David M. MacLean, Ph.D.

Contact Information

Faculty Appointments

Associate Professor - Department of Pharmacology and Physiology (SMD)
Paul Stark Professorship in Pharmacology - Department of Pharmacology and Physiology (SMD)

Biography

Research

Dr. MacLean's research program aims to understand the inter-relationships between ligand-gated ion channel form, function and physiology. Currently, the lab is focused on acid-sensing ion channels (ASICs), a class of pH-activated channels expressed throughout the brain and body. Another ongoing research interest is ionotropic glutamate receptors (ie. AMPA, NMDA and Kainate receptors). To study these receptors, the lab uses a combination of electrophysiology, fluorescence spectroscopy, protein purification, kinetic and molecular modelling as well as non-canonical amino acid incorporation.

Credentials

Education

2005
BSc | Canada - University of Toronto
Neuroscience

2011
PhD | Canada-McGill University
Pharmacology

Post-doctoral Training & Residency

01/09/2012 - 03/19/2017
UTHealth Science Center, Dept. of Biochemistry and Molecular Biology

Awards

Paul F. Cranefield Postdoctoral Award
Sponsor: Society for General Physiologists

Publications

Journal Articles

8/2/2021
Rook ML, Miaro M, Couch T, Kneisley DL, Musgaard M, MacLean DM. "Mutation of a conserved glutamine residue does not abolish desensitization of acid-sensing ion channel 1." The Journal of general physiology.. 2021 Aug 2; 153(8)Epub 2021 Jun 01.

7/22/2021
Couch T, Berger K, Kneisley DL, McCullock TW, Kammermeier P, Maclean DM. "Topography and motion of the acid-sensing ion channel intracellular domains." eLife.. 2021 Jul 22; 10Epub 2021 Jul 22.

2021
Rook ML, Ananchenko A, Musgaard M, MacLean DM. "Molecular Investigation of Chicken Acid-Sensing Ion Channel 1 ?11-12 Linker Isomerization and Channel Kinetics." Frontiers in cellular neuroscience.. 2021 15:761813. Epub 2021 Nov 24.

Books & Chapters

2015
Chapter Title: Constructing a rapid solution exchange system
Book Title: Ionotropic Glutamate Receptor Technologies
Author List: MacLean, DM
Edited By: Dr. Gabriela Popescu
Published By: Springer 2015

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