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Chia-Lung Wu, Ph.D.


Showing all 24 journal articles & 2 books available

Journal Articles

Ackerman JE, Best KT, Muscat SN, Pritchett EM, Nichols AEC, Wu CL, Loiselle AE. "Defining the spatial-molecular map of fibrotic tendon healing and the drivers of Scleraxis-lineage cell fate and function." Cell reports.. 2022 Nov 22; 41(8):111706.

Kenney HM, Wu CL, Loiselle AE, Xing L, Ritchlin CT, Schwarz EM. "Single-cell transcriptomics of popliteal lymphatic vessels and peripheral veins reveals altered lymphatic muscle and immune cell populations in the TNF-Tg arthritis model." Arthritis research & therapy.. 2022 Mar 7; 24(1):64. Epub 2022 Mar 07.

Wu CL, Dicks A, Steward N, Tang R, Katz DB, Choi YR, Guilak F. "Single cell transcriptomic analysis of human pluripotent stem cell chondrogenesis." Nature communications.. 2021 Jan 13; 12(1):362. Epub 2021 Jan 13.

Oestreich AK, Collins KH, Harasymowicz NS, Wu CL, Guilak F. "Is Obesity a Disease of Stem Cells?" Cell stem cell.. 2020 Jul 2; 27(1):15-18.

Wu CL, Harasymowicz NS, Klimak MA, Collins KH, Guilak F. "The role of macrophages in osteoarthritis and cartilage repair." Osteoarthritis and cartilage. 2020 May; 28(5):544-554. Epub 2020 Jan 08.

Bailey KN, Furman BD, Zeitlin J, Kimmerling KA, Wu CL, Guilak F, Olson SA. "Intra-articular depletion of macrophages increases acute synovitis and alters macrophage polarity in the injured mouse knee." Osteoarthritis and cartilage. 2020 May; 28(5):626-638. Epub 2020 Feb 08.

Tang R, Harasymowicz NS, Wu CL, Collins KH, Choi YR, Oswald SJ, Guilak F. "Gene therapy for follistatin mitigates systemic metabolic inflammation and post-traumatic arthritis in high-fat diet-induced obesity." Science advances.. 2020 May; 6(19):eaaz7492. Epub 2020 May 08.

Kimmerling KA, Oswald SJ, Huebner JL, Little D, Kraus VB, Kang JX, Wu CL, Guilak F. "Transgenic conversion of ?-6 to ?-3 polyunsaturated fatty acids via fat-1 reduces the severity of post-traumatic osteoarthritis." Arthritis research & therapy.. 2020 Apr 15; 22(1):83. Epub 2020 Apr 15.

Harasymowicz NS, Choi YR, Wu CL, Iannucci L, Tang R, Guilak F. "Intergenerational Transmission of Diet-Induced Obesity, Metabolic Imbalance, and Osteoarthritis in Mice." Arthritis & rheumatology.. 2020 Apr; 72(4):632-644. Epub 2020 Mar 05.

Dicks A, Wu CL, Steward N, Adkar SS, Gersbach CA, Guilak F. "Prospective isolation of chondroprogenitors from human iPSCs based on cell surface markers identified using a CRISPR-Cas9-generated reporter." Stem cell research & therapy.. 2020 Feb 18; 11(1):66. Epub 2020 Feb 18.

Choi, Y.-R.; Collins, K. H.; Springer, L. E.; Pferdehirt, L.; Ross, A. K.; Wu, C.-L.; Moutos, F. T.; Harasymowicz, N. S.; Brunger, J. M.; Pham, C. T. "Genome-engineered Bioartificial Implant for Autoregulated Anti-Cytokine Drug Delivery." bioRxiv. 2019; 535609.

Votava L, Schwartz AG, Harasymowicz NS, Wu CL, Guilak F. "Effects of dietary fatty acid content on humeral cartilage and bone structure in a mouse model of diet-induced obesity." Journal of orthopaedic research : official publication of the Orthopaedic Research Society.. 2019 Mar; 37(3):779-788. Epub 2019 Feb 12.

Harasymowicz NS, Dicks A, Wu CL, Guilak F. "Physiologic and pathologic effects of dietary free fatty acids on cells of the joint." Annals of the New York Academy of Sciences.. 2019 Mar; 1440(1):36-53. Epub 2019 Jan 15.

