URMC / Cardiovascular Research Institute / Research / Yao Lab / Publications Recent Publications Wu JHollinger JBonanno EJiang FYao P Cardiomyocyte-specific Loss of Glutamyl-prolyl-tRNA Synthetase Leads to Disturbed Protein Homeostasis and Dilated Cardiomyopathy.; bioRxiv : the preprint server for biology. 2023 Sep 22. Wu JSubbaiah KCVHedaya OChen SMunger JTang WHWYan CYao P FAM210A regulates mitochondrial translation and maintains cardiac mitochondrial homeostasis.; Cardiovascular research. 2023 Jul 31. Hollinger JWu JAwayda KMO'Connell MRYao P Expression and purification of the mitochondrial transmembrane protein FAM210A in Escherichia coli.; Protein expression and purification; Vol 210, pp. 106322. 2023 Jun 15. Hedaya OMSubbaiah KCVJiang FXie LHWu JKhor EZhu MMathews DHProschel CYao P Secondary structures that regulate mRNA translation provide insights for ASO-mediated modulation of cardiac hypertrophy.; bioRxiv : the preprint server for biology. 2023 Jun 15. Wu JSubbaiah KCVHedaya OChen SMunger JTang WHWYan CYao P FAM210A Regulates Mitochondrial Translation and Maintains Cardiac Mitochondrial Homeostasis.; bioRxiv : the preprint server for biology. 2023 May 22. Jiang FHedaya OMKhor EWu JAuguste MYao P RNA binding protein PRRC2B mediates translation of specific mRNAs and regulates cell cycle progression.; Nucleic acids research. 2023 May 01. Subbaiah KCVWu JTang WHWYao P Ciclopirox Inhibition of eIF5A Hypusination Attenuates Fibroblast Activation and Cardiac Fibrosis.; Journal of cardiovascular development and disease; Vol 10(2). 2023 Jan 29. Subbaiah KCVWu JTang WHWYao P FAM114A1 influences cardiac pathological remodeling by regulating angiotensin II signaling.; JCI insight. 2022 Jun 07. Wu JVenkata Subbaiah KCJiang FHedaya OMohan AYang TWelle KGhaemmaghami STang WHWSmall EYan CYao P MicroRNA-574 regulates FAM210A expression and influences pathological cardiac remodeling.; EMBO molecular medicine. 2020 Dec 28. Lyu QRYao PMiano JM Generating a CRISPR knockout mouse through a strong premature termination codon: a cautionary tale.; Journal of biomedical research; Vol 35(2). 2020 Dec 25. Wu JSubbaiah KCVXie LHJiang FKhor ESMickelsen DMMyers JRTang WWYao P Glutamyl-Prolyl-tRNA Synthetase Regulates Proline-Rich Pro-fibrotic Protein Synthesis During Cardiac Fibrosis.; Circulation research. 2020 Jul 01. Zhao SDejanovic DYao PBhilocha SSadler TSchirbel AWest GDoyon GLopez RMao RKurada SEl Ouali SGrassl GFox PLCruise MWorthley DLde la Motte CFiocchi CRieder F Selective deletion of MyD88 signaling in α-SMA positive cells ameliorates experimental intestinal fibrosis via post-transcriptional regulation.; Mucosal immunology; Vol 13(4). 2020 Jul. Yao PFox PL Aminoacyl-tRNA synthetases in cell signaling.; The Enzymes; Vol 48. 2020. Ji CLi YKittredge AHopiavuori AWard NYao PFukuda YZhang YTsang SHYang T Investigation and Restoration of BEST1 Activity in Patient-derived RPEs with Dominant Mutations.; Scientific reports; Vol 9(1). 2019 Dec 13. Chen SZhang YLighthouse JKMickelsen DMWu JYao PSmall EMYan C A Novel Role of Cyclic Nucleotide Phosphodiesterase 10A in Pathological Cardiac Remodeling and Dysfunction.; Circulation. 2019 Dec 05. Venkata Subbaiah KCWu JPotdar AYao P hnRNP L-mediated RNA switches function as a hypoxia-induced translational regulon.; Biochemical and biophysical research communications; Vol 516(3). 2019 Aug 27. Venkata Subbaiah KCHedaya OWu JJiang FYao P Mammalian RNA switches: Molecular rheostats in gene regulation, disease, and medicine.; Computational and structural biotechnology journal; Vol 17. 2019. Halawani DGogonea VDiDonato JAPipich VYao PChina ATopbas CVasu KArif AHazen SLFox PL Structural control of caspase-generated glutamyl-tRNA synthetase by appended noncatalytic WHEP domains.; The Journal of biological chemistry; Vol 293(23). 2018 Jun 08. Arif AYao PTerenzi FJia JRay PSFox PL The GAIT translational control system.; Wiley interdisciplinary reviews. RNA; Vol 9(2). 2018 Mar. Techasintana PEllis JSGlascock JGubin MMRidenhour SEMagee JDHart MLYao PZhou HWhitney MSFranklin CLMartindale JLGorospe MDavis WJFox PLLi XAtasoy U The RNA-Binding Protein HuR Posttranscriptionally Regulates IL-2 Homeostasis and CD4+ Th2 Differentiation.; ImmunoHorizons; Vol 1(6). 