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Kuan Hong Wang, Ph.D.

Kuan Hong Wang, Ph.D.

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Intellectual and Developmental Disabilities Research Center 

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About Me

Dr. Kuan Hong Wang is the endowed Dean’s Professor of Neuroscience at the University of Rochester School of Medicine and a faculty member of the Del Monte Institute for Neuroscience. His research seeks to understand how neural circuits develop, adapt, and regulate behavior, with particular emphasis ...
Dr. Kuan Hong Wang is the endowed Dean’s Professor of Neuroscience at the University of Rochester School of Medicine and a faculty member of the Del Monte Institute for Neuroscience. His research seeks to understand how neural circuits develop, adapt, and regulate behavior, with particular emphasis on cognitive–affective integration, neuromodulatory signaling, and brain–body interactions. Throughout his career, he has pursued an integrative approach spanning molecular, cellular, and systems neuroscience to uncover fundamental mechanisms of neural plasticity and their implications for neurological and psychiatric disorders.

Dr. Wang began his research training at Harvard College, graduating summa cum laude with highest honors in Biochemical Sciences, where he studied biochemical signal transduction with Dr. Raymond Erikson. He subsequently earned his PhD at the University of California, San Francisco (UCSF), working with Dr. Marc Tessier-Lavigne to identify Slit proteins as key molecular regulators of axon guidance and branching during neural development. During his postdoctoral training at the Massachusetts Institute of Technology (MIT) with Dr. Susumu Tonegawa, he developed innovative genetic and in vivo imaging approaches to track experience-dependent gene expression in the living brain and uncover mechanisms of cortical plasticity.

As a Principal Investigator in the intramural research program of the National Institute of Mental Health (NIMH) and subsequently at the University of Rochester, Dr. Wang has established a research program focused on the neural circuit mechanisms underlying adaptive behavior and disease vulnerability. His laboratory has made significant contributions to understanding frontal cortical mechanisms of goal-directed learning, adolescent plasticity of dopaminergic inputs to the frontal cortex, and corticospinal control of sensorimotor functions and peripheral physiology. Building on these discoveries, his current research encompasses insular-frontal circuit mechanisms of cognitive–affective integration and behavioral flexibility, neuroimmune regulation of dopamine circuit plasticity across development and aging, and cannabinoid modulation of pathological cellular states in neuropathic pain. Expanding this mechanistic framework to neurological disorders, his laboratory also investigates how widespread molecular pathology gives rise to selective neuronal and circuit dysfunction in neurodegenerative and lysosomal storage disorders. In parallel, his cross-species research, including studies in marmosets, advances translational technologies and investigates conserved principles of neural circuit organization and plasticity, helping bridge fundamental neuroscience with the understanding of human brain function and disease.

Dr. Wang’s research has received sustained support from multiple institutes of the National Institutes of Health (NIH). Beyond his research contributions, he holds leadership roles in the NIH-designated Intellectual and Developmental Disabilities Research Center (IDDRC) at the University of Rochester and the Network for Emotional Well-being and Brain Aging, an NIH-supported national research initiative. Through these interdisciplinary efforts, he fosters collaborations across basic and clinical neuroscience, advances the translation of fundamental discoveries toward clinical applications, and mentors the next generation of scientists.

Faculty Appointments

Professor - Department of Neuroscience (SMD)

Dean's Professorship - Department of Neuroscience (SMD)

Associate Chair, Research - Department of Neuroscience (SMD)

Professor - Department of Pharmacology and Physiology (SMD) - Joint

Credentials

Education

Ph.D. | University of California at San Francisco. 1999

BA | Harvard College. Biochemical Sciences. 1994

Research

A fundamental challenge in neuroscience is to understand how neural circuits are organized, develop specialized functions, and adapt to changing behavioral demands. Neurodevelopment and experience-dependent plasticity provide unique opportunities to uncover the principles governing circuit architect...
A fundamental challenge in neuroscience is to understand how neural circuits are organized, develop specialized functions, and adapt to changing behavioral demands. Neurodevelopment and experience-dependent plasticity provide unique opportunities to uncover the principles governing circuit architecture and function, while aging and neurological disease reveal mechanisms of circuit vulnerability and dysfunction. The long-term goal of Dr. Wang’s laboratory is to elucidate the molecular, cellular, and circuit mechanisms that enable adaptive behavior, and to translate these discoveries into new strategies for understanding and treating brain disorders.

