB, Moreno D, Van Lom K, Giudicelli V, Francova HS, Nguyen-Khac F, Panagiotidis P, Juliusson G, Angelis L, Anagnostopoulos A, Lefranc MP, Facco M, Trentin L, Catherwood M, Montillo M, Geisler CH, Langerak AW, Pospisilova S, Chiorazzi N, Oscier D, Jelinek DF, Darzentas N, Belessi C, Davi F, Ghia P, Rosenquist R, Stamatopoulos K. "Not all IGHV3-21 chronic lymphocytic leukemias are equal: prognostic considerations." Blood.. 2015 Jan 29; 125(5):856-9. Epub 2014 Dec 17.

11/2014
Baliakas P, Hadzidimitriou A, Sutton LA, Minga E, Agathangelidis A, Nichelatti M, Tsanousa A, Scarfò L, Davis Z, Yan XJ, Shanafelt T, Plevova K, Sandberg Y, Vojdeman FJ, Boudjogra M, Tzenou T, Chatzouli M, Chu CC, Veronese S, Gardiner A, Mansouri L, Smedby KE, Pedersen LB, van Lom K, Giudicelli V, Francova HS, Nguyen-Khac F, Panagiotidis P, Juliusson G, Angelis L, Anagnostopoulos A, Lefranc MP, Facco M, Trentin L, Catherwood M, Montillo M, Geisler CH, Langerak AW, Pospisilova S, Chiorazzi N, Oscier D, Jelinek DF, Darzentas N, Belessi C, Davi F, Rosenquist R, Ghia P, Stamatopoulos K. "Clinical effect of stereotyped B-cell receptor immunoglobulins in chronic lymphocytic leukaemia: a retrospective multicentre study." The Lancet. Haematology.. 2014 Nov 0; 1(2):e74-84. Epub 2014 Nov 03.

2014
Hwang KK, Trama AM, Kozink DM, Chen X, Wiehe K, Cooper AJ, Xia SM, Wang M, Marshall DJ, Whitesides J, Alam M, Tomaras GD, Allen SL, Rai KR, McKeating J, Catera R, Yan XJ, Chu CC, Kelsoe G, Liao HX, Chiorazzi N, Haynes BF. "IGHV1-69 B cell chronic lymphocytic leukemia antibodies cross-react with HIV-1 and hepatitis C virus antigens as well as intestinal commensal bacteria." PloS one.. 2014 9(3):e90725. Epub 2014 Mar 10.

4/2013
Cesano A, Perbellini O, Evensen E, Chu CC, Cioffi F, Ptacek J, Damle RN, Chignola R, Cordeiro J, Yan XJ, Hawtin RE, Nichele I, Ware JR, Cavallini C, Lovato O, Zanotti R, Rai KR, Chiorazzi N, Pizzolo G, Scupoli MT. "Association between B-cell receptor responsiveness and disease progression in B-cell chronic lymphocytic leukemia: results from single cell network profiling studies." Haematologica.. 2013 Apr 0; 98(4):626-34. Epub 2012 Nov 09.

12/6/2012
Patten PE, Chu CC, Albesiano E, Damle RN, Yan XJ, Kim D, Zhang L, Magli AR, Barrientos J, Kolitz JE, Allen SL, Rai KR, Roa S, Mongini PK, MacCarthy T, Scharff MD, Chiorazzi N. "IGHV-unmutated and IGHV-mutated chronic lymphocytic leukemia cells produce activation-induced deaminase protein with a full range of biologic functions." Blood.. 2012 Dec 6; 120(24):4802-11. Epub 2012 Oct 15.

5/10/2012
Agathangelidis A, Darzentas N, Hadzidimitriou A, Brochet X, Murray F, Yan XJ, Davis Z, van Gastel-Mol EJ, Tresoldi C, Chu CC, Cahill N, Giudicelli V, Tichy B, Pedersen LB, Foroni L, Bonello L, Janus A, Smedby K, Anagnostopoulos A, Merle-Beral H, Laoutaris N, Juliusson G, di Celle PF, Pospisilova S, Jurlander J, Geisler C, Tsaftaris A, Lefranc MP, Langerak AW, Oscier DG, Chiorazzi N, Belessi C, Davi F, Rosenquist R, Ghia P, Stamatopoulos K. "Stereotyped B-cell receptors in one-third of chronic lymphocytic leukemia: a molecular classification with implications for targeted therapies." Blood.. 2012 May 10; 119(19):4467-75. Epub 2012 Mar 13.