Adkar SS, Wu CL, Willard VP, Dicks A, Ettyreddy A, Steward N, Bhutani N, Gersbach CA, Guilak F. "Step-Wise Chondrogenesis of Human Induced Pluripotent Stem Cells and Purification Via a Reporter Allele Generated by CRISPR-Cas9 Genome Editing." Stem cells.. 2019 Jan; 37(1):65-76. Epub 2018 Oct 31.

Guilak F, Nims RJ, Dicks A, Wu CL, Meulenbelt I. "Osteoarthritis as a disease of the cartilage pericellular matrix." Matrix biology : journal of the International Society for Matrix Biology.. 2018 Oct; 71-72:40-50. Epub 2018 May 22.

Tang R, Jing L, Willard VP, Wu CL, Guilak F, Chen J, Setton LA. "Differentiation of human induced pluripotent stem cells into nucleus pulposus-like cells." Stem cell research & therapy.. 2018 Mar 9; 9(1):61. Epub 2018 Mar 09.

Adkar SS, Brunger JM, Willard VP, Wu CL, Gersbach CA, Guilak F. "Genome Engineering for Personalized Arthritis Therapeutics." Trends in molecular medicine.. 2017 Oct; 23(10):917-931. Epub 2017 Sep 05.

Wu CL, McNeill J, Goon K, Little D, Kimmerling K, Huebner J, Kraus V, Guilak F. "Conditional Macrophage Depletion Increases Inflammation and Does Not Inhibit the Development of Osteoarthritis in Obese Macrophage Fas-Induced Apoptosis-Transgenic Mice." Arthritis & rheumatology.. 2017 Sep; 69(9):1772-1783. Epub 2017 Aug 08.

Wu CL, Kimmerling KA, Little D, Guilak F. "Serum and synovial fluid lipidomic profiles predict obesity-associated osteoarthritis, synovitis, and wound repair." Scientific reports.. 2017 Mar 20; 7:44315. Epub 2017 Mar 20.

O'Conor CJ, Ramalingam S, Zelenski NA, Benefield HC, Rigo I, Little D, Wu CL, Chen D, Liedtke W, McNulty AL, Guilak F. "Cartilage-Specific Knockout of the Mechanosensory Ion Channel TRPV4 Decreases Age-Related Osteoarthritis." Scientific reports.. 2016 Jul 8; 6:29053. Epub 2016 Jul 08.

Wu CL, Jain D, McNeill JN, Little D, Anderson JA, Huebner JL, Kraus VB, Rodriguiz RM, Wetsel WC, Guilak F. "Dietary fatty acid content regulates wound repair and the pathogenesis of osteoarthritis following joint injury." Annals of the rheumatic diseases.. 2015 Nov; 74(11):2076-83. Epub 2014 Jul 10.

McNeill JN, Wu CL, Rabey KN, Schmitt D, Guilak F. "Life-long caloric restriction does not alter the severity of age-related osteoarthritis." Age.. 2014 36(4):9669. Epub 2014 Jul 01.

Wu CL, Diekman BO, Jain D, Guilak F. "Diet-induced obesity alters the differentiation potential of stem cells isolated from bone marrow, adipose tissue and infrapatellar fat pad: the effects of free fatty acids." International journal of obesity : journal of the International Association for the Study of Obesity.. 2013 Aug; 37(8):1079-87. Epub 2012 Nov 20.

Diekman BO, Wu CL, Louer CR, Furman BD, Huebner JL, Kraus VB, Olson SA, Guilak F. "Intra-articular delivery of purified mesenchymal stem cells from C57BL/6 or MRL/MpJ superhealer mice prevents posttraumatic arthritis." Cell transplantation.. 2013 22(8):1395-408. Epub 2012 Aug 10.

Books & Chapters

Chapter Title: Animal Models of Meniscal Injury in Post-Traumatic Arthritis
Book Title: Post-Traumatic Arthritis
Author List: Wu, C.L., Little D
Edited By: Steven A. Olson, MD; Farshid Guilak, PhD
Published By: Springer2015 in Boston, MA

Chapter Title: Survey of Animal Models in Post-Traumatic Arthritis: Choosing the Right Model to Answer the Right Question
Book Title: Post-Traumatic Arthritis
Author List: Furman D, Kimmerling K, Wu, C.L., Little D
Edited By: Steven A. Olson, MD; Farshid Guilak, PhD
Published By: Springer2015 in Boston, MA