Cardiovascular Function and Disease

Atherosclerosis
Heart Failure
Lung Biology
Cardiovascular Inflammation

The rapid advances in understanding the basic mechanisms responsible for normal function of the cardiovascular system have provided multiple approaches to study pathophysiology of cardiovascular disease. The overall goal of cardiovascular research is to understand how the cardiovascular system develops and responds to physiological and pathological changes. Understanding these processes will provide insight into new therapeutic approaches to treat diseases such as hypertension, coronary artery disease, atherosclerosis, stroke, myocardial infarction, and arrhythmias.

	Jun-Ichi Abe, M.D., Ph.D. Mechanism and significance of kinase and transcriptional factors in diabetes-related cardiovascular disease. View Full Profile
	Bradford C. Berk, M.D., Ph.D. Molecular biology and genetics of cardiovascular disease. View Full Profile
	Burns C. Blaxall, Ph.D. Cardiac gene expression and G-protein coupled receptor signaling. View Full Profile
	Paul S. Brookes, Ph.D. Mitochondrial interactions with free radicals (nitric oxide, superoxide) in the context of myocardial ischemia reperfusion. View Full Profile
	Robert T. Dirksen, Ph.D. Calcium channel structure and function. View Full Profile
	Keigi Fujiwara, Ph.D. Molecular mechanism of mechano-signaling and response by endothelial cells, especially the role of cytoskeleton and intercellular adhesion molecules. View Full Profile
	Angela J. Glading, Ph.D. Regulation of cell-cell contact in health and disease. View Full Profile
	Denise C. Hocking, Ph.D. Regulation of cell behavior by the extracellular matrix. View Full Profile
	Zheng-Gen Jin, Ph.D. Molecular regulation of vascular endothelial function and vascular diseases. View Full Profile
	Coeli M.B. Lopes, Ph.D. Molecular mechanisms of cardiac potassium channel regulation in health and disease. View Full Profile
	George A. Porter, Jr., M.D., Ph.D. Regulation of cardiac development by intracellular calcium signaling and mitochondrial biogenesis. View Full Profile
	Ingrid H. Sarelius, Ph.D. Vascular cell communication and signaling. View Full Profile
	Alan V. Smrcka, Ph.D. Molecular mechanisms of signal transduction. View Full Profile
	Jane Sottile, Ph.D. Molecular mechanisms by which the extracellular matrix controls cell behavior. View Full Profile
	Richard E. Waugh, Ph.D. Regulation and molecular basis of the mechanical stability of cells, cell membranes, and cell adhesion. View Full Profile
	Chen Yan, Ph.D. Regulation and function of cyclic nucleotide phosphodiesterases in the cardiovascular system. View Full Profile
	Yisang Yoon, Ph.D. Cell biology of mitochondria: Regulation of mitochondrial dynamics. View Full Profile