CONTACT INFORMATIONCREDENTIALSAWARDSPUBLICATIONSDavid M. MacLean, Ph.D.Contact InformationPhone NumbersOffice: (585) 276-3032Research LabsVisit Lab WebsiteLocationsUniversity of Rochester Medical CenterSchool of Medicine and Dentistry601 Elmwood Ave, Box 711Rochester, NY 14642Additional LinksMacleanlab.netFaculty AppointmentsAssistant Professor - Department of Pharmacology and Physiology (SMD) Paul Stark Professorship in Pharmacology - Department of Pharmacology and Physiology (SMD) BiographyResearchDr. MacLean's research program aims to understand the inter-relationships between ligand-gated ion channel form, function and physiology. Currently, the lab is focused on acid-sensing ion channels (ASICs), a class of pH-activated channels expressed throughout the brain and body. Another ongoing research interest is ionotropic glutamate receptors (ie. AMPA, NMDA and Kainate receptors). To study these receptors, the lab uses a combination of electrophysiology, fluorescence spectroscopy, protein purification, kinetic and molecular modelling as well as non-canonical amino acid incorporation.CredentialsEducation2005BSc | Canada - University of TorontoNeuroscience2011PhD | Canada-McGill UniversityPharmacologyPost-doctoral Training & Residency01/09/2012 - 03/19/2017UTHealth Science Center, Dept. of Biochemistry and Molecular BiologyAwardsPaul F. Cranefield Postdoctoral AwardSponsor: Society for General PhysiologistsPublicationsJournal Articles8/2/2021Rook ML, Miaro M, Couch T, Kneisley DL, Musgaard M, MacLean DM. "Mutation of a conserved glutamine residue does not abolish desensitization of acid-sensing ion channel 1." The Journal of general physiology.. 2021 Aug 2; 153(8)Epub 2021 Jun 01. 7/22/2021Couch T, Berger K, Kneisley DL, McCullock TW, Kammermeier P, Maclean DM. "Topography and motion of the acid-sensing ion channel intracellular domains." eLife.. 2021 Jul 22; 10Epub 2021 Jul 22. 4/19/2020Rook ML, Musgaard M, MacLean DM. "Coupling structure with function in acid-sensing ion channels: Challenges in pursuit of proton sensors." The Journal of physiology.. 2020 Apr 19; Epub 2020 Apr 19. Books & Chapters2015 Chapter Title: Constructing a rapid solution exchange system Book Title: Ionotropic Glutamate Receptor Technologies Author List: MacLean, DM Edited By: Dr. Gabriela Popescu Published By: Springer 2015VIEW ALL PUBLICATIONSClose WindowSchedule an appointment with David M. MacLean, Ph.D.Please answer the following questions to help us find the right appointment for you.Important: If you believe that you have a medical or psychiatric emergency, please call 911 or go to the nearest hospital. This website is not intended for emergency care.Have you seen this provider in the last 2 years?YesNoExisting Patient Schedule or request a follow up appointment online through MyChart. If you do not have a MyChart account, please close this window and call the appointment phone number. David M. MacLean, Ph.D. is currently scheduling for the following appointment type(s): Our policy does not permit patients to establish care with multiple providers within the same practice or specialty without prior approval. If you choose a new provider in the same office, we will cancel the appointment. Please contact the office directly with questions on this policy.