Dr. Hablitz is a chronobiologist focused on understanding how the body interacts with the environment over the course of a day. Some projects include how sleep affects brain function, how feeding might be used to improve stroke outcomes, and how circadian rhythms, present in every cell and process within the body, synchronize to protect against disease.
Dr. Hablitz earned a B.S. in Biology from The Pennsylvania State University in 2010. In 2015, Dr. Hablitz earned a Ph.D. in Cell, Molecular, and Developmental Biology from the University of Alabama Birmingham from the lab of Dr. Karen Gamble investigating conserved molecular mechanisms of nonphotic entrainment. After completing a postdoctoral research position at Oregon Health & Science University with Dr. Charles Allen, understanding the role of astrocytes in modulating cannabinoid signaling in the suprachiasmatic nucleus, Dr. Hablitz joined the Center for Translational Neuromedicine at the University of Rochester in 2017. Together with Dr. Maiken Nedergaard, Dr. Hablitz defined the endogenous, circadian rhythm of the glymphatic system and discovered a new rhythm in CSF distribution between the brain and the body.
Dr. Hablitz’s research focuses on basic biological mechanisms of circadian synchrony and entrainment in health and disease. Most recently, Dr. Hablitz has been using circadian rhythms and sleep to improve glymphatic, neuronal, and cerebrovascular function in pre-clinical models of chronic neuropathic pain and stroke.
Gomolka RS, Hablitz LM, Mestre H, Giannetto M, Du T, Hauglund NL, Xie L, Peng W, Martinez PM, Nedergaard M, Mori Y. "Loss of aquaporin-4 results in glymphatic system dysfunction via brain-wide interstitial fluid stagnation." eLife.. 2023 Feb 9; 12Epub 2023 Feb 09.
Plá V, Bork P, Harnpramukkul A, Olveda G, Ladrón-de-Guevara A, Giannetto MJ, Hussain R, Wang W, Kelley DH, Hablitz LM, Nedergaard M. "A real-time in vivo clearance assay for quantification of glymphatic efflux." Cell reports.. 2022 Sep 13; 40(11):111320.
Giannetto MJ, Hablitz LM. "Reading to the end(foot): translational readthrough of AQP4 increases amyloid-? clearance." Brain : a journal of neurology.. 2022 Aug 25; Epub 2022 Aug 25.
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