Research in Dr. Wang’s laboratory addresses interconnected questions about the organization, plasticity, and modulation of neural circuits underlying cognitive, emotional, and sensorimotor functions. How do interactions between frontal and insular cortical circuits support cognitive–affective integration and behavioral flexibility? How do neuroimmune mechanisms regulate the development, plasticity, and age-related vulnerability of dopaminergic and other neuromodulatory circuits? How do neuroactive compounds, including cannabinoids, modulate pathological cellular and circuit states in neuropathic pain and other neurological disorders? Extending these mechanistic investigations to neurodegenerative and lysosomal storage disorders, we examine how genetic mutations and widespread molecular pathology give rise to selective neuronal and circuit dysfunction. Together, these research directions seek to uncover fundamental links between circuit organization, adaptive function, and disease vulnerability, while identifying new opportunities for targeted therapeutic intervention.

To address these questions, our laboratory integrates molecular, cellular, and systems neuroscience approaches across rodent and non-human primate (marmoset) models. We develop and apply innovative technologies for monitoring and manipulating neural circuits, including in vivo imaging and electrophysiology, genetic and viral circuit tracing, optogenetic and chemogenetic neuromodulation, and computational approaches to neural activity and behavior. Cross-species investigations and collaborations with clinical researchers further enable us to examine conserved principles of brain organization, develop translational technologies and neurophysiological biomarkers, and bridge fundamental discoveries with the understanding of human brain function and disease.

Publications

Journal Articles

Functional ultrasound imaging reveals early pathway-specific reorganization of central visual circuits in a mouse model of Batten disease.

Yin F, Ding Y, Chang H, Prifti V, Feng J, Freedman EG, Foxe JJ, Doyley M, Wang KH

Neurobiology of disease.. 2026 August 22 :107578. Epub 08/22/2026.

A cross-species protocol for ultrasound-guided intrauterine injections across gestation.

Ribeiro Gomes AR, Hamel N, Mastwal S, Ide DC, Wang KH, Leopold DA

bioRxiv : the preprint server for biology.. 2026 July 11 Epub 07/11/2026.

Long-term effects of adolescent risperidone treatment on the mouse cortex.

Alicea-Pauneto AD, Choi H, Zhang W, Li X, Busque LA, Li M, Wu A, Zhang E, Marc AD, Preall J, Wang KH, Featherstone RE, Siegel SJ, Hahn CG, Borgmann-Winter KE

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology.. 2026 July 8 Epub 07/08/2026.

Protocol to prepare inclusion complex-enhanced cannabinoid nano-micelles for behavioral pharmacology and in vivo neurophysiology in mice.

Feng J, Page J, Chung L, He Z, Wang KH

STAR protocols.. 2026 July 17 (3):104650. Epub 07/01/2026.

Functional ultrasound imaging reveals pathway-specific visual system reorganization in young -/- mice.

Yin F, Ding Y, Chang H, Prifti V, Feng J, Freedman EG, Foxe JJ, Doyley M, Wang KH

bioRxiv : the preprint server for biology.. 2026 June 9 Epub 06/09/2026.

Distinct Auditory Thalamocortical Pathologies Underlie Emerging Neurophysiological Dysfunction in a Cln3 Mouse Model of Batten Disease.

Ding Y, Feng J, Prifti V, Rico GA, Solorzano AG, Chang HE, Spallina SA, Freedman EG, Foxe JJ, Wang KH

bioRxiv : the preprint server for biology.. 2026 June 4 Epub 06/04/2026.

