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Del Monte Institute for Neuroscience / IDD Research Center / Scientific Cores / Translational Neuroimaging and Neurophysiology

 

Translational Neuroimaging and Neurophysiology

Subject in MoBI setup with Drs. Foxe and Freedman

Director: Jianhui Zhong, Ph.D., Co-Directors: Ed Freedman, Ph.D.Madalina Tivarus, Ph.D.

Objectives

mock scanner in UR CABIN showing characters from Finding NemoThe Translational Neuroimaging and Neurophysiology (TNN) Core provides UR-IDDRC investigators with priority access to fully modernized high-quality multimodality human and small animal neuroimaging and neurophysiological recording facilities, with a primary emphasis on specialized resources to accommodate measurements in difficult-to-test vulnerable pediatric IDD populations. In addition to next-generation hardware solutions, software and applications, TNN houses technical support staff with a comprehensive array of expertise in the design, implementation, acquisition and analysis of neuroimaging and high-density EEG data. The epicenter of TNN is the Center for Advanced Brain Imaging and Neurophysiology (UR-CABIN), a dedicated 32,000 sq. ft. building, which has undergone a complete renovation and modernization over the past 24 months. CABIN houses a 3-Tesla state-of-art MRI system (dual transmission, 64 channel receivers, advanced gradients 80/200) for use with humans and large non-human primates. In addition, there are specialized facilities for ultra-high-density electrophysiology (hd-EEG), high-resolution eye-tracking facilities, mobile brain-body imaging (MoBI), an augmented and virtual reality (AR/VR) facility, 3D morphometric imaging capabilities, and extensive additional support services. A 9.4T small animal multi-nuclei MRI scanner with PET insert will be operational by early 2023.

Specific aims of the TNN Core include:

  • Provide turnkey access to state-of-the-art human and animal neuro-imaging tools optimized to address unique IDD-related experimental needs.
  • Provide prioritized access to ultra-high-density electrophysiologic recording facilities, including novel mobile-brain-body-imaging (MoBI) capabilities.
  • Make funds available for piloting new MRI/EEG projects.
  • Develop a broad, deep and highly accessible repository of data relating to normal development and disease states, in concert with the other IDDRC cores.
  • Develop novel data acquisition and analysis methods relevant to IDDRC projects.

How to Access the Core

To initiate an imaging study utilizing the TNN Core, IDDRC investigators are directed to guidelines for creating a proposal that is available on the CABIN website. An essential part of this process is consultation between the PI and a senior faculty member within the TNN Core. The extent of the consultation will vary based on the expertise of the PI in executing imaging and/or EEG studies, but TNN Core faculty are prepared to provide expertise in the design of a proposed study and assessing its feasibility. This process includes identification of any unique needs of a proposal, such as modifications of MR pulse sequences. Imaging provides a sophisticated and diverse palette of phenotyping measures. To maximize the yield from this data, the TNN Core collaborates with the Human Phenotyping and Recruitment (HPR) Core to maintain a comprehensive database of measures acquired on human subjects. Subject to administrative approval, IDDRC members can mine this database with respect to imaging as well as other clinical data.
A biweekly TNN user-group meeting led by Profs. Zhong and Freedman (Director and Co-Director of the TNN) provides a forum for both seasoned and new investigators to present new protocol ideas, discuss analysis approaches, and get feedback on pilot projects. Current and aspiring TNN users can benefit from the input of the Core leadership and their colleagues. All Core staff, including the MRI technologist, attend this meeting.


TNN Core Fee Schedule for Chargebacks

Type of Service

IDDRC Rate

non-IDDRC Rate

Human 3.0 Tesla MRI

$400/hr

$625/hr

Human 0.0 Tesla Mock MRI

Free

$40/hr

MoBI room

$150/hr

$300/hr

Eye Tracking

Free

$40/hr

Small animal MRI (operational early 2023)

$150/hr

$300/hr