Training Grant (T32)
Beginning in 2006, the Center was awarded a T32 training grant entitled ‘Training in Orthopaedic Research’. This Program, which currently provides support to 6 pre- and 2 post-doctoral trainees, is designed to enable us to accomplish a key mission in the Center for Musculoskeletal Research: To provide comprehensive training in musculoskeletal science with the aim of developing outstanding investigators in the field of orthopaedic research. In addition to providing the trainees with continued access to outstanding research opportunities that are described in the Research Programs link, the participating faculty utilizes several key training components that have been highly successful since the inception of the program:
- Center-wide Lab Meetings (2/week)
- The Foundations of Orthopaedic Science Curriculum (3 course series)
- Four concurrently running Journal Clubs
- Trainee access to a Grant Writing/Specific Aims Development Core
- A Visiting Scientist Seminar Series
- An annual Center for Musculoskeletal Research Symposium
(Dr. J. Edward Puzas)
(Dr. Edward Schwarz)
(Dr. Edward Schwarz)
(Dr. Matthew Hilton)
(Dr. Hani Awad)
Yan Xiu, MD
(Dr. Brendan Boyce)
Formal Training Activities
Center Lab Meetings occur weekly on Tuesday and Wednesday mornings. Each meeting is moderated by 2 trainees who take 30 minutes each to present either ‘dirty data’ for discussion of troubleshooting and research direction or formal presentations which provide background, hypotheses, experimental strategies, results and conclusions regarding a single project.
The Foundations of Orthopaedic Science Curriculum, which was developed specifically for trainees in our Center, is a cornerstone of the Program. It is a three course series (IND592, IND593, IND594). All Center for Musculoskeletal Research trainees (graduate or medical students, residents, post-doctoral fellows and technical staff as well as T32-supported trainees) attend the lectures.
Journal Clubs meet on a biweekly basis. The presenter at each Journal Club meeting is a student or fellow and the paper to be discussed (not more than 6 months past publication) is chosen by the trainee in consultation with their faculty mentor. During the meeting, the presenter is responsible for providing enough background to bring the group up to speed on the specific topic and then moderates the group’s discussion of each figure and how it contributes to the overall conclusion(s) of the study.
The William F. Neuman Visiting Scientist Seminar Series features invited distinguished speakers on a monthly basis. Over the past 5 years, we have been able to invite numerous internationally recognized skeletal biologists including Drs. Lawrence Raisz, Clifford Rosen, Nancy Lane, Christopher Evans, Ernesto Canalis, Mone Zaidi, David Roodman, Toshiyuki Yoneda, Larry Suva, Robert Gulberg, Tom Einhorn, Daniel Baron, Ian Cassady, Dan Gazit, Robert Heaney, Dana Gaddy, Larry Riggs, Roberto Pacifici, Greg Mundy, Robert Lindsay, Gerard Karsenty, Matt Warman, Henry Kronenberg, Maurizio Pacifici, Ben Alman and numerous others.
The annual Center for Musculoskeletal Research Symposium is a new initiative that takes place each summer. The Symposium includes several components including a poster session for all trainees in the Center (including the T32-supported trainees) as well as trainees outside the Center performing musculoskeletal research, two Plenary sessions with 45 minute presentations by faculty, a visiting keynote speaker, and two trainee travel awards (1 pre- and 1 post-doctoral).
Overall, the combination of these 5 programmatic components will continue to provide trainees with an outstanding educational experience that compliments and extends the research-specific training received from the individual research mentors/Program faculty.
- URMC Orthopaedics Ranks No. 1 in Nation in NIH Funding
March 15, 2013
Musculoskeletal Research Lab Earns Spotlight at National Meeting
October 12, 2012
- Laura Calvi, MD Receives the Fuller Albright Esteemed Award
October 2, 2012
- NIH Awards $7.5M, Designates URMC Orthopaedics as Center of Research Translation
August 30, 2012
- URMC Leads International Consortium to Fight Deadly Bone Infections
April 17, 2012
- Edward Schwarz, PhD, to head The Center for Musculoskeletal Research
December 15, 2011
8:00 am - 9:30 am
May 22, 2013
Tim Rutkowski - The Notch Target Genes, Hes1 and Hes5, Can Regulate Sox9 Expression during Skeletal Development
CuiCui Wang - Investigating the role of NOTCH signaling in fracture repair
Zhaoyang Liu - Investigating the role of Notch signaling in articular cartilage and joint maintenance