2/16/2012
Hwang KK, Chen X, Kozink DM, Gustilo M, Marshall DJ, Whitesides JF, Liao HX, Catera R, Chu CC, Yan XJ, Luftig MA, Haynes BF, Chiorazzi N. "Enhanced outgrowth of EBV-transformed chronic lymphocytic leukemia B cells mediated by coculture with macrophage feeder cells." Blood.. 2012 Feb 16; 119(7):e35-44. Epub 2011 Dec 12.

2011
Ghiotto F, Marcatili P, Tenca C, Calevo MG, Yan XJ, Albesiano E, Bagnara D, Colombo M, Cutrona G, Chu CC, Morabito F, Bruno S, Ferrarini M, Tramontano A, Fais F, Chiorazzi N. "Mutation pattern of paired immunoglobulin heavy and light variable domains in chronic lymphocytic leukemia B cells." Molecular medicine.. 2011 17(11-12):1188-95. Epub 2011 Jul 13.

2011
Chu CC, Zhang L, Dhayalan A, Agagnina BM, Magli AR, Fraher G, Didier S, Johnson LP, Kennedy WJ, Damle RN, Yan XJ, Patten PE, Teichberg S, Koduru P, Kolitz JE, Allen SL, Rai KR, Chiorazzi N. "Torque teno virus 10 isolated by genome amplification techniques from a patient with concomitant chronic lymphocytic leukemia and polycythemia vera." Molecular medicine.. 2011 17(11-12):1338-48. Epub 2011 Sep 21.

5/13/2010
Chu CC, Catera R, Zhang L, Didier S, Agagnina BM, Damle RN, Kaufman MS, Kolitz JE, Allen SL, Rai KR, Chiorazzi N. "Many chronic lymphocytic leukemia antibodies recognize apoptotic cells with exposed nonmuscle myosin heavy chain IIA: implications for patient outcome and cell of origin." Blood.. 2010 May 13; 115(19):3907-15. Epub 2010 Jan 28.

10/22/2009
Seiler T, Woelfle M, Yancopoulos S, Catera R, Li W, Hatzi K, Moreno C, Torres M, Paul S, Dohner H, Stilgenbauer S, Kaufman MS, Kolitz JE, Allen SL, Rai KR, Chu CC, Chiorazzi N. "Characterization of structurally defined epitopes recognized by monoclonal antibodies produced by chronic lymphocytic leukemia B cells." Blood.. 2009 Oct 22; 114(17):3615-24. Epub 2009 Aug 18.

12/15/2008
Chu CC, Catera R, Hatzi K, Yan XJ, Zhang L, Wang XB, Fales HM, Allen SL, Kolitz JE, Rai KR, Chiorazzi N. "Chronic lymphocytic leukemia antibodies with a common stereotypic rearrangement recognize nonmuscle myosin heavy chain IIA." Blood.. 2008 Dec 15; 112(13):5122-9. Epub 2008 Sep 23.

2008
Catera R, Silverman GJ, Hatzi K, Seiler T, Didier S, Zhang L, Hervé M, Meffre E, Oscier DG, Vlassara H, Scofield RH, Chen Y, Allen SL, Kolitz J, Rai KR, Chu CC, Chiorazzi N. "Chronic lymphocytic leukemia cells recognize conserved epitopes associated with apoptosis and oxidation." Molecular medicine.. 2008 14(11-12):665-74. Epub 2008 Sep 25.

1/1/2007
Benoff S, Chu CC, Marmar JL, Sokol RZ, Goodwin LO, Hurley IR. "Voltage-dependent calcium channels in mammalian spermatozoa revisited." Frontiers in bioscience : a journal and virtual library.. 2007 Jan 1; 12:1420-49. Epub 2007 Jan 01.

6/2005
Guzowski D, Chandrasekaran A, Gawel C, Palma J, Koenig J, Wang XP, Dosik M, Kaplan M, Chu CC, Chavan S, Furie R, Albesiano E, Chiorazzi N, Goodwin L. "Analysis of single nucleotide polymorphisms in the promoter region of interleukin-10 by denaturing high-performance liquid chromatography." Journal of biomolecular techniques : JBT.. 2005 Jun 0; 16(2):154-66.

