
Welcome to the Gail Johnson Lab
The primary focus of Dr. Gail Johnson’s research group is on the molecular mechanisms of neurodegeneration. The lab has a longstanding interest in the pathogenic processes in Alzheimer disease, and more recently in stroke and spinal cord injury (SCI). For their studies they use a wide variety of different approaches from in vitro enzyme assays with purified proteins, to studies in whole animals. This broad-based approach allows them to translate what they learn about a process or signaling pathway at the molecular level to the in vivo situation. Each of these 2 areas of research that are ongoing in the lab are discussed briefly below.

Gail V. Johnson, Ph.D.
Principal Investigator
Publications
View All Publications- Tunable Tau Expression in C. elegans Neurons Reveals that Early-AD Tau Phosphorylation Selectively Impacts Behavior and Mitochondrial Quality Control.; bioRxiv : the preprint server for biology. 2026 Jan 28.
- A missing link in the METTL3 chain: Chaperone regulation of METTL3 as a BAG:HSP70 client protein.; Neural regeneration research. 2026 Jan 27.
- BAG3 modulates clathrin-mediated endocytosis and tau uptake in astrocytes.; bioRxiv : the preprint server for biology. 2025 Dec 17.
- Tau clearance reverses touch neuron dysfunction in both young and aged C. elegans.; Journal of Alzheimer's disease : JAD. 2025 Nov 24.
- A Bioinformatic Analysis of BAG Protein Interactors and Pathways in Alzheimer's and Parkinson's Disease.; bioRxiv : the preprint server for biology. 2025 Jul 23.
Contact Us
Gail Johnson Lab
601 Elmwood Ave, Box 604
Rochester, NY 14642