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Shu-Chi Yeh, Ph.D.

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Professional Background

Dr. Yeh earned her Ph.D. in Biomedical Engineering at McMaster University in 2015. Her Ph.D. research in Dr. Qiyin Fang’s laboratory was dedicated to developing machine learning and optical imaging techniques for automatic detection and treatment optimization in Barrett’s Esophagus cellular models. She started the first postdoctoral training in Prof. Giuseppe Intini’s lab at Harvard School of Dental Medicine, and since then, she has been engaged in advancing intravital imaging technologies for studying bone and hematopoietic stem cells. She developed quantitative 3D bone histomorphometry in vivo to track skeletal stem cells for their roles in craniosynostosis and bone regeneration. Her work was recognized by the Dean’s Scholar Award and Outstanding Postdoctoral Award during the two-year fellowship. She then joined Dr. Charles Lin’s laboratory in the Wellman Center for Photomedicine, Massachusetts General Hospital in 2017. In collaboration with Prof. Fernando Camargo at Boston Children’s Hospital, she developed intravital microscopy techniques to investigate bone remodeling and discovered heterogeneous bone turnover that is critical to focal expansion of hematopoietic stem cells (HSCs) and acute myeloid leukemic cells. These findings led to some insightful follow-up investigations to understand the interplay between bone and the hematopoietic compartments, including the development of the first cell-resolution, quantitative calcium imaging for the bone marrow that uncovered varied extracellular calcium tied to bone remodeling and a high calcium ion concentration neighboring primitive HSCs. In Dr. Lin’s group, she has also participated in the research project using two-photon image-guided microbiopsy and orthotopic injection of cell clusters out of or into the bone marrow, a technology developed by Dr. Lin’s lab to allow spatially resolved transcriptomic profiling of the local bone marrow microenvironment. Her proposal to profile the vascular niche in multiple myeloma was recognized by receiving a Fund for Medical Discovery from MGH. She was later promoted to instructor in Harvard Medical School in 2020.


Bone marrow houses hematopoietic stem cells (HSCs) and is also the shelter of hematological malignancies. While bone is a major counterpart in the bone marrow microenvironment, how the two works in concert as a niche, a specialized microenvironment where the stem cells reside, to instruct the fate of HSCs and malignant cells remains to be elucidated. Dr. Yeh’s major research interest is to develop intravital imaging-based approaches for direct visualization, quantifications, and molecular profiling of the local regulatory machineries that harbor the skeletal, hematopoietic, and malignant stem cells. The long-term goal is to identify distinct pathways in the bone marrow microenvironment that can be targeted to confront hematopoietic malignancy and aging.


Merit Abstract and Travel Award
Sponsor: International Society for Stem Cell Research

2018 - 2019
Fund for Medical Discovery Award
Sponsor: Massachusetts General Hospital

Outstanding Postdoctoral Award
Sponsor: Harvard Medical School and School of Dental Medicine

2015 - 2017
Dean's Scholar Award
Sponsor: Harvard School of Dental Medicine

NSERC Michael Smith Foreign Study Supplement
Sponsor: Natural Sciences and Engineering Research Council of Canada
Location: France

2012 - 2014
NSERC Alexander Graham Bell CGS-D
Sponsor: Natural Sciences and Engineering Research Council of Canada

2011 - 2012
Ontario Graduate Scholarship
Sponsor: Government of Ontario

2010 - 2011
Queen Elizabeth II Graduate Scholarship in Science and Technology
Sponsor: Government of Ontario

2009 - 2010
NSERC Alexander Graham Bell CGS-M
Sponsor: Natural Sciences and Engineering Research Council of Canada

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Journal Articles

Zhang H, Liesveld JL, Calvi LM, Lipe BC, Xing L, Becker MW, Schwarz EM, Yeh SA. "The roles of bone remodeling in normal hematopoiesis and age-related hematological malignancies." Bone research.. 2023 Mar 14; 11(1):15. Epub 2023 Mar 14.

Haase C, Gustafsson K, Mei S, Yeh SC, Richter D, Milosevic J, Turcotte R, Kharchenko PV, Sykes DB, Scadden DT, Lin CP. "Image-seq: spatially resolved single-cell sequencing guided by in situ and in vivo imaging." Nature methods.. 2022 Nov 24; Epub 2022 Nov 24.

Yeh SA, Hou J, Wu JW, Yu S, Zhang Y, Belfield KD, Camargo FD, Lin CP. "Publisher Correction: Quantification of bone marrow interstitial pH and calcium concentration by intravital ratiometric imaging." Nature communications.. 2022 Mar 17; 13(1):1563. Epub 2022 Mar 17.