5/2005
Desai A, Victor-Vega C, Gadangi S, Montesinos MC, Chu CC, Cronstein BN. "Adenosine A2A receptor stimulation increases angiogenesis by down-regulating production of the antiangiogenic matrix protein thrombospondin 1." Molecular pharmacology.. 2005 May 0; 67(5):1406-13. Epub 2005 Jan 26.

10/1/2004
Mason JM, Naidu MD, Barcia M, Porti D, Chavan SS, Chu CC. "IL-4-induced gene-1 is a leukocyte L-amino acid oxidase with an unusual acidic pH preference and lysosomal localization." The Journal of immunology : official journal of the American Association of Immunologists.. 2004 Oct 1; 173(7):4561-7.

2003
Miura Y, Chu CC, Dines DM, Asnis SE, Furie RA, Chiorazzi N. "Diversification of the Ig variable region gene repertoire of synovial B lymphocytes by nucleotide insertion and deletion." Molecular medicine.. 2003 9(5-8):166-74.

7/2002
Tian W, Chua K, Strober W, Chu CC. "ILG1 : a new integrase-like gene that is a marker of bacterial contamination by the laboratory Escherichia coli strain TOP10F'." Molecular medicine.. 2002 Jul 0; 8(7):405-16.

6/7/2002
Chavan SS, Tian W, Hsueh K, Jawaheer D, Gregersen PK, Chu CC. "Characterization of the human homolog of the IL-4 induced gene-1 (Fig1)." Biochimica et biophysica acta.. 2002 Jun 7; 1576(1-2):70-80.

8/1999
Hirose N, Williams R, Alberts AR, Furie RA, Chartash EK, Jain RI, Sison C, Lahita RG, Merrill JT, Cucurull E, Gharavi AE, Sammaritano LR, Salmon JE, Hashimoto S, Sawada T, Chu CC, Gregersen PK, Chiorazzi N. "A role for the polymorphism at position 247 of the beta2-glycoprotein I gene in the generation of anti-beta2-glycoprotein I antibodies in the antiphospholipid syndrome." Arthritis and rheumatism.. 1999 Aug 0; 42(8):1655-61.

6/1998
Chu CC, Paul WE. "Expressed genes in interleukin-4 treated B cells identified by cDNA representational difference analysis." Molecular immunology.. 1998 Jun 0; 35(8):487-502.

3/18/1997
Chu CC, Paul WE. "Fig1, an interleukin 4-induced mouse B cell gene isolated by cDNA representational difference analysis." Proceedings of the National Academy of Sciences of the United States of America.. 1997 Mar 18; 94(6):2507-12.

4/18/1996
Shimoda K, van Deursen J, Sangster MY, Sarawar SR, Carson RT, Tripp RA, Chu C, Quelle FW, Nosaka T, Vignali DA, Doherty PC, Grosveld G, Paul WE, Ihle JN. "Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted Stat6 gene." Nature.. 1996 Apr 18; 380(6575):630-3.

2/1995
Nakanishi K, Yoshimoto T, Chu CC, Matsumoto H, Hase K, Nagai N, Tanaka T, Miyasaka M, Paul WE, Shinka S. "IL-2 inhibits IL-4-dependent IgE and IgG1 production in vitro and in vivo." International immunology.. 1995 Feb 0; 7(2):259-68.

11/1994
Clark AJ, Satin L, Chu CC. "Transcription of the Escherichia coli recE gene from a promoter in Tn5 and IS50." Journal of bacteriology.. 1994 Nov 0; 176(22):7024-31.

12/1993
Clark AJ, Sharma V, Brenowitz S, Chu CC, Sandler S, Satin L, Templin A, Berger I, Cohen A. "Genetic and molecular analyses of the C-terminal region of the recE gene from the Rac prophage of Escherichia coli K-12 reveal the recT gene." Journal of bacteriology.. 1993 Dec 0; 175(23):7673-82.

11/1/1993
Mandler R, Chu CC, Paul WE, Max EE, Snapper CM. "Interleukin 5 induces S mu-S gamma 1 DNA rearrangement in B cells activated with dextran-anti-IgD antibodies and interleukin 4: a three component model for Ig class switching." The Journal of experimental medicine.. 1993 Nov 1; 178(5):1577-86.