Targeting insulo-frontal pathway to reduce stress-evoked cognitive rigidity.

Ma S, Wang KH, Zuo Y

Nature communications.. 2026 April 27 Epub 04/27/2026.

Projection-specific intersectional optogenetics for precise excitation and inhibition in the marmoset brain.

Shaw L, Padmanabhan K, Bucklaew A, Mitchell JF, Wang KH

Cell reports methods.. 2026 March 30 :101368. Epub 03/30/2026.

Targeting insulo-frontal pathway to reduce stress-evoked cognitive rigidity.

Ma S, Wang KH, Zuo Y

bioRxiv : the preprint server for biology.. 2026 February 13 Epub 02/13/2026.

An implanted lennula approach to measure neural Ca responses in the awake marmoset visual cortex.

Park SH, Nti SA, Marcelle M, Esch EM, Wang KH, Silva AC, Leopold DA

Imaging neuroscience.. 2026 4 Epub 03/04/2026.

Cross-Species Behavioral Analysis via Multidimensional Knowledge Transfer.

Liu Y, Shaw L, Liu H, Wang KH, Vankee-Lin F, Zhao G

IEEE intelligent systems.. 2026 41 (4):98-107. Epub 05/12/2026.

Fiber parametric chirp-matched amplification.

Tirumala S, Guo Z, Zhang J, Ching-Roa V, Stowell R, Wang KH, Giacomelli MG, Renninger WH

Optics express.. 2025 December 2933 (26):54330-54345. Epub 1900 01 01.

Targeted gene transfer into developmentally defined cell populations of the primate brain.

Ribeiro Gomes AR, Hamel N, Mastwal S, Wright N, Ide DC, Richie CT, Usdin TB, Wang KH, Leopold DA

Cell reports.. 2025 December 2145 (1):116756. Epub 12/21/2025.

Rapid suppression of neuropathic pain and somatosensory hyperactivity by nano-formulated cannabidiol.

Feng J, Page J, Chung L, He Z, Wang KH

Cell chemical biology.. 2025 November 7 Epub 11/07/2025.

Sex-specific and age-related progression of auditory neurophysiological deficits in the Cln3 mouse model of Batten disease.

Ding Y, Feng J, Prifti V, Rico GA, Solorzano AG, Chang HE, Freedman EG, Foxe JJ, Wang KH

Journal of neurodevelopmental disorders.. 2025 November 617 (1):67. Epub 11/06/2025.

Bridging Social Isolation, Loneliness, and Brain Aging: A Narrative Review of Mechanisms and Translational Interventions.

Wnuk HK, Van Orden KA, Wang KH

Neuroscience and biobehavioral reviews.. 2025 October 30 :106451. Epub 10/30/2025.

From thought to action: The organization of spinal projecting neurons.

Winter CC, Wang KH, He Z

Cell reports.. 2025 August 2644 (8):116153. Epub 08/14/2025.

Dopaminergic signaling regulates microglial surveillance and adolescent plasticity in the mouse frontal cortex.

Stowell R, Wang KH

Nature communications.. 2025 August 2616 (1):7974. Epub 08/26/2025.

Projection-Specific Intersectional Optogenetics for Precise Excitation and Inhibition in the Marmoset Brain.

Shaw L, Padmanabhan K, Buckleaw A, Mitchell JF, Wang KH

bioRxiv : the preprint server for biology.. 2025 August 15 Epub 08/15/2025.

Cross-Species Framework for Emotional Well-Being and Brain Aging: Lessons From Behavioral Neuroscience.

Lin FV, Simmons JM, Turnbull A, Zuo Y, Conwell Y, Wang KH

JAMA psychiatry.. 2025 July 182 (7):734-741. Epub 1900 01 01.

Neural representation of self-initiated locomotion in the secondary motor cortex of mice across different environmental contexts.

