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Yao Lab

Peng Yao, Ph.D.

Peng Yao

Assistant Professor, Department of Medicine, Aab Cardiovascular Research Institute - Primary
2008| Ph.D. | Biochemistry and Molecular Biology | Shanghai Institute of Biochemistry and Cell Biology of Chinese Academy of Science
2003 | BS | Biotechnology | Wuhan University         Yao profile

Research Overview

Regulatory non-coding RNAs and RNA-binding proteins (RBPs) are important research areas in gene regulation and RNA biology. Our laboratory is interested in the understanding of pathophysiological function and molecular mechanism of new non-coding RNAs (and RBPs) and new modes of gene regulation in cardiac system and cardiovascular disease. We recently discovered a new type of stress-responsive, protein-directed human RNA switch that regulates expression of vascular endothelial growth factor-A in human monocytic cells (Ray, PS, et al. Nature 2008 457: 915-919; Yao, P, et al. Plos Biology 2013 11: e1001635) and may play a role in cardiovascular disorders and cancers. Intriguingly, some of these RNA switches involve the interplay between microRNA and RNA-binding protein (Jafarifar, F, et al. EMBO Journal 2011 30: 1324-1334). We also identified a novel mRNA processing mechanism that expands human proteome at the posttranscriptional level and regulates gene expression (Yao, P, et al. Cell 2012 149: 88-100). Our current research interest includes: (1) Pathophysiological function and regulatory mechanism of microRNA (and other noncoding RNA) and RNA-binding proteins in cardiac system and cardiovascular disorders; (2) Riboswitch-like RNA switch mechanisms of gene regulation in mammalian system; (3) The role of translation machinery and translational control in cardiovascular system and identification of therapeutic targets for treatment of cardiovascular diseases (e.g., cardiac hypertrophy and heart failure). We employ various approaches and methods of biochemistry and biophysics, molecular and cellular biology, and genetic and surgical mouse models, to dissect the convergent and divergent regulatory pathways. The long-term objective of our laboratory is to identify novel RNA-based molecular mechanisms that control gene expression and conduct pathophysiological function in cardiac system, as well as to develop novel therapeutic approaches for the prevention or treatment of human cardiovascular diseases.

Recent Publications

  1. Peng Yao, Sandeepa M. Eswarappa, Paul L. Fox. Translational control mechanisms in angiogenesis and vascular biology. Current Atherosclerosis Reports 2015 17: 30
  2. Qian Huang, Xiao-Long Zhou, Qing-Hua Hu, Hui-Yan Lei, Zhi-Peng Fang, Peng Yao, and En-Duo Wang. A bridge between the aminoacylation and editing domains of leucyl-tRNA synthetase is crucial for its synthetic activity. RNA 2014 20: 1440-1450
  3. Peng Yao, Alka A. Potdar, Partho Sarothi Ray, Sandeepa M. Eswarappa, Andrew C. Flagg, Belinda Willard, and Paul L. Fox. The HILDA complex coordinates a conditional switch in the 3´-untranslated region of the VEGFA mRNA. Plos Biology 2013 11: e1001635
  4. Hao Zhou, Minjia Yu, Koichi Fukuda, Jinteak Im, Peng Yao, Wei Cui, Katarzyna Bulek, Jarod Zepp, Youzhong Wan, Tae Whan Kim, Weiguo Yin, Victoria Ma, James Thomas, Jun Gu, Jian-an Wang, Paul E DiCorleto, Paul L Fox, Jun Qin and Xiaoxia Li. IRAK-M mediates Toll-like receptor/IL-1R-induced NFκB activation and cytokine production. EMBO Journal 2013 32: 583-596
  5. Tomasz Herjan, Peng Yao, Wen Qian, Xiao Li, Caini Liu, Katarzyna Bulek, Dongxu Sun, Wen-Pin Yang, Jun Zhu, Aiqing He, Julie A. Carman, Serpil C. Erzurum, Howard D. Lipshitz, Paul L. Fox, Thomas A. Hamilton and Xiaoxia Li. HuR is required for IL-17-induced Act1-mediated CXCL1 and CXCL5 mRNA stabilization. Journal of Immunology 2013 191: 640-649
  6. Peng Yao, Paul L. Fox. Aminoacyl-tRNA synthetases in medicine and disease. EMBO Molecular Medicine 2013 5: 332-343
  7. Peng Yao, Kiran Poruri, Susan A. Martinis, Paul L. Fox. Non-catalytic regulation of gene expression by aminoacyl-tRNA synthetases. Topics in Current Chemistry 2013 344: 167-187 (Springer)
  8. Jie Jia, Peng Yao, Abul Arif, and Paul L. Fox. Regulation and dysregulation of 3´UTR mediated translational control. Current Opinion in Genetics & Development 2013 23: 29-34
  9. Peng Yao, Alka A. Potdar, Abul Arif, Partho Sarothi Ray, Rupak Mukhopadhyay, Belinda Willard, Yichi Xu, Jun Yan, Gerald M. Saidel, and Paul L. Fox. Coding region polyadenylation generates a truncated tRNA synthetase that counters translation repression. Cell 2012 149: 88-100
  10. Peng Yao, Paul L. Fox. A truncated tRNA synthetase directs a ‘translational trickle’ of gene expression. Cell Cycle 2012 11: 10
  11. Qian Huang, Peng Yao, Gilbert Eriani, En-Duo Wang. In vivo identification of essential nucleotides in tRNALeu to its functions by using a constructed yeast tRNALeu knockout strain.  Nucleic Acids Research 2012 40: 10463-10477

More papers: PubMed