10/1/1993
Chu CC, Max EE, Paul WE. "DNA rearrangement can account for in vitro switching to IgG1." The Journal of experimental medicine.. 1993 Oct 1; 178(4):1381-90.

8/1/1992
Chu CC, Paul WE, Max EE. "Quantitation of immunoglobulin mu-gamma 1 heavy chain switch region recombination by a digestion-circularization polymerase chain reaction method." Proceedings of the National Academy of Sciences of the United States of America.. 1992 Aug 1; 89(15):6978-82.

2/1/1992
Tanaka T, Chu CC, Paul WE. "An antisense oligonucleotide complementary to a sequence in I gamma 2b increases gamma 2b germline transcripts, stimulates B cell DNA synthesis, and inhibits immunoglobulin secretion." The Journal of experimental medicine.. 1992 Feb 1; 175(2):597-607.

3/15/1991
Scappino LA, Chu C, Gritzmacher CA. "Extended nucleotide sequence of the switch region of the murine gene encoding immunoglobulin E." Gene.. 1991 Mar 15; 99(2):295-6.

6/1990
Mahajan SK, Chu CC, Willis DK, Templin A, Clark AJ. "Physical analysis of spontaneous and mutagen-induced mutants of Escherichia coli K-12 expressing DNA exonuclease VIII activity." Genetics.. 1990 Jun 0; 125(2):261-73.

11/1989
Chu CC, Clark AJ. "A 10- rather than 9-bp duplication associated with insertion of Tn5 in Escherichia coli K-12." Plasmid.. 1989 Nov 0; 22(3):260-4.

4/1989
Chu CC, Templin A, Clark AJ. "Suppression of a frameshift mutation in the recE gene of Escherichia coli K-12 occurs by gene fusion." Journal of bacteriology.. 1989 Apr 0; 171(4):2101-9.

1984
Clark AJ, Sandler SJ, Willis DK, Chu CC, Blanar MA, Lovett ST. "Genes of the RecE and RecF pathways of conjugational recombination in Escherichia coli." Cold Spring Harbor symposia on quantitative biology.. 1984 49:453-62.

Books & Chapters

2014
Chapter Title: Detection of de novo IGHV mutations by ultra-deep sequencing from in vitro activated B-cell chronic lymphocytic leukemia cells: Evidence for activation-induced deaminase function
Book Title: 15th International Congress of Immunology
Author List: Chu, C.C.; Patten, P.E.M.; MacCarthy, T.; Yan, X.-J.; Kolitz, J.E.; Allen, S.L.; Barrientos, J.C.; Rai, K.R; Chiorazzi,N.;
Published By: Medimond S.r.l., Monduzzi Editore2014 in Bologna, Italy

2013
Chapter Title: B-cell chronic lymphocytic leukemia/lymphoma
Book Title: Non-Hodgkin Lymphomas: Advanced Diagnostics and Personalized Therapies
Author List: Patten, P.E.M.; Chu, C.C.; Chiorazzi, N.;
Edited By: Carbone, A.; Younes, A.;
Published By: Future Medicine Ltd2013 in London, UK

2007
Chapter Title: Plasma from a B-cell chronic lymphocytic patient with polycythemia vera contains viral and bacterial DNA
Book Title: 13th International Congress of Immunology
Author List: Chu, C.C.; Zhang, L.; Teichberg, S.; Allen, S.L.; Rai, K.R.; Chiorazzi, N.;
Edited By: Kalil, J.; Cunha-Neto, E.; Rizzo, L.V.;
Published By: Medimond S.r.l., Monduzzi Editore2007 in Bologna, Italy

2004
Chapter Title: Interleukin-4 induced gene-1 (IL4I1) may affect antigen presenting cell function
Book Title: Immunology 2004
Author List: Chavan, S.S.; Mason, J.M.; Porti, D.; Barcia, M.; Chu, C.C.;
Published By: Medimond S.r.l., Monduzzi Editore2004 in Bologna, Italy

1994
Chapter Title: Detection of Isotype Switch Rearrangement in Bulk Culture by PCR
Book Title: Current Protocols in Immunology
Author List: Max, E.E.; Mills, F.C.; Chu, C.;
Edited By: Coligan, J.E.; Kruisbeek, A.M.; Margulies, D.H.; Shevach, E.M.; Strober, W.;
Published By: John Wiley & Sons, Inc.1994 in New York, NY