Sun G, Yu C, Cai R, Li M, Fan L, Sun H, Lyu C, Lin Y, Gao L, Wang KH, Li X

Communications biology.. 2025 May 108 (1):725. Epub 05/10/2025.

Targeted gene transfer into developmentally defined cell populations of the primate brain.

Gomes ARR, Hamel N, Mastwal S, Wright N, Ide DC, Richie CT, Usdin TB, Wang KH, Leopold DA

bioRxiv : the preprint server for biology.. 2025 April 17 Epub 04/17/2025.

Spinal projecting neurons in rostral ventromedial medulla co-regulate motor and sympathetic tone.

Zhang Z, Su J, Tang J, Chung L, Page JC, Winter CC, Liu Y, Kegeles E, Conti S, Zhang Y, Biundo J, Chalif JI, Hua CY, Yang Z, Yao X, Yang Y, Chen S, Schwab JM, Wang KH, Chen C, Prerau MJ, He Z

Cell.. 2024 June 20187 (13):3427-3444.e21. Epub 05/10/2024.

An ethologically motivated neurobiology of primate visually-guided reach-to-grasp behavior.

Mitchell JF, Wang KH, Batista AP, Miller CT

Current opinion in neurobiology.. 2024 June 86 :102872. Epub 04/01/2024.

Cholecystokinin facilitates motor skill learning by modulating neuroplasticity in the motor cortex.

Li H, Feng J, Chen M, Xin M, Chen X, Liu W, Wang L, Wang KH, He J

eLife.. 2024 May 313 Epub 05/03/2024.

Dopaminergic signaling regulates microglial surveillance and adolescent plasticity in the frontal cortex.

Stowell R, Wang KH

bioRxiv : the preprint server for biology.. 2024 March 13 Epub 03/13/2024.

Assessing the integrity of auditory sensory memory processing in CLN3 disease (Juvenile Neuronal Ceroid Lipofuscinosis (Batten disease)): an auditory evoked potential study of the duration-evoked mismatch negativity (MMN).

Brima T, Freedman EG, Prinsloo KD, Augustine EF, Adams HR, Wang KH, Mink JW, Shaw LH, Mantel EP, Foxe JJ

Journal of neurodevelopmental disorders.. 2024 January 616 (1):3. Epub 01/06/2024.

Adolescent neurostimulation of dopamine circuit reverses genetic deficits in frontal cortex function.

Mastwal S, Li X, Stowell R, Manion M, Zhang W, Kim NS, Yoon KJ, Song H, Ming GL, Wang KH

eLife.. 2023 October 1312 Epub 10/13/2023.

Assessing the integrity of auditory sensory memory processing in CLN disease (Juvenile Neuronal Ceroid Lipofuscinosis (Batten disease)): An auditory evoked potential study of the duration-evoked mismatch negativity (MMN).

Brima T, Freedman EG, Prinsloo KD, Augustine EF, Adams HR, Wang KH, Mink JW, Shaw LH, Mantel EP, Foxe JJ

Research square.. 2023 August 17 Epub 08/17/2023.

Adolescent neurostimulation of dopamine circuit reverses genetic deficits in frontal cortex function.

Mastwal S, Li X, Stowell R, Manion M, Zhang W, Kim NS, Yoon KJ, Song H, Ming GL, Wang KH

bioRxiv : the preprint server for biology.. 2023 July 12 Epub 07/12/2023.

Increased Central Auditory Gain and Decreased Parvalbumin-Positive Cortical Interneuron Density in the Mouse Model of Schizophrenia Correlate With Hearing Impairment.

Zinnamon FA, Harrison FG, Wenas SS, Liu Q, Wang KH, Linden JF

Biological psychiatry global open science.. 2023 July 3 (3):386-397. Epub 03/16/2022.

Fast prediction in marmoset reach-to-grasp movements for dynamic prey.

Shaw L, Wang KH, Mitchell J

Current biology : CB.. 2023 June 1933 (12):2557-2565.e4. Epub 06/05/2023.

