Healthy Living

Do You Still Need Your Antidepressant? What to Know Before You Stop

Oct. 29, 2026

Key Takeaways

  • Psychiatric medications should be reassessed regularly.
  • Feeling better doesn’t necessarily mean it’s time to stop a medication.
  • Some people experience withdrawal, or discontinuation symptoms, when they reduce or stop certain psychiatric medications.
  • Never stop or change a psychiatric medication on your own.
  • Deprescribing includes a detailed review of your medication plan to see if anything needs to be reduced or discontinued.
Do you have to take antidepressants forever? The answer isn’t the same for everyone, explains psychiatric medication expert Jane Sundberg, PharmD, BCPP of University of Rochester Medicine. Many people do not need to be on antidepressants for life, but feeling better doesn’t necessarily mean it’s time to stop.

If you’re thinking about changing or stopping a psychiatric medication, talk with your healthcare clinician first. Psychiatric medications need to be reassessed when symptoms, treatment goals, and side effects change. That process is called deprescribing—carefully reducing or stopping medication.

Do You Have to Take Antidepressants Forever?

Guidelines encourage continuing antidepressants for at least six months after symptoms resolve, but you may be able to stop treatment after this point.

Whether or not your clinician recommends stopping medication will depend on your history, symptoms, response to treatment, and risk of relapse.

Your clinician may consider your history with mental health challenges, how severe your symptoms were, and whether you have other health conditions. If you have experienced depression that returned after stopping medication in the past, they might suggest continuing treatment for longer.

It’s important to remember that feeling better is a sign that treatment may be working. It doesn’t necessarily mean you no longer need medication. Your healthcare expert can help you weigh the benefits of continuing treatment against potential side effects and other concerns.

What Happens When You Stop Antidepressants?

“Stopping antidepressants can result in discontinuation symptoms,” explains Dr. Sundberg. “Tapering the medication gradually can help reduce the risk of these symptoms.”

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Potential symptoms can include:

  • Dizziness and headaches
  • Nausea
  • Sleep problems
  • Anxiety/irritability
  • Flu-like feelings


These symptoms can vary depending on the medication, how long you’ve been taking it, and how quickly the dose is reduced. Some people experience mild symptoms, while others may have more severe symptoms that interfere with daily activities.

If symptoms develop while you’re reducing a medication, contact your clinician. They can help determine what’s causing the symptoms and whether your treatment plan needs to change.

Can I Stop Taking an Antidepressant?

Antidepressants should not be stopped cold turkey.

Your clinician can recommend a tapering plan based on the medication you take, your current dose, how you respond to dose changes, and your treatment history. Do not adjust your dose or change your schedule without their guidance.

What Does “Deprescribing” Mean?

Deprescribing is a planned, supervised process to reduce or discontinue medications. It may be recommended when the treatment is no longer necessary, or the risks outweigh the benefits.

Deprescribing can help address side effects, interactions between medications, or changes in your health and treatment goals. It doesn’t necessarily mean stopping a medication completely. Your provider may suggest changing the dose or switching to another medication.

The goal is to find a treatment plan that continues to support your health while avoiding unnecessary risks and symptoms.

How Do You Know When It's Time to Reassess a Psychiatric Medication?

If you think you may want to alter your treatment plan, contact your healthcare clinician. They may reevaluate your medication if you are experiencing:

  • Sustained symptom resolution
  • Partial response—symptoms initially improve, but then stall
  • New or worsening side effects
  • Changes in physical health
  • Major life changes
  • Polypharmacy concerns—when you take multiple medications and their combined effects, interactions, or side effects need to be reviewed

A medication review is also an opportunity to discuss your goals, concerns, and preferences. You can tell your provider if you are worried about side effects, find it difficult to take medication regularly, or want to understand whether other treatments could help.

Before your appointment, consider writing down any new symptoms, changes in your health, and questions about your medication. Bring an up-to-date list of your prescription medications, over-the-counter medicines, and supplements. This will help in assessing your treatment and next steps.

Whether you continue, change, or gradually stop a medication, your treatment plan should reflect your individual needs. You do not have to make that decision alone.


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