2017 Aug 01. Yao PWu JLindner DFox PL Interplay between miR-574-3p and hnRNP L regulates VEGFA mRNA translation and tumorigenesis.; Nucleic acids research. 2017 May 17. Yao PEswarappa SMFox PL "Translational control mechanisms in angiogenesis and vascular biology."; Current Atherosclerosis Reports. 2015 Jan 01. Huang QZhou XHu QLei HFang ZYao PWang AE "A bridge between the aminoacylation and editing domains of leucyl-tRNA synthetase is crucial for its synthetic activity."; RNA; Vol 20, pp. 1440-1450. 2014 Jan 01. Jia JYao PArif AFox PL Regulation and dysregulation of 3'UTR-mediated translational control.; Current opinion in genetics & development; Vol 23(1). 2013 Feb. Yao PPotdar AARay PSEswarappa SMFlagg ACWillard BFox PL The HILDA complex coordinates a conditional switch in the 3'-untranslated region of the VEGFA mRNA.; PLoS biology; Vol 11(8). 2013. Zhou HYu MFukuda KIm JYao PCui WBulek KZepp JWan YKim TWYin WMa VThomas JGu JWang JDiCorleto PEFox PLQin JLi AX "IRAK-M mediates Toll-like receptor/IL-1R-induced NFkB activation and cytokine production."; EMBO Journal; Vol 32, pp. 583-596. 2013 Jan 01. Herjan TYao PQian WLi XLiu CBulek KSun DYang WZhu JHe ACarman JAErzurum SCLipshitz HDFox PLHamilton TALi AX "HuR is required for IL-17-induced Act1-mediated CXCL1 and CXCL5 mRNA stabilization."; Journal of Immunology; Vol 191, pp. 640-649. 2013 Jan 01. Yao PFox PL "Aminoacyl-tRNA synthetases in medicine and disease."; EMBO Molecular Medicine; Vol 5, pp. 332-343. 2013 Jan 01. Yao PPoruri KMartinis SAFox PL "Non-catalytic regulation of gene expression by aminoacyl-tRNA synthetases."; Topics in Current Chemistry; Vol 344, pp. 167-187. 2013 Jan 01. Yao PPotdar AAArif ARay PSMukhopadhyay RWillard BXu YYan JSaidel GMFox PL Coding region polyadenylation generates a truncated tRNA synthetase that counters translation repression.; Cell; Vol 149(1). 2012 Mar 30. Yao PFox PL "A truncated tRNA synthetase directs a 'translational trickle' of gene expression."; Cell Cycle; Vol 11. 2012 Jan 01. Huang QYao PEriani GWang E "In vivo identification of essential nucleotides in tRNALeu to its functions by using a constructed yeast tRNALeu knockout strain."; Nucleic Acids Research; Vol 40, pp. 10463-10477. 2012 Jan 01. Jafarifar FYao PEswarappa SMFox PL "Repression of VEGFA by CA-rich element-binding microRNAs is modulated by hnRNP L."; EMBO Journal; Vol 30:, pp. 1324-1334. 2011 Jan 01. Chen XMa JTan MYao PHu QEriani GWang E "Modular pathways for editing non-cognate amino acids by human cytoplasmic leucyl-tRNA synthetase."; Nucleic Acids Research; Vol 39:, pp. 235-247. 2011 Jan 01. Yao PFox PL "Sex lethal and upstream ORFs: a bait-and-trap system for ribosomes."; Genome Biology; Vol 12:(12). 2011 Jan 01. Yin WWan YKim TWYao PXiao HZhou HXiao JFox PLi X "The kinase activity of interleukin-1 receptor-associated kinase 2 is essential for lipopolysaccharide-mediated cytokine and chemokine mRNA stability and translation."; J Interferon Cytokine Research; Vol 31:, pp. 415-422. 2011 Jan 01. Zhu BYao PTan MEriani GWang ED tRNA-independent pretransfer editing by class I leucyl-tRNA synthetase.; The Journal of biological chemistry; Vol 284(6). 2009 Feb 06. Zhou XYao PZhu BRuan LWang E "A unique insertion in the CP1 domain of Giardia lamblia leucyl-tRNA synthetase."; Biochemistry; Vol 48:, pp. 1340-1347. 2009 Jan 01. He RZu LYao PChen XWang E "Two non-redundant fragments in the N-terminal peptide of human cytosolic methionyl-tRNA synthetase were indispensable for the multi-synthetase complex incorporation and enzyme activity."; Biochimica et Biophysica Acta; Vol 1794:, pp. 347-354. 2009 Jan 01. Ray PSJia JYao PMajumder MHatzoglou MFox PL "A stress-responsive RNA switch regulates VEGFA expression."; Nature; Vol 457:, pp. 915-919. 2008 Jan 01. Yao PZhou XHe RXue MZheng YWang YWang E "Unique residues crucial for optimal editing in the yeast cytoplasmic leucyl-tRNA synthetase revealed by a novel knockout yeast strain."; Journal of Biological Chemistry; Vol 283:, pp. 22591-22600. 2008 Jan 01. Yao PZhu BJaeger SEriani GWang E "Recognition of tRNALeu by Aquifex aeolicus leucyl-tRNA synthetase during aminoacylation and editing steps."; Nucleic Acids Research; Vol 36:, pp. 2728-2738. 2008 Jan 01.