Can Emotional Well-Being Maintain Health and Prevent Suicide in Later Life? A National Priority for Research.

Conwell Y, Lin FV, Wang KH

The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry.. 2023 June 31 (6):425-427. Epub 01/25/2023.

New horizons in emotional well-being and brain aging: Potential lessons from cross-species research.

Lin FV, Zuo Y, Conwell Y, Wang KH

International journal of geriatric psychiatry.. 2023 June 38 (6):e5936. Epub 1900 01 01.

Emotional Well-Being: What It Is and Why It Matters.

Park CL, Kubzansky LD, Chafouleas SM, Davidson RJ, Keltner D, Parsafar P, Conwell Y, Martin MY, Hanmer J, Wang KH

Affective science.. 2023 March 4 (1):10-20. Epub 11/15/2022.

A Perfect Storm to Set the Stage for Ontological Exploration: Response to Commentaries on "Emotional Well-Being: What It Is and Why It Matters".

Park CL, Kubzansky LD, Chafouleas SM, Davidson RJ, Keltner D, Parsafar P, Conwell Y, Martin MY, Hanmer J, Wang KH

Affective science.. 2023 March 4 (1):52-58. Epub 12/14/2022.

A sex difference in mouse dopaminergic projections from the midbrain to basolateral amygdala.

Manion MTC, Glasper ER, Wang KH

Biology of sex differences.. 2022 December 3013 (1):75. Epub 12/30/2022.

Comparative anatomical analysis of dopamine systems in Mus musculus and Peromyscus californicus.

Buck J, Manion MTC, Zhang W, Glasper ER, Wang KH

Brain structure & function.. 2022 July 227 (6):2219-2227. Epub 05/02/2022.

Prior actions influence cost-benefit-related decision-making during mouse foraging behaviours.

Dylda E, Wang KH

The European journal of neuroscience.. 2022 July 56 (2):3861-3874. Epub 05/26/2022.

KCNH2-3.1 mediates aberrant complement activation and impaired hippocampal-medial prefrontal circuitry associated with working memory deficits.

Ren M, Hu Z, Chen Q, Jaffe A, Li Y, Sadashivaiah V, Zhu S, Rajpurohit N, Heon Shin J, Xia W, Jia Y, Wu J, Lang Qin S, Li X, Zhu J, Tian Q, Paredes D, Zhang F, Wang KH, Mattay VS, Callicott JH, Berman KF, Weinberger DR, Yang F

Molecular psychiatry.. 2020 January 25 (1):206-229. Epub 09/30/2019.

Developmental Exposure to Psychostimulant Primes Activity-dependent Gene Induction in Frontal Cortex.

Ye Y, Liu Q, Zhang W, Mastwal S, Wang KH

Developmental neurobiology.. 2019 January 79 (1):96-108. Epub 12/19/2018.

Touch and tactile neuropathic pain sensitivity are set by corticospinal projections.

Liu Y, Latremoliere A, Li X, Zhang Z, Chen M, Wang X, Fang C, Zhu J, Alexandre C, Gao Z, Chen B, Ding X, Zhou JY, Zhang Y, Chen C, Wang KH, Woolf CJ, He Z

Nature.. 2018 September 561 (7724):547-550. Epub 09/12/2018.

Mechanism and consequence of abnormal calcium homeostasis in Rett syndrome astrocytes.

Dong Q, Liu Q, Li R, Wang A, Bu Q, Wang KH, Chang Q

eLife.. 2018 March 297 Epub 03/29/2018.

Skin suturing and cortical surface viral infusion improves imaging of neuronal ensemble activity with head-mounted miniature microscopes.

Li X, Cao VY, Zhang W, Mastwal SS, Liu Q, Otte S, Wang KH

Journal of neuroscience methods.. 2017 November 1291 :238-248. Epub 08/19/2017.

Deconstruction of Corticospinal Circuits for Goal-Directed Motor Skills.

