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Edward G. Freedman, Ph.D.

Contact Information

Phone Numbers

Office: (585) 273-1892

Research Labs

Faculty Appointments

Biography

Research

Effects of mild traumatic brain injury (sports-related concussion) on eye-head-hand coordination.

Sports-related concussions (mild traumatic brain injuries or mTBI) are estimated to occur between 1.6 and 3.8 million times annually in the United States. The dangers of repeated injuries can be severe, particularly if additional impacts occur before full recovery. Prevention, identification, treatment, rehabilitation, and determination of recovery time-points are largely inadequate due to the paucity of parametric factors that can be easily and reliably measured both in the field and in the clinic. The overarching goal of the proposed study is to identify behavioral markers of mTBI that will ultimately help protect athletes from the dangers of premature return to full activity by tracking and facilitating recovery after injury. To accomplish this, a battery of visual-spatial tasks has been designed that require coordination of the eyes, head and hand and address sensorimotor plasticity, spatial working memory, and visuo-spatial orientation. These particular tasks have been selected because they permit a focused assessment of a variety of critical brain functions. Functions that when disrupted by mTBI can result in disorientation, dysmetria, and dyscoordination and are often symptoms of mild TBI in human subjects as well as in animal models of TBI. Careful analysis of movement kinematics and coordination during eye-head-hand orienting movements, movements to remembered target locations, visual guidance and control of hand trajectories, and tasks that require adaptive plasticity of coordination will yield parameters that pinpoint effects of mTBI, its progression and recovery to an extent that existing clinical exams and tests do not allow.

Credentials

Education

1986
BS | Brown University
Biology

1992
MS | Cornell University
Neurobiology

1996
PhD | Univ of Pennsylvania
Neuroscience

Post-doctoral Training & Residency

1997 - 1999
Post-doctoral Fellow, Univ. of Washington, Seattle WA

1996 - 1997
Post-doctoral Fellow, Univ. of Pennsylvania, Philadelphia PA.

Awards

2002
NSF CAREER Award

2001
Alfred P. Sloan Research Fellow.

1997
Donald B. Lindsley Prize in Behavioral Neuroscience, (The Grass Foundation/The Society for Neuroscience).

1997
Saul Winegrad, M.D. Award for outstanding dissertation (Neuroscience) - Biomedical Graduate Studies,
Location: Univ. of Pennsylvania.

1996
Louis B. Flexner Award for outstanding dissertation research - Institute of Neurological Sciences,
Location: Univ. of Pennsylvania

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Publications

Journal Articles

9/27/2019
Mazurek KA, Richardson D, Abraham N, Foxe JJ, Freedman EG. "Utilizing high-density electroencephalography and motion capture technology to characterize sensorimotor integration while performing complex actions." IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society.. 2019 Sep 27; Epub 2019 Sep 27.

8/12/2019
Hagler DJ, Hatton S, Cornejo MD, Makowski C, Fair DA, Dick AS, Sutherland MT, Casey BJ, Barch DM, Harms MP, Watts R, Bjork JM, Garavan HP, Hilmer L, Pung CJ, Sicat CS, Kuperman J, Bartsch H, Xue F, Heitzeg MM, Laird AR, Trinh TT, Gonzalez R, Tapert SF, Riedel MC, Squeglia LM, Hyde LW, Rosenberg MD, Earl EA, Howlett KD, Baker FC, Soules M, Diaz J, de Leon OR, Thompson WK, Neale MC, Herting M, Sowell ER, Alvarez RP, Hawes SW, Sanchez M, Bodurka J, Breslin FJ, Morris AS, Paulus MP, Simmons WK, Polimeni JR, van der Kouwe A, Nencka AS, Gray KM, Pierpaoli C, Matochik JA, Noronha A, Aklin WM, Conway K, Glantz M, Hoffman E, Little R, Lopez M, Pariyadath V, Weiss SR, Wolff-Hughes DL, DelCarmen-Wiggins R, Feldstein Ewing SW, Miranda-Dominguez O, Nagel BJ, Perrone AJ, Sturgeon DT, Goldstone A, Pfefferbaum A, Pohl KM, Prouty D, Uban K, Bookheimer SY, Dapretto M, Galvan A, Bagot K, Giedd J, Infante MA, Jacobus J, Patrick K, Shilling PD, Desikan R, Li Y, Sugrue L, Banich MT, Friedman N, Hewitt JK, Hopfer C, Sakai J, Tanabe J, Cottler LB, Nixon SJ, Chang L, Cloak C, Ernst T, Reeves G, Kennedy DN, Heeringa S, Peltier S, Schulenberg J, Sripada C, Zucker RA, Iacono WG, Luciana M, Calabro FJ, Clark DB, Lewis DA, Luna B, Schirda C, Brima T, Foxe JJ, Freedman EG, Mruzek DW, Mason MJ, Huber R, McGlade E, Prescot A, Renshaw PF, Yurgelun-Todd DA, Allgaier NA, Dumas JA, Ivanova M, Potter A, Florsheim P, Larson C, Lisdahl K, Charness ME, Fuemmeler B, Hettema JM, Maes HH, Steinberg J, Anokhin AP, Glaser P, Heath AC, Madden PA, Baskin-Sommers A, Constable RT, Grant SJ, Dowling GJ, Brown SA, Jernigan TL, Dale AM. "Image processing and analysis methods for the Adolescent Brain Cognitive Development Study." NeuroImage.. 2019 Aug 12; :116091. Epub 2019 Aug 12.

4/9/2019
Brima T, Molholm S, Molloy CJ, Sysoeva OV, Nicholas E, Djukic A, Freedman EG, Foxe JJ. "Auditory sensory memory span for duration is severely curtailed in females with Rett syndrome." Translational psychiatry.. 2019 Apr 9; 9(1):130. Epub 2019 Apr 09.

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