Wang X, Liu Y, Li X, Zhang Z, Yang H, Zhang Y, Williams PR, Alwahab NSA, Kapur K, Yu B, Zhang Y, Chen M, Ding H, Gerfen CR, Wang KH, He Z

Cell.. 2017 October 5171 (2):440-455.e14. Epub 09/21/2017.

Dopamine is Required for Activity-Dependent Amplification of Arc mRNA in Developing Postnatal Frontal Cortex.

Ye Y, Mastwal S, Cao VY, Ren M, Liu Q, Zhang W, Elkahloun AG, Wang KH

Cerebral cortex.. 2017 July 127 (7):3600-3608. Epub 1900 01 01.

Genetic Disruption of Arc/Arg3.1 in Mice Causes Alterations in Dopamine and Neurobehavioral Phenotypes Related to Schizophrenia.

Managò F, Mereu M, Mastwal S, Mastrogiacomo R, Scheggia D, Emanuele M, De Luca, Weinberger DR, Wang KH, Papaleo F

Cell reports.. 2016 August 2316 (8):2116-2128. Epub 08/11/2016.

Genetic Feedback Regulation of Frontal Cortical Neuronal Ensembles Through Activity-Dependent Arc Expression and Dopaminergic Input.

Mastwal S, Cao V, Wang KH

Frontiers in neural circuits.. 2016 10 :100. Epub 12/06/2016.

CHRNA7 and CHRFAM7A mRNAs: co-localized and their expression levels altered in the postmortem dorsolateral prefrontal cortex in major psychiatric disorders.

Kunii Y, Zhang W, Xu Q, Hyde TM, McFadden W, Shin JH, Deep-Soboslay A, Ye T, Li C, Kleinman JE, Wang KH, Lipska BK

The American journal of psychiatry.. 2015 November 1172 (11):1122-30. Epub 07/24/2015.

Motor Learning Consolidates Arc-Expressing Neuronal Ensembles in Secondary Motor Cortex.

Cao VY, Ye Y, Mastwal S, Ren M, Coon M, Liu Q, Costa RM, Wang KH

Neuron.. 2015 June 1786 (6):1385-92. Epub 06/04/2015.

Phasic dopamine neuron activity elicits unique mesofrontal plasticity in adolescence.

Mastwal S, Ye Y, Ren M, Jimenez DV, Martinowich K, Gerfen CR, Wang KH

The Journal of neuroscience : the official journal of the Society for Neuroscience.. 2014 July 1634 (29):9484-96. Epub 1900 01 01.

Arc regulates experience-dependent persistent firing patterns in frontal cortex.

Ren M, Cao V, Ye Y, Manji HK, Wang KH

The Journal of neuroscience : the official journal of the Society for Neuroscience.. 2014 May 734 (19):6583-95. Epub 1900 01 01.

Experience-induced Arc/Arg3.1 primes CA1 pyramidal neurons for metabotropic glutamate receptor-dependent long-term synaptic depression.

Jakkamsetti V, Tsai NP, Gross C, Molinaro G, Collins KA, Nicoletti F, Wang KH, Osten P, Bassell GJ, Gibson JR, Huber KM

Neuron.. 2013 October 280 (1):72-9. Epub 10/02/2013.

In vivo two-photon imaging of experience-dependent molecular changes in cortical neurons.

Cao VY, Ye Y, Mastwal SS, Lovinger DM, Costa RM, Wang KH

Journal of visualized experiments : JoVE.. 2013 January 5 (71)Epub 01/05/2013.

Dopamine, cognitive function, and gamma oscillations: role of D4 receptors.

Furth KE, Mastwal S, Wang KH, Buonanno A, Vullhorst D

Frontiers in cellular neuroscience.. 2013 7 :102. Epub 07/02/2013.

Optogenetic inactivation modifies monkey visuomotor behavior.

Cavanaugh J, Monosov IE, McAlonan K, Berman R, Smith MK, Cao V, Wang KH, Boyden ES, Wurtz RH

Neuron.. 2012 December 676 (5):901-7. Epub 1900 01 01.

Loss of Arc renders the visual cortex impervious to the effects of sensory experience or deprivation.

McCurry CL, Shepherd JD, Tropea D, Wang KH, Bear MF, Sur M

Nature neuroscience.. 2010 April 13 (4):450-7. Epub 03/14/2010.

Molecular mechanisms underlying neural circuit formation.

Lu B, Wang KH, Nose A

Current opinion in neurobiology.. 2009 April 19 (2):162-7. Epub 05/18/2009.

Differential gene expression between sensory neocortical areas: potential roles for Ten_m3 and Bcl6 in patterning visual and somatosensory pathways.

Leamey CA, Glendining KA, Kreiman G, Kang ND, Wang KH, Fassler R, Sawatari A, Tonegawa S, Sur M

Cerebral cortex.. 2008 January 18 (1):53-66. Epub 05/02/2007.

In vivo two-photon imaging reveals a role of arc in enhancing orientation specificity in visual cortex.

Wang KH, Majewska A, Schummers J, Farley B, Hu C, Sur M, Tonegawa S

Cell.. 2006 July 28126 (2):389-402. Epub 1900 01 01.

Diversity and specificity of actions of Slit2 proteolytic fragments in axon guidance.

Nguyen Ba-Charvet KT, Brose K, Ma L, Wang KH, Marillat V, Sotelo C, Tessier-Lavigne M, Chédotal A

The Journal of neuroscience : the official journal of the Society for Neuroscience.. 2001 June 1521 (12):4281-9. Epub 1900 01 01.

Functional annotation of a full-length mouse cDNA collection.

Kawai J, Shinagawa A, Shibata K, Yoshino M, Itoh M, Ishii Y, Arakawa T, Hara A, Fukunishi Y, Konno H, Adachi J, Fukuda S, Aizawa K, Izawa M, Nishi K, Kiyosawa H, Kondo S, Yamanaka I, Saito T, Okazaki Y, Gojobori T, Bono H, Kasukawa T, Saito R, Kadota K, Matsuda H, Ashburner M, Batalov S, Casavant T, Fleischmann W, Gaasterland T, Gissi C, King B, Kochiwa H, Kuehl P, Lewis S, Matsuo Y, Nikaido I, Pesole G, Quackenbush J, Schriml LM, Staubli F, Suzuki R, Tomita M, Wagner L, Washio T, Sakai K, Okido T, Furuno M, Aono H, Baldarelli R, Barsh G, Blake J, Boffelli D, Bojunga N, Carninci P, de Bonaldo MF, Brownstein MJ, Bult C, Fletcher C, Fujita M, Gariboldi M, Gustincich S, Hill D, Hofmann M, Hume DA, Kamiya M, Lee NH, Lyons P, Marchionni L, Mashima J, Mazzarelli J, Mombaerts P, Nordone P, Ring B, Ringwald M, Rodriguez I, Sakamoto N, Sasaki H, Sato K, Schönbach C, Seya T, Shibata Y, Storch KF, Suzuki H, Toyo-oka K, Wang KH, Weitz C, Whittaker C, Wilming L, Wynshaw-Boris A, Yoshida K, Hasegawa Y, Kawaji H, Kohtsuki S, Hayashizaki Y,

Nature.. 2001 February 8409 (6821):685-90. Epub 1900 01 01.

Biochemical purification of a mammalian slit protein as a positive regulator of sensory axon elongation and branching.

Wang KH, Brose K, Arnott D, Kidd T, Goodman CS, Henzel W, Tessier-Lavigne M

Cell.. 1999 March 1996 (6):771-84. Epub 1900 01 01.

Slit proteins bind Robo receptors and have an evolutionarily conserved role in repulsive axon guidance.

Brose K, Bland KS, Wang KH, Arnott D, Henzel W, Goodman CS, Tessier-Lavigne M, Kidd T

Cell.. 1999 March 1996 (6):795-806. Epub 1900 01 01.